On the public citation graph

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS

https://doi.org/10.1371/journal.pone.0042714
0 signed · 191 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cncr.10916openalex-snapshot
Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck
inferredcites →https://doi.org/10.1002/path.2277openalex-snapshot
Cellular and molecular mechanisms of fibrosis
inferredcites →https://doi.org/10.1007/978-0-387-74672-2_6openalex-snapshot
The Vascular Actions of Relaxin
inferredcites →https://doi.org/10.1007/s00018-007-6543-yopenalex-snapshot
Drugs of the future: the hormone relaxin
inferredcites →https://doi.org/10.1007/s004670000461openalex-snapshot
Molecular basis of renal fibrosis
inferredcites →https://doi.org/10.1007/s10741-008-9129-3openalex-snapshot
Relaxin, a pleiotropic vasodilator for the treatment of heart failure
inferredcites →https://doi.org/10.1016/0076-6879(95)48033-1openalex-snapshot
[31] Quantification of matrix metalloproteinases in tissue samples
inferredcites →https://doi.org/10.1016/0735-1097(89)90360-4openalex-snapshot
Cardiac interstitium in health and disease: The fibrillar collagen network
inferredcites →https://doi.org/10.1016/b978-012515400-0/50021-xopenalex-snapshot
Physiology and Molecular Biology of the Relaxin Peptide Family
inferredcites →https://doi.org/10.1016/j.ajpath.2011.08.018openalex-snapshot
Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis
inferredcites →https://doi.org/10.1016/j.cardiores.2005.12.002openalex-snapshot
Structure and function of matrix metalloproteinases and TIMPs
inferredcites →https://doi.org/10.1016/j.niox.2010.11.003openalex-snapshot
Nitric oxide regulates the repair of injured skeletal muscle
inferredcites →https://doi.org/10.1016/j.trsl.2009.03.007openalex-snapshot
Relaxin and its role in the development and treatment of fibrosis
inferredcites →https://doi.org/10.1016/s0006-2952(03)00403-9openalex-snapshot
Inhibition of markers of hepatic stellate cell activation by the hormone relaxin
inferredcites →https://doi.org/10.1016/s0008-6363(00)00003-1openalex-snapshot
Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling
inferredcites →https://doi.org/10.1016/s0021-9258(18)87000-4openalex-snapshot
Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts.
inferredcites →https://doi.org/10.1016/s0031-6997(25)06663-3openalex-snapshot
Nitric oxide: physiology, pathophysiology, and pharmacology.
inferredcites →https://doi.org/10.1016/s1357-2725(96)00121-5openalex-snapshot
Therapeutic approaches to organ fibrosis
inferredcites →https://doi.org/10.1021/bi052233eopenalex-snapshot
Relaxin-3: Improved Synthesis Strategy and Demonstration of Its High-Affinity Interaction with the Relaxin Receptor LGR7 BothIn VitroandIn Vivo
inferredcites →https://doi.org/10.1021/bi1013968openalex-snapshot
H3 Relaxin Demonstrates Antifibrotic Properties via the RXFP1 Receptor
inferredcites →https://doi.org/10.1038/22780openalex-snapshot
Creation of human tumour cells with defined genetic elements
inferredcites →https://doi.org/10.1038/labinvest.2010.198openalex-snapshot
Relaxin remodels fibrotic healing following myocardial infarction
inferredcites →https://doi.org/10.1038/nrcardio.2009.198openalex-snapshot
Cardiovascular effects of relaxin: from basic science to clinical therapy
inferredcites →https://doi.org/10.1038/sj.bjp.0704879openalex-snapshot
Protective effect of relaxin in cardiac anaphylaxis: involvement of the nitric oxide pathway
inferredcites →https://doi.org/10.1074/jbc.270.11.5872openalex-snapshot
Matrix Metalloproteinase-2 Is an Interstitial Collagenase
inferredcites →https://doi.org/10.1074/jbc.m111.282194openalex-snapshot
The Minimal Active Structure of Human Relaxin-2
inferredcites →https://doi.org/10.1084/jem.178.2.605openalex-snapshot
Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.
