On the public citation graph
Overexpression of HTRA1 Leads to Ultrastructural Changes in the Elastic Layer of Bruch's Membrane via Cleavage of Extracellular Matrix Components
0 signed · 199 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/art.30120openalex-snapshot
Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage
inferredcites →https://doi.org/10.1002/humu.20344openalex-snapshot
Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa
inferredcites →https://doi.org/10.1006/excr.2002.5611openalex-snapshot
Binding of Mouse Nidogen-2 to Basement Membrane Components and Cells and Its Expression in Embryonic and Adult Tissues Suggest Complementary Functions of the Two Nidogens
inferredcites →https://doi.org/10.1006/jmbi.1997.1244openalex-snapshot
Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules
inferredcites →https://doi.org/10.1016/j.clinbiochem.2008.12.020openalex-snapshot
DANCE/fibulin-5 promotes elastic fiber formation in a tropoelastin isoform-dependent manner
inferredcites →https://doi.org/10.1016/j.matbio.2009.03.004openalex-snapshot
Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly
inferredcites →https://doi.org/10.1016/j.ophtha.2004.10.047openalex-snapshot
Risk Factors for the Incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS)AREDS report no. 19
inferredcites →https://doi.org/10.1016/j.ophtha.2007.10.032openalex-snapshot
Alleles in the HtrA Serine Peptidase 1 Gene Alter the Risk of Neovascular Age-Related Macular Degeneration
inferredcites →https://doi.org/10.1016/s0014-5793(99)01362-9openalex-snapshot
Tropoelastin binding to fibulins, nidogen‐2 and other extracellular matrix proteins
inferredcites →https://doi.org/10.1016/s0945-053x(01)00180-9openalex-snapshot
Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix
inferredcites →https://doi.org/10.1038/415171aopenalex-snapshot
Fibulin-5/DANCE is essential for elastogenesis in vivo
inferredcites →https://doi.org/10.1038/cdd.2008.82openalex-snapshot
HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival
inferredcites →https://doi.org/10.1038/ng.170openalex-snapshot
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA
inferredcites →https://doi.org/10.1038/sj.emboj.7601768openalex-snapshot
Latent TGF‐β‐binding protein 2 binds to DANCE/fibulin‐5 and regulates elastic fiber assembly
inferredcites →https://doi.org/10.1038/sj.eye.6701978openalex-snapshot
Smoking and age-related macular degeneration: a review of association
inferredcites →https://doi.org/10.1042/bj20050368openalex-snapshot
Fibulin-5 interacts with fibrillin-1 molecules and microfibrils
inferredcites →https://doi.org/10.1046/j.1365-2141.2000.02011.xopenalex-snapshot
Association of extracellular matrix proteins fibulin‐1 and fibulin‐2 with fibronectin in bone marrow stroma
inferredcites →https://doi.org/10.1056/nejmoa040833openalex-snapshot
Missense Variations in the Fibulin 5 Gene and Age-Related Macular Degeneration
inferredcites →https://doi.org/10.1056/nejmoa0801560openalex-snapshot
Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease
inferredcites →https://doi.org/10.1056/nejmra062326openalex-snapshot
Age-Related Macular Degeneration
inferredcites →https://doi.org/10.1073/pnas.0703933104openalex-snapshot
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration
inferredcites →https://doi.org/10.1074/jbc.m003441200openalex-snapshot
The Upstream Region of the Rpe65 Gene Confers Retinal Pigment Epithelium-specific Expression in Vivo and in Vitro and Contains Critical Octamer and E-box Binding Sites
inferredcites →https://doi.org/10.1074/jbc.m109.037051openalex-snapshot
