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GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archpsyc.1995.03950160008002openalex-snapshot
Gene Expression for Glutamic Acid Decarboxylase Is Reduced Without Loss of Neurons in Prefrontal Cortex of Schizophrenics
inferredcites →https://doi.org/10.1001/archpsyc.57.11.1061openalex-snapshot
Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder
inferredcites →https://doi.org/10.1002/jnr.20122openalex-snapshot
GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia
inferredcites →https://doi.org/10.1016/j.brainresrev.2006.04.001openalex-snapshot
Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
inferredcites →https://doi.org/10.1016/j.jneumeth.2006.02.018openalex-snapshot
Chromatin immunoprecipitation in postmortem brain
inferredcites →https://doi.org/10.1016/j.schres.2004.02.017openalex-snapshot
GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum
inferredcites →https://doi.org/10.1016/j.tig.2003.09.007openalex-snapshot
Histone lysine methylation: a signature for chromatin function
inferredcites →https://doi.org/10.1016/s0092-8674(03)00360-xopenalex-snapshot
Tails of Intrigue
inferredcites →https://doi.org/10.1016/s0893-133x(01)00225-1openalex-snapshot
GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder
inferredcites →https://doi.org/10.1038/nrn1648openalex-snapshot
Cortical inhibitory neurons and schizophrenia
inferredcites →https://doi.org/10.1038/sj.mp.4001599openalex-snapshot
GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss
inferredcites →https://doi.org/10.1038/sj.mp.4001988openalex-snapshot
Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
inferredcites →https://doi.org/10.1073/pnas.0409665102openalex-snapshot
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1
inferredcites →https://doi.org/10.1073/pnas.0503736102openalex-snapshot
Reelin promoter hypermethylation in schizophrenia
inferredcites →https://doi.org/10.1093/hmg/ddl253openalex-snapshot
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
inferredcites →https://doi.org/10.1111/j.1471-4159.2004.02725.xopenalex-snapshot
The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells
inferredcites →https://doi.org/10.1111/j.1471-4159.2005.03190.xopenalex-snapshot
Histone methylation at gene promoters is associated with developmental regulation and region‐specific expression of ionotropic and metabotropic glutamate receptors in human brain
inferredcites →https://doi.org/10.1139/jpn.0535openalex-snapshot
Chromatin, DNA methylation and neuron gene regulation — the purpose of the package
inferredcites →https://doi.org/10.1159/000444713openalex-snapshot
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
inferredcites →https://doi.org/10.1523/jneurosci.0766-05.2005openalex-snapshot
DNA Methylation Status ofSOX10Correlates with Its Downregulation and Oligodendrocyte Dysfunction in Schizophrenia

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Lysine (K)-Deacetylase Inhibitors: The Real Next Step To Neuropsychiatric And Neurodegenerative Disorders?
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Circuit- and Diagnosis-Specific DNA Methylation Changes at γ-Aminobutyric Acid–Related Genes in Postmortem Human Hippocampus in Schizophrenia and Bipolar Disorder
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Hypomethylation of the serotonin receptor type‐2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder
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No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia
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Hippocampal reelin and GAD67 gene expression and methylation in the GFAP.HMOX1 mouse model of schizophrenia
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Gene expression of methylation cycle and related genes in lymphocytes and brain of patients with schizophrenia and non-psychotic controls
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Prefrontal Cortical Dysfunction After Overexpression of Histone Deacetylase 1
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GAD1 alleviates injury-induced optic neurodegeneration by inhibiting retinal ganglion cell apoptosis
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White matter neuron alterations in schizophrenia and related disorders
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Prenatal exposure to cigarette smoke causes persistent changes in the oxidative balance and in DNA structural integrity in rats submitted to the animal model of schizophrenia
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GAD1 gene polymorphisms are associated with bipolar I disorder and with blood homovanillic acid levels but not with plasma GABA levels
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Extracellular matrix abnormalities in schizophrenia
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Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects
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Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder
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Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome
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Transcriptional regulation of GAD1 GABA synthesis gene in the prefrontal cortex of subjects with schizophrenia
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DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients
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Epigenetic Regulation of the Social Brain
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MK-801, a NMDA receptor antagonist, increases phosphorylation of histone H3 in the rat medial prefrontal cortex
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The neurobiology of chromatin-associated mechanisms in the context of psychosisand mood spectrum disorders
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Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers
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DNA methylation reactivates GAD1 expression in cancer by preventing CTCF-mediated polycomb repressive complex 2 recruitment
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A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme
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Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility
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Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders
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Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients
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The Impact of Epigenetics in Schizophrenia Research
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Snapshot of Schizophrenia: Current Knowledge and Prospects
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HDAC1 links early life stress to schizophrenia-like phenotypes
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Is Schizophrenia the Price of Human Central Nervous System Complexity?
