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A Single Crossing-Over Event in Voltage-Sensitive Na+ Channel Genes May Cause Critical Failure of Dengue Mosquito Control by Insecticides

https://doi.org/10.1371/journal.pntd.0003085
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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P450 monooxygenases are an important mechanism of permethrin resistance inCulex quinquefasciatusSay larvae
inferredcites →https://doi.org/10.1016/0006-8993(95)01449-7openalex-snapshot
Differential effects of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant single sodium channels
inferredcites →https://doi.org/10.1016/0092-8674(95)90279-1openalex-snapshot
Cloning and functional analysis of tipE, a novel membrane protein that enhances drosophila para sodium channel function
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Site-directed mutagenesis by overlap extension using the polymerase chain reaction
inferredcites →https://doi.org/10.1016/b978-0-443-06668-9.50077-6openalex-snapshot
Dengue and Dengue Hemorrhagic Fever
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The molecular basis of insecticide resistance in mosquitoes
inferredcites →https://doi.org/10.1016/j.ibmb.2010.09.005openalex-snapshot
A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids
inferredcites →https://doi.org/10.1016/j.ibmb.2011.05.004openalex-snapshot
Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT
inferredcites →https://doi.org/10.1016/j.pestbp.2003.08.003openalex-snapshot
Increased frequency of the T929I and L932F mutations associated with knockdown resistance in permethrin-resistant populations of the human head louse, Pediculus capitis, from California, Florida, and Texas
inferredcites →https://doi.org/10.1016/j.pestbp.2012.05.008openalex-snapshot
Insecticide resistance in the major dengue vectors Aedes albopictus and Aedes aegypti
inferredcites →https://doi.org/10.1016/j.pestbp.2013.07.005openalex-snapshot
The pyrethroid resistance status and mechanisms in Aedes aegypti from the Guerrero state, Mexico
inferredcites →https://doi.org/10.1016/j.pestbp.2013.08.004openalex-snapshot
Biochemical and molecular analyses to determine pyrethroid resistance in Aedes aegypti
inferredcites →https://doi.org/10.1016/j.taap.2008.10.006openalex-snapshot
Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides
inferredcites →https://doi.org/10.1016/s0022-3565(25)22418-1openalex-snapshot
Differential mechanism of action of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.
inferredcites →https://doi.org/10.1016/s0965-1748(01)00122-9openalex-snapshot
Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin
inferredcites →https://doi.org/10.1073/pnas.1305118110openalex-snapshot
Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel
inferredcites →https://doi.org/10.1080/15216540701352042openalex-snapshot
DDT, pyrethrins, pyrethroids and insect sodium channels
inferredcites →https://doi.org/10.1085/jgp.115.3.305openalex-snapshot
Activation ofDrosophilaSodium Channels Promotes Modification by Deltamethrin
inferredcites →https://doi.org/10.1085/jgp.70.5.549openalex-snapshot
Inactivation of the sodium channel. I. Sodium current experiments.
inferredcites →https://doi.org/10.1093/genetics/141.1.203openalex-snapshot
Conserved alternative splicing patterns and splicing signals in the Drosophila sodium channel gene para.
inferredcites →https://doi.org/10.1093/jee/97.3.1036openalex-snapshot
Frequency of kdr Gene in House Fly Field Populations: Correlation of Pyrethroid Resistance and kdr Frequency
inferredcites →https://doi.org/10.1124/mol.104.006205openalex-snapshot
Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding
inferredcites →https://doi.org/10.1128/cmr.11.3.480openalex-snapshot
Dengue and Dengue Hemorrhagic Fever
inferredcites →https://doi.org/10.1186/1756-3305-6-253openalex-snapshot
Detection of the V1016G mutation in the voltage-gated sodium channel gene of Aedes aegypti (Diptera: Culicidae) by allele-specific PCR assay, and its distribution and effect on deltamethrin resistance in Thailand
inferredcites →https://doi.org/10.1186/1756-3305-7-25openalex-snapshot
Distribution and dissemination of the Val1016Ile and Phe1534Cys Kdr mutations in Aedes aegypti Brazilian natural populations
inferredcites →https://doi.org/10.1303/aez.2010.275openalex-snapshot
Point mutations in domain II of the voltage-gated sodium channel gene in deltamethrin-resistant Aedes aegypti (Diptera: Culicidae)
inferredcites →https://doi.org/10.1371/journal.pntd.0000527openalex-snapshot
Widespread Distribution of a Newly Found Point Mutation in Voltage-Gated Sodium Channel in Pyrethroid-Resistant Aedes aegypti Populations in Vietnam
inferredcites →https://doi.org/10.1371/journal.pntd.0002948openalex-snapshot
Mechanisms of Pyrethroid Resistance in the Dengue Mosquito Vector, Aedes aegypti: Target Site Insensitivity, Penetration, and Metabolism
inferredcites →https://doi.org/10.1371/journal.pone.0030989openalex-snapshot
Insecticide Resistance in the Dengue Vector Aedes aegypti from Martinique: Distribution, Mechanisms and Relations with Environmental Factors
inferredcites →https://doi.org/10.1534/genetics.108.087924openalex-snapshot
Quantitative Trait Loci Mapping of Genome Regions Controlling Permethrin Resistance in the Mosquito Aedes aegypti
inferredcites →https://doi.org/10.1584/jpestics.10.141openalex-snapshot
Pyrethroid Resistance: Importance of the kdr-Type Mechanism
inferredcites →https://doi.org/10.4269/ajtmh.2010.09-0623openalex-snapshot
