On the public citation graph

The fbpA/sapM Double Knock Out Strain of Mycobacterium tuberculosis Is Highly Attenuated and Immunogenic in Macrophages

https://doi.org/10.1371/journal.pone.0036198

0 signed · 117 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/emmm.201000125openalex-snapshot

Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis

inferredcites →https://doi.org/10.1016/0076-6879(91)04027-lopenalex-snapshot

[25] Genetic systems for mycobacteria

inferredcites →https://doi.org/10.1016/0966-842x(96)81528-9openalex-snapshot

Characterization of the Mycobacterium tuberculosis phagosome

inferredcites →https://doi.org/10.1016/j.coi.2010.04.006openalex-snapshot

Novel tuberculosis vaccines on the horizon

inferredcites →https://doi.org/10.1016/j.imlet.2005.10.011openalex-snapshot

Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis

inferredcites →https://doi.org/10.1016/j.micinf.2005.03.008openalex-snapshot

The use of animal models to guide rational vaccine design

inferredcites →https://doi.org/10.1016/j.micinf.2005.04.001openalex-snapshot

Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis

inferredcites →https://doi.org/10.1016/j.tube.2004.09.008openalex-snapshot

NIH pre-clinical screening program: overview and current status

inferredcites →https://doi.org/10.1016/j.vaccine.2005.11.051openalex-snapshot

Immunogenicity and protection induced by Mycobacterium tuberculosis mce-2 and mce-3 mutants in a Balb/c mouse model of progressive pulmonary tuberculosis

inferredcites →https://doi.org/10.1016/j.vaccine.2006.03.017openalex-snapshot

The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs

inferredcites →https://doi.org/10.1016/j.vaccine.2006.05.097openalex-snapshot

Mycobacterium tuberculosis ΔRD1 ΔpanCD: A safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis

inferredcites →https://doi.org/10.1016/j.vaccine.2007.07.042openalex-snapshot

A mutant of Mycobacterium tuberculosis lacking the 19-kDa lipoprotein Rv3763 is highly attenuated in vivo but retains potent vaccinogenic properties

inferredcites →https://doi.org/10.1016/j.vaccine.2009.05.050openalex-snapshot

Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates

inferredcites →https://doi.org/10.1016/s0140-6736(95)92348-9openalex-snapshot

Variation in protection by BCG: implications of and for heterologous immunity

inferredcites →https://doi.org/10.1016/s0966-842x(98)01286-4openalex-snapshot

What does `inhibition of phagosome–lysosome fusion' really mean?

inferredcites →https://doi.org/10.1016/s1471-4906(01)01865-8openalex-snapshot

TB vaccines: progress and problems

inferredcites →https://doi.org/10.1016/s1472-9792(03)00050-7openalex-snapshot

Nitric oxide regulation of l-arginine uptake in murine and human macrophages

inferredcites →https://doi.org/10.1038/35085034openalex-snapshot

Mycobacterium tuberculosis: here today, and here tomorrow

inferredcites →https://doi.org/10.1038/ncb0903-776openalex-snapshot

Phagosomes, fatty acids and tuberculosis

inferredcites →https://doi.org/10.1038/nm.1928openalex-snapshot

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

inferredcites →https://doi.org/10.1038/nm765openalex-snapshot

A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis

inferredcites →https://doi.org/10.1038/nm859openalex-snapshot

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

inferredcites →https://doi.org/10.1038/nrmicro1211openalex-snapshot

The success and failure of BCG — implications for a novel tuberculosis vaccine

inferredcites →https://doi.org/10.1038/nrmicro1419openalex-snapshot

Advances in tuberculosis vaccine strategies

inferredcites →https://doi.org/10.1038/nrmicro1703openalex-snapshot

Tuberculosis vaccines — an update

inferredcites →https://doi.org/10.1046/j.1365-2958.1999.01383.xopenalex-snapshot

Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays

inferredcites →https://doi.org/10.1073/pnas.0409716102openalex-snapshot

Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis

inferredcites →https://doi.org/10.1073/pnas.250480397openalex-snapshot

Recombinant bacillus Calmette–Guérin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model

inferredcites →https://doi.org/10.1073/pnas.95.9.5299openalex-snapshot

Mycobacterium bovis bacille Calmette–Guérin strains secreting listeriolysin of Listeria monocytogenes

inferredcites →https://doi.org/10.1074/jbc.272.20.13326openalex-snapshot

Arrest of Mycobacterial Phagosome Maturation Is Caused by a Block in Vesicle Fusion between Stages Controlled by rab5 and rab7

inferredcites →https://doi.org/10.1084/jem.142.1.1openalex-snapshot

Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival.

