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Enhanced Edar Signalling Has Pleiotropic Effects on Craniofacial and Cutaneous Glands

https://doi.org/10.1371/journal.pone.0007591

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Clinical Spectrum of Anhidrotic Ectodermal Dysplasia

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Races: A Study of the Problems of Race Formation in Man

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Ectodysplasin receptor‐mediated signaling is essential for embryonic submandibular salivary gland development

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Intercellular growth factor signaling and the development of mouse tracheal submucosal glands

inferredcites →https://doi.org/10.1002/humu.20795openalex-snapshot

Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form

inferredcites →https://doi.org/10.1007/s003359900884openalex-snapshot

YAC rescue of downless locus mutations in mice

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Ocular symptoms and signs in patients with ectodermal dysplasia syndromes

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A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland

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A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia

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Tear evaporimeter for measuring water evaporation rate from the tear film under controlled conditions in humans

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Adaptive Evolution of UGT2B17 Copy-Number Variation

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Correlations in a Change in Aqueous Tear Evaporation With a Change in Relative Humidity and the Impact

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Functional aspects of the tear film lipid layer

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Salivary gland development

inferredcites →https://doi.org/10.1016/s0012-1606(03)00157-xopenalex-snapshot

Stimulation of ectodermal organ development by Ectodysplasin-A1

inferredcites →https://doi.org/10.1016/s0014-4835(03)00203-3openalex-snapshot

The lipid layer of tears: dependent on meibomian gland function

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Teleconnection of climatic events between East Asia and polar, high latitude areas during the last deglaciation

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Last Glacial Maximum over China: Sensitivities of climate to paleovegetation and Tibetan ice sheet

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Low Relative Humidity and Aircraft Cabin Air Quality

inferredcites →https://doi.org/10.1038/11937openalex-snapshot

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia

inferredcites →https://doi.org/10.1038/11943openalex-snapshot

Involvement of a novel Tnf receptor homologue in hair follicle induction

inferredcites →https://doi.org/10.1038/jhg.2009.61openalex-snapshot

FGFR2 is associated with hair thickness in Asian populations

inferredcites →https://doi.org/10.1038/jid.2009.8openalex-snapshot

Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

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Genome-wide detection and characterization of positive selection in human populations

inferredcites →https://doi.org/10.1038/nrg2187openalex-snapshot

Recent and ongoing selection in the human genome

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Towards a new classification of ectodermal dysplasias

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The vital role of the skin in human natural history

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Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice

inferredcites →https://doi.org/10.1046/j.1524-4725.2002.01194.xopenalex-snapshot

The Distribution of Follicular Units in the Chinese Scalp: Implications for Reconstruction of Natural-Appearing Hairlines in Orientals

inferredcites →https://doi.org/10.1055/s-2007-961807openalex-snapshot

Sexual Hormones in Human Skin

inferredcites →https://doi.org/10.1067/mjd.2002.119558openalex-snapshot

Hair counts from scalp biopsy specimens in Asians

inferredcites →https://doi.org/10.1073/pnas.94.24.13069openalex-snapshot

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains

inferredcites →https://doi.org/10.1074/jbc.m109.014225openalex-snapshot

Skin-specific Deletion of Stearoyl-CoA Desaturase-1 Alters Skin Lipid Composition and Protects Mice from High Fat Diet-induced Obesity

inferredcites →https://doi.org/10.1086/273542openalex-snapshot

Transactions of the Kansas Academy of Science for 1881-2

inferredcites →https://doi.org/10.1093/hmg/ddg325openalex-snapshot

Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles

inferredcites →https://doi.org/10.1093/hmg/ddm355openalex-snapshot

A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness

inferredcites →https://doi.org/10.1093/ije/30.5.959openalex-snapshot

Ethnic differences in mammographic densities

inferredcites →https://doi.org/10.1093/molbev/msn038openalex-snapshot

Conserved Features and Evolutionary Shifts of the EDA Signaling Pathway Involved in Vertebrate Skin Appendage Development

inferredcites →https://doi.org/10.1096/fj.09-129098openalex-snapshot

Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?