Pyrethroid Resistance in Aedes aegypti from Grand Cayman
inferredcites →https://doi.org/10.7883/yoken.64.217openalex-snapshot
First Detection of a Putative Knockdown Resistance Gene in Major Mosquito Vector, Aedes albopictus

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Glycine to Valine Substitution Enhances I1011m-Mediated Sodium Channel Resistance to Type I Pyrethroids, But Not Type Ii Pyrethroids
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Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti
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A New A1022T Knockdown Resistance (kdr) Mutation in Pyrethroid Resistant Aedes aegypti Populations From Southern West Bengal, India
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Phenotypic and genotypic pyrethroid resistance of Aedes albopictus , with focus on the 2017 chikungunya outbreak in Italy
inferred← citeshttps://doi.org/10.1002/ps.5763openalex-snapshot
The F1534C voltage‐sensitive sodium channel mutation confers 7‐ to 16‐fold resistance to pyrethroid insecticides in Aedes aegypti
inferred← citeshttps://doi.org/10.1002/ps.6324openalex-snapshot
A first, naturally occurring substitution at the second pyrethroid receptor of voltage‐gated sodium channel of Aedes aegypti
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Amplicon sequencing detects mutations associated with pyrethroid resistance in Bemisia tabaci (Hemiptera: Aleyrodidae)
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Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti
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Insecticide resistance status of Aedes aegypti in border areas of Yunnan Province
inferred← citeshttps://doi.org/10.1002/ps.8625openalex-snapshot
Alanine to glycine substitution in the PyR2 confers sodium channel resistance to Type I pyrethroids
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Pesticide Resistance
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The V1016G mutation of the voltage-gated sodium channel (VGSC) gene contributes to the insecticide resistance of Aedes aegypti from Makassar, Indonesia
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Epigenetics: A Hidden Target of Insecticides
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Temporal frequency of knockdown resistance mutations, F1534C and V1016G, in Aedes aegypti in Chiang Mai city, Thailand and the impact of the mutations on the efficiency of thermal fogging spray with pyrethroids
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Insecticide susceptibility and detection of kdr-gene mutations in Aedes aegypti of Peshawar, Pakistan
inferred← citeshttps://doi.org/10.1016/j.actatropica.2025.107736openalex-snapshot
Insecticide susceptibility and knockdown resistance mutations in Aedes aegypti and Culex species in Bangladesh
inferred← citeshttps://doi.org/10.1016/j.actatropica.2026.108348openalex-snapshot
Resistance phenotyping and kdr genotyping in Aedes aegypti and Aedes albopictus from Thailand
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Evaluation of larvicidal activity of a nanoemulsion of Rosmarinus officinalis essential oil
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Review: Synergistic effects of environmental pollutants: Multiple stressors driving the transmission of vector-borne diseases and the vicious cycle
inferred← citeshttps://doi.org/10.1016/j.cois.2024.101178openalex-snapshot
Recent advances in the study of knockdown resistance mutations in Aedes mosquitoes with a focus on several remarkable mutations
inferred← citeshttps://doi.org/10.1016/j.ibmb.2017.01.007openalex-snapshot
Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.145280openalex-snapshot
Functional characterization of CYP9J26, a cytochrome P450 associated with insecticide resistance in the arbovirus vector Aedes albopictus
inferred← citeshttps://doi.org/10.1016/j.indcrop.2021.113892openalex-snapshot
Apiaceae essential oils and their constituents as insecticides against mosquitoes—A review
inferred← citeshttps://doi.org/10.1016/j.jori.2026.100014openalex-snapshot
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Synergistic action of octopamine receptor agonists on the activity of selected novel insecticides for control of dengue vector Aedes aegypti (Diptera: Culicidae) mosquito
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Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human diseases
inferred← citeshttps://doi.org/10.1016/j.pestbp.2019.07.011openalex-snapshot
CYP-mediated resistance and cross-resistance to pyrethroids and organophosphates in Aedes aegypti in the presence and absence of kdr
inferred← citeshttps://doi.org/10.1016/j.pestbp.2022.105172openalex-snapshot
Novel real-time PCR assay detects widespread distribution of knock down resistance (kdr) mutations associated with pyrethroid resistance in the mosquito, Culex quinquefasciatus, in Thailand
inferred← citeshttps://doi.org/10.1016/j.pestbp.2023.105490openalex-snapshot
Leucine to tryptophane substitution in the pore helix IIP1 confer sodium channel resistance to pyrethroids and DDT
inferred← citeshttps://doi.org/10.1016/j.pestbp.2024.105994openalex-snapshot
Glycine to valine substitution in the short intracellular linkers of domain II enhances I1011M-mediated sodium channel resistance to Type I pyrethroids, but not Type II pyrethroids
inferred← citeshttps://doi.org/10.1016/j.pt.2018.02.003openalex-snapshot
Transgenic Mosquitoes – Fact or Fiction?
