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Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study

https://doi.org/10.1371/journal.pmed.1002730
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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International consensus guidelines for scoring the histopathological growth patterns of liver metastasis
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Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy
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inferredcites →https://doi.org/10.1200/jco.2011.35.9307openalex-snapshot
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inferredcites →https://doi.org/10.1200/jco.2015.65.9128openalex-snapshot
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SqueezeNet: AlexNet-level accuracy with 50x fewer parameters and <0.5MB model size

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/978-3-031-98688-8_7openalex-snapshot
Persistent Homology and Gabor Features Reveal Inconsistencies Between Widely Used Colorectal Cancer Training and Testing Datasets
inferred← citeshttps://doi.org/10.1007/978-3-031-98694-9_7openalex-snapshot
A Hybrid Transformer-Graph Model for Multi-Class Lymph Node Segmentation in Histopathology
inferred← citeshttps://doi.org/10.1007/978-3-032-03985-9_22openalex-snapshot
AI-Assisted Histopathological Image Analysis for Automated Gastric Cancer Detection
inferred← citeshttps://doi.org/10.1007/978-3-032-04971-1_22openalex-snapshot
Hierarchical Vision-Language Learning for Medical Out-of-Distribution Detection
inferred← citeshttps://doi.org/10.1007/978-3-032-04978-0_53openalex-snapshot
Revisiting Automatic Data Curation for Vision Foundation Models in Digital Pathology
inferred← citeshttps://doi.org/10.1007/978-3-032-05185-1_6openalex-snapshot
Conservative-Radical Complementary Learning for Class-Incremental Medical Image Analysis with Pre-trained Foundation Models
inferred← citeshttps://doi.org/10.1007/978-3-032-13961-0_33openalex-snapshot
Debunking Optimization Myths in Federated Learning for Medical Image Classification
inferred← citeshttps://doi.org/10.1007/978-3-032-21200-9_19openalex-snapshot
Predicting Mutations and Metastases in Colorectal Tumors Using Artificial Intelligence
inferred← citeshttps://doi.org/10.1007/978-3-032-23945-7_1openalex-snapshot
Histopathological Image Classification on PathMNIST Using Pretrained CNN Models
inferred← citeshttps://doi.org/10.1007/978-3-032-25029-2_23openalex-snapshot
Using Diffusion Models for Enhancing the Performance of Semi-supervised Image Classifiers
inferred← citeshttps://doi.org/10.1007/978-3-032-25180-0_10openalex-snapshot
A Bag of Tricks for Real-Time Mitotic Figure Detection
inferred← citeshttps://doi.org/10.1007/978-3-032-29615-3_3openalex-snapshot
Artificial Intelligence and Its Role in Early Detection of Lung Cancer
inferred← citeshttps://doi.org/10.1007/978-3-032-29909-3_38openalex-snapshot
Hybrid Privacy-preserving Histopathological Image Classification Using Fully Homomorphic Encryption
inferred← citeshttps://doi.org/10.1007/978-3-032-30438-4_30openalex-snapshot
Explainable AI for Multi-modal Medical Image Analysis and Radio-Genomics: A Comprehensive Review
inferred← citeshttps://doi.org/10.1007/978-3-032-37933-7_31openalex-snapshot
Label-Attractor Contrastive Network: A Framework for Centroid-Driven Histology Samples
inferred← citeshttps://doi.org/10.1007/978-3-032-38059-3_47openalex-snapshot
Reasoning Trace Divergence: An Empirical Signal for Trustworthy Black-Box MLLMs in Histopathology Classification
inferred← citeshttps://doi.org/10.1007/978-3-032-38072-2_48openalex-snapshot
Selective Rank-1 Orthogonality Regularization: Rethinking Stability-Plasticity Balance in Continual Medical Image Classification
inferred← citeshttps://doi.org/10.1007/978-3-032-39382-1_15openalex-snapshot
Foundation Model Representations for Scalable Content-Based Retrieval in Whole-Slide Histopathology
inferred← citeshttps://doi.org/10.1007/978-981-16-1086-8_40openalex-snapshot
Colorectal Cancer Segmentation Using Atrous Convolution and Residual Enhanced UNet
inferred← citeshttps://doi.org/10.1007/978-981-16-6775-6_10openalex-snapshot