inferredcites →https://doi.org/10.1084/jem.194.10.1421openalex-snapshot

Processing of Mycobacterium tuberculosis Antigen 85B Involves Intraphagosomal Formation of Peptide–Major Histocompatibility Complex II Complexes and Is Inhibited by Live Bacilli that Decrease Phagosome Maturation

inferredcites →https://doi.org/10.1091/mbc.e03-05-0307openalex-snapshot

Mycobacterium tuberculosisPhagosome Maturation Arrest: Mycobacterial Phosphatidylinositol Analog Phosphatidylinositol Mannoside Stimulates Early Endosomal Fusion

inferredcites →https://doi.org/10.1099/00221287-146-8-1969openalex-snapshot

Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement

inferredcites →https://doi.org/10.1111/j.1365-2249.2005.02832.xopenalex-snapshot

Immunogenicity and protective efficacy of the Mycobacterium tuberculosis fadD26 mutant

inferredcites →https://doi.org/10.1111/j.1365-2249.2006.03284.xopenalex-snapshot

Immunological responses and protective immunity against tuberculosis conferred by vaccination of Balb/C mice with the attenuated Mycobacterium tuberculosis (phoP) SO2 strain

inferredcites →https://doi.org/10.1111/j.1462-5822.2008.01126.xopenalex-snapshot

The ΔfbpA mutant derived from Mycobacterium tuberculosis H37Rv has an enhanced susceptibility to intracellular antimicrobial oxidative mechanisms, undergoes limited phagosome maturation and activates macrophages and dendritic cells

inferredcites →https://doi.org/10.1126/science.284.5419.1520openalex-snapshot

Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray

inferredcites →https://doi.org/10.1126/science.8098550openalex-snapshot

Sequestration From Immune CD4 + T Cells of Mycobacteria Growing in Human Macrophages

inferredcites →https://doi.org/10.1128/9781555818845openalex-snapshot

Molecular Genetics of Mycobacteria

inferredcites →https://doi.org/10.1128/cmr.00042-10openalex-snapshot

HIV and Tuberculosis: a Deadly Human Syndemic

inferredcites →https://doi.org/10.1128/iai.00023-10openalex-snapshot

Immunogenicity and Protection Induced by a Mycobacterium tuberculosis sigE Mutant in a BALB/c Mouse Model of Progressive Pulmonary Tuberculosis

inferredcites →https://doi.org/10.1128/iai.67.6.2867-2873.1999openalex-snapshot

Persistence and Protective Efficacy of a Mycobacterium tuberculosis Auxotroph Vaccine

inferredcites →https://doi.org/10.1128/iai.68.2.767-778.2000openalex-snapshot

Disruption of the Genes Encoding Antigen 85A and Antigen 85B of Mycobacterium tuberculosis H37Rv: Effect on Growth in Culture and in Macrophages

inferredcites →https://doi.org/10.1128/iai.68.5.2888-2898.2000openalex-snapshot

Attenuation of and Protection Induced by a Leucine Auxotroph ofMycobacterium tuberculosis

inferredcites →https://doi.org/10.1128/iai.69.2.1442-1150.2001openalex-snapshot

Characterization of Auxotrophic Mutants of Mycobacterium tuberculosis and Their Potential as Vaccine Candidates

inferredcites →https://doi.org/10.1128/iai.69.5.2773-2778.2001openalex-snapshot

Protection of Mice with a Tuberculosis Subunit Vaccine Based on a Fusion Protein of Antigen 85B and ESAT-6