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c05625openalex-snapshot
Functional Characterization of Knockdown Resistance Mutation L1014S in the German Cockroach, Blattella germanica (Linnaeus)
inferred← citeshttps://doi.org/10.1021/acsomega.5c11595openalex-snapshot
Molecular and Biochemical Characterization of Insecticide Resistance in Field-Caught Aedes aegypti from Al-Madinah Al-Munawarah, Saudi Arabia
inferred← citeshttps://doi.org/10.1038/s41598-021-84669-wopenalex-snapshot
The discovery of a novel knockdown resistance (kdr) mutation A1007G on Aedes aegypti (Diptera: Culicidae) from Malaysia
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Resistance to pyrethroids and the relationship between adult resistance and knockdown resistance (kdr) mutations in Aedes albopictus in dengue surveillance areas of Guizhou Province, China
inferred← citeshttps://doi.org/10.1038/s41598-026-41000-9openalex-snapshot
The susceptibility status of Aedes aegypti (Diptera: Culicidae) mosquitoes in Malaysia on pyrethroid and organophosphate insecticides with first detection of T1520I mutation
inferred← citeshttps://doi.org/10.1038/srep46549openalex-snapshot
Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control
inferred← citeshttps://doi.org/10.1093/jme/tjaa238openalex-snapshot
Novel CONCOMITANT mutations L932F and I936V in the Voltage-Gated Sodium Channel and Its Association With Pyrethroid Resistance inCulex quinquefasciatus(Diptera: Culicidae)
inferred← citeshttps://doi.org/10.1093/jme/tjab048openalex-snapshot
Molecular Analysis of Targeted Insecticide Resistance Gene Mutations in Field-Caught Mosquitos of Medical Importance From Saudi Arabia
inferred← citeshttps://doi.org/10.1093/jme/tjad015openalex-snapshot
A Globally Distributed Insecticide Resistance Allele Confers a Fitness Cost in the Absence of Insecticide in Aedes aegypti (Diptera: Culicidae), the Yellow Fever Mosquito
inferred← citeshttps://doi.org/10.1093/jme/tjaf161openalex-snapshot
Insecticide resistance profiles and mechanisms in field populations of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in Taiwan
inferred← citeshttps://doi.org/10.1093/jme/tjw115openalex-snapshot
Knockdown Resistance Mutations in Aedes aegypti (Diptera: Culicidae) From Puerto Rico
inferred← citeshttps://doi.org/10.1093/jme/tjx143openalex-snapshot
Resistance Status and Resistance Mechanisms in a Strain of Aedes aegypti (Diptera: Culicidae) From Puerto Rico
inferred← citeshttps://doi.org/10.1093/jme/tjx145openalex-snapshot
Pyrethroid Susceptibility Has Been Maintained in the Dengue Vector, Aedes aegypti (Diptera: Culicidae), in Queensland, Australia
inferred← citeshttps://doi.org/10.1093/jme/tjy037openalex-snapshot
Effect of Relaxation of Deltamethrin Pressure on Metabolic Resistance in a Pyrethroid-Resistant Aedes aegypti (Diptera: Culicidae) Strain Harboring Fixed P989P and G1016G kdr Alleles
inferred← citeshttps://doi.org/10.1093/jme/tjz035openalex-snapshot
V1016G Point Mutation: The Key Mutation in the Voltage-Gated Sodium Channel (Vgsc) Gene of Pyrethroid-Resistant Aedes aegypti (Diptera: Culicidae) in Indonesia.