inferredcites →https://doi.org/10.1097/00005537-200206000-00005openalex-snapshot

Ectodermal Dysplasia: Otolaryngologic Manifestations and Management

inferredcites →https://doi.org/10.1097/00044067-200311000-00006openalex-snapshot

Role of Vernix Caseosa in the Neonate

inferredcites →https://doi.org/10.1101/gr.4326505openalex-snapshot

Genomic regions exhibiting positive selection identified from dense genotype data

inferredcites →https://doi.org/10.1101/gr.5157306openalex-snapshot

Genomic signatures of positive selection in humans and the limits of outlier approaches

inferredcites →https://doi.org/10.1111/1523-1747.ep12456718openalex-snapshot

Anhidrosis and Absence of Sweat Glands in Mice Hemizygous for the Tabby Gene; Supportive Evidence for the Hypothesis of Homology Between Tabby and Human Anhidrotic (Hypohidrotic) Ectodermal Dysplasia (Christ-Siemens-Touraine Syndrome)

inferredcites →https://doi.org/10.1111/j.1365-2133.2008.08643.xopenalex-snapshot

Glycerol and the skin: holistic approach to its origin and functions

inferredcites →https://doi.org/10.1111/j.1365-263x.2006.00812.xopenalex-snapshot

Whole saliva in X‐linked hypohidrotic ectodermal dysplasia

inferredcites →https://doi.org/10.1111/j.1365-2842.2007.01794.xopenalex-snapshot

Salivary secretion, taste and hyposalivation

inferredcites →https://doi.org/10.1111/j.1365-4632.2005.02800.xopenalex-snapshot

Diversity of hair growth profiles

inferredcites →https://doi.org/10.1111/j.1469-1809.2007.00390.xopenalex-snapshot

Identification and Analysis of Genomic Regions with Large Between‐Population Differentiation in Humans

inferredcites →https://doi.org/10.1111/j.1469-1809.2008.00489.xopenalex-snapshot

Large Allele Frequency Differences between Human Continental Groups are more Likely to have Occurred by Drift During range Expansions than by Selection

inferredcites →https://doi.org/10.1111/j.1558-5646.1956.tb02835.xopenalex-snapshot

ADAPTATION OF MAN TO COLD CLIMATES

inferredcites →https://doi.org/10.1113/jphysiol.2003.052779openalex-snapshot

Liquid secretion properties of airway submucosal glands

inferredcites →https://doi.org/10.11141/ia.11.2openalex-snapshot

A GIS-based Vegetation Map of the World at the Last Glacial Maximum (25,000-15,000 BP)

inferredcites →https://doi.org/10.1136/adc.62.10.989openalex-snapshot

Clinical aspects of X-linked hypohidrotic ectodermal dysplasia.

inferredcites →https://doi.org/10.1136/jmg.24.11.659openalex-snapshot

Hypohidrotic ectodermal dysplasia.

inferredcites →https://doi.org/10.1152/physrev.1989.69.2.383openalex-snapshot

Control and function of sebaceous glands

inferredcites →https://doi.org/10.1177/014107680109400509openalex-snapshot

Why do we have Apocrine and Sebaceous Glands?

inferredcites →https://doi.org/10.1210/jc.2005-1643openalex-snapshot

Large Differences in Testosterone Excretion in Korean and Swedish Men Are Strongly Associated with a UDP-Glucuronosyl Transferase 2B17 Polymorphism

inferredcites →https://doi.org/10.1242/dev.005439openalex-snapshot

Mammary development in the embryo and adult: a journey of morphogenesis and commitment

inferredcites →https://doi.org/10.1371/journal.pbio.0040072openalex-snapshot

A Map of Recent Positive Selection in the Human Genome

inferredcites →https://doi.org/10.1371/journal.pbio.0050171openalex-snapshot

A New Approach for Using Genome Scans to Detect Recent Positive Selection in the Human Genome

inferredcites →https://doi.org/10.1371/journal.pone.0002209openalex-snapshot

Positive Selection in East Asians for an EDAR Allele that Enhances NF-κB Activation

inferredcites →https://doi.org/10.1515/bc.2007.046openalex-snapshot

Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 -/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation

inferredcites →https://doi.org/10.2114/jpa2.25.7openalex-snapshot

Physiological and Subjective Responses to Low Relative Humidity

inferredcites →https://doi.org/10.2307/3626638openalex-snapshot

Some Aspects of Human Racial Adaptation

inferredcites →https://doi.org/10.2500/ajr.2007.21.2989openalex-snapshot

Rhinologic Manifestations of Ectodermal Dysplasia

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3188440openalex-extracted

Correlated Evolution of Two Copulatory Organs via a Single Cis-Regulatory Nucleotide Change

inferred← citeshttps://doi.org/10.1002/1873-3468.13447openalex-snapshot

How well do we understand the basis of classic selective sweeps in humans?

inferred← citeshttps://doi.org/10.1002/9781118768853.refsopenalex-snapshot

References

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Scanning the human genome for “signatures” of positive selection: Transformative opportunities and ethical obligations

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Salivary gland development and disease

inferred← citeshttps://doi.org/10.1007/978-1-4419-6612-4_3openalex-snapshot

The Edar Subfamily in Hair and Exocrine Gland Development

inferred← citeshttps://doi.org/10.1007/s00018-016-2312-0openalex-snapshot

Genetically modified laboratory mice with sebaceous glands abnormalities

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Cell signaling regulation in salivary gland development

