On the public citation graph

ARID1A regulates R-loop associated DNA replication stress

https://doi.org/10.1371/journal.pgen.1009238

0 signed · 119 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.ccell.2017.10.007openalex-snapshot

Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

inferredcites →https://doi.org/10.1016/j.ccell.2017.12.011openalex-snapshot

Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

inferredcites →https://doi.org/10.1016/j.ccell.2018.05.002openalex-snapshot

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

inferredcites →https://doi.org/10.1016/j.ccr.2012.05.015openalex-snapshot

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

inferredcites →https://doi.org/10.1016/j.cell.2016.10.001openalex-snapshot

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

inferredcites →https://doi.org/10.1016/j.cell.2017.07.043openalex-snapshot

Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

inferredcites →https://doi.org/10.1016/j.celrep.2016.03.011openalex-snapshot

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

inferredcites →https://doi.org/10.1016/j.celrep.2018.03.093openalex-snapshot

A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor Resistance

inferredcites →https://doi.org/10.1016/j.celrep.2018.05.097openalex-snapshot

The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II

inferredcites →https://doi.org/10.1016/j.celrep.2018.12.084openalex-snapshot

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

inferredcites →https://doi.org/10.1016/j.molcel.2013.10.006openalex-snapshot

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation

inferredcites →https://doi.org/10.1016/j.molcel.2015.09.012openalex-snapshot

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

inferredcites →https://doi.org/10.1016/j.molcel.2019.01.024openalex-snapshot

R-Loops as Cellular Regulators and Genomic Threats

inferredcites →https://doi.org/10.1016/j.trecan.2019.08.006openalex-snapshot

R Loops and Their Composite Cancer Connections

inferredcites →https://doi.org/10.1038/nature12146openalex-snapshot

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

inferredcites →https://doi.org/10.1038/nature13374openalex-snapshot

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

inferredcites →https://doi.org/10.1038/nature25748openalex-snapshot

EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

inferredcites →https://doi.org/10.1038/ncb1895openalex-snapshot

BRIT1/MCPH1 links chromatin remodelling to DNA damage response

inferredcites →https://doi.org/10.1038/ncomms13087openalex-snapshot

Increased global transcription activity as a mechanism of replication stress in cancer

inferredcites →https://doi.org/10.1038/ncomms13837openalex-snapshot

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

inferredcites →https://doi.org/10.1038/ng.3672openalex-snapshot

Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability

inferredcites →https://doi.org/10.1038/nmeth.2089openalex-snapshot

NIH Image to ImageJ: 25 years of image analysis

inferredcites →https://doi.org/10.1038/nsmb.3384openalex-snapshot

TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin

inferredcites →https://doi.org/10.1038/onc.2010.592openalex-snapshot

Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors

inferredcites →https://doi.org/10.1038/s41467-017-01180-5openalex-snapshot

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

inferredcites →https://doi.org/10.1038/s41467-019-12271-wopenalex-snapshot

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

inferredcites →https://doi.org/10.1038/s41467-020-14595-4openalex-snapshot

H3K4 methylation at active genes mitigates transcription-replication conflicts during replication stress

inferredcites →https://doi.org/10.1038/s41586-018-0261-5openalex-snapshot

High speed of fork progression induces DNA replication stress and genomic instability

inferredcites →https://doi.org/10.1038/s41588-017-0015-6openalex-snapshot

Identification of H3K4me1-associated proteins at mammalian enhancers

inferredcites →https://doi.org/10.1056/nejmoa1008433openalex-snapshot

ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

inferredcites →https://doi.org/10.1073/pnas.0912599106openalex-snapshot

Streamlined analysis schema for high-throughput identification of endogenous protein complexes

inferredcites →https://doi.org/10.1083/jcb.201208060openalex-snapshot

The level of origin firing inversely affects the rate of replication fork progression

inferredcites →https://doi.org/10.1083/jcb.201703168openalex-snapshot

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability

inferredcites →https://doi.org/10.1083/jcb.201709121openalex-snapshot

SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks

inferredcites →https://doi.org/10.1093/nar/gkq559openalex-snapshot

BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression

inferredcites →https://doi.org/10.1101/cshperspect.a026930openalex-snapshot

The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer

inferredcites →https://doi.org/10.1101/gad.1180204openalex-snapshot

TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival

inferredcites →https://doi.org/10.1126/sciadv.aaw5294openalex-snapshot

ARID1A spatially partitions interphase chromosomes

inferredcites →https://doi.org/10.1128/mcb.00415-16openalex-snapshot

DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks

inferredcites →https://doi.org/10.1146/annurev-biochem-060815-014908openalex-snapshot