inferred← citeshttps://doi.org/10.1093/jme/tjz148openalex-snapshot
Distribution and Frequency of the kdr Mutation V410L in Natural Populations of Aedes aegypti (L.) (Diptera: Culicidae) From Eastern and Southern Mexico
inferred← citeshttps://doi.org/10.1093/jme/tjz241openalex-snapshot
Co-occurrence of kdr Mutations V1016I and F1534C and Its Association With Phenotypic Resistance to Pyrethroids in Aedes aegypti (Diptera: Culicidae) Populations From Costa Rica
inferred← citeshttps://doi.org/10.1093/molbev/msad072openalex-snapshot
Strong Positive Selection in Aedes aegypti and the Rapid Evolution of Insecticide Resistance
inferred← citeshttps://doi.org/10.1101/2023.08.05.552101openalex-snapshot
Multiplexed amplicon sequencing reveals the heterogeneous spatial distribution of pyrethroid resistance mutations in Aedes albopictus mosquito populations in Southern France
inferred← citeshttps://doi.org/10.1101/2024.12.04.626773openalex-snapshot
Genetic diversity in the IIS6 domain of Voltage Gated Sodium Channel ( VGSC ) gene among Aedes aegypti populations from different geographical regions in India
inferred← citeshttps://doi.org/10.1101/2024.12.11.627862openalex-snapshot
Knockdown-resistance ( kdr ) mutations in Indian Aedes aegypti populations: lack of recombination among haplotypes bearing V1016G, F1534C, and F1534L kdr alleles
inferred← citeshttps://doi.org/10.1101/2025.10.31.685655openalex-snapshot
The contribution of transposable element insertions to genetic diversity in Aedes aegypti populations
inferred← citeshttps://doi.org/10.1101/740829openalex-snapshot
A new knockdown resistance ( kdr ) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegypti , co-occurring with F1534C, S989P and V1016G
inferred← citeshttps://doi.org/10.1111/eva.12787openalex-snapshot
Tracking genetic invasions: Genome‐wide single nucleotide polymorphisms reveal the source of pyrethroid‐resistant Aedes aegypti (yellow fever mosquito) incursions at international ports
inferred← citeshttps://doi.org/10.1111/eva.12867openalex-snapshot
Combining genetic crosses and pool targeted DNA‐seq for untangling genomic variations associated with resistance to multiple insecticides in the mosquito Aedes aegypti
inferred← citeshttps://doi.org/10.1111/eva.13269openalex-snapshot
Rapid evolution of knockdown resistance haplotypes in response to pyrethroid selection in Aedes aegypti
inferred← citeshttps://doi.org/10.1111/imb.12575openalex-snapshot
Exome‐wide association of deltamethrin resistance in Aedes aegypti from Mexico
inferred← citeshttps://doi.org/10.1111/imb.12605openalex-snapshot
Conservation of the voltage‐sensitive sodium channel protein within the Insecta
inferred← citeshttps://doi.org/10.1111/jnc.13290openalex-snapshot
The neonicotinoid imidacloprid, and the pyrethroid deltamethrin, are antagonists of the insect Rdl GABA receptor
inferred← citeshttps://doi.org/10.1111/jvec.12298openalex-snapshot
Two novel mutations in the voltage-gated sodium channel associated with knockdown resistance (kdr) in the dengue vectorAedes aegyptiin Vietnam
inferred← citeshttps://doi.org/10.1111/mec.15430openalex-snapshot
Heterogeneous genetic invasions of three insecticide resistance mutations in Indo‐Pacific populations of Aedes aegypti (L.)
inferred← citeshttps://doi.org/10.1111/mve.12580openalex-snapshot
Detection of pyrethroid resistance mutations and intron variants in the voltage‐gated sodium channel of Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus mosquitoes from Lao People's Democratic Republic
inferred← citeshttps://doi.org/10.1111/tmi.14102openalex-snapshot
Genetic diversity in the IIS6 domain of voltage gated sodium channel gene among Aedes aegypti populations from different geographical regions in India
inferred← citeshttps://doi.org/10.1126/sciadv.abq7345openalex-snapshot
Discovery of super–insecticide-resistant dengue mosquitoes in Asia: Threats of concomitant knockdown resistance mutations
inferred← citeshttps://doi.org/10.1146/annurev-ento-011118-112420openalex-snapshot
Life and Death at the Voltage-Sensitive Sodium Channel: Evolution in Response to Insecticide Use
inferred← citeshttps://doi.org/10.1155/2018/1735358openalex-snapshot
Current Status of Aedes aegypti Insecticide Resistance Development from Banjarmasin, Kalimantan, Indonesia
inferred← citeshttps://doi.org/10.1155/2021/8874092openalex-snapshot
Voltage‐Gated Sodium Channel (Vgsc) Mutation‐Based Pyrethroid Resistance in Aedes aegypti Populations of Three Endemic Dengue Risk Areas of Sri Lanka
inferred← citeshttps://doi.org/10.1186/s13071-015-0933-zopenalex-snapshot
Relationship between insecticide resistance and kdr mutations in the dengue vector Aedes aegypti in Southern China
inferred← citeshttps://doi.org/10.1186/s13071-016-1713-0openalex-snapshot
Additive effect of knockdown resistance mutations, S989P, V1016G and F1534C, in a heterozygous genotype conferring pyrethroid resistance in Aedes aegypti in Thailand
inferred← citeshttps://doi.org/10.1186/s13071-017-2096-6openalex-snapshot
Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia
inferred← citeshttps://doi.org/10.1186/s13071-017-2215-4openalex-snapshot
Knockdown resistance (kdr) of the voltage-gated sodium channel gene of Aedes aegypti population in Denpasar, Bali, Indonesia