inferredcites →https://doi.org/10.1089/ars.2006.8.949openalex-snapshot
Cross-Talk Between Constitutive and Inducible NO Synthase: An Update
inferredcites →https://doi.org/10.1093/hmg/ddr062openalex-snapshot
Matrix metalloproteinase-2 ablation in dystrophin-deficient mdx muscles reduces angiogenesis resulting in impaired growth of regenerated muscle fibers
inferredcites →https://doi.org/10.1093/ndt/gfg598openalex-snapshot
Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro
inferredcites →https://doi.org/10.1096/fasebj.5.8.1850705openalex-snapshot
Matrix metalloproteinases and their inhibitors in connective tissue remodeling
inferredcites →https://doi.org/10.1096/fj.02-0449fjeopenalex-snapshot
Relaxin deficiency in mice is associated with an age‐related progression of pulmonary fibrosis
inferredcites →https://doi.org/10.1096/fj.08-120857openalex-snapshot
Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
inferredcites →https://doi.org/10.1097/00041552-200003000-00006openalex-snapshot
The role of tubulointerstitial injury in chronic renal failure
inferredcites →https://doi.org/10.1111/j.1523-1755.2005.00384.xopenalex-snapshot
The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
inferredcites →https://doi.org/10.1111/j.1524-475x.2000.00361.xopenalex-snapshot
Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites
inferredcites →https://doi.org/10.1113/jphysiol.1992.sp019273openalex-snapshot
Inhibition of cytokine‐induced nitric oxide production by transforming growth factor‐beta 1 in human smooth muscle cells.
inferredcites →https://doi.org/10.1124/jpet.110.170977openalex-snapshot
Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity
inferredcites →https://doi.org/10.1152/ajpcell.1999.277.1.c1openalex-snapshot
Myofibroblasts. I. Paracrine cells important in health and disease
inferredcites →https://doi.org/10.1152/ajpregu.00156.2011openalex-snapshot
Maternal vasodilation in pregnancy: the emerging role of relaxin
inferredcites →https://doi.org/10.1161/01.hyp.0000171930.00697.2fopenalex-snapshot
Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats
inferredcites →https://doi.org/10.1161/01.hyp.31.6.1240openalex-snapshot
Relaxin Activates the l -Arginine–Nitric Oxide Pathway in Vascular Smooth Muscle Cells in Culture
inferredcites →https://doi.org/10.1161/01.res.0000070112.80711.3dopenalex-snapshot
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
inferredcites →https://doi.org/10.1161/01.res.71.5.1088openalex-snapshot
Platelet-derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Effects on cell proliferation.
inferredcites →https://doi.org/10.1165/ajrcmb.21.6.3720openalex-snapshot
Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β1
inferredcites →https://doi.org/10.1172/jci119099openalex-snapshot
Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo.
inferredcites →https://doi.org/10.1186/ar1451openalex-snapshot
Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants
inferredcites →https://doi.org/10.1186/ar3218openalex-snapshot
Adiponectin is a potential catabolic mediator in osteoarthritis cartilage
inferredcites →https://doi.org/10.1196/annals.1282.047openalex-snapshot
Relaxin Restores Altered Ileal Spontaneous Contractions in Dystrophic (mdx) Mice
inferredcites →https://doi.org/10.1210/en.142.8.3405openalex-snapshot
Relaxin Positively Regulates Matrix Metalloproteinase Expression in Human Lower Uterine Segment Fibroblasts Using a Tyrosine Kinase Signaling Pathway
inferredcites →https://doi.org/10.1210/en.2004-0209openalex-snapshot
Relaxin Modulates Cardiac Fibroblast Proliferation, Differentiation, and Collagen Production and Reverses Cardiac Fibrosis in Vivo
inferredcites →https://doi.org/10.1210/en.2006-1324openalex-snapshot
Relaxin Antagonizes Hypertrophy and Apoptosis in Neonatal Rat Cardiomyocytes