Identification of a Novel HtrA1-susceptible Cleavage Site in Human Aggrecan
inferredcites →https://doi.org/10.1074/jbc.m403026200openalex-snapshot
Tissue Inhibitor of Metalloproteinases-3 (TIMP-3) Is a Binding Partner of Epithelial Growth Factor-containing Fibulin-like Extracellular Matrix Protein 1 (EFEMP1)
inferredcites →https://doi.org/10.1074/jbc.m500361200openalex-snapshot
The Role of Human HtrA1 in Arthritic Disease
inferredcites →https://doi.org/10.1074/jbc.m608204200openalex-snapshot
Fibrillin-1 Interactions with Fibulins Depend on the First Hybrid Domain and Provide an Adaptor Function to Tropoelastin
inferredcites →https://doi.org/10.1083/jcb.200611026openalex-snapshot
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo
inferredcites →https://doi.org/10.1086/444437openalex-snapshot
Susceptibility Genes for Age-Related Maculopathy on Chromosome 10q26
inferredcites →https://doi.org/10.1093/hmg/ddi230openalex-snapshot
Meta-analysis of genome scans of age-related macular degeneration
inferredcites →https://doi.org/10.1093/hmg/ddi353openalex-snapshot
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
inferredcites →https://doi.org/10.1093/hmg/ddr063openalex-snapshot
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1
inferredcites →https://doi.org/10.1093/jb/mvn014openalex-snapshot
Characterization of the Molecular Interaction between Tropoelastin and DANCE/Fibulin-5
inferredcites →https://doi.org/10.1111/j.1432-1033.1991.tb16258.xopenalex-snapshot
Collagen‐binding domain of human plasma fibronectin contains a latent type‐IV collagenase
inferredcites →https://doi.org/10.1126/science.1133807openalex-snapshot
HTRA1 Promoter Polymorphism in Wet Age-Related Macular Degeneration
inferredcites →https://doi.org/10.1126/science.1133811openalex-snapshot
A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
inferredcites →https://doi.org/10.1128/jb.01187-08openalex-snapshot
Characterization of the Autocleavage Process of the Escherichia coli HtrA Protein: Implications for its Physiological Role
inferredcites →https://doi.org/10.1128/mcb.01330-06openalex-snapshot
Molecular Analysis of Fibulin-5 Function during De Novo Synthesis of Elastic Fibers
inferredcites →https://doi.org/10.1128/mcb.24.2.638-650.2004openalex-snapshot
EMILIN-1 Deficiency Induces Elastogenesis and Vascular Cell Defects
inferredcites →https://doi.org/10.1167/iovs.04-1277openalex-snapshot
Serum Elastin-Derived Peptides in Age-Related Macular Degeneration
inferredcites →https://doi.org/10.1167/iovs.07-1508openalex-snapshot
Increased Choroidal Neovascularization following Laser Induction in Mice Lacking Lysyl Oxidase-like 1
inferredcites →https://doi.org/10.1167/iovs.08-2495openalex-snapshot
Biologically Active Fibronectin Fragments Stimulate Release of MCP-1 and Catabolic Cytokines from Murine Retinal Pigment Epithelium
inferredcites →https://doi.org/10.1167/iovs.09-3850openalex-snapshot
ARMS2 Is a Constituent of the Extracellular Matrix Providing a Link between Familial and Sporadic Age-Related Macular Degenerations
inferredcites →https://doi.org/10.1167/iovs.09-4853openalex-snapshot
Identification of Novel Substrates for the Serine Protease HTRA1 in the Human RPE Secretome
inferredcites →https://doi.org/10.1212/wnl.0b013e3181ff96acopenalex-snapshot
A missense HTRA1 mutation expands CARASIL syndrome to the Caucasian population
inferredcites →https://doi.org/10.1371/journal.pgen.1000836openalex-snapshot
Genetic and Functional Dissection of HTRA1 and LOC387715 in Age-Related Macular Degeneration
inferredcites →https://doi.org/10.14670/hh-25.599openalex-snapshot
Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration.