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Maternal immune activation inducesGAD1andGAD2promoter remodeling in the offspring prefrontal cortex
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Advancing Neuroscience Through Epigenetics: Molecular Mechanisms of Learning and Memory
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DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons
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Epigenetic Regulation of Glutamic Acid Decarboxylase 67 in a Hippocampal Circuit
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Effects of Bisphenol-A and Other Endocrine Disruptors Compared With Abnormalities of Schizophrenia: An Endocrine-Disruption Theory of Schizophrenia
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Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia
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Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF‐1 gene
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Targeting MLL1 / WDR5 ‐Mediated Epigenetic Regulation Mitigates Peritoneal Fibrosis by Reducing p16 INK4a
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Epigenetic Mechanisms in the Pathophysiology of Psychotic Disorders
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Recent advances in postmortem pathology and neurochemistry in schizophrenia
inferred← citeshttps://doi.org/10.1101/2024.10.29.24315982openalex-snapshot
CLOZAPINE-RELATED BRAIN NRN1 EXPRESSION PATTERNS ARE ASSOCIATED WITH METHYLATION AND GENETIC VARIANTS IN SCHIZOPHRENIA
inferred← citeshttps://doi.org/10.1111/gbb.12131openalex-snapshot
Glutamic acid decarboxylase 67 haplodeficiency impairs social behavior in mice
inferred← citeshttps://doi.org/10.1111/j.1460-9568.2009.06787.xopenalex-snapshot
Epigenetic dysregulation in cognitive disorders
inferred← citeshttps://doi.org/10.1111/j.1476-5381.2009.00526.xopenalex-snapshot
Pharmacology of epigenetics in brain disorders
inferred← citeshttps://doi.org/10.1111/j.2042-7158.2012.01475.xopenalex-snapshot
Epigenetics of psychoactive drugs
inferred← citeshttps://doi.org/10.1136/gpsych-2021-100685openalex-snapshot
Consensus on potential biomarkers developed for use in clinical tests for schizophrenia
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-010814-124527openalex-snapshot
DNA Methylation and Its Implications and Accessibility for Neuropsychiatric Therapeutics
inferred← citeshttps://doi.org/10.1152/physrev.00012.2010openalex-snapshot
Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes
inferred← citeshttps://doi.org/10.1155/2009/409562openalex-snapshot
Chromatin from Peripheral Blood Mononuclear Cells as Biomarkers for Epigenetic Abnormalities in Schizophrenia
inferred← citeshttps://doi.org/10.1155/2018/2682037openalex-snapshot
Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats
inferred← citeshttps://doi.org/10.1159/000234811openalex-snapshot
Epigenetic Profiling in Schizophrenia and Major Mental Disorders
inferred← citeshttps://doi.org/10.1159/000336731openalex-snapshot
Modeling Interneuron Dysfunction in Schizophrenia
inferred← citeshttps://doi.org/10.1159/000444713openalex-snapshot
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
inferred← citeshttps://doi.org/10.1159/000495063openalex-snapshot
Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches
inferred← citeshttps://doi.org/10.1176/foc.8.3.foc358openalex-snapshot
Epigenetic Alterations in Schizophrenia
inferred← citeshttps://doi.org/10.1177/1073858410386967openalex-snapshot
Epigenetic Mechanisms
inferred← citeshttps://doi.org/10.1177/1073858411386967openalex-snapshot
Epigenetic Mechanisms: Critical Contributors to Long-Term Memory Formation
inferred← citeshttps://doi.org/10.1177/1073858415608147openalex-snapshot
Epigenetic Basis of Mental Illness
inferred← citeshttps://doi.org/10.1177/1744806919847366openalex-snapshot
