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Expression of SLC2A9 Isoforms in the Kidney and Their Localization in Polarized Epithelial Cells

https://doi.org/10.1371/journal.pone.0084996
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/geno.2000.6195openalex-snapshot
Cloning and Expression Analysis of a Novel Member of the Facilitative Glucose Transporter Family, SLC2A9 (GLUT9)
inferredcites →https://doi.org/10.1007/s00467-012-2174-0openalex-snapshot
Acute kidney injury in two children caused by renal hypouricaemia type 2
inferredcites →https://doi.org/10.1007/s11010-013-1564-3openalex-snapshot
The apical sorting signal for human GLUT9b resides in the N-terminus
inferredcites →https://doi.org/10.1016/j.ajhg.2008.11.001openalex-snapshot
Mutations in Glucose Transporter 9 Gene SLC2A9 Cause Renal Hypouricemia
inferredcites →https://doi.org/10.1016/j.ymgme.2010.12.016openalex-snapshot
Novel homozygous insertion in SLC2A9 gene caused renal hypouricemia
inferredcites →https://doi.org/10.1038/nature742openalex-snapshot
Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
inferredcites →https://doi.org/10.1038/ng.106openalex-snapshot
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
inferredcites →https://doi.org/10.1038/ng.2500openalex-snapshot
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
inferredcites →https://doi.org/10.1038/ng.531openalex-snapshot
Genome-wide association study of hematological and biochemical traits in a Japanese population
inferredcites →https://doi.org/10.1042/0264-6021:3580517openalex-snapshot
Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells
inferredcites →https://doi.org/10.1073/pnas.0904411106openalex-snapshot
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy
inferredcites →https://doi.org/10.1074/jbc.c800156200openalex-snapshot
Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans
inferredcites →https://doi.org/10.1074/jbc.m312226200openalex-snapshot
Identification and Characterization of Human Glucose Transporter-like Protein-9 (GLUT9)
inferredcites →https://doi.org/10.1080/09687680701298143openalex-snapshot
A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity
inferredcites →https://doi.org/10.1080/15257770.2011.628354openalex-snapshot
Increased Expression ofSLC2A9Decreases Urate Excretion From the Kidney
inferredcites →https://doi.org/10.1084/jem.20021109openalex-snapshot
Vaginal Submucosal Dendritic Cells, but Not Langerhans Cells, Induce Protective Th1 Responses to Herpes Simplex Virus-2
inferredcites →https://doi.org/10.1091/mbc.e08-05-0478openalex-snapshot
Exon Loss Accounts for Differential Sorting of Na-K-Cl Cotransporters in Polarized Epithelial Cells
inferredcites →https://doi.org/10.1093/ndt/gfr419openalex-snapshot
Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2
inferredcites →https://doi.org/10.1152/ajpcell.00502.2003openalex-snapshot
A dileucine motif targets the sulfate anion transporter sat-1 to the basolateral membrane in renal cell lines
inferredcites →https://doi.org/10.1152/ajprenal.00134.2012openalex-snapshot
Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses
inferredcites →https://doi.org/10.1152/ajprenal.00215.2002openalex-snapshot
Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells
inferredcites →https://doi.org/10.1242/jcs.02943openalex-snapshot
Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the β2-adaptin subunit of the AP-2 adaptor complex
inferredcites →https://doi.org/10.1371/journal.pgen.0030194openalex-snapshot
The GLUT9 Gene Is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts
inferredcites →https://doi.org/10.1371/journal.pgen.1000504openalex-snapshot
Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations
inferredcites →https://doi.org/10.1371/journal.pmed.0050197openalex-snapshot
SLC2A9 Is a High-Capacity Urate Transporter in Humans
inferredcites →https://doi.org/10.1681/asn.2009040406openalex-snapshot
Homozygous SLC2A9 Mutations Cause Severe Renal Hypouricemia

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Lysosome-Dependent Na +-K +-ATpase Signalling in Hyperuricaemia-Induced Renal Tubular Injury and Abnormal Urate Reabsorption
inferred← citeshttps://doi.org/10.2139/ssrn.4007036openalex-extracted
Lysosome-Dependent Na +-K +-Atpase Signalling In Hyperuricaemia-Induced Renal Tubular Injury and Abnormal Urate Reabsorption
inferred← citeshttps://doi.org/10.1002/art.42940openalex-snapshot
Caffeine Inhibits Both Basal and Insulin‐Activated Urate Transport
inferred← citeshttps://doi.org/10.1002/bdd.1909openalex-snapshot
SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria
inferred← citeshttps://doi.org/10.1002/cphy.c210030openalex-snapshot
Renal Tubular Handling of Glucose and Fructose in Health and Disease
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2022.tb00207.xopenalex-snapshot
Renal Tubular Handling of Glucose and Fructose in Health and Disease
inferred← citeshttps://doi.org/10.1007/978-981-16-1037-0_40openalex-snapshot
Endocrine and Metabolic Diseases
inferred← citeshttps://doi.org/10.1007/s00125-015-3650-4openalex-snapshot
Fructose and uric acid in diabetic nephropathy
inferred← citeshttps://doi.org/10.1007/s00424-018-2190-4openalex-snapshot
SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney
inferred← citeshttps://doi.org/10.1007/s10157-015-1186-zopenalex-snapshot