inferredcites →https://doi.org/10.1681/asn.v12188openalex-snapshot
Induction of Metalloproteinases by Glomerular Mesangial Cells Stimulated by Proteins of the Extracellular Matrix
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.3979180openalex-extracted
Inter-Subunit Crosstalk via PDZ Synergistically Governs Allosteric Activation of Proapoptotic HtrA2
inferred← citeshttps://doi.org/10.1002/art.38124openalex-snapshot
Lipopolysaccharide Increases the Incidence of Collagen‐Induced Arthritis in Mice Through Induction of Protease HTRA‐1 Expression
inferred← citeshttps://doi.org/10.1002/stem.2297openalex-snapshot
Novel Function of Serine Protease HTRA1 in Inhibiting Adipogenic Differentiation of Human Mesenchymal Stem Cells via MAP Kinase-Mediated MMP Upregulation
inferred← citeshttps://doi.org/10.1007/978-3-030-27378-1_1openalex-snapshot
AMD-Associated HTRA1 Variants Do Not Influence TGF-β Signaling in Microglia
inferred← citeshttps://doi.org/10.1007/978-3-030-28384-1_19openalex-snapshot
Animal Models of Diseases of the Retinal Pigment Epithelium
inferred← citeshttps://doi.org/10.1007/978-3-031-27681-1_5openalex-snapshot
Current Views on Chr10q26 Contribution to Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1007/978-3-031-35055-9_19openalex-snapshot
Tiermodelle von Erkrankungen des retinalen Pigmentepithels
inferred← citeshttps://doi.org/10.1007/978-981-15-9184-6_6openalex-snapshot
Genetics of Age-Related Macular Degeneration in Asia
inferred← citeshttps://doi.org/10.1007/978-981-96-0131-8_9openalex-snapshot
The Role of the Extracellular Matrix in TGFBI-Related Corneal Dystrophy Development
inferred← citeshttps://doi.org/10.1007/s00018-017-2592-zopenalex-snapshot
Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1
inferred← citeshttps://doi.org/10.1007/s00401-018-1853-8openalex-snapshot
CADASIL brain vessels show a HTRA1 loss-of-function profile
inferred← citeshttps://doi.org/10.1007/s00417-014-2901-2openalex-snapshot
Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells
inferred← citeshttps://doi.org/10.1007/s00417-024-06442-9openalex-snapshot
The hypothetical molecular mechanism of the ethnic variations in the manifestation of age-related macular degeneration; focuses on the functions of the most significant susceptibility genes
inferred← citeshttps://doi.org/10.1007/s11033-013-2656-6openalex-snapshot
Cumulative association between age-related macular degeneration and less studied genetic variants in PLEKHA1/ARMS2/HTRA1: a meta and gene-cluster analysis
inferred← citeshttps://doi.org/10.1007/s40123-021-00402-wopenalex-snapshot
Association of the HtrA1 rs11200638 Polymorphism with Neovascular Age-Related Macular Degeneration in Indonesia
inferred← citeshttps://doi.org/10.1016/b978-0-12-386456-7.04706-7openalex-snapshot
Pathobiology of the Outer Retina: Genetic and Nongenetic Causes of Disease
inferred← citeshttps://doi.org/10.1016/j.abb.2017.04.004openalex-snapshot
Structural insights into the activation mechanisms of human HtrA serine proteases
inferred← citeshttps://doi.org/10.1016/j.ajo.2012.10.018openalex-snapshot
Age-Related Macular Degeneration Revisited – Piecing the Puzzle: The LXIX Edward Jackson Memorial Lecture
inferred← citeshttps://doi.org/10.1016/j.ajo.2021.06.017openalex-snapshot
Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration
inferred← citeshttps://doi.org/10.1016/j.ajo.2024.02.021openalex-snapshot
Drug Approval for the Treatment of Geographic Atrophy: How We Got Here and Where We Need to Go
inferred← citeshttps://doi.org/10.1016/j.ajo.2025.03.021openalex-snapshot
Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1016/j.ajpath.2012.06.028openalex-snapshot
Adrenomedullin Inhibits Choroidal Neovascularization via CCL2 in the Retinal Pigment Epithelium
inferred← citeshttps://doi.org/10.1016/j.ajpath.2017.06.018openalex-snapshot
Deletion of Endothelial Transforming Growth Factor–β Signaling Leads to Choroidal Neovascularization
inferred← citeshttps://doi.org/10.1016/j.ajpath.2017.08.025openalex-snapshot
Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy
inferred← citeshttps://doi.org/10.1016/j.ajpath.2018.08.012openalex-snapshot
High-Temperature Requirement A 1 Causes Photoreceptor Cell Death in Zebrafish Disease Models
inferred← citeshttps://doi.org/10.1016/j.ebiom.2017.12.011openalex-snapshot
HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
inferred← citeshttps://doi.org/10.1016/j.exer.2012.03.007openalex-snapshot
Characterization of the 10q26-orthologue in rhesus monkeys corroborates a functional connection between ARMS2 and HTRA1
inferred← citeshttps://doi.org/10.1016/j.exer.2013.04.013openalex-snapshot
HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway
inferred← citeshttps://doi.org/10.1016/j.exer.2013.04.019openalex-snapshot
Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina
inferred← citeshttps://doi.org/10.1016/j.exer.2013.06.014openalex-snapshot
Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice
inferred← citeshttps://doi.org/10.1016/j.exer.2013.09.012openalex-snapshot
1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey – A plausible explanation for the influence of vitamin D on age-related macular degeneration?
