On the public citation graph

Tauroursodeoxycholic Acid Mitigates High Fat Diet-Induced Cardiomyocyte Contractile and Intracellular Ca2+ Anomalies

https://doi.org/10.1371/journal.pone.0063615

0 signed · 91 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

2 of the 46 references listed on this page are in the Retraction Watch database as retracted (export 2026-10-28): 10.1016/j.yjmcc.2010.10.023 (notice 2023-10-28), 10.2337/db09-1637 (notice 2026-07-20).

Dataset join, best-effort; this page does not check the publisher record. Retraction Watch data via Crossref Labs, used with credit; OpenCitations Index (CC0) and Meta (CC BY 4.0); dataset doi:10.7910/DVN/WT8VOA (CC BY 4.0).

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00125-007-0735-8openalex-snapshot

Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification

inferredcites →https://doi.org/10.1016/j.bbrc.2006.09.009openalex-snapshot

ER stress contributes to ischemia-induced cardiomyocyte apoptosis

inferredcites →https://doi.org/10.1016/j.bbrc.2007.08.151openalex-snapshot

Effects of triglyceride on ER stress and insulin resistance

inferredcites →https://doi.org/10.1016/j.cardiores.2006.10.001openalex-snapshot

PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress

inferredcites →https://doi.org/10.1016/j.cmet.2011.10.001openalex-snapshot

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

inferredcites →https://doi.org/10.1016/j.ecl.2008.06.004openalex-snapshot

Impact of Obesity on Cardiovascular Disease

inferredcites →https://doi.org/10.1016/j.yjmcc.2009.03.018openalex-snapshot

Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction

inferredcites →https://doi.org/10.1016/j.yjmcc.2009.10.026openalex-snapshot

ER stress in cardiovascular disease

inferredcites →https://doi.org/10.1016/j.yjmcc.2009.11.003openalex-snapshot

Cardiac overexpression of metallothionein rescues cardiac contractile dysfunction and endoplasmic reticulum stress but not autophagy in sepsis

inferredcites →https://doi.org/10.1016/j.yjmcc.2010.10.023openalex-snapshot

RETRACTED: Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction

inferredcites →https://doi.org/10.1016/j.yjmcc.2010.12.007openalex-snapshot

Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction

inferredcites →https://doi.org/10.1016/s0304-3835(02)00624-9openalex-snapshot

The effect of ursodeoxycholic acid on the survivin in thapsigargin-induced apoptosis

inferredcites →https://doi.org/10.1038/oby.2008.325openalex-snapshot

The Effect of Obesity and Cardiometabolic Risk Factors on Expenditures and Productivity in the United States

inferredcites →https://doi.org/10.1038/oby.2008.545openalex-snapshot

Adiponectin Improves Cardiomyocyte Contractile Function in db/db Diabetic Obese Mice

inferredcites →https://doi.org/10.1038/oby.2009.8openalex-snapshot

Cardiac Health in Women With Metabolic Syndrome: Clinical Aspects and Pathophysiology

inferredcites →https://doi.org/10.1038/sj.ijo.0802389openalex-snapshot

Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes

inferredcites →https://doi.org/10.1042/bj20070392openalex-snapshot

Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats

inferredcites →https://doi.org/10.1053/jhep.2002.35441openalex-snapshot

Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation

inferredcites →https://doi.org/10.1093/cvr/cvn128openalex-snapshot

Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition

inferredcites →https://doi.org/10.1097/shk.0b013e318164ca29openalex-snapshot

ISCHEMIC POSTCONDITIONING PROTECTS MYOCARDIUM FROM ISCHEMIA/REPERFUSION INJURY THROUGH ATTENUATING ENDOPLASMIC RETICULUM STRESS

inferredcites →https://doi.org/10.1111/j.1463-1326.2010.01282.xopenalex-snapshot

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases

inferredcites →https://doi.org/10.1111/j.1742-4658.2007.05639.xopenalex-snapshot

ER stress and diseases

inferredcites →https://doi.org/10.1111/j.1872-034x.2007.00297.xopenalex-snapshot

Ursodeoxycholic acid: Mechanism of action and novel clinical applications

inferredcites →https://doi.org/10.1124/mol.106.032060openalex-snapshot

Conjugated Bile Acids Regulate Hepatocyte Glycogen Synthase Activity In Vitro and In Vivo via Gαi Signaling

inferredcites →https://doi.org/10.1126/science.1103160openalex-snapshot

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

inferredcites →https://doi.org/10.1126/science.1128294openalex-snapshot

Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

inferredcites →https://doi.org/10.1128/mcb.25.21.9554-9575.2005openalex-snapshot

AMP-Activated Protein Kinase Protects Cardiomyocytes against Hypoxic Injury through Attenuation of Endoplasmic Reticulum Stress

inferredcites →https://doi.org/10.1152/ajpheart.00860.2010openalex-snapshot

Cardioprotection of the aged rat heart by GSK-3β inhibitor is attenuated: age-related changes in mitochondrial permeability transition pore modulation

inferredcites →https://doi.org/10.1152/ajpheart.01378.2005openalex-snapshot

Activation of endoplasmic reticulum stress response during the development of ischemic heart disease

inferredcites →https://doi.org/10.1152/physrev.00024.2010openalex-snapshot

Myocardial AKT: The Omnipresent Nexus

inferredcites →https://doi.org/10.1159/000148209openalex-snapshot

Effect of Taurine-Conjugated Ursodeoxycholic Acid on Endoplasmic Reticulum Stress and Apoptosis Induced by Advanced Glycation End Products in Cultured Mouse Podocytes

inferredcites →https://doi.org/10.1161/01.cir.0000137836.95625.d4openalex-snapshot

