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Brevilin A, a Novel Natural Product, Inhibits Janus Kinase Activity and Blocks STAT3 Signaling in Cancer Cells

https://doi.org/10.1371/journal.pone.0063697

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line

inferredcites →https://doi.org/10.1002/pros.20072openalex-snapshot

RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells

inferredcites →https://doi.org/10.1007/bf02258360openalex-snapshot

Activation of STAT Transcription Factors in Oncogenic Tyrosine Kinase Signaling

inferredcites →https://doi.org/10.1007/s12038-012-9202-xopenalex-snapshot

STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway

inferredcites →https://doi.org/10.1016/0006-291x(90)90519-sopenalex-snapshot

Staurosporine inhibits a tyrosine protein kinase in human hepatoma cell membranes

inferredcites →https://doi.org/10.1016/j.bbrc.2008.10.025openalex-snapshot

Development of a STAT3 reporter prostate cancer cell line for high throughput screening of STAT3 activators and inhibitors

inferredcites →https://doi.org/10.1016/j.ccr.2005.03.023openalex-snapshot

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

inferredcites →https://doi.org/10.1016/j.ccr.2009.02.015openalex-snapshot

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

inferredcites →https://doi.org/10.1016/j.cell.2009.11.025openalex-snapshot

Tumor Self-Seeding by Circulating Cancer Cells

inferredcites →https://doi.org/10.1016/j.immuni.2012.03.013openalex-snapshot

The JAK-STAT Pathway at Twenty

inferredcites →https://doi.org/10.1016/j.intimp.2010.09.017openalex-snapshot

The fungal metabolite, citrinin, inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells

inferredcites →https://doi.org/10.1016/s0140-6736(05)71142-9openalex-snapshot

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

inferredcites →https://doi.org/10.1038/nature03546openalex-snapshot

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

inferredcites →https://doi.org/10.1038/nbt0611-467openalex-snapshot

Pfizer's JAK inhibitor sails through phase 3 in rheumatoid arthritis

inferredcites →https://doi.org/10.1038/nrc2734openalex-snapshot

STATs in cancer inflammation and immunity: a leading role for STAT3

inferredcites →https://doi.org/10.1038/nri1604openalex-snapshot

Mechanisms of type-I- and type-II-interferon-mediated signalling

inferredcites →https://doi.org/10.1038/sj.onc.1203527openalex-snapshot

STATs in oncogenesis

inferredcites →https://doi.org/10.1038/sj.onc.1204349openalex-snapshot

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

inferredcites →https://doi.org/10.1038/sj.onc.1205859openalex-snapshot

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

inferredcites →https://doi.org/10.1038/sj.onc.1206047openalex-snapshot

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

inferredcites →https://doi.org/10.1038/sj.onc.1206479openalex-snapshot

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

inferredcites →https://doi.org/10.1038/sj.onc.1207383openalex-snapshot

Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis

inferredcites →https://doi.org/10.1038/sj.onc.1209149openalex-snapshot

Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells

inferredcites →https://doi.org/10.1038/sj.onc.1210031openalex-snapshot

A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

inferredcites →https://doi.org/10.1056/nejmoa051113openalex-snapshot

A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders

inferredcites →https://doi.org/10.1073/pnas.0409467102openalex-snapshot

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

inferredcites →https://doi.org/10.1073/pnas.0609757104openalex-snapshot

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

inferredcites →https://doi.org/10.1073/pnas.0811761106openalex-snapshot

JAK mutations in high-risk childhood acute lymphoblastic leukemia

inferredcites →https://doi.org/10.1073/pnas.1016147107openalex-snapshot

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

inferredcites →https://doi.org/10.1073/pnas.1121606109openalex-snapshot

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

inferredcites →https://doi.org/10.1073/pnas.97.8.4227openalex-snapshot

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

inferredcites →https://doi.org/10.1074/jbc.274.33.22932openalex-snapshot

Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis

inferredcites →https://doi.org/10.1074/jbc.m707429200openalex-snapshot

Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function

inferredcites →https://doi.org/10.1097/00000421-198206000-00020openalex-snapshot

Doxorubicin

inferredcites →https://doi.org/10.1126/science.8511589openalex-snapshot

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

inferredcites →https://doi.org/10.1128/.20.10.3387-3395.2000openalex-snapshot

Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain

inferredcites →https://doi.org/10.1128/mcb.11.4.2057openalex-snapshot

Two Novel Protein-Tyrosine Kinases, Each with a Second Phosphotransferase-Related Catalytic Domain, Define a New Class of Protein Kinase

inferredcites →https://doi.org/10.1128/mcb.18.5.2545openalex-snapshot

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

inferredcites →https://doi.org/10.1146/annurev.bi.64.070195.003201openalex-snapshot

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

inferredcites →https://doi.org/10.1158/0008-5472.can-08-2575openalex-snapshot

Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells

inferredcites →https://doi.org/10.1158/0008-5472.can-10-4660openalex-snapshot

STAT3 Is Necessary for Proliferation and Survival in Colon Cancer–Initiating Cells

