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IFN-α Is Constitutively Expressed in the Human Thymus, but Not in Peripheral Lymphoid Organs
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/1521-4141(200011)30:11<3228::aid-immu3228>3.0.co;2-bopenalex-snapshot
Human T cells elicit IFN-α secretion from dendritic cells following cell to cell interactions
inferredcites →https://doi.org/10.1002/eji.1830200920openalex-snapshot
The human intracellular Mx‐homologous protein is specifically induced by type I interferons
inferredcites →https://doi.org/10.1006/meth.1998.0629openalex-snapshot
MxA GTPase: Oligomerization and GTP-Dependent Interaction with Viral RNP Target Structures
inferredcites →https://doi.org/10.1016/0092-8674(86)90493-9openalex-snapshot
Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus
inferredcites →https://doi.org/10.1016/s0166-0934(97)00177-8openalex-snapshot
The MxA protein levels in whole blood lysates of patients with various viral infections
inferredcites →https://doi.org/10.1038/11360openalex-snapshot
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
inferredcites →https://doi.org/10.1038/372100a0openalex-snapshot
T-cell apoptosis detected in situ during positive and negative selection in the thymus
inferredcites →https://doi.org/10.1038/nature06116openalex-snapshot
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
inferredcites →https://doi.org/10.1038/sj.icb.7100141openalex-snapshot
What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain
inferredcites →https://doi.org/10.1073/pnas.0337679100openalex-snapshot
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
inferredcites →https://doi.org/10.1073/pnas.052430399openalex-snapshot
Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes
inferredcites →https://doi.org/10.1073/pnas.1006539107openalex-snapshot
Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
inferredcites →https://doi.org/10.1073/pnas.80.7.1910openalex-snapshot
Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus.
inferredcites →https://doi.org/10.1073/pnas.95.16.9541openalex-snapshot
The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface
inferredcites →https://doi.org/10.1084/jem.185.3.517openalex-snapshot
Virus-induced Transient Bone Marrow Aplasia: Major Role of Interferon-α/β during Acute Infection with the Noncytopathic Lymphocytic Choriomeningitis Virus
inferredcites →https://doi.org/10.1084/jem.187.1.79openalex-snapshot
Impairment of T and B Cell Development by Treatment with a Type I Interferon
inferredcites →https://doi.org/10.1084/jem.192.2.219openalex-snapshot
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
inferredcites →https://doi.org/10.1084/jem.20090480openalex-snapshot
Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
inferredcites →https://doi.org/10.1089/jir.2006.26.214openalex-snapshot
Stimulus-Dependent and Domain-Dependent Cell Death Acceleration by an IFN-Inducible Protein, Human MxA
inferredcites →https://doi.org/10.1089/jir.2010.0076openalex-snapshot
Human MxA Protein: An Interferon-Induced Dynamin-Like GTPase with Broad Antiviral Activity
inferredcites →https://doi.org/10.1093/nar/gkh192openalex-snapshot
Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome
inferredcites →https://doi.org/10.1097/00001432-200206000-00008openalex-snapshot
The interferon antiviral response: from viral invasion to evasion
inferredcites →https://doi.org/10.1097/00002030-199002000-00004openalex-snapshot
The interferon-induced Mx-homologous protein in people with symptomatic HIV-1 infection
inferredcites →https://doi.org/10.1097/00002030-199606001-00001openalex-snapshot
Differential tropism of HIV-1 isolates for distinct thymocyte subsets in vitro
inferredcites →https://doi.org/10.1111/j.0105-2896.2004.00204.xopenalex-snapshot