Prolonged Endoplasmic Reticulum Stress in Hypertrophic and Failing Heart After Aortic Constriction

inferredcites →https://doi.org/10.1161/01.res.0000220643.65941.8dopenalex-snapshot

Endoplasmic Reticulum Stress Gene Induction and Protection From Ischemia/Reperfusion Injury in the Hearts of Transgenic Mice With a Tamoxifen-Regulated Form of ATF6

inferredcites →https://doi.org/10.1161/circresaha.110.227033openalex-snapshot

Biology of Endoplasmic Reticulum Stress in the Heart

inferredcites →https://doi.org/10.1172/jci200422683openalex-snapshot

AMP-activated protein kinase: the guardian of cardiac energy status

inferredcites →https://doi.org/10.1172/jci26373openalex-snapshot

Endoplasmic reticulum stress: cell life and death decisions

inferredcites →https://doi.org/10.1210/er.2007-0015openalex-snapshot

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

inferredcites →https://doi.org/10.2174/187152907781745260openalex-snapshot

Endoplasmic Reticulum Stress as a Novel Therapeutic Target in Heart Diseases

inferredcites →https://doi.org/10.2337/db06-1596openalex-snapshot

Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction

inferredcites →https://doi.org/10.2337/db08-0604openalex-snapshot

Increase in Endoplasmic Reticulum Stress–Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

inferredcites →https://doi.org/10.2337/db08-1183openalex-snapshot

Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice

inferredcites →https://doi.org/10.2337/db09-0158openalex-snapshot

Endoplasmic Reticulum Stress in Diabetic Hearts Abolishes Erythropoietin-Induced Myocardial Protection by Impairment of Phospho–Glycogen Synthase Kinase-3β–Mediated Suppression of Mitochondrial Permeability Transition

inferredcites →https://doi.org/10.2337/db09-1637openalex-snapshot

Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo

inferredcites →https://doi.org/10.2337/db10-0308openalex-snapshot

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

inferredcites →https://doi.org/10.2337/diabetes.48.8.1662openalex-snapshot

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

inferredcites →https://doi.org/10.2337/diabetes.54.2.452openalex-snapshot

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4152835openalex-extracted

XBP1: An Adaptor in the Pathogenesis of Atherosclerosis

inferred← citeshttps://doi.org/10.1007/978-3-319-73344-9_19openalex-snapshot

Modulation of Cell Fate by Tauroursodeoxycholic Acid: All Paths Lead to Mitochondria

inferred← citeshttps://doi.org/10.1007/s00394-015-1017-8openalex-snapshot

Time-dependent cellular response in the liver and heart in a dietary-induced obese mouse model: the potential role of ER stress and autophagy

inferred← citeshttps://doi.org/10.1016/b978-0-12-816093-0.00011-2openalex-snapshot

Nutrients and Obesity

inferred← citeshttps://doi.org/10.1016/b978-0-12-817728-0.00065-6openalex-snapshot

Sex and cardiac electrophysiology

inferred← citeshttps://doi.org/10.1016/b978-0-323-99570-2.00009-6openalex-snapshot

Does endoplasmic reticulum stress break the heart?

inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.06.009openalex-snapshot

ER stress disturbs SR/ER-mitochondria Ca2+ transfer: Implications in Duchenne muscular dystrophy

inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.12.039openalex-snapshot

Heart and bile acids – Clinical consequences of altered bile acid metabolism

inferred← citeshttps://doi.org/10.1016/j.bbagen.2022.130245openalex-snapshot

Deficiency in Beclin1 attenuates alcohol-induced cardiac dysfunction via inhibition of ferroptosis

inferred← citeshttps://doi.org/10.1016/j.bbalip.2014.07.016openalex-snapshot

Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo

inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116567openalex-snapshot

Role of the microbiota–gut–heart axis between bile acids and cardiovascular disease

inferred← citeshttps://doi.org/10.1016/j.endmts.2020.100076openalex-snapshot

Effects of obesity on the cardiac proteome

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.10.292openalex-snapshot

Modulation of the JNK/c-Jun/HSP27 pathway in cardiomyocytes under chronic stress-induced cardiac dysfunction: Therapeutic implications of Tauroursodeoxycholic acid