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-4839openalex-snapshot

Somatic Mutations of JAK1 and JAK3 in Acute Leukemias and Solid Cancers

inferredcites →https://doi.org/10.1186/bcr1680openalex-snapshot

Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer

inferredcites →https://doi.org/10.1371/journal.pone.0020965openalex-snapshot

Deactivation of Signal Transducer and Activator of Transcription 3 Reverses Chemotherapeutics Resistance of Leukemia Cells via Down-Regulating P-gp

inferredcites →https://doi.org/10.3324/haematol.13587openalex-snapshot

JAK1 mutation analysis in T-cell acute lymphoblastic leukemia cell lines

inferredcites →https://doi.org/10.3892/ijo.31.1.129openalex-snapshot

Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides

inferredcites →https://doi.org/10.3892/or.15.6.1445openalex-snapshot

Activation of STAT3 is a marker of poor prognosis in human colorectal cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Racemic Bisindole Alkaloids: Structure, Bioactivity, and Computational Study

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Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling

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Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3

inferred← citeshttps://doi.org/10.1007/s11010-015-2424-0openalex-snapshot

Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro

inferred← citeshttps://doi.org/10.1007/s11626-023-00783-1openalex-snapshot

Brevilin A inhibits RANKL-induced osteoclast differentiation and bone resorption

inferred← citeshttps://doi.org/10.1007/s12033-024-01183-wopenalex-snapshot

Brevilin A Inhibits Prostate Cancer Progression by Decreasing PAX5-Activated SOX4

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Pharmacological Activities of Brevilin A: A Mini-Review

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Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation

inferred← citeshttps://doi.org/10.1016/j.bmcl.2021.127989openalex-snapshot

Anti-fibrotic effects of brevilin A in hepatic fibrosis via inhibiting the STAT3 signaling pathway

inferred← citeshttps://doi.org/10.1016/j.canlet.2014.07.007openalex-snapshot

Anti-cancer effect of tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3

inferred← citeshttps://doi.org/10.1016/j.canlet.2014.07.043openalex-snapshot

N6-Substituted adenosine analogues, a novel class of JAK2 inhibitors, potently block STAT3 signaling in human cancer cells

inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111664openalex-snapshot

Natural products as important tyrosine kinase inhibitors

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110924openalex-snapshot

Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1/Nrf2/GPX4 signaling pathway

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Qualitative and quantitative analysis of chemical constituents of Centipeda minima by HPLC-QTOF-MS & HPLC-DAD

inferred← citeshttps://doi.org/10.1016/j.lfs.2019.117169openalex-snapshot

The JAK2/STAT3 pathway is involved in the anti-melanoma effects of brevilin A

inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106357openalex-snapshot

Inhibiting STAT3 signaling pathway by natural products for cancer prevention and therapy: In vitro and in vivo activity and mechanisms of action

inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154397openalex-snapshot

Promising anticancer activities and mechanisms of action of active compounds from the medicinal herb Centipeda minima (L.) A. Braun & Asch

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Non-canonical programmed cell death mechanisms triggered by natural compounds

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00278openalex-snapshot

Structural Optimization of Marine Natural Product Pretrichodermamide B for the Treatment of Colon Cancer by Targeting the JAK/STAT3 Signaling Pathway

inferred← citeshttps://doi.org/10.1021/acsomega.0c01276openalex-snapshot

Synthesis and Evaluation of Novel Anticancer Compounds Derived from the Natural Product Brevilin A

inferred← citeshttps://doi.org/10.1038/nrd4088openalex-snapshot

Therapeutic modulators of STAT signalling for human diseases

inferred← citeshttps://doi.org/10.1039/9781782624011-00055openalex-snapshot

Natural Products as Promising Leads Against Oncogenic Transcription Factors and Associated Signalling Pathways

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In vitro evaluation of anti-hepatoma activity of brevilin A: involvement of Stat3/Snail and Wnt/β-catenin pathways

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Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer

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Protein kinase inhibitors in the management of cancer: therapeutic opportunities from natural compounds

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SP2509, an inhibitor of LSD1, exerts potential antitumor effects by targeting the JAK/STAT3 signaling

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Alopecia areata treated with topical and systemic brevilin A: A case series

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Scaffold compound L971 exhibits anti‐inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways

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Dehydrocrenatidine Is a Novel Janus Kinase Inhibitor

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Brevilin A Inhibits VEGF‐Induced Angiogenesis through ROS‐Dependent Mitochondrial Dysfunction

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Investigação de moduladores da tubulina com propriedades anticâncer

inferred← citeshttps://doi.org/10.1186/s12906-024-04516-zopenalex-snapshot

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inferred← citeshttps://doi.org/10.1186/s12967-023-04087-6openalex-snapshot

Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay

inferred← citeshttps://doi.org/10.12692/ijb/3.8.241-250openalex-snapshot

Targeting JAK-STAT signal transduction pathways in human carcinomas

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Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway

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Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells

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Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways

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Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management

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Hecogenin Acetate Inhibits Reactive Oxygen Species Production and Induces Cell Cycle Arrest and Senescence in the A549 Human Lung Cancer Cell Line

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Role of STAT3 in the pathogenesis of nasopharyngeal carcinoma and its significance in anticancer therapy

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Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma

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A Review of the Research Applications of Centipeda minima

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Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda minima

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Cytokines, the Tumor Microenvironment, and Selected Plant-Derived Natural Products

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Brevilin A, a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo

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Signal transducers and activators of transcription 3 function in lung cancer

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Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro

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Additional file 1 of Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay

inferred← citeshttps://doi.org/10.7150/jca.40983openalex-snapshot

Brevilin A induces ROS-dependent apoptosis and suppresses STAT3 activation by direct binding in human lung cancer cells

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