Interferons, interferon‐like cytokines, and their receptors
inferredcites →https://doi.org/10.1111/j.1348-0421.2002.tb02673.xopenalex-snapshot
Promoted Cell Death of Cells Expressing Human MxA by Influenza Virus Infection
inferredcites →https://doi.org/10.1126/science.284.5421.1835openalex-snapshot
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
inferredcites →https://doi.org/10.1128/cvi.00184-06openalex-snapshot
Human Immunodeficiency Virus Persistence and Production in T-Cell Development
inferredcites →https://doi.org/10.1128/jvi.00546-06openalex-snapshot
Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon Signaling
inferredcites →https://doi.org/10.1128/jvi.69.10.6259-6264.1995openalex-snapshot
In vivo pathogenic properties of two clonal human immunodeficiency virus type 1 isolates
inferredcites →https://doi.org/10.1128/jvi.71.11.8245-8253.1997openalex-snapshot
High viral burden and rapid CD4+ cell depletion in human immunodeficiency virus type 1-infected SCID-hu mice suggest direct viral killing of thymocytes in vivo
inferredcites →https://doi.org/10.1128/jvi.71.9.6928-6934.1997openalex-snapshot
CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus
inferredcites →https://doi.org/10.1128/jvi.72.12.10108-10117.1998openalex-snapshot
CCR5- and CXCR4-Utilizing Strains of Human Immunodeficiency Virus Type 1 Exhibit Differential Tropism and Pathogenesis In Vivo
inferredcites →https://doi.org/10.1128/jvi.72.12.9441-9452.1998openalex-snapshot
Differential Tropism and Replication Kinetics of Human Immunodeficiency Virus Type 1 Isolates in Thymocytes: Coreceptor Expression Allows Viral Entry, but Productive Infection of Distinct Subsets Is Determined at the Postentry Level
inferredcites →https://doi.org/10.1128/jvi.76.21.11033-11041.2002openalex-snapshot
Productive Infection of Plasmacytoid Dendritic Cells with Human Immunodeficiency Virus Type 1 Is Triggered by CD40 Ligation
inferredcites →https://doi.org/10.1128/jvi.76.21.11148-11154.2002openalex-snapshot
Comparative Analysis of Anti-Hepatitis C Virus Activity and Gene Expression Mediated by Alpha, Beta, and Gamma Interferons
inferredcites →https://doi.org/10.1128/jvi.77.6.3777-3784.2003openalex-snapshot
Natural Alpha Interferon-Producing Cells Respond to Human Immunodeficiency Virus Type 1 with Alpha Interferon Production and Maturation into Dendritic Cells
inferredcites →https://doi.org/10.1172/jci11734openalex-snapshot
Human thymus contains IFN-α–producing CD11c–, myeloid CD11c+, and mature interdigitating dendritic cells
inferredcites →https://doi.org/10.1182/blood-2006-02-004978openalex-snapshot
Stimulated plasmacytoid dendritic cells impair human T-cell development
inferredcites →https://doi.org/10.1182/blood-2009-10-248260openalex-snapshot
Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development
inferredcites →https://doi.org/10.1182/blood.v94.8.2647.420k06_2647_2657openalex-snapshot
Expression of pT mRNA in a Committed Dendritic Cell Precursor in the Human Thymus
inferredcites →https://doi.org/10.1182/blood.v97.6.1733openalex-snapshot
Human thymus contains 2 distinct dendritic cell populations
inferredcites →https://doi.org/10.1371/journal.pmed.0030289openalex-snapshot
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
inferredcites →https://doi.org/10.1385/ir:28:3:295openalex-snapshot
TRAIL, Bim, and Thymic-Negative Selection
inferredcites →https://doi.org/10.3181/00379727-116-29292openalex-snapshot
Inheritance of Resistance to Influenza Virus in Mice.
inferredcites →https://doi.org/10.4049/jimmunol.0804106openalex-snapshot
Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus
inferredcites →https://doi.org/10.4049/jimmunol.152.9.4649openalex-snapshot
CD4+ blood dendritic cells are potent producers of IFN-alpha in response to in vitro HIV-1 infection.