Transcription as a Threat to Genome Integrity

inferredcites →https://doi.org/10.1158/0008-5472.can-17-2056openalex-snapshot

ATR Is a Therapeutic Target in Synovial Sarcoma

inferredcites →https://doi.org/10.1158/1078-0432.ccr-18-4222openalex-snapshot

Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy

inferredcites →https://doi.org/10.1158/2159-8290.cd-14-0849openalex-snapshot

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

inferredcites →https://doi.org/10.1242/jcs.159103openalex-snapshot

BRG1 promotes DNA double-strand break repair by facilitating the replacement of RPA with RAD51

inferredcites →https://doi.org/10.1371/journal.pgen.1005674openalex-snapshot

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

inferredcites →https://doi.org/10.1371/journal.pgen.1008524openalex-snapshot

Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency

inferredcites →https://doi.org/10.3390/ncrna4020009openalex-snapshot

Strengths and Weaknesses of the Current Strategies to Map and Characterize R-Loops

inferredcites →https://doi.org/10.7554/elife.31723openalex-snapshot

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3931637openalex-extracted

inferred← citeshttps://doi.org/10.1002/1873-3468.14947openalex-snapshot

Looping forward: exploring R‐loop processing and therapeutic potential

inferred← citeshttps://doi.org/10.1002/advs.202512074openalex-snapshot

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

inferred← citeshttps://doi.org/10.1002/bies.70025openalex-snapshot

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

inferred← citeshttps://doi.org/10.1002/path.5849openalex-snapshot

Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8 + TIL infiltration, and provides no independent prognostic value in endometriosis‐associated ovarian carcinomas

inferred← citeshttps://doi.org/10.1007/978-3-031-30065-3_14openalex-snapshot

Targeting ATR in Cancer Medicine

inferred← citeshttps://doi.org/10.1007/s00335-026-10211-wopenalex-snapshot

Cancer-associated TRF1 mutations alter PARP1 interaction dynamics: an in silico study

inferred← citeshttps://doi.org/10.1007/s10142-024-01288-0openalex-snapshot

Unscheduled excessive R-loops in immune response

inferred← citeshttps://doi.org/10.1016/j.cell.2024.04.025openalex-snapshot

ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112148openalex-snapshot

DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops

inferred← citeshttps://doi.org/10.1016/j.celrep.2024.113779openalex-snapshot

The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116277openalex-snapshot

ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

inferred← citeshttps://doi.org/10.1016/j.ctrv.2025.102977openalex-snapshot

Clearer Horizons: The latest advances in clear cell ovarian cancer treatment

inferred← citeshttps://doi.org/10.1016/j.dnarep.2021.103199openalex-snapshot

Toxic R-loops: Cause or consequence of replication stress?

inferred← citeshttps://doi.org/10.1016/j.dnarep.2023.103609openalex-snapshot

Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses

inferred← citeshttps://doi.org/10.1016/j.dnarep.2025.103859openalex-snapshot

Harnessing R-loop dynamics: Challenging cancer therapy resistance

inferred← citeshttps://doi.org/10.1016/j.dnarep.2025.103884openalex-snapshot

Inhibition of both SWI/SNF ATPases by BRM014 impairs homologous recombination, sensitizes cells to DNA damage and PARP inhibitors, and activates the cGAS/STING response

inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111161openalex-snapshot

Loss of ATM causes R-loop–associated transcriptional dysregulation and attenuates the related response to DNA damage

inferred← citeshttps://doi.org/10.1016/j.molcel.2022.04.014openalex-snapshot

Walking a tightrope: The complex balancing act of R-loops in genome stability

inferred← citeshttps://doi.org/10.1016/j.molcel.2022.05.004openalex-snapshot

Hallmarks of DNA replication stress

inferred← citeshttps://doi.org/10.1038/s12276-021-00673-0openalex-snapshot

Bromodomain proteins: protectors against endogenous DNA damage and facilitators of genome integrity