inferredcites →https://doi.org/10.1210/en.2008-0250openalex-snapshot
Relaxin Ameliorates Fibrosis in Experimental Diabetic Cardiomyopathy
inferredcites →https://doi.org/10.1210/en.2008-1457openalex-snapshot
Relaxin Reverses Airway Remodeling and Airway Dysfunction in Allergic Airways Disease
inferredcites →https://doi.org/10.1210/en.2010-0286openalex-snapshot
Antifibrotic Properties of Relaxin: In Vivo Mechanism of Action in Experimental Renal Tubulointerstitial Fibrosis
inferredcites →https://doi.org/10.1210/en.2010-1126openalex-snapshot
Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries via PI3 Kinase and Nitric Oxide
inferredcites →https://doi.org/10.1210/er.2003-0013openalex-snapshot
Relaxin’s Physiological Roles and Other Diverse Actions
inferredcites →https://doi.org/10.1371/journal.pone.0004845openalex-snapshot
Receptor-Induced Dilatation in the Systemic and Intrarenal Adaptation to Pregnancy in Rats
inferredcites →https://doi.org/10.2174/187152507780363179openalex-snapshot
Relaxin as a Cardiovascular Hormone: Physiology, Pathophysiology and Therapeutic Promises
inferredcites →https://doi.org/10.2353/ajpath.2010.091121openalex-snapshot
Relaxin Regulates MMP Expression and Promotes Satellite Cell Mobilization During Muscle Healing in Both Young and Aged Mice
inferredcites →https://doi.org/10.3181/00379727-195-43118openalex-snapshot
Abnormal Growth and Clonal Proliferation of Fibroblasts Derived from Kidneys with Interstitial Fibrosis
inferredcites →https://doi.org/10.7326/0003-4819-109-2-176_1openalex-snapshot
The Physiology of Reproduction

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4627115openalex-extracted
Review the Diverse Influences of Relaxin-Like Peptide Family on Tumor Progression: Potential Opportunities and Emerging Challenges
inferred← citeshttps://doi.org/10.1002/9781118907474.ch51openalex-snapshot
Mesenchymal stromal cells targeting kidney disease
inferred← citeshttps://doi.org/10.1002/iid3.70045openalex-snapshot
The SRC/NF‐κB‐AKT/NOS3 axis as a key mediator of Kaempferol's protective effects against oxidative stress‐induced osteoclastogenesis
inferred← citeshttps://doi.org/10.1002/jcb.25132openalex-snapshot
Methylene Blue Attenuates iNOS Induction Through Suppression of Transcriptional Factor Binding Amid iNOS mRNA Transcription
inferred← citeshttps://doi.org/10.1002/mgg3.1194openalex-snapshot
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
inferred← citeshttps://doi.org/10.1002/path.4257openalex-snapshot
C1q‐tumour necrosis factor‐related protein 8 ( CTRP8 ) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells
inferred← citeshttps://doi.org/10.1002/phar.1548openalex-snapshot
Relaxin: A Novel Agent for the Treatment of Acute Heart Failure
inferred← citeshttps://doi.org/10.1007/978-1-4614-6438-9_362-1openalex-snapshot
Relaxin Family Peptide Receptors RXFP1 and RXFP2
inferred← citeshttps://doi.org/10.1007/978-3-030-25886-3_6openalex-snapshot
Changes in Parameters of Aqueous Humor Dynamics Throughout Life
inferred← citeshttps://doi.org/10.1007/978-3-319-26587-2_182-1openalex-snapshot
Mechanisms of Invasion and Metastasis: Tissue Invasion
inferred← citeshttps://doi.org/10.1007/978-3-319-26956-6_182openalex-snapshot
Mechanisms of Invasion and Metastasis: Tissue Invasion
inferred← citeshttps://doi.org/10.1007/978-3-319-67199-4_362openalex-snapshot
Relaxin Family Peptide Receptors RXFP1 and RXFP2
inferred← citeshttps://doi.org/10.1007/978-94-007-7693-7_12openalex-snapshot
Hormone Relaxin as Biomarker for Bone Health and Disease
inferred← citeshttps://doi.org/10.1007/978-94-007-7745-3_12-1openalex-snapshot
Hormone Relaxin as Biomarker for Bone Health and Disease
inferred← citeshttps://doi.org/10.1007/s00210-017-1394-zopenalex-snapshot