The etiological contribution of GABAergic plasticity to the pathogenesis of neuropathic pain
inferred← citeshttps://doi.org/10.1186/1471-2202-9-42openalex-snapshot
Isolation of neuronal chromatin from brain tissue
inferred← citeshttps://doi.org/10.1186/1476-4598-10-124openalex-snapshot
MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma
inferred← citeshttps://doi.org/10.1186/s12859-018-2037-1openalex-snapshot
Defiant: (DMRs: easy, fast, identification and ANnoTation) identifies differentially Methylated regions from iron-deficient rat hippocampus
inferred← citeshttps://doi.org/10.1186/s12991-023-00466-xopenalex-snapshot
DNMT1 SNPs (rs2114724 and rs2228611) associated with positive symptoms in Chinese patients with schizophrenia
inferred← citeshttps://doi.org/10.12659/msm.895896openalex-snapshot
DNA Methylation of BDNF Gene in Schizophrenia
inferred← citeshttps://doi.org/10.1272/manms.12.118openalex-snapshot
Epigenetics and It's Detailed Mechanisms in Life Phenomena: A Review
inferred← citeshttps://doi.org/10.12740/app/147876openalex-snapshot
The role of the attachment relation in the pathogenesis of auditory hallucinations – literature overview
inferred← citeshttps://doi.org/10.12740/app/153480openalex-snapshot
Facial emotion recognition deficits in schizophrenia - a review of research and a model of pathogenesis
inferred← citeshttps://doi.org/10.13028/9s7h-s649openalex-snapshot
Inflammation Alters Histone Methylation in the Central Nervous System: Implications for Neuropsychiatric Disease: A Dissertation
inferred← citeshttps://doi.org/10.13028/a1cy-7882openalex-snapshot
Chromatin Remodeling in Transgenic Mouse Brain: Implications for the Neurobiology of Depression: A Dissertation
inferred← citeshttps://doi.org/10.13028/h312-hs12openalex-snapshot
Epigenetic Determinants of Altered Gene Expression in Schizophrenia: a Dissertation
inferred← citeshttps://doi.org/10.13028/m2q60qopenalex-snapshot
Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation
inferred← citeshttps://doi.org/10.1371/journal.pone.0000895openalex-snapshot
DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons
inferred← citeshttps://doi.org/10.1371/journal.pone.0170805openalex-snapshot
GAD1 Gene Expression in Blood of Patients with First-Episode Psychosis
inferred← citeshttps://doi.org/10.1371/journal.pone.0182778openalex-snapshot
Exome sequencing in schizophrenic patients with high levels of homozygosity identifies novel and extremely rare mutations in the GABA/glutamatergic pathways
inferred← citeshttps://doi.org/10.1517/17460441.2015.976552openalex-snapshot
Genomics and epigenomics in novel schizophrenia drug discovery: translating animal models to clinical research and back
inferred← citeshttps://doi.org/10.1523/jneurosci.3272-07.2007openalex-snapshot
Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters
inferred← citeshttps://doi.org/10.1523/jneurosci.3732-09.2010openalex-snapshot
Histone Methylation Regulates Memory Formation
inferred← citeshttps://doi.org/10.1523/jneurosci.5286-12.2013openalex-snapshot
Hypoxia-Induced Developmental Delays of Inhibitory Interneurons Are Reversed by Environmental Enrichment in the Postnatal Mouse Forebrain
inferred← citeshttps://doi.org/10.17827/aktd.1096901openalex-snapshot
Epigenetic Perspective in Schizophrenia: DNA Methylation Patterns
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1802640/v1openalex-snapshot
The correlation between promoter methylation status and expression of KLF9 and MYH11 in Schizophrenia
inferred← citeshttps://doi.org/10.2174/1570159x15666170404144522openalex-snapshot
Epigenetic Regulation of Memory-Therapeutic Potential for Disorders
inferred← citeshttps://doi.org/10.2174/1871527320666210825101915openalex-snapshot
Epigenetic Basis of Psychiatric Disorders: A Narrative Review
inferred← citeshttps://doi.org/10.2217/epi.10.22openalex-snapshot
Schizophrenia and the Epigenetic Hypothesis