Functional analysis of novel allelic variants in URAT1 and GLUT9 causing renal hypouricemia type 1 and 2
inferred← citeshttps://doi.org/10.1007/s11926-016-0587-7openalex-snapshot
Urate Handling in the Human Body
inferred← citeshttps://doi.org/10.1007/s12325-015-0272-7openalex-snapshot
Management of Chronic Kidney Disease: The Relationship Between Serum Uric Acid and Development of Nephropathy
inferred← citeshttps://doi.org/10.1016/j.cca.2018.02.030openalex-snapshot
URAT1 and GLUT9 mutations in Spanish patients with renal hypouricemia
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.01.043openalex-snapshot
Pharmacological urate-lowering approaches in chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175237openalex-snapshot
Autophagy-dependent Na+-K+-ATPase signalling and abnormal urate reabsorption in hyperuricaemia-induced renal tubular injury
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A review on gout: Looking back and looking ahead
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Hyperuricemia and Gout Reduction by SGLT2 Inhibitors in Diabetes and Heart Failure
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Cellular arsenic transport pathways in mammals
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The anti-hyperuricemia potential of bioactive natural products and extracts derived from traditional Chinese medicines: A review and perspective
inferred← citeshttps://doi.org/10.1016/j.jtbi.2014.10.015openalex-snapshot
In silico aided thoughts on mitochondrial vitamin C transport
inferred← citeshttps://doi.org/10.1016/j.nefro.2018.08.010openalex-snapshot
Hipouricemia renal hereditaria tipo 1 y 2 en tres niños españoles. Revisión de casos pediátricos publicados
inferred← citeshttps://doi.org/10.1016/j.nefroe.2018.08.007openalex-snapshot
Hereditary renal hypouricaemia type 1 and 2 in three Spanish children. Review of published paediatric cases
inferred← citeshttps://doi.org/10.1016/j.neulet.2017.09.001openalex-snapshot
Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains
inferred← citeshttps://doi.org/10.1016/j.rdc.2017.04.004openalex-snapshot
Genomic Influences on Hyperuricemia and Gout
inferred← citeshttps://doi.org/10.1016/j.semnephrol.2020.12.006openalex-snapshot
Molecular Pathophysiology of Uric Acid Homeostasis
inferred← citeshttps://doi.org/10.1016/j.slasd.2024.100193openalex-snapshot
The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of GLUT9/SLC2A9 isoforms in a drug discovery program
inferred← citeshttps://doi.org/10.1016/j.tifs.2025.105134openalex-snapshot
Preparation, functional mechanism, and deep-learning application of food-derived xanthine oxidase-inhibitory peptides: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.06.016openalex-snapshot
Substrate Transport Properties of the Human Peptide/Histidine Transporter PHT2 in Transfected MDCK Cells
inferred← citeshttps://doi.org/10.1016/s0140-6736(21)00569-9openalex-snapshot
Gout
inferred← citeshttps://doi.org/10.1016/s2665-9913(19)30108-0openalex-snapshot
Repurposing antidiabetic medications for gout: the potential of sodium glucose co-transporter 2 inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c02797openalex-snapshot
Coffee Leaf Tea Extracts Improve Hyperuricemia Nephropathy and Its Associated Negative Effect in Gut Microbiota and Amino Acid Metabolism in Rats
inferred← citeshttps://doi.org/10.1038/s41467-021-27198-4openalex-snapshot
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus
inferred← citeshttps://doi.org/10.1038/s41467-024-49420-9openalex-snapshot
Structural basis for urate recognition and apigenin inhibition of human GLUT9
inferred← citeshttps://doi.org/10.1074/jbc.m114.611178openalex-snapshot
Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport
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An update of genetics, co‐morbidities and management of hyperuricaemia
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A review on the fruit components affecting uric acid level and their underlying mechanisms
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E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-030322-084058openalex-snapshot
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory
inferred← citeshttps://doi.org/10.1146/annurev-physiol-021113-170343openalex-snapshot
The Molecular Physiology of Uric Acid Homeostasis
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Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus
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Learning Physiology from Inherited Kidney Disorders
inferred← citeshttps://doi.org/10.1155/2023/6677236openalex-snapshot
SLC2A9 Gene Polymorphism Is Associated with Elevated Serum Uric Acid Caused by Pyrazinamide
inferred← citeshttps://doi.org/10.1159/000445845openalex-snapshot
A Novel Homozygous SLC2A9 Mutation Associated with Renal-Induced Hypouricemia
inferred← citeshttps://doi.org/10.1177/20406223221083509openalex-snapshot
Effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on serum urate levels in patients with and without diabetes: a systematic review and meta-regression of 43 randomized controlled trials
inferred← citeshttps://doi.org/10.1186/s12576-023-00894-0openalex-snapshot
Identification of three distinct cell populations for urate excretion in human kidneys
inferred← citeshttps://doi.org/10.1186/s12916-017-0878-5openalex-snapshot
The genetics of gout: towards personalised medicine?
