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SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis

https://doi.org/10.1371/journal.pone.0074250
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Assessment of evaluation criteria for survival prediction from genomic data
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Modelling Survival Data in Medical Research
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RecurrenceOnline: an online analysis tool to determine breast cancer recurrence and hormone receptor status using microarray data
inferredcites →https://doi.org/10.1016/s0140-6736(05)17947-1openalex-snapshot
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
inferredcites →https://doi.org/10.1038/nature04296openalex-snapshot
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
inferredcites →https://doi.org/10.1038/nature11412openalex-snapshot
Comprehensive molecular portraits of human breast tumours
inferredcites →https://doi.org/10.1038/nm.1790openalex-snapshot
Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
inferredcites →https://doi.org/10.1056/nejmoa041588openalex-snapshot
A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
inferredcites →https://doi.org/10.1056/nejmoa060096openalex-snapshot
A Five-Gene Signature and Clinical Outcome in Non–Small-Cell Lung Cancer
inferredcites →https://doi.org/10.1073/pnas.0809444106openalex-snapshot
Prognostic gene signatures for non-small-cell lung cancer
inferredcites →https://doi.org/10.1080/00401706.1995.10485920openalex-snapshot
Modelling for Survival Data in Medical Research
inferredcites →https://doi.org/10.1093/database/bas060openalex-snapshot
bc-GenExMiner 3.0: new mining module computes breast cancer gene expression correlation analyses
inferredcites →https://doi.org/10.1093/jnci/djq025openalex-snapshot
Gene Expression-Based Prognostic Signatures in Lung Cancer: Ready for Clinical Use?
inferredcites →https://doi.org/10.1093/nar/gkj022openalex-snapshot
ITTACA: a new database for integrated tumor transcriptome array and clinical data analysis
inferredcites →https://doi.org/10.1093/nar/gkr972openalex-snapshot
Disease Ontology: a backbone for disease semantic integration
inferredcites →https://doi.org/10.1111/j.0006-341x.2005.030814.xopenalex-snapshot
Survival Model Predictive Accuracy and ROC Curves
inferredcites →https://doi.org/10.1158/0008-5472.can-05-4414openalex-snapshot
Genetic Reclassification of Histologic Grade Delineates New Clinical Subtypes of Breast Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1191openalex-snapshot
Gene Expression Signatures for Predicting Prognosis of Squamous Cell and Adenocarcinomas of the Lung
inferredcites →https://doi.org/10.1158/0008-5472.can-11-1403openalex-snapshot
Identification of Genes Upregulated in ALK -Positive and EGFR/KRAS/ALK -Negative Lung Adenocarcinomas
inferredcites →https://doi.org/10.1158/0008-5472.can-12-3232openalex-snapshot
Why Your New Cancer Biomarker May Never Work: Recurrent Patterns and Remarkable Diversity in Biomarker Failures
inferredcites →https://doi.org/10.1186/1471-2105-10-s12-s10openalex-snapshot
Survival Online: a web-based service for the analysis of correlations between gene expression and clinical and follow-up data
inferredcites →https://doi.org/10.1186/1471-2407-11-143openalex-snapshot
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization
inferredcites →https://doi.org/10.1186/1755-8794-2-18openalex-snapshot
PrognoScan: a new database for meta-analysis of the prognostic value of genes
inferredcites →https://doi.org/10.1200/jco.2009.26.4325openalex-snapshot
Prognostic and Predictive Gene Signature for Adjuvant Chemotherapy in Resected Non–Small-Cell Lung Cancer
inferredcites →https://doi.org/10.1371/journal.pcbi.1002240openalex-snapshot
Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome
inferredcites →https://doi.org/10.1371/journal.pone.0010312openalex-snapshot
Gene Expression-Based Classification of Non-Small Cell Lung Carcinomas and Survival Prediction
inferredcites →https://doi.org/10.1371/journal.pone.0017911openalex-snapshot
GOBO: Gene Expression-Based Outcome for Breast Cancer Online
inferredcites →https://doi.org/10.1371/journal.pone.0051862openalex-snapshot