inferred← citeshttps://doi.org/10.2217/epi.11.86openalex-snapshot
Epigenetic Mechanisms in Experience-Driven Memory Formation and Behavior
inferred← citeshttps://doi.org/10.2217/epi.12.37openalex-snapshot
Sensitive Periods in Epigenetics: Bringing us Closer to Complex Behavioral Phenotypes
inferred← citeshttps://doi.org/10.26717/bjstr.2021.37.006073openalex-snapshot
Schizophrenia: Current and Perspectives
inferred← citeshttps://doi.org/10.29001/2073-8552-2021-36-4-37-44openalex-snapshot
Recent studies of the genetics of complex diseases associated with impaired cognitive functions
inferred← citeshttps://doi.org/10.31887/dcns.2010.12.1/cptakopenalex-snapshot
Epigenetic approaches to psychiatric disorders
inferred← citeshttps://doi.org/10.31887/dcns.2014.16.3/jdayopenalex-snapshot
New approaches to manipulating the epigenome
inferred← citeshttps://doi.org/10.31887/dcns.2014.16.3/mmorrisopenalex-snapshot
Role of DNA methylation and the DNA methyltransferases in learning and memory
inferred← citeshttps://doi.org/10.31887/dcns.2014.16.3/sakbarianopenalex-snapshot
Epigenetic mechanisms in schizophrenia
inferred← citeshttps://doi.org/10.31887/dcns.2016.18.3/dsweattopenalex-snapshot
An epigenomics approach to individual differences and its translation to neuropsychiatric conditions
inferred← citeshttps://doi.org/10.31887/dcns.2019.21.4/sakbarianopenalex-snapshot
Use of the epigenetic toolbox to contextualize common variants associated with schizophrenia risk
inferred← citeshttps://doi.org/10.3389/fgene.2022.878508openalex-snapshot
L1 Retrotransposons: A Potential Endogenous Regulator for Schizophrenia
inferred← citeshttps://doi.org/10.3389/fncel.2023.1139357openalex-snapshot
Emerging epigenetic dynamics in gut-microglia brain axis: experimental and clinical implications for accelerated brain aging in schizophrenia
inferred← citeshttps://doi.org/10.3389/fncel.2023.1220030openalex-snapshot
The computational power of the human brain
inferred← citeshttps://doi.org/10.3389/fneur.2026.1883887openalex-snapshot
DNMT1 as an environmental sensor: epigenetic pathways linking environmental exposures, sex hormone signaling, and vulnerability to neurodevelopmental and neurodegenerative diseases
inferred← citeshttps://doi.org/10.3389/fnins.2016.00202openalex-snapshot
From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia
inferred← citeshttps://doi.org/10.3389/fnins.2020.586133openalex-snapshot
DNA Methylation-Dependent Dysregulation of GABAergic Interneuron Functionality in Neuropsychiatric Diseases
inferred← citeshttps://doi.org/10.3389/fnmol.2013.00014openalex-snapshot
Alcohol and NMDA receptor: current research and future direction
inferred← citeshttps://doi.org/10.3389/fphar.2026.1871913openalex-snapshot
DNA methylation in bipolar disorder: mechanistic insights and translational challenges
inferred← citeshttps://doi.org/10.3390/cells10112890openalex-snapshot
DNA Methylation and Schizophrenia: Current Literature and Future Perspective
inferred← citeshttps://doi.org/10.3390/genes15030272openalex-snapshot
Epigenetic Regulation in Schizophrenia: Focus on Methylation and Histone Modifications in Human Studies
inferred← citeshttps://doi.org/10.3390/ijms18040790openalex-snapshot
Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia
inferred← citeshttps://doi.org/10.3390/ijms21072609openalex-snapshot
Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1+/− Mice
inferred← citeshttps://doi.org/10.3390/ijms22147671openalex-snapshot
Hidden Role of Gut Microbiome Dysbiosis in Schizophrenia: Antipsychotics or Psychobiotics as Therapeutics?
inferred← citeshttps://doi.org/10.3390/ijms25010636openalex-snapshot
Distinctive Patterns of 5-Methylcytosine and 5-Hydroxymethylcytosine in Schizophrenia
inferred← citeshttps://doi.org/10.3791/717openalex-snapshot
A Chromatin Assay for Human Brain Tissue
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