inferred← citeshttps://doi.org/10.1016/j.exer.2013.11.009openalex-snapshot
Chromosome 10q26 locus and age-related macular degeneration: A progress update
inferred← citeshttps://doi.org/10.1016/j.exer.2015.12.008openalex-snapshot
Hypoxic preconditioning protects photoreceptors against light damage independently of hypoxia inducible transcription factors in rods
inferred← citeshttps://doi.org/10.1016/j.exer.2019.107894openalex-snapshot
Predictive genetics for AMD: Hype and hopes for genetics-based strategies for treatment and prevention
inferred← citeshttps://doi.org/10.1016/j.exer.2021.108605openalex-snapshot
Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degeneration
inferred← citeshttps://doi.org/10.1016/j.exer.2022.109164openalex-snapshot
Elastin turnover in ocular diseases: A special focus on age-related macular degeneration
inferred← citeshttps://doi.org/10.1016/j.exer.2026.110892openalex-snapshot
Methylome profiling reveals epigenetic alterations in the trabecular meshwork of primary open-angle glaucoma
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100456openalex-snapshot
Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro
inferred← citeshttps://doi.org/10.1016/j.joca.2022.02.622openalex-snapshot
Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
inferred← citeshttps://doi.org/10.1016/j.kint.2026.02.036openalex-snapshot
Serine protease HTRA1 is a common autoantigen in membranous nephropathy in patients of 80 years and older
inferred← citeshttps://doi.org/10.1016/j.mam.2012.04.004openalex-snapshot
Genetic insights into age-related macular degeneration: Controversies addressing risk, causality, and therapeutics
inferred← citeshttps://doi.org/10.1016/j.matbio.2018.03.013openalex-snapshot
N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration
inferred← citeshttps://doi.org/10.1016/j.matbio.2024.10.007openalex-snapshot
Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression
inferred← citeshttps://doi.org/10.1016/j.mcp.2025.102031openalex-snapshot
Screening and identification Hub genes associated with immune cell infiltration and critical biomarkers in osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2026.102914openalex-snapshot
HTRA1 and brain disorders: A balancing act across neurodegeneration and repair
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2017.04.004openalex-snapshot
Roles of exosomes in the normal and diseased eye
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2020.100843openalex-snapshot
Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2020.100880openalex-snapshot
Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2022.101154openalex-snapshot
10q26 – The enigma in age-related macular degeneration
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2022.101159openalex-snapshot
Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2024.101247openalex-snapshot
Modeling complex age-related eye disease
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2025.101358openalex-snapshot
Characterizing Bruch's membrane: State-of-the-art imaging, computational segmentation, and biologic models in retinal disease and health
inferred← citeshttps://doi.org/10.1016/j.sjbs.2021.11.056openalex-snapshot
Interplay between HTRA1 and classical signalling pathways in organogenesis and diseases
inferred← citeshttps://doi.org/10.1016/j.str.2022.06.001openalex-snapshot
Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2
inferred← citeshttps://doi.org/10.1016/j.trsl.2014.04.005openalex-snapshot
The role of proteases and inflammatory molecules in triggering neovascular age-related macular degeneration: basic science to clinical relevance
inferred← citeshttps://doi.org/10.1016/j.xops.2020.100002openalex-snapshot
Genetic Association between MMP9 and Choroidal Neovascularization in Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1016/j.xops.2026.101287openalex-snapshot