inferredcites →https://doi.org/10.1128/iai.71.7.4190-4192.2003openalex-snapshot

Vaccine Efficacy of a Lysine Auxotroph of Mycobacterium tuberculosis

inferredcites →https://doi.org/10.1128/iai.72.12.7084-7095.2004openalex-snapshot

A Mutant of Mycobacterium tuberculosis H37Rv That Lacks Expression of Antigen 85A Is Attenuated in Mice but Retains Vaccinogenic Potential

inferredcites →https://doi.org/10.1128/iai.73.2.1097-1105.2005openalex-snapshot

Phagosomal Processing ofMycobacterium tuberculosisAntigen 85B Is Modulated Independently of Mycobacterial Viability and Phagosome Maturation

inferredcites →https://doi.org/10.1128/iai.73.2.1196-1203.2005openalex-snapshot

Long-Term Protection against Tuberculosis following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph ofMycobacterium tuberculosis

inferredcites →https://doi.org/10.1128/jb.178.5.1274-1282.1996openalex-snapshot

Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis

inferredcites →https://doi.org/10.1128/jb.182.23.6850-6853.2000openalex-snapshot

Secretion of an Acid Phosphatase (SapM) by Mycobacterium tuberculosis That Is Similar to Eukaryotic Acid Phosphatases

inferredcites →https://doi.org/10.1128/jb.186.11.3590-3598.2004openalex-snapshot

Methionine Sulfoxide Reductase A (MsrA) Deficiency Affects the Survival ofMycobacterium smegmatiswithin Macrophages

inferredcites →https://doi.org/10.1146/annurev.immunol.021908.132703openalex-snapshot

Cell-Mediated Immune Responses in Tuberculosis

inferredcites →https://doi.org/10.1172/jci24617openalex-snapshot

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin

inferredcites →https://doi.org/10.1371/journal.pone.0012978openalex-snapshot

Interactions of Attenuated Mycobacterium tuberculosis phoP Mutant with Human Macrophages

inferredcites →https://doi.org/10.1371/journal.pone.0015857openalex-snapshot

Lysine Auxotrophy Combined with Deletion of the SecA2 Gene Results in a Safe and Highly Immunogenic Candidate Live Attenuated Vaccine for Tuberculosis

inferredcites →https://doi.org/10.1517/14712598.8.2.201openalex-snapshot

Live tuberculosis vaccines based onphoPmutants: a step towards clinical trials

inferredcites →https://doi.org/10.2741/2417openalex-snapshot

Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis

inferredcites →https://doi.org/10.4049/jimmunol.174.10.6332openalex-snapshot

Exchanging ESAT6 with TB10.4 in an Ag85B Fusion Molecule-Based Tuberculosis Subunit Vaccine: Efficient Protection and ESAT6-Based Sensitive Monitoring of Vaccine Efficacy

inferredcites →https://doi.org/10.4049/jimmunol.177.5.3250openalex-snapshot

Processing and Presentation of a Mycobacterial Antigen 85B Epitope by Murine Macrophages Is Dependent on the Phagosomal Acquisition of Vacuolar Proton ATPase and In Situ Activation of Cathepsin D

inferredcites →https://doi.org/10.4049/jimmunol.177.7.4688openalex-snapshot

The Reduced Bactericidal Function of Complement C5-Deficient Murine Macrophages Is Associated with Defects in the Synthesis and Delivery of Reactive Oxygen Radicals to Mycobacterial Phagosomes

inferredcites →https://doi.org/10.4049/jimmunol.179.8.5137openalex-snapshot

Mycobacterium bovis Bacillus Calmette-Guerin Secreting Active Cathepsin S Stimulates Expression of Mature MHC Class II Molecules and Antigen Presentation in Human Macrophages

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3750667openalex-extracted

inferred← citeshttps://doi.org/10.1007/978-3-030-25381-3_3openalex-snapshot

Trehalose Dimycolate (Cord Factor) as a Contributing Factor to Tuberculosis Pathogenesis

inferred← citeshttps://doi.org/10.1007/s12088-016-0625-1openalex-snapshot

Bacterial Virulence Factors: Secreted for Survival

inferred← citeshttps://doi.org/10.1016/b978-0-12-809819-6.00004-6openalex-snapshot