Community Detection in Medical Image Datasets: Using Wavelets and Spectral Methods
inferred← citeshttps://doi.org/10.1007/978-981-16-9221-5_22openalex-snapshot
Computational Intelligence-Based Gene Expression Analysis in Colorectal Cancer: A Review
inferred← citeshttps://doi.org/10.1007/978-981-16-9650-3_43openalex-snapshot
A Novel Classification of Cancer Based on Tumor RNA-Sequence (RNA-Seq) Gene Expression
inferred← citeshttps://doi.org/10.1007/978-981-19-9876-8_27openalex-snapshot
Comparative Analysis of Transfer Learning Models in Classification of Histopathological Whole Slide Images
inferred← citeshttps://doi.org/10.1007/978-981-32-9902-3_6openalex-snapshot
AI-Aided Disease Prediction in Visualized Medicine
inferred← citeshttps://doi.org/10.1007/978-981-95-5631-1_36openalex-snapshot
Digital Pathology Image Domain Generalization Based on Collaborative Feature Matching and Uncertainty Perturbation
inferred← citeshttps://doi.org/10.1007/978-981-96-3863-5_27openalex-snapshot
Patch-Level Up-Sampling for Multi-instance Learning in H&E Tissue Micro-Array Based Recurrence Prediction
inferred← citeshttps://doi.org/10.1007/978-981-96-6403-0_22openalex-snapshot
Ablation Studies of KRAS in Colon Cancer: Predictive Power and Diagnostic Accuracy
inferred← citeshttps://doi.org/10.1007/978-981-96-6585-3_26openalex-snapshot
Active Learning by Feature Perturbation for Medical Image Classification
inferred← citeshttps://doi.org/10.1007/978-981-96-8327-7_12openalex-snapshot
Colorectal Cancer Histopathology Images Classification Using Visual Foundation Models
inferred← citeshttps://doi.org/10.1007/978-981-96-8441-0_9openalex-snapshot
A Novel Approach to Multiclass Colon Cancer Detection Using Convolutional Neural Networks
inferred← citeshttps://doi.org/10.1007/978-981-97-0700-3_19openalex-snapshot
A Novel Ensemble Approach for Colon Cancer Detection Over the Multiclass Colon Dataset
inferred← citeshttps://doi.org/10.1007/978-981-97-3299-9_43openalex-snapshot
Multimodal Metadata Augmentation for Federated Learning in Medical Applications
inferred← citeshttps://doi.org/10.1007/978-981-97-5937-8_7openalex-snapshot
An Attention-Driven Hybrid Network for Survival Analysis of Tumorigenesis Patients Using Whole Slide Images
inferred← citeshttps://doi.org/10.1007/978-981-97-8096-9_17openalex-snapshot
Histopathological Image Classification Using Fine-Tuned Deep Learning Models for Lung and Colon Cancer
inferred← citeshttps://doi.org/10.1007/978-981-97-9693-9_6openalex-snapshot
KI-unterstützte Krankheitsvorhersage in der visualisierten Medizin
inferred← citeshttps://doi.org/10.1007/978-981-99-0835-6_11openalex-snapshot
Fuzzy Metadata Augmentation for Multimodal Data Classification
inferred← citeshttps://doi.org/10.1007/978-981-99-4518-4_16openalex-snapshot
A Study of Deep Learning Methods for Automatic Cancer Detection and Classification in Histopathological Whole-Slide Images
inferred← citeshttps://doi.org/10.1007/978-981-99-4634-1_79openalex-snapshot
Histopathological Colorectal Cancer Image Classification by Using Inception V4 CNN Model
inferred← citeshttps://doi.org/10.1007/978-981-99-7077-3_39openalex-snapshot
Deep Learning-Based Multi-state Colorectal Cancer Histological Image Classification
inferred← citeshttps://doi.org/10.1007/978-981-99-8558-6_26openalex-snapshot
Task-Incremental Medical Image Classification with Task-Specific Batch Normalization
inferred← citeshttps://doi.org/10.1007/978-981-99-9342-0_20openalex-snapshot
Ensemble Deep Learning Techniques for Advancing Breast Cancer Detection and Diagnosis
inferred← citeshttps://doi.org/10.1007/s00262-021-03079-zopenalex-snapshot
The Crohn’s-like lymphoid reaction density: a new artificial intelligence quantified prognostic immune index in colon cancer
inferred← citeshttps://doi.org/10.1007/s00345-023-04489-7openalex-snapshot
A self-supervised vision transformer to predict survival from histopathology in renal cell carcinoma
inferred← citeshttps://doi.org/10.1007/s00424-024-03002-2openalex-snapshot
Decoding pathology: the role of computational pathology in research and diagnostics
inferred← citeshttps://doi.org/10.1007/s00428-023-03509-6openalex-snapshot
High-multiplex tissue imaging in routine pathology—are we there yet?