inferred← citeshttps://doi.org/10.1016/j.lfs.2021.120020openalex-snapshot

Effects of tauroursodeoxycholic acid on glucose homeostasis: Potential binding of this bile acid with the insulin receptor

inferred← citeshttps://doi.org/10.1016/j.lfs.2025.123591openalex-snapshot

Akt mitigates ER stress-instigated cardiac dysfunction via regulation of ferroptosis and mitochondrial integrity in a DHODH-dependent manner

inferred← citeshttps://doi.org/10.1016/j.metabol.2019.02.003openalex-snapshot

Combination of exercise and calorie restriction exerts greater efficacy on cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation

inferred← citeshttps://doi.org/10.1016/j.phrs.2015.05.004openalex-snapshot

The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice

inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107263openalex-snapshot

Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress

inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108224openalex-snapshot

Multiple roles of bile acids in ferroptosis regulation: Opportunities for disease therapy

inferred← citeshttps://doi.org/10.1016/j.toxlet.2014.12.018openalex-snapshot

Moderate ethanol administration accentuates cardiomyocyte contractile dysfunction and mitochondrial injury in high fat diet-induced obesity

inferred← citeshttps://doi.org/10.1038/s41401-021-00635-2openalex-snapshot

Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis

inferred← citeshttps://doi.org/10.1038/s41569-021-00511-wopenalex-snapshot

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

inferred← citeshttps://doi.org/10.1038/s41598-017-13974-0openalex-snapshot

Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice

inferred← citeshttps://doi.org/10.1038/srep21358openalex-snapshot

Hydrophobic bile acids relax rat detrusor contraction via inhibiting the opening of the Na+/Ca2+ exchanger

inferred← citeshttps://doi.org/10.1039/c4nr05509hopenalex-snapshot

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.1093/abbs/gmaa041openalex-snapshot

Parkin deficiency accentuates chronic alcohol intake-induced tissue injury and autophagy defects in brain, liver and skeletal muscle

inferred← citeshttps://doi.org/10.1095/biolreprod.113.113480openalex-snapshot

Developmental Competence of Bovine Early Embryos Depends on the Coupled Response Between Oxidative and Endoplasmic Reticulum Stress1

inferred← citeshttps://doi.org/10.1111/cts.13828openalex-snapshot

Metabolomic signatures of carfilzomib‐related cardiotoxicity in patients with multiple myeloma

inferred← citeshttps://doi.org/10.1111/jcmm.17839openalex-snapshot

Calreticulin: Endoplasmic reticulum Ca 2+ gatekeeper

inferred← citeshttps://doi.org/10.1152/physrev.00030.2020openalex-snapshot

Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

inferred← citeshttps://doi.org/10.1161/hypertensionaha.114.03811openalex-snapshot

Endoplasmic Reticulum Stress Sensor Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) Protects Against Pressure Overload–Induced Heart Failure and Lung Remodeling

inferred← citeshttps://doi.org/10.1210/endrev/bnab006openalex-snapshot

ER Stress in Cardiometabolic Diseases: From Molecular Mechanisms to Therapeutics

inferred← citeshttps://doi.org/10.1371/journal.pone.0154907openalex-snapshot

Correction: Tauroursodeoxycholic Acid Mitigates High Fat Diet-Induced Cardiomyocyte Contractile and Intracellular Ca2+ Anomalies

inferred← citeshttps://doi.org/10.1371/journal.pone.0176071openalex-snapshot

Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.14336/ad.2022.0824openalex-snapshot

X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis

inferred← citeshttps://doi.org/10.1590/1414-431x20198085openalex-snapshot

Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity

inferred← citeshttps://doi.org/10.2174/1381612825666190708221539openalex-snapshot

Trehalose Protects against Insulin Resistance-Induced Tissue Injury and Excessive Autophagy in Skeletal Muscles and Kidney

inferred← citeshttps://doi.org/10.3389/fcimb.2025.1537576openalex-snapshot

The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF

inferred← citeshttps://doi.org/10.3389/fnbeh.2014.00285openalex-snapshot

Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66Shc−/− mouse

inferred← citeshttps://doi.org/10.3389/fnetp.2022.849253openalex-snapshot

Pathogenic Mechanisms Underlying Cirrhotic Cardiomyopathy

inferred← citeshttps://doi.org/10.3390/cells14050324openalex-snapshot

Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential

inferred← citeshttps://doi.org/10.3390/cells8121471openalex-snapshot

Tauroursodeoxycholate—Bile Acid with Chaperoning Activity: Molecular and Cellular Effects and Therapeutic Perspectives

inferred← citeshttps://doi.org/10.3390/cimb47040224openalex-snapshot

Tauroursodeoxycholic Acid Confers Protection Against Oxidative Stress via Autophagy Induction in Retinal Pigment Epithelial Cells

inferred← citeshttps://doi.org/10.3390/ijms22073321openalex-snapshot

Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure

inferred← citeshttps://doi.org/10.7453/gahmj.2014.017openalex-snapshot

The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.