inferred← citeshttps://doi.org/10.1186/s13071-017-2224-3openalex-snapshot
International workshop on insecticide resistance in vectors of arboviruses, December 2016, Rio de Janeiro, Brazil
inferred← citeshttps://doi.org/10.1186/s13071-017-2416-xopenalex-snapshot
A multiplex PCR for detection of knockdown resistance mutations, V1016G and F1534C, in pyrethroid-resistant Aedes aegypti
inferred← citeshttps://doi.org/10.1186/s13071-018-2899-0openalex-snapshot
Pyrethroid resistance in the dengue vector Aedes aegypti in Southeast Asia: present situation and prospects for management
inferred← citeshttps://doi.org/10.1186/s13071-019-3423-xopenalex-snapshot
Knockdown resistance (kdr) mutations within seventeen field populations of Aedes albopictus from Beijing China: first report of a novel V1016G mutation and evolutionary origins of kdr haplotypes
inferred← citeshttps://doi.org/10.1186/s13071-019-3472-1openalex-snapshot
Enzymatic and molecular characterization of insecticide resistance mechanisms in field populations of Aedes aegypti from Selangor, Malaysia
inferred← citeshttps://doi.org/10.1186/s13071-020-04201-3openalex-snapshot
A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegypti, co-occurring with F1534C, S989P and V1016G
inferred← citeshttps://doi.org/10.1186/s13071-020-04204-0openalex-snapshot
Bioassay and molecular monitoring of insecticide resistance status in Aedes albopictus populations from Greece, to support evidence-based vector control
inferred← citeshttps://doi.org/10.1186/s13071-020-04238-4openalex-snapshot
Identifying the fitness costs of a pyrethroid-resistant genotype in the major arboviral vector Aedes aegypti
inferred← citeshttps://doi.org/10.1186/s13071-020-04304-xopenalex-snapshot
Frequency of kdr mutations in the voltage-sensitive sodium channel (VSSC) gene in Aedes aegypti from Yogyakarta and implications for Wolbachia-infected mosquito trials
inferred← citeshttps://doi.org/10.1186/s13071-020-04503-6openalex-snapshot
Insecticide resistance status of Aedes aegypti in Bangladesh
inferred← citeshttps://doi.org/10.1186/s13071-021-04785-4openalex-snapshot
Dengue fever and insecticide resistance in Aedes mosquitoes in Southeast Asia: a review
inferred← citeshttps://doi.org/10.1186/s13071-021-04867-3openalex-snapshot
Voltage-sensitive sodium channel (Vssc) mutations associated with pyrethroid insecticide resistance in Aedes aegypti (L.) from two districts of Jeddah, Kingdom of Saudi Arabia: baseline information for a Wolbachia release program
inferred← citeshttps://doi.org/10.1186/s13071-022-05156-3openalex-snapshot
Monitoring insecticide resistance of adult and larval Aedes aegypti (Diptera: Culicidae) in Phnom Penh, Cambodia
inferred← citeshttps://doi.org/10.1186/s13071-022-05192-zopenalex-snapshot
Knockdown resistance (kdr) gene of Aedes aegypti in Malaysia with the discovery of a novel regional specific point mutation A1007G
inferred← citeshttps://doi.org/10.1186/s13071-022-05241-7openalex-snapshot
Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.1186/s13071-022-05407-3openalex-snapshot
Geographic distribution of the V1016G knockdown resistance mutation in Aedes albopictus: a warning bell for Europe
inferred← citeshttps://doi.org/10.1186/s13071-022-05525-yopenalex-snapshot
Molecular analysis of knockdown resistance (kdr) mutations in the voltage-gated sodium channel gene of Aedes aegypti populations from Saudi Arabia
inferred← citeshttps://doi.org/10.1186/s13071-023-05743-yopenalex-snapshot
Association of 410L, 1016I and 1534C kdr mutations with pyrethroid resistance in Aedes aegypti from Ouagadougou, Burkina Faso, and development of a one-step multiplex PCR method for the simultaneous detection of 1534C and 1016I kdr mutations
inferred← citeshttps://doi.org/10.1186/s13071-024-06123-wopenalex-snapshot
Kdr genotyping and the first report of V410L and V1016I kdr mutations in voltage-gated sodium channel gene in Aedes aegypti (Diptera: Culicidae) from Iran
inferred← citeshttps://doi.org/10.1186/s13071-024-06124-9openalex-snapshot
Pyrethroid resistance status and co-occurrence of V1016G, F1534C and S989P mutations in the Aedes aegypti population from two dengue outbreak counties along the China-Myanmar border
inferred← citeshttps://doi.org/10.1186/s13071-024-06405-3openalex-snapshot
First detection of V410L kdr mutation in Aedes aegypti populations of Argentina supported by toxicological evidence
inferred← citeshttps://doi.org/10.1186/s13071-024-06485-1openalex-snapshot
Study on the cross-resistance of Aedes albopictus (Skuse) (Diptera: Culicidae) to deltamethrin and pyriproxyfen
inferred← citeshttps://doi.org/10.1186/s13071-024-06632-8openalex-snapshot
Multiplexed amplicon sequencing reveals the heterogeneous spatial distribution of pyrethroid resistance mutations in Aedes albopictus mosquito populations in southern France
inferred← citeshttps://doi.org/10.1186/s13071-025-07010-8openalex-snapshot
Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control
inferred← citeshttps://doi.org/10.1186/s13071-025-07130-1openalex-snapshot
Tracking pyrethroid resistance in arbovirus mosquito vectors: mutations I1532T and F1534C in Aedes albopictus across Europe