Interactions Between Epidermal Growth Factor–Containing Fibulin-Like Extracellular Matrix Protein 1 and Tissue Inhibitor of Metalloproteinases-3 and Relevance to Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1016/j.ydbio.2014.10.015openalex-snapshot
Abnormal development of placenta in HtrA1-deficient mice
inferred← citeshttps://doi.org/10.1021/acschembio.4c00818openalex-snapshot
Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface
inferred← citeshttps://doi.org/10.1038/labinvest.2016.117openalex-snapshot
Protective effects of an HTRA1 insertion–deletion variant against age-related macular degeneration in the Chinese populations
inferred← citeshttps://doi.org/10.1038/nchembio.1931openalex-snapshot
Determinants of amyloid fibril degradation by the PDZ protease HTRA1
inferred← citeshttps://doi.org/10.1038/s41433-018-0225-xopenalex-snapshot
Asian age-related macular degeneration: from basic science research perspective
inferred← citeshttps://doi.org/10.1038/s41433-021-01706-8openalex-snapshot
Polymorphism rs11200638 enhanced HtrA1 responsiveness and expression are associated with age-related macular degeneration
inferred← citeshttps://doi.org/10.1038/s41433-021-01765-xopenalex-snapshot
Complement cascade inhibition in geographic atrophy: a review
inferred← citeshttps://doi.org/10.1038/s41514-019-0039-5openalex-snapshot
Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration
inferred← citeshttps://doi.org/10.1038/s41598-017-14208-zopenalex-snapshot
HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication
inferred← citeshttps://doi.org/10.1038/s41598-019-48527-0openalex-snapshot
Effect of Protease Inhibitors in Healing of the Vaginal Wall
inferred← citeshttps://doi.org/10.1038/s41598-022-15232-4openalex-snapshot
Retinal drusen counts are increased in inflammatory bowel disease, and with longer disease duration, more complications and associated IgA glomerulonephritis
inferred← citeshttps://doi.org/10.1038/s41598-023-33886-6openalex-snapshot
Intravitreal injection of fibrillin 2 (Fbn2) recombinant protein for therapy of retinopathy in a retina-specific Fbn2 knock-down mouse model
inferred← citeshttps://doi.org/10.1038/s41598-025-96570-xopenalex-snapshot
Role of alpha-1 antitrypsin in Bruch’s membrane integrity
inferred← citeshttps://doi.org/10.1042/bj20150601openalex-snapshot
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody
inferred← citeshttps://doi.org/10.1073/pnas.1418087111openalex-snapshot
Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling
inferred← citeshttps://doi.org/10.1073/pnas.2103617118openalex-snapshot
Chromosome 10q26–driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium
inferred← citeshttps://doi.org/10.1074/jbc.m111.316232openalex-snapshot
Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates
inferred← citeshttps://doi.org/10.1074/jbc.m114.593384openalex-snapshot
HTRA1 (High Temperature Requirement A Serine Peptidase 1) Gene Is Transcriptionally Regulated by Insertion/Deletion Nucleotides Located at the 3′ End of the ARMS2 (Age-related Maculopathy Susceptibility 2) Gene in Patients with Age-related Macular Degeneration
inferred← citeshttps://doi.org/10.1080/10799893.2020.1805625openalex-snapshot
rs10490924 surrounding HTRA1/ARMS2 regulates the susceptibility of age-related macular degeneration
inferred← citeshttps://doi.org/10.1080/13816810.2020.1768555openalex-snapshot
Associations between IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, and HTRA1 rs11200638 gene polymorphisms and development of optic neuritis with or without multiple sclerosis
inferred← citeshttps://doi.org/10.1089/jop.2021.0067openalex-snapshot
Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models
inferred← citeshttps://doi.org/10.1093/femsle/fnab141openalex-snapshot
High Temperature Requirement A (HtrA) protease ofListeria monocytogenesand its interaction with extracellular matrix molecules
inferred← citeshttps://doi.org/10.1093/hmg/ddv346openalex-snapshot
Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling
inferred← citeshttps://doi.org/10.1093/jmcb/mjx024openalex-snapshot
ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity
inferred← citeshttps://doi.org/10.1097/iae.0000000000000263openalex-snapshot
COMPARISON OF DRUSEN AND MODIFYING GENES IN AUTOSOMAL DOMINANT RADIAL DRUSEN AND AGE-RELATED MACULAR DEGENERATION
inferred← citeshttps://doi.org/10.1097/opx.0000000000000322openalex-snapshot
Studying Age‐Related Macular Degeneration Using Animal Models
inferred← citeshttps://doi.org/10.1101/cshperspect.a017202openalex-snapshot
Highly Penetrant Alleles in Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1111/acel.12710openalex-snapshot
HTRA 1, an age‐related macular degeneration protease, processes extracellular matrix proteins EFEMP 1 and TSP 1
inferred← citeshttps://doi.org/10.1111/aos.12437openalex-snapshot
Environmental and genetic risk factors for retinal angiomatous proliferation
inferred← citeshttps://doi.org/10.1111/liv.12337openalex-snapshot
Matrix metalloproteinase‐10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair
inferred← citeshttps://doi.org/10.1111/mmi.12276openalex-snapshot
L yme disease spirochaetes possess an aggrecan‐binding protease with aggrecanase activity
inferred← citeshttps://doi.org/10.1111/mmi.12377openalex-snapshot
B orrelia burgdorferi BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokines in vitro
inferred← citeshttps://doi.org/10.1111/mmi.13251openalex-snapshot
The salt‐sensitive structure and zinc inhibition of B orrelia burgdorferi protease BbHtrA
inferred← citeshttps://doi.org/10.1128/mcb.01283-12openalex-snapshot
Age-Related Macular Degeneration-Associated Silent Polymorphisms in HtrA1 Impair Its Ability To Antagonize Insulin-Like Growth Factor 1
inferred← citeshttps://doi.org/10.1152/ajpcell.00060.2023openalex-snapshot
Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity
inferred← citeshttps://doi.org/10.1155/2015/821918openalex-snapshot
Joint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population
inferred← citeshttps://doi.org/10.1159/000355488openalex-snapshot
Polypoidal Choroidal Vasculopathy: Clinical Features and Genetic Predisposition
inferred← citeshttps://doi.org/10.1161/atvbaha.113.301893openalex-snapshot
LRP1 Protects the Vasculature by Regulating Levels of Connective Tissue Growth Factor and HtrA1
inferred← citeshttps://doi.org/10.1161/atvbaha.113.301924openalex-snapshot
Low-Density Lipoprotein Receptor–Related Protein-1
inferred← citeshttps://doi.org/10.1167/iovs.12-9652openalex-snapshot
Single Nucleotide Polymorphism in the Cholesterol-24S-Hydroxylase ( CYP46A1 ) Gene and Its Association with CFH and LOC387715 Gene Polymorphisms in Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1167/iovs.13-13111openalex-snapshot
Angiographic Features of Transgenic Mice With Increased Expression of Human Serine Protease HTRA1 in Retinal Pigment Epithelium
inferred← citeshttps://doi.org/10.1167/iovs.13-13420openalex-snapshot
Genetic and Environmental Risk Factors for Age-Related Macular Degeneration in Persons 90 Years and Older
inferred← citeshttps://doi.org/10.1167/iovs.14-14453openalex-snapshot
Overexpression of HtrA1 and Exposure to Mainstream Cigarette Smoke Leads to Choroidal Neovascularization and Subretinal Deposits in Aged Mice
inferred← citeshttps://doi.org/10.1167/iovs.14-15670openalex-snapshot
A Functional Approach to Examine the Role of HTRA1 Versus ARMS2 in AMD
inferred← citeshttps://doi.org/10.1167/iovs.15-18855openalex-snapshot
Association of Hyperreflective Foci Present in Early Forms of Age-Related Macular Degeneration With Known Age-Related Macular Degeneration Risk Polymorphisms
inferred← citeshttps://doi.org/10.1167/iovs.16-20922openalex-snapshot
HTRA1 and TGF-β1 Concentrations in the Aqueous Humor of Patients With Neovascular Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1172/jci.insight.178827openalex-snapshot