Increased Immunogenicity Through Autophagy

inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.04.051openalex-snapshot

Autophagy regulation revealed by SapM-induced block of autophagosome-lysosome fusion via binding RAB7

inferred← citeshttps://doi.org/10.1016/j.isci.2024.109671openalex-snapshot

Mycobacterial SapM hampers host autophagy initiation for intracellular bacillary survival via dephosphorylating Raptor

inferred← citeshttps://doi.org/10.1016/j.pep.2020.105663openalex-snapshot

Expression and purification of soluble recombinant SapM from Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.1016/j.tim.2012.09.002openalex-snapshot

Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development

inferred← citeshttps://doi.org/10.1016/j.tube.2019.04.009openalex-snapshot

Enhanced delivery of Mycobacterium tuberculosis antigens to antigen presenting cells using RVG peptide

inferred← citeshttps://doi.org/10.1016/j.vaccine.2015.10.116openalex-snapshot

Superior protection elicited by live-attenuated vaccines in the murine model of paratuberculosis

inferred← citeshttps://doi.org/10.1016/j.vaccine.2019.05.022openalex-snapshot

SapM mutation to improve the BCG vaccine: Genomic, transcriptomic and preclinical safety characterization

inferred← citeshttps://doi.org/10.1016/j.xcrm.2021.100372openalex-snapshot

A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice

inferred← citeshttps://doi.org/10.1021/acsinfecdis.3c00446openalex-snapshot

MptpB Inhibitor Improves the Action of Antibiotics against Mycobacterium tuberculosis and Nontuberculous Mycobacterium avium Infections

inferred← citeshttps://doi.org/10.1038/nmicrobiol.2016.232openalex-snapshot

Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation

inferred← citeshttps://doi.org/10.1038/s41541-019-0122-8openalex-snapshot

An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice

inferred← citeshttps://doi.org/10.1038/s41598-019-46731-6openalex-snapshot

Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs

inferred← citeshttps://doi.org/10.1038/s41598-021-87117-xopenalex-snapshot

Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.1038/s42003-022-03387-9openalex-snapshot

Human M1 Macrophages Express Unique Innate Immune Response Genes After Mycobacterial Infection to Defend Against Tuberculosis

inferred← citeshttps://doi.org/10.1042/bst20221424openalex-snapshot

Mapping lipid pathways during phagocytosis

inferred← citeshttps://doi.org/10.1073/pnas.1806904115openalex-snapshot

Ehrlichia type IV secretion system effector Etf-2 binds to active RAB5 and delays endosome maturation

inferred← citeshttps://doi.org/10.1080/19420889.2016.1174798openalex-snapshot

Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis

inferred← citeshttps://doi.org/10.1080/21505594.2020.1869441openalex-snapshot

Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria

inferred← citeshttps://doi.org/10.1080/21645515.2016.1212145openalex-snapshot

Crucial requirement for standardization during the development of novel recombinant BCG vaccines: Does the corresponding substrain background matter?

inferred← citeshttps://doi.org/10.1080/21645515.2017.1382788openalex-snapshot

The patterns of in vitro cell-death and inflammatory cytokines induced by distinct BCG vaccine strains are differentially induced in human mononuclear cells

inferred← citeshttps://doi.org/10.1093/femspd/fty037openalex-snapshot

Tuberculosis and the art of macrophage manipulation

inferred← citeshttps://doi.org/10.1099/mic.0.001041openalex-snapshot

From infection niche to therapeutic target: the intracellular lifestyle of Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.1101/2021.09.16.460717openalex-snapshot

Enterococcus faecalis persists and replicates within epithelial cells in vitro and in vivo during wound infection

inferred← citeshttps://doi.org/10.1111/febs.16369openalex-snapshot

Secretory proteins of Mycobacterium tuberculosis and their roles in modulation of host immune responses: focus on therapeutic targets

inferred← citeshttps://doi.org/10.1128/ec.00290-12openalex-snapshot

Candida albicans Induces Arginine Biosynthetic Genes in Response to Host-Derived Reactive Oxygen Species

inferred← citeshttps://doi.org/10.1128/iai.00217-24openalex-snapshot

The SapM phosphatase can arrest phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG

inferred← citeshttps://doi.org/10.1128/iai.00500-25openalex-snapshot

Construction and characterization of novel Mycobacterium tuberculosis -derived triple and quadruple knockout vaccines against tuberculosis

inferred← citeshttps://doi.org/10.11606/d.10.2023.tde-11052023-141856openalex-snapshot

