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Multiple Low-Dose Radiation Prevents Type 2 Diabetes-Induced Renal Damage through Attenuation of Dyslipidemia and Insulin Resistance and Subsequent Renal Inflammation and Oxidative Stress

https://doi.org/10.1371/journal.pone.0092574
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Outgoing claims: the papers this work cites, builds on, or argues with.

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C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
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Curcumin attenuates diabetic nephropathy by inhibiting PKC‐α and PKC‐β1 activity in streptozotocin‐induced type I diabetic rats
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Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
inferredcites →https://doi.org/10.1007/s00592-003-0113-zopenalex-snapshot
Pathogenesis of angiopathy in diabetes
inferredcites →https://doi.org/10.1007/s10522-013-9436-5openalex-snapshot
Low doses of radiation can enhance insect lifespans
inferredcites →https://doi.org/10.1016/j.amjmed.2006.01.009openalex-snapshot
Etiology of Insulin Resistance
inferredcites →https://doi.org/10.1016/j.phrs.2005.05.004openalex-snapshot
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening
inferredcites →https://doi.org/10.1016/j.physbeh.2007.11.016openalex-snapshot
Child and adolescent obesity: Epidemiology and developmental perspectives
inferredcites →https://doi.org/10.1016/j.semnephrol.2007.01.006openalex-snapshot
AGE, RAGE, and ROS in Diabetic Nephropathy
inferredcites →https://doi.org/10.1016/j.toxlet.2009.11.011openalex-snapshot
Repetitive exposures to low-dose X-rays attenuate testicular apoptotic cell death in streptozotocin-induced diabetes rats
inferredcites →https://doi.org/10.1016/j.toxlet.2010.11.001openalex-snapshot
Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice
inferredcites →https://doi.org/10.1016/j.yexmp.2003.08.002openalex-snapshot
Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation
inferredcites →https://doi.org/10.1016/s0026-0495(98)90027-0openalex-snapshot
Nongenetic mouse models of non—insulin-dependent diabetes mellitus
inferredcites →https://doi.org/10.1016/s0360-3016(02)04415-2openalex-snapshot
Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy
inferredcites →https://doi.org/10.1016/s0940-9602(04)80017-7openalex-snapshot
Low-dose radiation modifies the progression of chronic renal failure
inferredcites →https://doi.org/10.1016/s1016-8478(23)07359-4openalex-snapshot
Low-Dose Radiation Stimulates the Proliferation of Normal Human Lung Fibroblasts Via a Transient Activation of Raf and Akt
inferredcites →https://doi.org/10.1038/cdd.2009.150openalex-snapshot
PI3K p110α and p110β have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts
inferredcites →https://doi.org/10.1038/ki.2012.107openalex-snapshot
The association of genetic variants of type 2 diabetes with kidney function
inferredcites →https://doi.org/10.1038/nrneph.2010.59openalex-snapshot
Role of triglyceride-rich lipoproteins in diabetic nephropathy
inferredcites →https://doi.org/10.1038/sj.ki.5002286openalex-snapshot
Diabetic nephropathy and proximal tubule ROS: Challenging our glomerulocentricity
inferredcites →https://doi.org/10.1042/cs20070123openalex-snapshot
Aldosterone and end-organ damage
inferredcites →https://doi.org/10.1042/cs20080394openalex-snapshot
Pathogenic perspectives for the role of inflammation in diabetic nephropathy
inferredcites →https://doi.org/10.1046/j.1523-1755.1999.07106.xopenalex-snapshot
Lipoprotein abnormalities in diabetic nephropathy
inferredcites →https://doi.org/10.1053/j.ackd.2008.01.002openalex-snapshot
Racial and Ethnic Differences in Trends of End-Stage Renal Disease: United States, 1995 to 2005
inferredcites →https://doi.org/10.1080/08916930902831233openalex-snapshot