Ablation of Htra1 leads to sub-RPE deposits and photoreceptor abnormalities
inferred← citeshttps://doi.org/10.1172/jci140555openalex-snapshot
Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model
inferred← citeshttps://doi.org/10.1177/0192623320976095openalex-snapshot
Nonclinical Safety Assessment of FHTR2163, An Antigen-Binding Fragment Against HTRA1 for the Treatment of Geographic Atrophy
inferred← citeshttps://doi.org/10.1177/1120672120919337openalex-snapshot
Bruch’s membrane pathology: A mechanistic perspective
inferred← citeshttps://doi.org/10.1186/1471-2164-13-130openalex-snapshot
Gene expression in Atlantic salmon skin in response to infection with the parasitic copepod Lepeophtheirus salmonis, cortisol implant, and their combination
inferred← citeshttps://doi.org/10.1186/s12885-016-2873-1openalex-snapshot
The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation
inferred← citeshttps://doi.org/10.1186/s13024-018-0243-yopenalex-snapshot
Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia
inferred← citeshttps://doi.org/10.1186/s13073-015-0183-xopenalex-snapshot
Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration
inferred← citeshttps://doi.org/10.1186/s40478-021-01303-6openalex-snapshot
Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates
inferred← citeshttps://doi.org/10.1186/s40662-026-00495-zopenalex-snapshot
Differential regulation of myopia progression by ON and OFF stimulation in guinea pigs
inferred← citeshttps://doi.org/10.1242/dmm.052253openalex-snapshot
HTRA1-dependent proteolysis induces age-related retinal degeneration and exacerbates choroidal neovascularization
inferred← citeshttps://doi.org/10.12659/msm.882447openalex-snapshot
A69S and R38X ARMS2 and Y402H CFH gene polymorphisms as risk factors for neovascular age-related macular degeneration in Poland – a brief report
inferred← citeshttps://doi.org/10.1371/journal.pone.0046115openalex-snapshot
Overexpression of HTRA1 Leads to Down-Regulation of Fibronectin and Functional Changes in RF/6A Cells and HUVECs
inferred← citeshttps://doi.org/10.1371/journal.pone.0056376openalex-snapshot
Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse
inferred← citeshttps://doi.org/10.1371/journal.pone.0068088openalex-snapshot
Interaction of Complement Factor H and Fibulin3 in Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1371/journal.pone.0074094openalex-snapshot
Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation
inferred← citeshttps://doi.org/10.1371/journal.pone.0109483openalex-snapshot
Alpha-1-Antitrypsin: A Novel Human High Temperature Requirement Protease A1 (HTRA1) Substrate in Human Placental Tissue
inferred← citeshttps://doi.org/10.1371/journal.pone.0115362openalex-snapshot
Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease
inferred← citeshttps://doi.org/10.1371/journal.pone.0216808openalex-snapshot
HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression
inferred← citeshttps://doi.org/10.1681/asn.2020101395openalex-snapshot
Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
inferred← citeshttps://doi.org/10.18632/oncotarget.24484openalex-snapshot
Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer
inferred← citeshttps://doi.org/10.20517/2574-1209.2020.48openalex-snapshot
The interplay of oxidative stress and ARMS2-HTRA1 genetic risk in neovascular AMD
inferred← citeshttps://doi.org/10.21203/rs.3.rs-8588203/v1openalex-snapshot
Dynamic ON stimulation preserves choroidal homeostasis and attenuates lens-induced myopia in guinea pigs
inferred← citeshttps://doi.org/10.2147/ijgm.s456912openalex-snapshot
Progress in the Study of the Role and Mechanism of HTRA1 in Diseases Related to Vascular Abnormalities
inferred← citeshttps://doi.org/10.2217/fmeb2013.13.255openalex-snapshot
Genetic markers for age-related macular degeneration
inferred← citeshttps://doi.org/10.32657/10356/155373openalex-snapshot