Differences in the renal antifibrotic cGMP/cGKI-dependent signaling of serelaxin, zaprinast, and their combination
inferred← citeshttps://doi.org/10.1007/s40256-014-0069-0openalex-snapshot
Serelaxin: A Novel Therapy for Acute Heart Failure with a Range of Hemodynamic and Non-Hemodynamic Actions
inferred← citeshttps://doi.org/10.1016/b978-0-12-397175-3.00043-0openalex-snapshot
Maternal Adaptations to Pregnancy
inferred← citeshttps://doi.org/10.1016/b978-0-443-22266-5.00007-0openalex-snapshot
Sex differences in relaxin responses in adults and with aging
inferred← citeshttps://doi.org/10.1016/bs.apha.2022.04.002openalex-snapshot
Relaxin/serelaxin for cardiac dysfunction and heart failure in hypertension
inferred← citeshttps://doi.org/10.1016/bs.ctm.2023.02.005openalex-snapshot
The effects of female sexual hormones on the endothelial glycocalyx
inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114884openalex-snapshot
Relaxin as an anti-fibrotic treatment: Perspectives, challenges and future directions
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116130openalex-snapshot
The involvement of the Wnt/β-catenin signaling cascade in fibrosis progression and its therapeutic targeting by relaxin
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116273openalex-snapshot
Relaxin as a treatment for musculoskeletal fibrosis: What we know and future directions
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116401openalex-snapshot
Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116407openalex-snapshot
Relaxin suppresses atrial fibrillation, reverses fibrosis and reduces inflammation in aged hearts
inferred← citeshttps://doi.org/10.1016/j.biocel.2021.106090openalex-snapshot
Beyond TGFβ1 - novel treatment strategies targeting lung fibrosis
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114370openalex-snapshot
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy
inferred← citeshttps://doi.org/10.1016/j.bone.2014.05.005openalex-snapshot
RELAXIN enhances differentiation and matrix mineralization through Relaxin/insulin-like family peptide receptor 2 (Rxfp2) in MC3T3-E1 cells in vitro
inferred← citeshttps://doi.org/10.1016/j.bonr.2019.100202openalex-snapshot
Relaxin 2 carried by magnetically directed liposomes accelerates rat midpalatal suture expansion and subsequent new bone formation
inferred← citeshttps://doi.org/10.1016/j.cont.2023.100573openalex-snapshot
Quantification of the TGF- β /SMAD fibrosis pathway in bladder wall samples from children with congenital lower urinary tract anomalies
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e24463openalex-snapshot
The diverse influences of relaxin-like peptide family on tumor progression: Potential opportunities and emerging challenges
inferred← citeshttps://doi.org/10.1016/j.jacbts.2021.10.012openalex-snapshot
Cardiac Gene Therapy With Relaxin Receptor 1 Overexpression Protects Against Acute Myocardial Infarction
inferred← citeshttps://doi.org/10.1016/j.jddst.2026.108327openalex-snapshot
B7-33 modulates fibrotic signalling in hypertrophic scar fibroblasts: An in vitro study supporting a novel therapeutic strategy
inferred← citeshttps://doi.org/10.1016/j.jpba.2023.115271openalex-snapshot
Deciphering in vivo metabolic profile and pharmacological mechanisms of Jitongning Tablet for the treatment of Ankylosing spondylitis
inferred← citeshttps://doi.org/10.1016/j.kint.2024.10.025openalex-snapshot
Activating soluble guanylyl cyclase attenuates ischemic kidney damage
inferred← citeshttps://doi.org/10.1016/j.knee.2019.01.010openalex-snapshot
Regulation of MMP and TIMP expression in synovial fibroblasts from knee osteoarthritis with flexion contracture using adenovirus-mediated relaxin gene therapy
inferred← citeshttps://doi.org/10.1016/j.lfs.2026.124472openalex-snapshot