inferred← citeshttps://doi.org/10.1007/s00428-023-03518-5openalex-snapshot
Artificial intelligence–assisted cancer diagnosis improves the efficiency of pathologists in prostatic biopsies
inferred← citeshttps://doi.org/10.1007/s00428-025-04064-yopenalex-snapshot
Implementing digital pathology: qualitative and financial insights from eight leading European laboratories
inferred← citeshttps://doi.org/10.1007/s00432-022-03976-5openalex-snapshot
A retrospective analysis using deep-learning models for prediction of survival outcome and benefit of adjuvant chemotherapy in stage II/III colorectal cancer
inferred← citeshttps://doi.org/10.1007/s00432-022-04435-xopenalex-snapshot
Computer-aided detection and prognosis of colorectal cancer on whole slide images using dual resolution deep learning
inferred← citeshttps://doi.org/10.1007/s00432-022-04446-8openalex-snapshot
Using deep learning to predict survival outcome in non-surgical cervical cancer patients based on pathological images
inferred← citeshttps://doi.org/10.1007/s00432-023-04838-4openalex-snapshot
Deep learning-based methods for classification of microsatellite instability in endometrial cancer from HE-stained pathological images
inferred← citeshttps://doi.org/10.1007/s00500-021-06555-xopenalex-snapshot
Deep learning for single-lead ECG beat arrhythmia-type detection using novel iris spectrogram representation
inferred← citeshttps://doi.org/10.1007/s00521-022-07953-4openalex-snapshot
A survey on deep learning applied to medical images: from simple artificial neural networks to generative models
inferred← citeshttps://doi.org/10.1007/s00521-026-12453-wopenalex-snapshot
RDA-ResNet50: reaction-diffusion-attention-based ResNet50 for skin cancer diagnosis
inferred← citeshttps://doi.org/10.1007/s00535-022-01894-4openalex-snapshot
Utility of artificial intelligence with deep learning of hematoxylin and eosin-stained whole slide images to predict lymph node metastasis in T1 colorectal cancer using endoscopically resected specimens; prediction of lymph node metastasis in T1 colorectal cancer
inferred← citeshttps://doi.org/10.1007/s00595-021-02380-9openalex-snapshot
Machine learning in gastrointestinal surgery
inferred← citeshttps://doi.org/10.1007/s00761-023-01359-0openalex-snapshot
Künstliche Intelligenz und digitale Pathologie als Treiber der Präzisionsonkologie
inferred← citeshttps://doi.org/10.1007/s10120-020-01093-1openalex-snapshot
Development and validation of a deep learning system for ascites cytopathology interpretation
inferred← citeshttps://doi.org/10.1007/s10120-022-01328-3openalex-snapshot
Deep learning predicts resistance to neoadjuvant chemotherapy for locally advanced gastric cancer: a multicenter study
inferred← citeshttps://doi.org/10.1007/s10278-023-00797-xopenalex-snapshot
DeepBLS: Deep Feature-Based Broad Learning System for Tissue Phenotyping in Colorectal Cancer WSIs
inferred← citeshttps://doi.org/10.1007/s10278-024-01049-2openalex-snapshot
From Pixels to Prognosis: A Survey on AI-Driven Cancer Patient Survival Prediction Using Digital Histology Images
inferred← citeshttps://doi.org/10.1007/s10278-026-02095-8openalex-snapshot
Domain-Specific Transfer Learning for Gastric Cancer Tissue Classification
inferred← citeshttps://doi.org/10.1007/s10278-026-02107-7openalex-snapshot
Embedding Anisotropy in Medical Image Foundation Models: Post Hoc Whitening Degradation and Spectral-Aware Standardization
inferred← citeshttps://doi.org/10.1007/s10278-026-02371-7openalex-snapshot
Person-Based Progression in Acute Myeloid Leukemia Classification: A Multi-View Convolutional Neural Network Approach
inferred← citeshttps://doi.org/10.1007/s10462-024-10887-zopenalex-snapshot
A comprehensive review of tubule formation in histopathology images: advancement in tubule and tumor detection techniques
inferred← citeshttps://doi.org/10.1007/s10845-024-02549-2openalex-snapshot
Deep learning-based rotational alignment technique using image generation and Fourier transform
inferred← citeshttps://doi.org/10.1007/s11042-022-11946-9openalex-snapshot
Improving machine learning recognition of colorectal cancer using 3D GLCM applied to different color spaces
inferred← citeshttps://doi.org/10.1007/s11042-023-17968-1openalex-snapshot
Medical images under tampering
inferred← citeshttps://doi.org/10.1007/s11042-024-18357-yopenalex-snapshot
Multi-headed CNN for colon cancer classification using histopathological images with tikhonov-based unsharp masking
inferred← citeshttps://doi.org/10.1007/s11042-026-21358-8openalex-snapshot
Prototypical aggregate network - boosting few-shot learning for medical image classification
inferred← citeshttps://doi.org/10.1007/s11060-024-04665-8openalex-snapshot