inferred← citeshttps://doi.org/10.1186/s41182-018-0134-5openalex-snapshot
High frequencies of F1534C and V1016I kdr mutations and association with pyrethroid resistance in Aedes aegypti from Somgandé (Ouagadougou), Burkina Faso
inferred← citeshttps://doi.org/10.1186/s41182-021-00321-3openalex-snapshot
Phenotypic and haplotypic profiles of insecticide resistance in populations of Aedes aegypti larvae (Diptera: Culicidae) from central Lao PDR
inferred← citeshttps://doi.org/10.1186/s41182-025-00806-5openalex-snapshot
First report of the pyrethroid-resistance-associated V1016I mutation in Aedes aegypti at the seaport of Cotonou, Benin, West Africa
inferred← citeshttps://doi.org/10.1371/journal.pntd.0005625openalex-snapshot
Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans
inferred← citeshttps://doi.org/10.1371/journal.pntd.0007291openalex-snapshot
Voltage-gated sodium channel intron polymorphism and four mutations comprise six haplotypes in an Aedes aegypti population in Taiwan
inferred← citeshttps://doi.org/10.1371/journal.pntd.0007432openalex-snapshot
Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti
inferred← citeshttps://doi.org/10.1371/journal.pntd.0007439openalex-snapshot
Insecticide resistance levels and mechanisms in Aedes aegypti populations in and around Ouagadougou, Burkina Faso
inferred← citeshttps://doi.org/10.1371/journal.pntd.0007554openalex-snapshot
Complex interplay of evolutionary forces shaping population genomic structure of invasive Aedes albopictus in southern Europe
inferred← citeshttps://doi.org/10.1371/journal.pntd.0007852openalex-snapshot
Distribution of insecticide resistance and mechanisms involved in the arbovirus vector Aedes aegypti in Laos and implication for vector control
inferred← citeshttps://doi.org/10.1371/journal.pntd.0008154openalex-snapshot
Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes aegypti
inferred← citeshttps://doi.org/10.1371/journal.pntd.0009546openalex-snapshot
Sodium channel activation underlies transfluthrin repellency in Aedes aegypti
inferred← citeshttps://doi.org/10.1371/journal.pntd.0009549openalex-snapshot
Levels of cross-resistance to pyrethroids conferred by the Vssc knockdown resistance allele 410L+1016I+1534C in Aedes aegypti
inferred← citeshttps://doi.org/10.1371/journal.pntd.0010780openalex-snapshot
The role of voltage-gated sodium channel genotypes in pyrethroid resistance in Aedes aegypti in Taiwan
inferred← citeshttps://doi.org/10.1371/journal.pntd.0012768openalex-snapshot
First detection of the S989P+V1016G+D1763Y haplotype and expansion of voltage-gated sodium channel mutations in Aedes aegypti in Taiwan in 2016–2023
inferred← citeshttps://doi.org/10.1371/journal.pntd.0013126openalex-snapshot
Knockdown-resistance (kdr) mutations in Indian Aedes aegypti populations: Lack of recombination among haplotypes bearing V1016G, F1534C, and F1534L kdr alleles
inferred← citeshttps://doi.org/10.1371/journal.pntd.0013657openalex-snapshot
Entomological surveys and insecticide resistance in the dengue vector Aedes aegypti in Dakar, Senegal: First detection of the kdr mutation
inferred← citeshttps://doi.org/10.1371/journal.pntd.0013792openalex-snapshot
Insecticide resistance levels, spatial distribution, and kdr mutations in the dengue vector Aedes albopictus of Hong Kong
inferred← citeshttps://doi.org/10.1371/journal.pntd.0014393openalex-snapshot
Discovery of two novel mutations, R52H and N868D, in the voltage-gated sodium channel of Aedes aegypti associated with pyrethroid resistance
inferred← citeshttps://doi.org/10.1371/journal.pone.0189680openalex-snapshot
Aedes aegypti resistance development to commonly used insecticides in Jakarta, Indonesia
inferred← citeshttps://doi.org/10.1371/journal.pone.0285883openalex-snapshot
Reconsideration of importance of the point mutation L982W in the voltage-sensitive sodium channel of the pyrethroid resistant Aedes aegypti (L.)(Diptera: Culicidae) in Vietnam
inferred← citeshttps://doi.org/10.1584/jpestics.d25-023openalex-snapshot
Effect of capsaicin on voltage-gated sodium channels with kdr mutation from German cockroaches (Blattella germanica)
inferred← citeshttps://doi.org/10.1584/jpestics.j16-01openalex-snapshot
Studies on the mode of action of neurotoxic insecticides
inferred← citeshttps://doi.org/10.1584/jpestics.w16-05openalex-snapshot
Studies on the mode of actions of neurotoxic insecticides
inferred← citeshttps://doi.org/10.17660/actahortic.2017.1169.14openalex-snapshot
Molecular mechanisms underlying pyrethroid resistance in dengue mosquito vectors collected from Singapore
inferred← citeshttps://doi.org/10.21203/rs.3.rs-102568/v1openalex-snapshot
Molecular Insight into the Knockdown Resistance (kdr) in the Voltage Gated Sodium Channel (vgsc) Gene of the Main Dengue Vector, Aedes aegypti (Diptera: Culicidae) and the Discovery of Novel Regional Specific Point Mutation A1007G in Malaysia.
inferred← citeshttps://doi.org/10.21203/rs.3.rs-102568/v2openalex-snapshot
Molecular Insight into the Knockdown Resistance (kdr) in the Voltage Gated Sodium Channel (vgsc) Gene of the Main Dengue Vector, Aedes aegypti (Diptera: Culicidae) and the Discovery of Novel Regional Specific Point Mutation A1007G in Malaysia.