>b i /i< e >i /i<>/b<

inferred← citeshttps://doi.org/10.1172/jci.insight.195947openalex-snapshot

Development and preclinical evaluation of next-generation ΔsigH-based live candidate vaccines

inferred← citeshttps://doi.org/10.1242/dmm.050698openalex-snapshot

Exploring host–pathogen interactions in the Dictyostelium discoideum–Mycobacterium marinum infection model of tuberculosis

inferred← citeshttps://doi.org/10.1371/journal.pone.0070514openalex-snapshot

Secreted Acid Phosphatase (SapM) of Mycobacterium tuberculosis Is Indispensable for Arresting Phagosomal Maturation and Growth of the Pathogen in Guinea Pig Tissues

inferred← citeshttps://doi.org/10.1371/journal.pone.0077930openalex-snapshot

Secretory Phosphatases Deficient Mutant of Mycobacterium tuberculosis Imparts Protection at the Primary Site of Infection in Guinea Pigs

inferred← citeshttps://doi.org/10.1371/journal.ppat.1010434openalex-snapshot

Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells

inferred← citeshttps://doi.org/10.1517/14712598.2012.721768openalex-snapshot

An update on vaccines for tuberculosis – there is more to it than just waning of BCG efficacy with time

inferred← citeshttps://doi.org/10.1586/14760584.2015.1089175openalex-snapshot

Current efforts and future prospects in the development of live mycobacteria as vaccines

inferred← citeshttps://doi.org/10.1586/eri.12.95openalex-snapshot

Elimination of intracellularly residingMycobacterium tuberculosisthrough targeting of host and bacterial signaling mechanisms

inferred← citeshttps://doi.org/10.3389/fcimb.2012.00154openalex-snapshot

Current and novel approaches to vaccine development against tuberculosis

inferred← citeshttps://doi.org/10.3389/fcimb.2014.00126openalex-snapshot

A rational framework for evaluating the next generation of vaccines against Mycobacterium avium subspecies paratuberculosis

inferred← citeshttps://doi.org/10.3389/fcimb.2014.00180openalex-snapshot

The complexity of Rab5 to Rab7 transition guarantees specificity of pathogen subversion mechanisms

inferred← citeshttps://doi.org/10.3389/fcimb.2020.595029openalex-snapshot

Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.3389/fimmu.2022.865503openalex-snapshot

Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.3389/fimmu.2022.938895openalex-snapshot

Virulence-Associated Secretion in Mycobacterium abscessus

inferred← citeshttps://doi.org/10.3389/fimmu.2024.1321657openalex-snapshot

The ΔfbpAΔsapM candidate vaccine derived from Mycobacterium tuberculosis H37Rv is markedly immunogenic in macrophages and induces robust immunity to tuberculosis in mice

inferred← citeshttps://doi.org/10.3389/fimmu.2025.1583439openalex-snapshot

Comparative transcriptomic analysis of mouse macrophages infected with live attenuated vaccine strains of Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1810985openalex-snapshot

Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.3389/fimmu.2026.1833963openalex-snapshot

The functions and inhibitors of protein tyrosine phosphatase B from Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.3390/vaccines11010086openalex-snapshot

The BCG Moreau Vaccine Upregulates In Vitro the Expression of TLR4, B7-1, Dectin-1 and EP2 on Human Monocytes

inferred← citeshttps://doi.org/10.3390/vaccines12050530openalex-snapshot

Live Attenuated Vaccines against Tuberculosis: Targeting the Disruption of Genes Encoding the Secretory Proteins of Mycobacteria

inferred← citeshttps://doi.org/10.4172/2329-8731.1000108openalex-snapshot

Novel Recombinant BCG Vaccines: Do the Ordinary Platforms Matter?

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.