Machine learning-based pathomics signature of histology slides as a novel prognostic indicator in primary central nervous system lymphoma
inferred← citeshttps://doi.org/10.1007/s11227-020-03575-6openalex-snapshot
A novel transfer learning approach for the classification of histological images of colorectal cancer
inferred← citeshttps://doi.org/10.1007/s11255-025-04878-4openalex-snapshot
Artificial intelligence in nephrology: predicting CKD progression and personalizing treatment
inferred← citeshttps://doi.org/10.1007/s11263-020-01373-4openalex-snapshot
A Comprehensive Analysis of Weakly-Supervised Semantic Segmentation in Different Image Domains
inferred← citeshttps://doi.org/10.1007/s11265-025-01967-6openalex-snapshot
A Lightweight Deep Feature Selection Contour for Emotion Recognition from Human Faces
inferred← citeshttps://doi.org/10.1007/s11517-025-03292-3openalex-snapshot
PEDRA-EFB0: colorectal cancer prognostication using deep learning with patch embeddings and dual residual attention
inferred← citeshttps://doi.org/10.1007/s11684-024-1085-3openalex-snapshot
Artificial intelligence methods available for cancer research
inferred← citeshttps://doi.org/10.1007/s11845-023-03479-3openalex-snapshot
Artificial Intelligence in pathology: current applications, limitations, and future directions
inferred← citeshttps://doi.org/10.1007/s12072-022-10321-yopenalex-snapshot
Deep learning for prediction of hepatocellular carcinoma recurrence after resection or liver transplantation: a discovery and validation study
inferred← citeshttps://doi.org/10.1007/s12204-024-2743-yopenalex-snapshot
TshFNA-Examiner: A Nuclei Segmentation and Cancer Assessment Framework for Thyroid Cytology Image
inferred← citeshttps://doi.org/10.1007/s12288-025-02244-zopenalex-snapshot
Artificial Intelligence in Hematology
inferred← citeshttps://doi.org/10.1007/s12530-023-09491-3openalex-snapshot
A survey on recent trends in deep learning for nucleus segmentation from histopathology images
inferred← citeshttps://doi.org/10.1007/s12530-026-09849-3openalex-snapshot
Next-gen colorectal cancer diagnosis using depthwise separable convolution in histopathology image analysis
inferred← citeshttps://doi.org/10.1007/s12672-025-04009-6openalex-snapshot
Chemotherapy and age stratified survival outcomes in colorectal cancer based on a population analysis from the surveillance epidemiology and end results program 2010 to 2020
inferred← citeshttps://doi.org/10.1007/s13205-025-04518-9openalex-snapshot
Artificial intelligence in cancer care: revolutionizing diagnosis, treatment, and precision medicine amid emerging challenges and future opportunities
inferred← citeshttps://doi.org/10.1007/s13258-025-01677-0openalex-snapshot
Deep learning-driven whole-slide image analysis predicts chemo-resistance and motility subtypes in muscle-invasive bladder cancer
inferred← citeshttps://doi.org/10.1007/s13304-026-02533-wopenalex-snapshot
Two decades of artificial intelligence in colon cancer diagnosis and treatment: a bibliometric analysis of research trends (2003–2023)
inferred← citeshttps://doi.org/10.1007/s13369-026-11085-5openalex-snapshot
GCN-QuadNet: A Lightweight and Efficient Graph-Based Framework for Colorectal Cancer Segmentation in Whole Slide Histopathology Images
inferred← citeshttps://doi.org/10.1007/s13369-026-11411-xopenalex-snapshot
DQSD-Net: Dynamic Quantum State Fusion and Self-Distillation Enhanced CNN for Classifying Colorectal Cancer Images
inferred← citeshttps://doi.org/10.1007/s13402-023-00851-4openalex-snapshot
Prognostic significance of collagen signatures at breast tumor boundary obtained by combining multiphoton imaging and imaging analysis
inferred← citeshttps://doi.org/10.1007/s40745-026-00729-wopenalex-snapshot
A Secure and Efficient Federated Learning Privacy Protection Scheme Based on DCT and Top-k Sparsity
inferred← citeshttps://doi.org/10.1007/s44427-025-00003-6openalex-snapshot
On Background Classes in Prototype-Based Architectures
inferred← citeshttps://doi.org/10.1007/s44443-026-00490-3openalex-snapshot
GEM-Net: a compact Ghost-ECA CNN with multi-stage feature fusion for multi-domain histopathology classification
inferred← citeshttps://doi.org/10.1016/b978-0-12-821259-2.00017-xopenalex-snapshot
Meaningful incorporation of artificial intelligence for personalized patient management during cancer: Quantitative imaging, risk assessment, and therapeutic outcomes
inferred← citeshttps://doi.org/10.1016/b978-0-12-824297-1.00014-2openalex-snapshot
Imaging of colorectal nodal disease
inferred← citeshttps://doi.org/10.1016/b978-0-323-85240-1.00007-9openalex-snapshot
Integrative data analysis and automated deep learning technique for ovary cancer detection
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