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In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci

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The adaptive variant EDARV370A is associated with straight hair in East Asians

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Ectodysplasin/NF-κB Signaling in Embryonic Mammary Gland Development

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Need for Animal Models of Meibomian Gland Dysfunction

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Human Evolutionary Genetics

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Molecular aspects governing epidermal stem cell niches

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Epithelial Skin Biology

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Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant

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Correlated Evolution of Two Copulatory Organs via a Single cis-Regulatory Nucleotide Change

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Ectodysplasin A (EDA) – EDA receptor signalling and its pharmacological modulation

inferred← citeshttps://doi.org/10.1016/j.jdermsci.2022.01.003openalex-snapshot

Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population

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Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis

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Early inductive events in ectodermal appendage morphogenesis

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Ectodysplasin research—Where to next?

inferred← citeshttps://doi.org/10.1038/495325aopenalex-snapshot

Detecting selection

inferred← citeshttps://doi.org/10.1038/cdd.2011.55openalex-snapshot

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

inferred← citeshttps://doi.org/10.1038/jhg.2012.60openalex-snapshot

Effects of an Asian-specific nonsynonymous EDAR variant on multiple dental traits

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Roles of dental development and adaptation in rodent evolution

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How culture shaped the human genome: bringing genetics and the human sciences together

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Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia

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Characterisation of a second gain of function EDAR variant, encoding EDAR380R, in East Asia

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Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty

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Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB

inferred← citeshttps://doi.org/10.1073/pnas.1711788115openalex-snapshot

Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

inferred← citeshttps://doi.org/10.1093/bib/bbag041openalex-snapshot

Divergent Eurasian ancestry and local adaptation shape the genetic landscapes of the Yugur and Uyghur

inferred← citeshttps://doi.org/10.1093/hmg/ddw202openalex-snapshot

Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology

inferred← citeshttps://doi.org/10.1093/iob/obac018openalex-snapshot

Evidence of Selection in the Ectodysplasin Pathway among Endangered Aquatic Mammals

inferred← citeshttps://doi.org/10.1093/molbev/msad054openalex-snapshot

Comparative Genomic and Transcriptomic Analyses Reveal the Impacts of Genetic Admixture in Kazaks, Uyghurs, and Huis

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Genomic diversity and post-admixture adaptation in the Uyghurs

inferred← citeshttps://doi.org/10.1101/2024.12.01.626243openalex-snapshot

Differential Expression of Edar and Xedar During Mouse and Rat Tail Appendage Development

inferred← citeshttps://doi.org/10.1101/cshperspect.a015222openalex-snapshot

Sweat Gland Progenitors in Development, Homeostasis, and Wound Repair

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Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion

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Downstream activation of NF-κB in the EDA-A1/EDAR signalling in Sjögren's syndrome and its regulation by the ubiquitin-editing enzyme A20

inferred← citeshttps://doi.org/10.1111/evo.13990openalex-snapshot

Co‐evolving wing spots and mating displays are genetically separable traits in Drosophila

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The biology of hair diversity

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Selective advantages, selective mismatches, chronic inflammation, obesity, and type 2 diabetes: a new hypothesis to explain the effects of natural selection on genetic variation at the ectodysplasin A receptor locus

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The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland

inferred← citeshttps://doi.org/10.1186/1471-2156-12-91openalex-snapshot

A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene

inferred← citeshttps://doi.org/10.1242/dev.057711openalex-snapshot

Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis

inferred← citeshttps://doi.org/10.1242/dmm.037804openalex-snapshot

Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia

inferred← citeshttps://doi.org/10.1371/journal.pone.0112840openalex-snapshot

Pharmacological Activation of the EDA/EDAR Signaling Pathway Restores Salivary Gland Function following Radiation-Induced Damage

inferred← citeshttps://doi.org/10.1371/journal.pone.0258212openalex-snapshot

Association of EDARV370A with breast density and metabolic syndrome in Latinos

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Mutant Lef1 controls Gata6 in sebaceous gland development and cancer

inferred← citeshttps://doi.org/10.26575/daj.v34i1.317openalex-snapshot

A Morphofunctional Hypothesis for Selection on EDAR V370A and Associated Elements of Sinodonty

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Studies of genes involved in craniofacial development and tumorigenesis:FGF3contributes to isolated oral clefts and may interact withPAX9

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Anatomy and Development of the Mammalian External Auditory Canal: Implications for Understanding Canal Disease and Deformity

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Dental Phenotype with Minor Ectodermal Symptoms Suggestive of WNT10A Deficiency

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Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland

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