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1979481/v1openalex-snapshot
Association of 410L, 1016I and 1534C kdr mutations with pyrethroid resistance in Aedes aegypti from Ouagadougou, Burkina Faso, and development of a one-step multiplex PCR method for the simultaneous detection of 1534C and 1016I kdr mutations
inferred← citeshttps://doi.org/10.21203/rs.3.rs-28170/v1openalex-snapshot
Molecular Analysis of Targeted Insecticide Resistance Gene Mutations in field Aedes Aegypti and Culex Quinquefasciatus Mosquito Vectors of Arboviruses from Saudi Arabia
inferred← citeshttps://doi.org/10.21203/rs.3.rs-35782/v1openalex-snapshot
Molecular analysis of targeted insecticide resistance gene mutations in field Aedes aegypti and Culex quinquefasciatus mosquito vectors of arboviruses from Saudi Arabia
inferred← citeshttps://doi.org/10.21203/rs.3.rs-35782/v2openalex-snapshot
Molecular analysis of targeted insecticide resistance gene mutations in field Aedes aegypti and Culex quinquefasciatus mosquito vectors of arboviruses from Saudi Arabia
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9025253/v1openalex-snapshot
Resistance profiles and mechanisms in pyrethroid-resistant Aedes aegypti populations: first detection of the V1016G kdr mutation in Abidjan, Côte d’Ivoire
inferred← citeshttps://doi.org/10.24072/pcjournal.497openalex-snapshot
A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti
inferred← citeshttps://doi.org/10.26719/emhj.19.081openalex-snapshot
Knockdown resistance mutations contributing to pyrethroid resistance in Aedes aegypti population, Saudi Arabia
inferred← citeshttps://doi.org/10.2807/1560-7917.es.2019.24.5.1700847openalex-snapshot
First detection of a Vssc allele V1016G conferring a high level of insecticide resistance in Aedes albopictus collected from Europe (Italy) and Asia (Vietnam), 2016: a new emerging threat to controlling arboviral diseases
inferred← citeshttps://doi.org/10.32473/jfmca.71.1.135292openalex-snapshot
NEW MULTIPLEX SNP GENOTYPING ASSAY TO SIMUTANEOUSLY SCREEN FOR EIGHT VOLTAGE-GATED SODIUM CHANNEL MUTATIONS IN AEDES AEGYPTI
inferred← citeshttps://doi.org/10.32473/jfmca.v69i1.130622openalex-snapshot
TWO NOVEL SINGLE NUCLEOTIDE POLYMORPHISMS IN THE VOLTAGE-GATED SODIUM CHANNEL GENE IDENTIFIED IN AEDES AEGYPTI MOSQUITOES FROM FLORIDA
inferred← citeshttps://doi.org/10.3389/fcimb.2023.1265873openalex-snapshot
Evolution of knockdown resistance (kdr) mutations of Aedes aegypti and Aedes albopictus in Hainan Island and Leizhou Peninsula, China
inferred← citeshttps://doi.org/10.3390/genes12060828openalex-snapshot
Analyses of Insecticide Resistance Genes in Aedes aegypti and Aedes albopictus Mosquito Populations from Cameroon
inferred← citeshttps://doi.org/10.3390/ijerph15020220openalex-snapshot
Aedes Mosquitoes and Aedes-Borne Arboviruses in Africa: Current and Future Threats
inferred← citeshttps://doi.org/10.3390/insects13111035openalex-snapshot
Insecticide Susceptibility Status of Anopheles and Aedes Mosquitoes in Malaria and Dengue Endemic Areas, Thai–Myanmar Border
inferred← citeshttps://doi.org/10.3390/insects15110863openalex-snapshot
Detection of the 1016Gly and 989Pro Knockdown Resistance Mutations in Florida, USA Aedes aegypti
inferred← citeshttps://doi.org/10.3390/insects6030658openalex-snapshot
Association between Three Mutations, F1565C, V1023G and S996P, in the Voltage-Sensitive Sodium Channel Gene and Knockdown Resistance in Aedes aegypti from Yogyakarta, Indonesia
inferred← citeshttps://doi.org/10.3390/insects7040060openalex-snapshot
Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti
inferred← citeshttps://doi.org/10.3390/insects9020043openalex-snapshot
Susceptibility Status and Resistance Mechanisms in Permethrin-Selected, Laboratory Susceptible and Field-Collected Aedes aegypti from Malaysia
inferred← citeshttps://doi.org/10.4103/0972-9062.328972openalex-snapshot
First detection of voltage-gated sodium channel mutations in Phlebotomus argentipes collected from Bangladesh
inferred← citeshttps://doi.org/10.4103/apjtm.apjtm_438_25openalex-snapshot
Pyrethroid resistance in Aedes albopictus in Pudong New Area, Shanghai China
inferred← citeshttps://doi.org/10.46471/gigabyte.185openalex-snapshot
Tracking kdr alleles associated with pyrethroid resistance in Aedes albopictus across Italy: a nationwide genotypic dataset by MosqIRIT network
inferred← citeshttps://doi.org/10.55446/ije.2025.3408openalex-snapshot
Pyrethroid Resistance in Aedes aegypti L. across Southeast Asia: Mechanisms and Implications for Vector Control