inferredcites →https://doi.org/10.4049/jimmunol.166.5.2961openalex-snapshot
Differential Regulation of Human Blood Dendritic Cell Subsets by IFNs
inferredcites →https://doi.org/10.4049/jimmunol.168.1.325openalex-snapshot
IFN-α Secretion by Type 2 Predendritic Cells Up-Regulates MHC Class I in the HIV-1-Infected Thymus
inferredcites →https://doi.org/10.4049/jimmunol.173.12.7269openalex-snapshot
Endogenous IFN-α Production by Plasmacytoid Dendritic Cells Exerts an Antiviral Effect on Thymic HIV-1 Infection
inferredcites →https://doi.org/10.4049/jimmunol.180.11.7134openalex-snapshot
TLR Ligand-Induced Type I IFNs Affect Thymopoiesis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/eji.201444787openalex-snapshot
BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells
inferred← citeshttps://doi.org/10.1007/s00005-017-0462-xopenalex-snapshot
Acute Thymic Involution and Mechanisms for Recovery
inferred← citeshttps://doi.org/10.1007/s00018-012-1124-0openalex-snapshot
MicroRNA-29 in the adaptive immune system: setting the threshold
inferred← citeshttps://doi.org/10.1007/s10522-025-10353-5openalex-snapshot
Activation of cGAS-STING signaling in senescent cells promotes the aging process by remodeling the functions of the immune system
inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167500openalex-snapshot
MicroRNAs and human viral diseases: A focus on the role of microRNA-29
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111050openalex-snapshot
A Single Cell Analysis of Thymopoiesis and Thymic iNKT Cell Development in Pigs
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115579openalex-snapshot
Establishment of a microwell-array-based miniaturized thymic organoid model suitable for high-throughput applications
inferred← citeshttps://doi.org/10.1016/j.devcel.2023.08.017openalex-snapshot
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus
inferred← citeshttps://doi.org/10.1016/j.immuni.2025.12.010openalex-snapshot
A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages
inferred← citeshttps://doi.org/10.1016/j.isci.2021.102322openalex-snapshot
Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19
inferred← citeshttps://doi.org/10.1016/j.isci.2023.106223openalex-snapshot
Thymus antibody-secreting cells possess an interferon gene signature and are preferentially expanded in young female mice
inferred← citeshttps://doi.org/10.1016/j.isci.2026.116530openalex-snapshot
Type I IFN-controlled Qa-2 expression identifies and maps the generation of Eomes+ thymic innate CD8 T cells
inferred← citeshttps://doi.org/10.1016/j.jaci.2015.12.1339openalex-snapshot
Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery
inferred← citeshttps://doi.org/10.1016/j.mucimm.2024.03.011openalex-snapshot
Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells
inferred← citeshttps://doi.org/10.1016/j.pep.2022.106125openalex-snapshot
Improved yield of recombinant human IFN-α2b from mammalian cells using heterologous signal peptide approach
inferred← citeshttps://doi.org/10.1016/j.stem.2020.08.001openalex-snapshot
Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth
inferred← citeshttps://doi.org/10.1016/j.virusres.2022.199028openalex-snapshot
NS2 is a key determinant of compatibility in reassortant avian influenza virus with heterologous H7N9-derived NS segment
inferred← citeshttps://doi.org/10.1038/ncomms8089openalex-snapshot
Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8+ T cells
inferred← citeshttps://doi.org/10.1038/s41598-017-18225-wopenalex-snapshot
miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)
inferred← citeshttps://doi.org/10.1084/jem.20241403openalex-snapshot
Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα
inferred← citeshttps://doi.org/10.1093/intimm/dxy073openalex-snapshot
Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus
inferred← citeshttps://doi.org/10.1093/jimmun/vkaf048openalex-snapshot
Sterile production of interferons in the thymus
inferred← citeshttps://doi.org/10.1097/qad.0000000000000249openalex-snapshot
Modified interferon-α subtypes production and chemokine networks in the thymus during acute simian immunodeficiency virus infection, impact on thymopoiesis
inferred← citeshttps://doi.org/10.1101/2023.07.12.548732openalex-snapshot
Transposable elements regulate thymus development and function
inferred← citeshttps://doi.org/10.1101/2024.09.23.614441openalex-snapshot
Watch-breaker: establishment of a microwell array-based miniaturized thymic organoid model suitable for high throughput applications
inferred← citeshttps://doi.org/10.1111/imr.70037openalex-snapshot
Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond
inferred← citeshttps://doi.org/10.1111/imr.70038openalex-snapshot
Thymic Interferons: A Little Goes a Long Way
inferred← citeshttps://doi.org/10.1111/imr.70091openalex-snapshot
AIRE's Complex Role Beyond Promiscuous Gene Expression
inferred← citeshttps://doi.org/10.1126/sciimmunol.ado4720openalex-snapshot
Distinct type I and II interferon responses direct cortical and medullary thymic epithelial cell development
inferred← citeshttps://doi.org/10.1155/2016/9523628openalex-snapshot
Thymic and Postthymic Regulation of Naïve CD4+T-Cell Lineage Fates in Humans and Mice Models
inferred← citeshttps://doi.org/10.1155/2022/3861518openalex-snapshot
Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling
inferred← citeshttps://doi.org/10.1186/s12985-025-02816-5openalex-snapshot
Abundance of single filamentous bacteria, and expression of differentiated Th17 cells, their signature cytokine IL-17 A, and retinoic acid receptor are predictive of poor rotavirus vaccine take
inferred← citeshttps://doi.org/10.1186/s13099-024-00672-2openalex-snapshot
Significant abundance of bacterial flagellin and expression of its surface localized receptor toll-like receptor 5 and cytokine interleukin-22 in South African infants with poor oral rotavirus vaccine take
inferred← citeshttps://doi.org/10.1371/journal.pone.0089869openalex-snapshot
Critical Role of Interferon-α Constitutively Produced in Human Hepatocytes in Response to RNA Virus Infection
inferred← citeshttps://doi.org/10.15252/embr.201846303openalex-snapshot
ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2124035/v1openalex-snapshot
HIV-1 infection results in upregulation of Sphingosine-1-phosphate receptor 1 in the human thymus
inferred← citeshttps://doi.org/10.21203/rs.3.rs-6320780/v1openalex-snapshot
Abundance of single filamentous bacteria and expression of differentiated Th17 cells, cytokines IL-17A and IL-22, and retinoic acid receptor are significantly high in infants with abysmal oral rotavirus vaccine replication
inferred← citeshttps://doi.org/10.3389/fimmu.2013.00334openalex-snapshot
Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2
inferred← citeshttps://doi.org/10.3389/fimmu.2021.635569openalex-snapshot
Post-Aire Medullary Thymic Epithelial Cells and Hassall’s Corpuscles as Inducers of Tonic Pro-Inflammatory Microenvironment
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1170438openalex-snapshot
Thymus antibody-secreting cells: once forgotten but not lost
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1327784openalex-snapshot
Interferon autoantibodies as signals of a sick thymus
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1339787openalex-snapshot
Comparative transcriptome analysis of T lymphocyte subpopulations and identification of critical regulators defining porcine thymocyte identity
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1517893openalex-snapshot
Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1689906openalex-snapshot
Decoding thymic development: a single-cell atlas of tree shrew immunity
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1824198openalex-snapshot
CD19, immunoglobulin level, and varied anti-cytokine autoantibodies underline dichotomous susceptibility to types of infection in patients with thymomas
inferred← citeshttps://doi.org/10.3390/cells12020296openalex-snapshot
Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals
inferred← citeshttps://doi.org/10.3390/ijms241813865openalex-snapshot
HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus
inferred← citeshttps://doi.org/10.3390/pharmaceutics15020672openalex-snapshot
Inhibition of Hepatitis B Virus (HBV) by Tachyplesin, a Marine Antimicrobial Cell-Penetrating Peptide
inferred← citeshttps://doi.org/10.3390/pharmaceutics15122715openalex-snapshot
Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways
inferred← citeshttps://doi.org/10.70675/3fad0443za1c1z45e4zb4d5z6d99660ec7d8openalex-snapshot
Infectious susceptibilities due to inborn errors of type I or II interferon immunity or their autoimmune phenocopies
inferred← citeshttps://doi.org/10.7554/elife.91037openalex-snapshot
Transposable elements regulate thymus development and function
inferred← citeshttps://doi.org/10.7554/elife.91037.1openalex-snapshot
Transposable elements regulate thymus development and function
inferred← citeshttps://doi.org/10.7554/elife.91037.2openalex-snapshot
Transposable elements regulate thymus development and function
inferred← citeshttps://doi.org/10.7554/elife.91037.3openalex-snapshot
Transposable elements regulate thymus development and function
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