Serelaxin has greater anti-fibrotic potential than perindopril but maintains its anti-fibrotic efficacy in the presence of perindopril in normotensive mouse models of heart disease
inferred← citeshttps://doi.org/10.1016/j.mce.2018.12.016openalex-snapshot
Cardioprotective actions of relaxin
inferred← citeshttps://doi.org/10.1016/j.mce.2018.12.017openalex-snapshot
Understanding relaxin signalling at the cellular level
inferred← citeshttps://doi.org/10.1016/j.mce.2019.01.008openalex-snapshot
Single chain peptide agonists of relaxin receptors
inferred← citeshttps://doi.org/10.1016/j.mce.2019.01.015openalex-snapshot
Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways
inferred← citeshttps://doi.org/10.1016/j.mce.2019.02.001openalex-snapshot
Emerging roles for the relaxin/RXFP1 system in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.mce.2019.02.005openalex-snapshot
Relaxin and fibrosis: Emerging targets, challenges, and future directions
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2018.02.004openalex-snapshot
Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2018.02.008openalex-snapshot
The relaxin receptor as a therapeutic target – perspectives from evolution and drug targeting
inferred← citeshttps://doi.org/10.1016/j.taap.2016.07.010openalex-snapshot
Triazine herbicides inhibit relaxin signaling and disrupt nitric oxide homeostasis
inferred← citeshttps://doi.org/10.1016/j.tips.2016.02.007openalex-snapshot
Antifibrotic Actions of Serelaxin – New Roles for an Old Player
inferred← citeshttps://doi.org/10.1021/acsptsci.3c00053openalex-snapshot
Development of Novel High-Affinity Antagonists for the Relaxin Family Peptide Receptor 1
inferred← citeshttps://doi.org/10.1021/acsptsci.9b00095openalex-snapshot
Serelaxin and the AT2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil
inferred← citeshttps://doi.org/10.1038/ki.2013.518openalex-snapshot
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
inferred← citeshttps://doi.org/10.1038/ki.2014.22openalex-snapshot
New targets for renal interstitial fibrosis: relaxin family peptide receptor 1–angiotensin type 2 receptor heterodimers
inferred← citeshttps://doi.org/10.1038/s41598-017-02916-5openalex-snapshot
ML290 is a biased allosteric agonist at the relaxin receptor RXFP1
inferred← citeshttps://doi.org/10.1038/s41598-017-10521-9openalex-snapshot
In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis
inferred← citeshttps://doi.org/10.1039/9781849737081-00060openalex-snapshot
Relaxin and its role in fibrotic diseases
inferred← citeshttps://doi.org/10.1039/c5sc04754dopenalex-snapshot
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
inferred← citeshttps://doi.org/10.1042/cs20256619openalex-snapshot
The role of relaxins in blood cell modulation: interactions with relaxin family peptide receptor 1 (RXFP1) and glucocorticoid receptor (GR)
inferred← citeshttps://doi.org/10.1074/jbc.m114.589325openalex-snapshot
Relaxin Activates Peroxisome Proliferator-activated Receptor γ (PPARγ) through a Pathway Involving PPARγ Coactivator 1α (PGC1α)
inferred← citeshttps://doi.org/10.1080/0886022x.2022.2044351openalex-snapshot
Relaxin inhibits renal fibrosis and the epithelial-to-mesenchymal transition via the Wnt/β-catenin signaling pathway
inferred← citeshttps://doi.org/10.1089/cbr.2019.3278openalex-snapshot
Long Noncoding RNA UCA1 Facilitates Endometrial Cancer Development by Regulating KLF5 and RXFP1 Gene Expressions
inferred← citeshttps://doi.org/10.1093/ehjcvp/pvv046openalex-snapshot
Serelaxin for the treatment of acute heart failure: a review with a focus on end-organ protection
inferred← citeshttps://doi.org/10.1093/ejo/cjw037openalex-snapshot
A preliminary investigation of the effect of relaxin on bone remodelling in suture expansion
inferred← citeshttps://doi.org/10.1096/fj.14-254789openalex-snapshot
Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy
inferred← citeshttps://doi.org/10.1096/fj.201901079rropenalex-snapshot
Serelaxin inhibits the profibrotic TGF‐β1/IL‐1β axis by targeting TLR‐4 and the NLRP3 inflammasome in cardiac myofibroblasts
inferred← citeshttps://doi.org/10.1096/fj.201902506ropenalex-snapshot
The anti‐fibrotic actions of relaxin are mediated through AT 2 R‐associated protein phosphatases via RXFP1‐AT 2 R functional crosstalk in human cardiac myofibroblasts
inferred← citeshttps://doi.org/10.1097/crd.0000000000000089openalex-snapshot
Relaxin for the Treatment of Acute Decompensated Heart Failure
inferred← citeshttps://doi.org/10.1097/fjc.0000000000000228openalex-snapshot
Tongxinluo Induces nNOS Expression Through ERK Activation
inferred← citeshttps://doi.org/10.1097/md.0000000000027508openalex-snapshot
Comparison of critical biomarkers in 2 erectile dysfunction models based on GEO and NOS-cGMP-PDE5 pathway
inferred← citeshttps://doi.org/10.1097/md.0000000000035438openalex-snapshot
Exploring the action mechanism of Jinxin oral liquid on asthma by network pharmacology, molecular docking, and microRNA recognition
inferred← citeshttps://doi.org/10.1101/2024.08.01.606219openalex-snapshot
mosGraphFlow: a novel integrative graph AI model mining disease targets from multi-omic data
inferred← citeshttps://doi.org/10.1101/2025.06.10.656785openalex-snapshot
Distinct Transcriptomic Biomarkers and Pathways Associated with Cardiovascular and Neurovascular Dysregulation in Long COVID-19 Brain Fog
inferred← citeshttps://doi.org/10.1111/1755-5922.12231openalex-snapshot
Serelaxin in acute heart failure: Most recent update on clinical and preclinical evidence
inferred← citeshttps://doi.org/10.1111/bph.12964openalex-snapshot
EXPRESSION OF CONCERN: Serelaxin‐mediated signal transduction in human vascular cells: bell‐shaped concentration–response curves reflect differential coupling to G proteins
inferred← citeshttps://doi.org/10.1111/bph.13523openalex-snapshot
The actions of relaxin on the human cardiovascular system
inferred← citeshttps://doi.org/10.1111/bph.13529openalex-snapshot
Anti‐fibrotic actions of relaxin
inferred← citeshttps://doi.org/10.1111/bph.15361openalex-snapshot
Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt‐induced hypertension
inferred← citeshttps://doi.org/10.1111/bph.16019openalex-snapshot
Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis
inferred← citeshttps://doi.org/10.1111/liv.12247openalex-snapshot
Relaxin decreases the severity of established hepatic fibrosis in mice
inferred← citeshttps://doi.org/10.1124/pr.114.009472openalex-snapshot
International Union of Basic and Clinical Pharmacology. XCV. Recent Advances in the Understanding of the Pharmacology and Biological Roles of Relaxin Family Peptide Receptors 1–4, the Receptors for Relaxin Family Peptides
inferred← citeshttps://doi.org/10.1152/ajpregu.00528.2012openalex-snapshot
The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease
inferred← citeshttps://doi.org/10.1159/000514043openalex-snapshot
Insulin-Like Growth Factor 1 Increases GABAergic Neurotransmission to GnRH Neurons via Suppressing the Retrograde Tonic Endocannabinoid Signaling Pathway in Mice
inferred← citeshttps://doi.org/10.1161/hypertensionaha.114.03594openalex-snapshot
Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease
inferred← citeshttps://doi.org/10.1161/jaha.119.015748openalex-snapshot
B7‐33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction–Related Adverse Cardiac Remodeling in Mice
inferred← citeshttps://doi.org/10.1186/s12987-024-00616-7openalex-snapshot
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats
inferred← citeshttps://doi.org/10.1210/me.2014-1201openalex-snapshot
Role of Sphingosine Kinase/S1P Axis in ECM Remodeling of Cardiac Cells Elicited by Relaxin