Cutoff Finder: A Comprehensive and Straightforward Web Application Enabling Rapid Biomarker Cutoff Optimization

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The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death
inferred← citeshttps://doi.org/10.1016/j.omto.2020.04.002openalex-snapshot
GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17
inferred← citeshttps://doi.org/10.1016/j.oraloncology.2020.104592openalex-snapshot
Increased DSG2 plasmatic levels identified by transcriptomic-based secretome analysis is a potential prognostic biomarker in laryngeal carcinoma
inferred← citeshttps://doi.org/10.1016/j.prp.2018.07.015openalex-snapshot
Bioinformatics analysis of gene expression profiles to diagnose crucial and novel genes in glioblastoma multiform
inferred← citeshttps://doi.org/10.1016/j.prp.2019.152510openalex-snapshot
Key genes associated with diabetes mellitus and hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.redox.2019.101413openalex-snapshot
AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis
inferred← citeshttps://doi.org/10.1016/j.tiv.2019.06.003openalex-snapshot
CID-6033590 inhibits p38MAPK pathway and induces S-phase cell cycle arrest and apoptosis in DU145 and PC-3 cells
inferred← citeshttps://doi.org/10.1016/j.tranon.2020.100955openalex-snapshot
Progression-free survival of prostate cancer patients is prolonged with a higher regucalcin expression in the tumor tissues: Overexpressed regucalcin suppresses the growth and bone activity in human prostate cancer cells
inferred← citeshttps://doi.org/10.1016/j.tranon.2022.101499openalex-snapshot
Construction of the prognostic enhancer RNA regulatory network in osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.tranon.2022.101571openalex-snapshot
Single-cell RNA-seq analysis to identify potential biomarkers for diagnosis, and prognosis of non-small cell lung cancer by using comprehensive bioinformatics approaches
inferred← citeshttps://doi.org/10.1016/j.urology.2016.04.041openalex-snapshot
Screening of Differently Expressed miRNA and mRNA in Prostate Cancer by Integrated Analysis of Transcription Data
inferred← citeshttps://doi.org/10.1016/j.yexcr.2016.03.023openalex-snapshot
A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.ygeno.2020.06.003openalex-snapshot
Novel molecular signatures and potential therapeutics in renal cell carcinomas: Insights from a comparative analysis of subtypes
inferred← citeshttps://doi.org/10.1016/j.ygeno.2024.110834openalex-snapshot
Boosting edgeR (Robust) by dealing with missing observations and gene-specific outliers in RNA-Seq profiles and its application to explore biomarker genes for diagnosis and therapies of ovarian cancer
inferred← citeshttps://doi.org/10.1017/nws.2019.55openalex-snapshot
Symmetry in cancer networks identified: Proposal for multicancer biomarkers
inferred← citeshttps://doi.org/10.1021/acs.jcim.2c01317openalex-snapshot
Serverless Prediction of Peptide Properties with Recurrent Neural Networks
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01520openalex-snapshot
Discovery of Novel Indazoles as Potent and Selective PI3Kδ Inhibitors with High Efficacy for Treatment of Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1021/acs.jproteome.1c00763openalex-snapshot
Integration of Automatic Text Mining and Genomic and Proteomic Analysis to Unravel Prostate Cancer Biomarkers
inferred← citeshttps://doi.org/10.1021/acsomega.3c07206openalex-snapshot
Identifying Biomarkers and Therapeutic Targets by Multiomic Analysis for HNSCC: Precision Medicine and Healthcare Management
inferred← citeshttps://doi.org/10.1038/bjc.2015.362openalex-snapshot
Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1038/bjc.2017.247openalex-snapshot
Non-conventional role of haemoglobin beta in breast malignancy
inferred← citeshttps://doi.org/10.1038/cdd.2016.5openalex-snapshot
Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation
inferred← citeshttps://doi.org/10.1038/ncomms7285openalex-snapshot
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
inferred← citeshttps://doi.org/10.1038/onc.2017.144openalex-snapshot
Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression
inferred← citeshttps://doi.org/10.1038/onc.2017.165openalex-snapshot
GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis
inferred← citeshttps://doi.org/10.1038/onc.2017.185openalex-snapshot
β-catenin downregulates Dicer to promote ovarian cancer metastasis
inferred← citeshttps://doi.org/10.1038/oncsis.2017.31openalex-snapshot
Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma
inferred← citeshttps://doi.org/10.1038/s41374-018-0114-8openalex-snapshot
Overexpression of HIF-1α contributes to melphalan resistance in multiple myeloma cells by activation of ERK1/2, Akt, and NF-κB
inferred← citeshttps://doi.org/10.1038/s41379-018-0043-5openalex-snapshot
Programmed cell death ligand-1 expression in tumor and immune cells is associated with better patient outcome and decreased tumor-infiltrating lymphocytes in uveal melanoma
inferred← citeshttps://doi.org/10.1038/s41388-018-0533-4openalex-snapshot
IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells
inferred← citeshttps://doi.org/10.1038/s41388-018-0557-9openalex-snapshot
Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
inferred← citeshttps://doi.org/10.1038/s41388-019-0970-8openalex-snapshot
Lactoferrin deficiency induces a pro-metastatic tumor microenvironment through recruiting myeloid-derived suppressor cells in mice
inferred← citeshttps://doi.org/10.1038/s41388-019-1051-8openalex-snapshot
A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism
inferred← citeshttps://doi.org/10.1038/s41388-019-1103-0openalex-snapshot
A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis
inferred← citeshttps://doi.org/10.1038/s41388-020-01428-3openalex-snapshot
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3
inferred← citeshttps://doi.org/10.1038/s41388-020-01584-6openalex-snapshot
STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway
inferred← citeshttps://doi.org/10.1038/s41388-022-02344-4openalex-snapshot
YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through enhancer in breast cancer
inferred← citeshttps://doi.org/10.1038/s41392-023-01706-yopenalex-snapshot
Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity
inferred← citeshttps://doi.org/10.1038/s41416-018-0135-5openalex-snapshot
Agrin has a pathological role in the progression of oral cancer
inferred← citeshttps://doi.org/10.1038/s41416-019-0400-2openalex-snapshot
HAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasis
inferred← citeshttps://doi.org/10.1038/s41416-019-0501-yopenalex-snapshot
Notch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry
inferred← citeshttps://doi.org/10.1038/s41416-020-01094-yopenalex-snapshot
Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer
inferred← citeshttps://doi.org/10.1038/s41416-020-0892-9openalex-snapshot
Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC
inferred← citeshttps://doi.org/10.1038/s41416-023-02295-xopenalex-snapshot
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
inferred← citeshttps://doi.org/10.1038/s41416-024-02758-9openalex-snapshot
Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation
inferred← citeshttps://doi.org/10.1038/s41417-019-0109-7openalex-snapshot
PROM1 and PROM2 expression differentially modulates clinical prognosis of cancer: a multiomics analysis
inferred← citeshttps://doi.org/10.1038/s41419-018-0899-9openalex-snapshot
DBC1 regulates Wnt/β-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer
inferred← citeshttps://doi.org/10.1038/s41419-019-2065-4openalex-snapshot
Pancreatic cancer-educated macrophages protect cancer cells from complement-dependent cytotoxicity by up-regulation of CD59
inferred← citeshttps://doi.org/10.1038/s41420-022-00899-5openalex-snapshot
FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis
inferred← citeshttps://doi.org/10.1038/s41424-018-0058-8openalex-snapshot
Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Novel Potential Biomarker in Gastroenteropancreatic Neuroendocrine Tumors
inferred← citeshttps://doi.org/10.1038/s41467-018-05084-wopenalex-snapshot
UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
inferred← citeshttps://doi.org/10.1038/s41467-019-12184-8openalex-snapshot
Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer
inferred← citeshttps://doi.org/10.1038/s41467-023-42178-6openalex-snapshot
Inhibiting stromal Class I HDACs curbs pancreatic cancer progression
inferred← citeshttps://doi.org/10.1038/s41467-024-47536-6openalex-snapshot
Wild-type IDH2 is a therapeutic target for triple-negative breast cancer