inferred← citeshttps://doi.org/10.6084/m9.figshare.14462520openalex-snapshot
Additional file 1 of Phenotypic and haplotypic profiles of insecticide resistance in populations of Aedes aegypti larvae (Diptera: Culicidae) from central Lao PDR
inferred← citeshttps://doi.org/10.6084/m9.figshare.14767117openalex-snapshot
Additional file 1 of Dengue fever and insecticide resistance in Aedes mosquitoes in Southeast Asia: a review
inferred← citeshttps://doi.org/10.6084/m9.figshare.14956001openalex-snapshot
Additional file 1 of Voltage-sensitive sodium channel (Vssc) mutations associated with pyrethroid insecticide resistance in Aedes aegypti (L.) from two districts of Jeddah, Kingdom of Saudi Arabia: baseline information for a Wolbachia release program
inferred← citeshttps://doi.org/10.6084/m9.figshare.19703820openalex-snapshot
Additional file 1 of Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.6084/m9.figshare.19703823openalex-snapshot
Additional file 2 of Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.6084/m9.figshare.19703826openalex-snapshot
Additional file 3 of Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.6084/m9.figshare.19703829openalex-snapshot
Additional file 4 of Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.6084/m9.figshare.19703832openalex-snapshot
Additional file 5 of Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.6084/m9.figshare.19703835openalex-snapshot
Additional file 6 of Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.6084/m9.figshare.19703838openalex-snapshot
Additional file 7 of Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.6084/m9.figshare.19703841openalex-snapshot
Additional file 8 of Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China
inferred← citeshttps://doi.org/10.6084/m9.figshare.21365990openalex-snapshot
Additional file 1 of Molecular analysis of knockdown resistance (kdr) mutations in the voltage-gated sodium channel gene of Aedes aegypti populations from Saudi Arabia
inferred← citeshttps://doi.org/10.6084/m9.figshare.26583648openalex-snapshot
Additional file 1 of Association of 410L, 1016I and 1534C kdr mutations with pyrethroid resistance in Aedes aegypti from Ouagadougou, Burkina Faso, and development of a one-step multiplex PCR method for the simultaneous detection of 1534C and 1016I kdr mutations
inferred← citeshttps://doi.org/10.6084/m9.figshare.26583651openalex-snapshot
Additional file 2 of Association of 410L, 1016I and 1534C kdr mutations with pyrethroid resistance in Aedes aegypti from Ouagadougou, Burkina Faso, and development of a one-step multiplex PCR method for the simultaneous detection of 1534C and 1016I kdr mutations
inferred← citeshttps://doi.org/10.6084/m9.figshare.26685894openalex-snapshot
Additional file 1 of Pyrethroid resistance status and co-occurrence of V1016G, F1534C and S989P mutations in the Aedes aegypti population from two dengue outbreak counties along the China-Myanmar border
inferred← citeshttps://doi.org/10.6084/m9.figshare.26685897openalex-snapshot
Additional file 2 of Pyrethroid resistance status and co-occurrence of V1016G, F1534C and S989P mutations in the Aedes aegypti population from two dengue outbreak counties along the China-Myanmar border
inferred← citeshttps://doi.org/10.6084/m9.figshare.27124112openalex-snapshot
Additional file 1 of Study on the cross-resistance of Aedes albopictus (Skuse) (Diptera: Culicidae) to deltamethrin and pyriproxyfen
inferred← citeshttps://doi.org/10.6084/m9.figshare.27124115openalex-snapshot
Additional file 2 of Study on the cross-resistance of Aedes albopictus (Skuse) (Diptera: Culicidae) to deltamethrin and pyriproxyfen
inferred← citeshttps://doi.org/10.6084/m9.figshare.27124118openalex-snapshot
Additional file 3 of Study on the cross-resistance of Aedes albopictus (Skuse) (Diptera: Culicidae) to deltamethrin and pyriproxyfen
inferred← citeshttps://doi.org/10.6084/m9.figshare.27124121openalex-snapshot
Additional file 4 of Study on the cross-resistance of Aedes albopictus (Skuse) (Diptera: Culicidae) to deltamethrin and pyriproxyfen
inferred← citeshttps://doi.org/10.70675/8a150e43z6dadz4bd2z8a4ez6db71df79890openalex-snapshot
Étude du potentiel des biomarqueurs sérologiques pour évaluer le risque de transmission de la dengue dans le nord-est de la Thaïlande
inferred← citeshttps://doi.org/10.7601/mez.68.19openalex-snapshot
Characterization of metabolic detoxifying enzymes in an insecticide resistant strain of Aedes aegypti harboring homozygous S989P and V1016G kdr mutations
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