inferred← citeshttps://doi.org/10.1253/circj.cj-14-0014openalex-snapshot
Therapeutic Effects of Serelaxin in Acute Heart Failure
inferred← citeshttps://doi.org/10.1371/journal.pone.0063896openalex-snapshot
Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling
inferred← citeshttps://doi.org/10.1371/journal.pone.0254466openalex-snapshot
Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1
inferred← citeshttps://doi.org/10.14295/bds.2020.v23i1.1846openalex-snapshot
Preventive and therapeutic effects of relaxin on bisphosphonaterelated osteonecrosis of the jaw: an experimental study in rats
inferred← citeshttps://doi.org/10.1586/17512433.2015.1073587openalex-snapshot
Serelaxin a novel treatment for acute heart failure
inferred← citeshttps://doi.org/10.1681/asn.2019060597openalex-snapshot
AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis
inferred← citeshttps://doi.org/10.18632/oncotarget.15483openalex-snapshot
Relaxin abrogates renal interstitial fibrosis by regulating macrophage polarization via inhibition of Toll-like receptor 4 signaling
inferred← citeshttps://doi.org/10.20944/preprints202003.0037.v1openalex-snapshot
Effect of Orally Administered Relaxin in Experimental Nash
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4512510/v1openalex-snapshot
Network pharmacology reveals physiological manifestations of viperid envenomation and role of nitric oxide in their treatment
inferred← citeshttps://doi.org/10.2147/dddt.s85399openalex-snapshot
Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway
inferred← citeshttps://doi.org/10.2147/ijgm.s553186openalex-snapshot
Potential Mechanisms of Tetramethylpyrazine in the Treatment of Traumatic Brain Injury Based on Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and in vivo Experiments
inferred← citeshttps://doi.org/10.2174/1566524021666210309113650openalex-snapshot
Human Recombinant Relaxin (Serelaxin) as Anti-fibrotic Agent: Pharmacology, Limitations and Actual Perspectives
inferred← citeshttps://doi.org/10.2218/gtopdb/f60/2019.4openalex-snapshot
Relaxin family peptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
inferred← citeshttps://doi.org/10.2218/gtopdb/f60/2021.3openalex-snapshot
Relaxin family peptide receptors in GtoPdb v.2021.3
inferred← citeshttps://doi.org/10.2218/gtopdb/f60/2023.1openalex-snapshot
Relaxin family peptide receptors in GtoPdb v.2023.1
inferred← citeshttps://doi.org/10.25163/angiotherapy.1200032116160818openalex-snapshot
Targeting inducible Nitric Oxide Synthase (iNOS) in the prevention of vascular damage and cardiac inflammation in CVD
inferred← citeshttps://doi.org/10.25259/jksus_1101_2025openalex-snapshot
Endocrine modulation of myofibroblast differentiation in skin wound healing: A systematic review and meta-analysis of preclinical models
inferred← citeshttps://doi.org/10.3346/jkms.2016.31.6.983openalex-snapshot
Relaxin Receptor RXFP1 and RXFP2 Expression in Ligament, Tendon, and Shoulder Joint Capsule of Rats
inferred← citeshttps://doi.org/10.3389/fcell.2023.1131481openalex-snapshot
Relaxin in fibrotic ligament diseases: Its regulatory role and mechanism
inferred← citeshttps://doi.org/10.3389/fgene.2021.809600openalex-snapshot
Landscape Analysis of Matrix Metalloproteinases Unveils Key Prognostic Markers for Patients With Breast Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1506204openalex-snapshot
Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors
inferred← citeshttps://doi.org/10.3389/fncel.2016.00214openalex-snapshot
Glucagon-Like Peptide-1 Excites Firing and Increases GABAergic Miniature Postsynaptic Currents (mPSCs) in Gonadotropin-Releasing Hormone (GnRH) Neurons of the Male Mice via Activation of Nitric Oxide (NO) and Suppression of Endocannabinoid Signaling Pathways