inferred← citeshttps://doi.org/10.1186/s12987-016-0046-xopenalex-snapshot
Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain
inferred← citeshttps://doi.org/10.1186/s13075-015-0609-2openalex-snapshot
An update on the genetic architecture of hyperuricemia and gout
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Effects of dapagliflozin on serum and urinary uric acid levels in patients with type 2 diabetes: a prospective pilot trial
inferred← citeshttps://doi.org/10.1253/circrep.cr-20-0016openalex-snapshot
Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock
inferred← citeshttps://doi.org/10.1371/journal.pone.0107902openalex-snapshot
Complex Analysis of Urate Transporters SLC2A9, SLC22A12 and Functional Characterization of Non-Synonymous Allelic Variants of GLUT9 in the Czech Population: No Evidence of Effect on Hyperuricemia and Gout
inferred← citeshttps://doi.org/10.14814/phy2.12013openalex-snapshot
Paracellular route is the major urate transport pathway across the blood-placental barrier
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Genetic and Physiological Effects of Insulin-Like Growth Factor-1 (IGF-1) on Human Urate Homeostasis
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Recent advances on uric acid transporters
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The rs13129697 polymorphism of the SLC2A9 gene, but not rs7442295 is associated with impaired glucose tolerance/impaired fasting glucose complicated with hyperuricaemia in Han Chinese males
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Structure of, and functional insight into the GLUT family of membrane transporters
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The Mechanism of Sodium-Glucose Cotransporter-2 Inhibitors in Reducing Uric Acid in Type 2 Diabetes Mellitus
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Comprehensive Treatment of Gout with Traditional Chinese Medicine: A Modern Pathophysiological Perspective
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Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout
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Sodium–Glucose Cotransporter 2 Inhibitors: A Case Study in Translational Research
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Research Progress in the Prevention and Treatment of Hyperuricemia with Gout by Traditional Chinese Medicine
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Molecular Structure, Biochemical Functions, Genetics, and Emerging Clinical Relevance of Glucose Transporters
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Different Pharmacological Properties of GLUT9a and GLUT9b: Potential Implications in Preeclampsia
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Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project
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Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia
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New insight into the management of renal excretion and hyperuricemia: Potential therapeutic strategies with natural bioactive compounds
inferred← citeshttps://doi.org/10.3389/fphys.2019.01323openalex-snapshot
Interaction Between ITM2B and GLUT9 Links Urate Transport to Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.3389/fphys.2021.713710openalex-snapshot
Genetic and Physiological Effects of Insulin on Human Urate Homeostasis
inferred← citeshttps://doi.org/10.3390/cells11040633openalex-snapshot
Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System
inferred← citeshttps://doi.org/10.3390/cells11223703openalex-snapshot
Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice
inferred← citeshttps://doi.org/10.3390/foods14223843openalex-snapshot
Dandelion Leaf Aqueous Extract Relieves Hyperuricemia and Its Complications via Modulating Uric Acid Metabolism, Renal Inflammation, and Gut Microbes
inferred← citeshttps://doi.org/10.3390/genes14091823openalex-snapshot
New SLC22A12 (URAT1) Variant Associated with Renal Hypouricemia Identified by Whole-Exome Sequencing Analysis and Bioinformatics Predictions
inferred← citeshttps://doi.org/10.3390/gucdd2020014openalex-snapshot
SGLT2 Inhibitors and Uric Acid Homeostasis
inferred← citeshttps://doi.org/10.3390/ijms24098455openalex-snapshot
Pathogenic Variants of SLC22A12 (URAT1) and SLC2A9 (GLUT9) in Spanish Patients with Renal Hypouricemia: Founder Effect of SLC2A9 Variant c.374C>T; p.(T125M)
inferred← citeshttps://doi.org/10.3390/pharmaceutics17070865openalex-snapshot
Could Sodium-Glucose Co-Transporter-2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists Play a Role in Gout Treatment?
inferred← citeshttps://doi.org/10.3892/mmr.2019.10426openalex-snapshot
Urate transport capacity of glucose transporter 9 and urate transporter 1 in cartilage chondrocytes
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Idiopathic renal hypouricemia: A case report and literature review
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Urate Transporters in the Kidney: What Clinicians Need to Know
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Role of Transporters in Hyperuricemia
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