Elucidating endothelial pathology in polypoidal choroidal vasculopathy : a patient-derived cellular model approach
inferred← citeshttps://doi.org/10.3389/fcell.2019.00031openalex-snapshot
Low Density Receptor-Related Protein 1 Interactions With the Extracellular Matrix: More Than Meets the Eye
inferred← citeshttps://doi.org/10.3389/fcell.2020.604220openalex-snapshot
New Technologies to Study Functional Genomics of Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.3389/fimmu.2020.589863openalex-snapshot
Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization
inferred← citeshttps://doi.org/10.3389/fmed.2023.1239056openalex-snapshot
Development and validation of risk prediction and neural network models for dilated cardiomyopathy based on WGCNA
inferred← citeshttps://doi.org/10.3389/fphar.2019.01363openalex-snapshot
Choroidal Neovascularization: Mechanisms of Endothelial Dysfunction
inferred← citeshttps://doi.org/10.3390/biom15111571openalex-snapshot
Translational Molecular and Fluid Biomarkers for Age-Related Macular Degeneration: Practical Insights from Animal Models and Humans
inferred← citeshttps://doi.org/10.3390/biom16020234openalex-snapshot
Molecular Crosstalk in Age-Related Macular Degeneration: Integrating Oxidative Stress, Inflammation, microRNAs, and Genetic Susceptibility Toward Precision Therapeutics
inferred← citeshttps://doi.org/10.3390/books978-3-03897-399-7openalex-snapshot
Recent Advances in Scar Biology
inferred← citeshttps://doi.org/10.3390/cancers14133038openalex-snapshot
Proteases and HPV-Induced Carcinogenesis
inferred← citeshttps://doi.org/10.3390/cells12091308openalex-snapshot
Exploring the Therapeutic Potential of Elastase Inhibition in Age-Related Macular Degeneration in Mouse and Human
inferred← citeshttps://doi.org/10.3390/genes17030283openalex-snapshot
Precision Is Not Enough: When Tools Outpace Translation in Ocular Gene Therapy
inferred← citeshttps://doi.org/10.3390/ijms19051275openalex-snapshot
HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development
inferred← citeshttps://doi.org/10.3390/ijms221910756openalex-snapshot
Overview of Human HtrA Family Proteases and Their Distinctive Physiological Roles and Unique Involvement in Diseases, Especially Cancer and Pregnancy Complications
inferred← citeshttps://doi.org/10.3934/molsci.2016.2.196openalex-snapshot
Oxidative stress, innate immunity, and age-related macular degeneration
inferred← citeshttps://doi.org/10.4049/jimmunol.1302700openalex-snapshot
The Inhibitory Effect of IFN-γ on Protease HTRA1 Expression in Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.4081/ejh.2016.2724openalex-snapshot
High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling
inferred← citeshttps://doi.org/10.4103/jovr.jovr_125_18openalex-snapshot
Role of the choroid in age-related macular degeneration: A current review
inferred← citeshttps://doi.org/10.4103/tjo.tjo-d-23-00152openalex-snapshot
Role of ARMS2/HTRA1 risk alleles in the pathogenesis of neovascular age-related macular degeneration
inferred← citeshttps://doi.org/10.6084/m9.figshare.19029563openalex-snapshot
Additional file 4 of Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates
inferred← citeshttps://doi.org/10.70675/1033a824z7048z4435zbbeczcd650e1e8e21openalex-snapshot
La sérine protéase HTRA1 et l'inflammation sous-rétinienne dans le contexte de la dégénérescence maculaire liée à l'âge
inferred← citeshttps://doi.org/10.70675/449f345azbf90z4a81zaa22z4d6385c15f1eopenalex-snapshot
Genomic depiction of human iPSC differentiation into smooth muscle cells and application to assess the functional regulation at LRP1, a pleiotropic genetic risk locus for several cardiovascular diseases
inferred← citeshttps://doi.org/10.70675/d9dc4ed9zdf25z4c75z9e2ez4776a72bb628openalex-snapshot
Étude des mécanismes extracellulaires régulant la fonction du récepteur MerTK au cours de la phagocytose rétinienne
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.