inferred← citeshttps://doi.org/10.1038/s41388-024-03179-xopenalex-snapshot

GLTSCR1 deficiency promotes colorectal cancer development through regulating non-homologous end joining

inferred← citeshttps://doi.org/10.1038/s41388-025-03539-1openalex-snapshot

ARID1A: gene, protein, and function in endometrial cancer

inferred← citeshttps://doi.org/10.1038/s41467-021-27530-yopenalex-snapshot

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability

inferred← citeshttps://doi.org/10.1038/s41467-023-42653-0openalex-snapshot

The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

inferred← citeshttps://doi.org/10.1038/s41467-024-51784-xopenalex-snapshot

RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability

inferred← citeshttps://doi.org/10.1038/s41467-024-55637-5openalex-snapshot

KLF5 loss sensitizes cells to ATR inhibition and is synthetic lethal with ARID1A deficiency

inferred← citeshttps://doi.org/10.1038/s41467-025-59804-0openalex-snapshot

ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer

inferred← citeshttps://doi.org/10.1038/s41467-026-69479-wopenalex-snapshot

SFPQ directs histone H3.3 deposition to R-loops in DNA repeats to protect genome stability

inferred← citeshttps://doi.org/10.1038/s41573-022-00558-5openalex-snapshot

Targeting replication stress in cancer therapy

inferred← citeshttps://doi.org/10.1038/s41580-022-00474-xopenalex-snapshot

Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

inferred← citeshttps://doi.org/10.1038/s41588-021-00884-1openalex-snapshot

SWI/SNF complexes as determinants of R-loop metabolism

inferred← citeshttps://doi.org/10.1042/bst20210691openalex-snapshot

The role of chromatin at transcription-replication conflicts as a genome safeguard

inferred← citeshttps://doi.org/10.1080/23723556.2021.1976582openalex-snapshot

The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential

inferred← citeshttps://doi.org/10.1093/g3journal/jkac142openalex-snapshot

Integrative analysis and prediction of human R-loop binding proteins

inferred← citeshttps://doi.org/10.1093/nar/gkad609openalex-snapshot

Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination

inferred← citeshttps://doi.org/10.1097/cco.0000000000000867openalex-snapshot

Targeting the DNA damage response beyond poly(ADP-ribose) polymerase inhibitors: novel agents and rational combinations

inferred← citeshttps://doi.org/10.1101/2021.08.09.454968openalex-snapshot

Global Prediction of Candidate R-Loop Binding and R-Loop Regulatory Proteins

inferred← citeshttps://doi.org/10.1101/2024.09.13.612941openalex-snapshot

SMARCAD1 Regulates R-Loops at Active Replication Forks Linked to Cancer Mutation Hotspots

inferred← citeshttps://doi.org/10.1111/ejn.70513openalex-snapshot

When R‐Loops Go Awry: Genome Instability and Neurological Diseases

inferred← citeshttps://doi.org/10.1126/sciadv.aed7880openalex-snapshot

Clonal lineage tracing and parallel multiomics profiling reveal transcriptional heterogeneity induced by ARID1A deficiency

inferred← citeshttps://doi.org/10.1146/annurev-arplant-102820-093218openalex-snapshot

The Role and Activity of SWI/SNF Chromatin Remodelers

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-24-1867openalex-snapshot

A Translational Study of the ATR Inhibitor Berzosertib as Monotherapy in Four Molecularly Defined Cohorts of Advanced Solid Tumors

inferred← citeshttps://doi.org/10.1158/2767-9764.crc-24-0260openalex-snapshot

PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia

inferred← citeshttps://doi.org/10.1177/17588359251392106openalex-snapshot

Targeting synthetic lethality: an effective therapeutic approach in ovarian and endometrial cancers

inferred← citeshttps://doi.org/10.1186/s12929-022-00856-5openalex-snapshot

Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response

inferred← citeshttps://doi.org/10.1186/s12943-024-02148-yopenalex-snapshot

R-loops’ m6A modification and its roles in cancers

inferred← citeshttps://doi.org/10.1186/s12943-026-02629-2openalex-snapshot

Inhibition of PRMT5 triggers synthetic lethality in ARID1A-deficient endometrial cancer by promoting aberrant R-loop accumulation