inferred← citeshttps://doi.org/10.1038/s41467-025-58923-yopenalex-snapshot
Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41523-022-00474-2openalex-snapshot
ZNF92, an unexplored transcription factor with remarkably distinct breast cancer over-expression associated with prognosis and cell-of-origin
inferred← citeshttps://doi.org/10.1038/s41525-022-00321-0openalex-snapshot
Alternative ANKHD1 transcript promotes proliferation and inhibits migration in uterine corpus endometrial carcinoma
inferred← citeshttps://doi.org/10.1038/s41591-019-0566-4openalex-snapshot
Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity
inferred← citeshttps://doi.org/10.1038/s41598-017-00916-zopenalex-snapshot
Deficiency of CCN5/WISP-2-Driven Program in breast cancer Promotes Cancer Epithelial cells to mesenchymal stem cells and Breast Cancer growth
inferred← citeshttps://doi.org/10.1038/s41598-017-01207-3openalex-snapshot
In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies
inferred← citeshttps://doi.org/10.1038/s41598-017-07043-9openalex-snapshot
Lumican delays melanoma growth in mice and drives tumor molecular assembly as well as response to matrix-targeted TAX2 therapeutic peptide
inferred← citeshttps://doi.org/10.1038/s41598-018-21123-4openalex-snapshot
Transcriptome analysis and prognosis of ALDH isoforms in human cancer
inferred← citeshttps://doi.org/10.1038/s41598-019-41625-zopenalex-snapshot
Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data
inferred← citeshttps://doi.org/10.1038/s41598-019-48051-1openalex-snapshot
Low infiltration of tumor-associated macrophages in high c-Myb-expressing breast tumors
inferred← citeshttps://doi.org/10.1038/s41598-019-48243-9openalex-snapshot
A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma
inferred← citeshttps://doi.org/10.1038/s41598-019-50874-xopenalex-snapshot
Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis
inferred← citeshttps://doi.org/10.1038/s41598-020-59605-zopenalex-snapshot
Identification of Key Components in Colon Adenocarcinoma Using Transcriptome to Interactome Multilayer Framework
inferred← citeshttps://doi.org/10.1038/s41598-020-60127-xopenalex-snapshot
Pan-cancer mapping of differential protein-protein interactions
inferred← citeshttps://doi.org/10.1038/s41598-020-61422-3openalex-snapshot
Edgetic perturbation signatures represent known and novel cancer biomarkers
inferred← citeshttps://doi.org/10.1038/s41598-020-61510-4openalex-snapshot
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/s41598-020-70774-9openalex-snapshot
Aberrant pregnancy-associated plasma protein-A expression in breast cancers prognosticates clinical outcomes
inferred← citeshttps://doi.org/10.1038/s41598-021-01508-8openalex-snapshot
Integrative Bioinformatics approaches to therapeutic gene target selection in various cancers for Nitroglycerin
inferred← citeshttps://doi.org/10.1038/s41598-021-86888-7openalex-snapshot
Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma
inferred← citeshttps://doi.org/10.1038/s41598-022-18620-yopenalex-snapshot
Identification of key genes of the ccRCC subtype with poor prognosis
inferred← citeshttps://doi.org/10.1038/s41598-023-28527-xopenalex-snapshot
ANXA10 is a prognostic biomarker and suppressor of hepatocellular carcinoma: a bioinformatics analysis and experimental validation
inferred← citeshttps://doi.org/10.1038/s41598-023-31276-6openalex-snapshot
Bioinformatics-based investigation on the genetic influence between SARS-CoV-2 infections and idiopathic pulmonary fibrosis (IPF) diseases, and drug repurposing
inferred← citeshttps://doi.org/10.1038/s42003-021-02258-zopenalex-snapshot
Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
inferred← citeshttps://doi.org/10.1038/s42003-023-05668-3openalex-snapshot
Transcriptional state dynamics lead to heterogeneity and adaptive tumor evolution in urothelial bladder carcinoma
inferred← citeshttps://doi.org/10.1038/srep11966openalex-snapshot
Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm
inferred← citeshttps://doi.org/10.1038/srep22051openalex-snapshot
Roles of Distal and Genic Methylation in the Development of Prostate Tumorigenesis Revealed by Genome-wide DNA Methylation Analysis
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