inferred← citeshttps://doi.org/10.3389/fncel.2019.00371openalex-snapshot
Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice
inferred← citeshttps://doi.org/10.3389/fphar.2016.00091openalex-snapshot
The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate
inferred← citeshttps://doi.org/10.3389/fphar.2016.00195openalex-snapshot
Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of Serelaxin
inferred← citeshttps://doi.org/10.3389/fphar.2017.00318openalex-snapshot
Novel Anti-fibrotic Therapies
inferred← citeshttps://doi.org/10.3389/fphar.2020.01201openalex-snapshot
Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1
inferred← citeshttps://doi.org/10.3389/fphar.2022.960267openalex-snapshot
The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19
inferred← citeshttps://doi.org/10.3389/fphys.2018.00105openalex-snapshot
Oxidative Stress and Renal Fibrosis: Recent Insights for the Development of Novel Therapeutic Strategies
inferred← citeshttps://doi.org/10.3389/fphys.2021.694135openalex-snapshot
The Release of Nitric Oxide Is Involved in the β-Arrestin1-Induced Antihypertensive Effect in the Rostral Ventrolateral Medulla
inferred← citeshttps://doi.org/10.3390/ijms16022320openalex-snapshot
Cyclic Nucleotide Signalling in Kidney Fibrosis
inferred← citeshttps://doi.org/10.3390/ijms23116035openalex-snapshot
Enhancing the Therapeutic Potential of Mesenchymal Stromal Cell-Based Therapies with an Anti-Fibrotic Agent for the Treatment of Chronic Kidney Disease
inferred← citeshttps://doi.org/10.3390/ijms23158413openalex-snapshot
Relaxin Affects Airway Remodeling Genes Expression through Various Signal Pathways Connected with Transcription Factors
inferred← citeshttps://doi.org/10.3390/ijms232214039openalex-snapshot
The Novel AT2 Receptor Agonist β-Pro7-AngIII Exerts Cardiac and Renal Anti-Fibrotic and Anti-Inflammatory Effects in High Salt-Fed Mice
inferred← citeshttps://doi.org/10.3390/ijms24076616openalex-snapshot
A Lipidated Single-B-Chain Derivative of Relaxin Exhibits Improved In Vitro Serum Stability without Altering Activity
inferred← citeshttps://doi.org/10.3390/ijms27020638openalex-snapshot
Description of a Large Family with Periodic Fever Carrying a Variant in RXFP1 Gene: A Possible Novel Modulator of Inflammation in Autoinflammatory Diseases
inferred← citeshttps://doi.org/10.3390/jcdd11020062openalex-snapshot
Cardiac and Renal Fibrosis, the Silent Killer in the Cardiovascular Continuum: An Up-to-Date
inferred← citeshttps://doi.org/10.3892/etm.2024.12649openalex-snapshot
Expression of MMP2 , MMP9 , TIMP2 and TIMP3 genes in aortic dissection
inferred← citeshttps://doi.org/10.47328/ufvbbt.2022.755openalex-snapshot
Could endocrine stimuli regulate fibroblasts/myofibroblasts dynamics during skin wound healing? A systematic review of preclinical models
inferred← citeshttps://doi.org/10.5281/zenodo.21445506openalex-snapshot
The gut-brain axis in long COVID
inferred← citeshttps://doi.org/10.53846/goediss-6299openalex-snapshot
Analyse des antifibrotischen Potenzials der betaadrenergen Signalkaskade und des PKA-Effektors Protein-Phosphatase-Inhibitor-1
inferred← citeshttps://doi.org/10.53846/goediss-7336openalex-snapshot
Serelaxin-vermittelte Inhibition von Fibroblastenaktivierung bei renaler Fibrogenese
inferred← citeshttps://doi.org/10.53846/goediss-9970openalex-snapshot
Hypermethylierte DNA als Biomarker für Herz- und Nierenerkrankungen
inferred← citeshttps://doi.org/10.64898/2025.12.08.692836openalex-snapshot
Relaxin-2 drives regenerative healing and suppresses scar formation
inferred← citeshttps://doi.org/10.7150/ijms.6283openalex-snapshot
Sex-Steroid Regulation of Relaxin Receptor Isoforms (RXFP1 & RXFP2) Expression in the Patella Tendon and Lateral Collateral Ligament of Female WKY Rats
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.