inferred← citeshttps://doi.org/10.1186/s13059-026-04151-6openalex-snapshot

DNA-contact mutant p53 displaces BRCA2 from chromatin and drives R-loop-associated genome instability

inferred← citeshttps://doi.org/10.1371/journal.pgen.1012040openalex-snapshot

An essential gene screening identifies yeast Mot1 as a suppressor of R-loops and genome instability

inferred← citeshttps://doi.org/10.1371/journal.pone.0256440openalex-snapshot

Virus–host interactions in carcinogenesis of Epstein-Barr virus-associated gastric carcinoma: Potential roles of lost ARID1A expression in its early stage

inferred← citeshttps://doi.org/10.3168/jds.2024-24768openalex-snapshot

Investigating the genomic background of calving-related traits in Canadian Jersey cattle

inferred← citeshttps://doi.org/10.3389/fcell.2021.666156openalex-snapshot

Genetic Characterization of Cancer of Unknown Primary Using Liquid Biopsy Approaches

inferred← citeshttps://doi.org/10.3389/fcell.2022.1071786openalex-snapshot

The role of SWI/SNF chromatin remodelers in the repair of DNA double strand breaks and cancer therapy

inferred← citeshttps://doi.org/10.3389/fgene.2021.742434openalex-snapshot

The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes

inferred← citeshttps://doi.org/10.3389/fonc.2022.999626openalex-snapshot

Selective vulnerability of ARID1A deficient colon cancer cells to combined radiation and ATR-inhibitor therapy

inferred← citeshttps://doi.org/10.3389/fonc.2023.1136248openalex-snapshot

ARID1A in cancer: Friend or foe?

inferred← citeshttps://doi.org/10.3390/cancers13205242openalex-snapshot

Genomic Sub-Classification of Ovarian Clear Cell Carcinoma Revealed by Distinct Mutational Signatures

inferred← citeshttps://doi.org/10.3390/cancers14010025openalex-snapshot

Genomic Instability and Replicative Stress in Multiple Myeloma: The Final Curtain?

inferred← citeshttps://doi.org/10.3390/cancers16172949openalex-snapshot

Genome-Wide CRISPR Screen Identifies KEAP1 Perturbation as a Vulnerability of ARID1A-Deficient Cells

inferred← citeshttps://doi.org/10.3390/epigenomes8010007openalex-snapshot

Targeting SWI/SNF Complexes in Cancer: Pharmacological Approaches and Implications

inferred← citeshttps://doi.org/10.3390/genes15010005openalex-snapshot

The Role of the AT-Rich Interaction Domain 1A Gene (ARID1A) in Human Carcinogenesis

inferred← citeshttps://doi.org/10.3390/ijms232112815openalex-snapshot

Targeting Chromatin-Remodeling Factors in Cancer Cells: Promising Molecules in Cancer Therapy

inferred← citeshttps://doi.org/10.3390/ijms232213670openalex-snapshot

The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer

inferred← citeshttps://doi.org/10.3390/ijms24108724openalex-snapshot

NatB Catalytic Subunit Depletion Disrupts DNA Replication Initiation Leading to Senescence in MEFs

inferred← citeshttps://doi.org/10.3390/life11070637openalex-snapshot

Consequences and Resolution of Transcription–Replication Conflicts

inferred← citeshttps://doi.org/10.36401/jipo-22-37openalex-snapshot

Therapeutic Role of Synthetic Lethality in ARID1A -Deficient Malignancies

inferred← citeshttps://doi.org/10.53846/goediss-9549openalex-snapshot

Molecular mechanisms of replication stress-induced mitotic chromosome missegregation

inferred← citeshttps://doi.org/10.64898/2026.02.25.706532openalex-snapshot

Loss of Brg1 promotes seizure development via GABAergic system disruption

inferred← citeshttps://doi.org/10.70675/838e1563z0a0ez4ecdza7c4zc6dc0a36d63fopenalex-snapshot

Étude du rôle des protéines Ribonucléases H dans la réponse cellulaire au stress réplicatif

inferred← citeshttps://doi.org/10.70675/9ac3610bz2f0ez4ce2zac24zd9863979d34eopenalex-snapshot

Characterizing the interplay between DNA : RNA hybrids and genome stability

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.