Activation-induced cell death and total Akt content of granulocytes show a biphasic course after low-dose radiation
inferredcites →https://doi.org/10.1080/095530000138303openalex-snapshot
Long-term effects of total-body irradiation on the kidney of Rhesus monkeys
inferredcites →https://doi.org/10.1080/10408440701493061openalex-snapshot
Apoptotic Cell Death Induced by Low-Dose Radiation in Male Germ Cells: Hormesis and Adaptation
inferredcites →https://doi.org/10.1093/aob/mcf118openalex-snapshot
Antioxidants, Oxidative Damage and Oxygen Deprivation Stress: a Review
inferredcites →https://doi.org/10.1093/ndt/gfp103openalex-snapshot
Antifibrotic effects of pioglitazone on the kidney in a rat model of type 2 diabetes mellitus
inferredcites →https://doi.org/10.1093/ndt/gfr613openalex-snapshot
High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α pathway
inferredcites →https://doi.org/10.1097/01.mnh.0000165889.60254.98openalex-snapshot
Aldosterone and end-organ damage
inferredcites →https://doi.org/10.1097/mnh.0b013e32833aa4acopenalex-snapshot
Renal lipid metabolism and lipotoxicity
inferredcites →https://doi.org/10.1101/gad.1550907openalex-snapshot
Mechanisms of obesity-associated insulin resistance: many choices on the menu
inferredcites →https://doi.org/10.1111/j.1600-0463.2007.apm_514.xopenalex-snapshot
Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies
inferredcites →https://doi.org/10.1152/ajpendo.00430.2012openalex-snapshot
Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice
inferredcites →https://doi.org/10.1152/ajpendo.00478.2009openalex-snapshot
Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation
inferredcites →https://doi.org/10.1152/ajpheart.00293.2009openalex-snapshot
Molecular mechanism underlying Akt activation in zinc-induced cardioprotection
inferredcites →https://doi.org/10.1152/ajpheart.00630.2004openalex-snapshot
Sex differences in renal injury and nitric oxide production in renal wrap hypertension
inferredcites →https://doi.org/10.1152/ajpheart.01307.2005openalex-snapshot
ANG II-induced cardiac molecular and cellular events: role of aldosterone
inferredcites →https://doi.org/10.1152/ajpheart.2001.281.4.h1524openalex-snapshot
Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance
inferredcites →https://doi.org/10.1152/ajprenal.00032.2009openalex-snapshot
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy
inferredcites →https://doi.org/10.1155/2011/416254openalex-snapshot
Development of a Nongenetic Mouse Model of Type 2 Diabetes
inferredcites →https://doi.org/10.1155/2012/216512openalex-snapshot
Prevention of Diabetic Complications by Activation of Nrf2: Diabetic Cardiomyopathy and Nephropathy
inferredcites →https://doi.org/10.1155/2012/291087openalex-snapshot
Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice: A Potential Mechanism to Prevent Diabetic Nephropathy
inferredcites →https://doi.org/10.1155/2012/687867openalex-snapshot
Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus
inferredcites →https://doi.org/10.1161/01.atv.0000250972.83623.61openalex-snapshot
Activation of PPARβ/δ Induces Endothelial Cell Proliferation and Angiogenesis
inferredcites →https://doi.org/10.1191/096032799678840291openalex-snapshot
Research of the adaptive response induced by low-dose radiation: where have we been and where should we go?
inferredcites →https://doi.org/10.1269/jrr.06063openalex-snapshot
Whole Body Exposure to Low-dose Gamma Radiation Promotes Kidney Antioxidant Status in Balb/c Mice
inferredcites →https://doi.org/10.1269/jrr.07032openalex-snapshot
Low-dose of Ionizing Radiation Enhances Cell Proliferation Via Transient ERK1/2 and p38 Activation in Normal Human Lung Fibroblasts
inferredcites →https://doi.org/10.1371/journal.pone.0058472openalex-snapshot
Association Analysis of Dyslipidemia-Related Genes in Diabetic Nephropathy
inferredcites →https://doi.org/10.1517/14656560903575654openalex-snapshot
Impact of managing atherogenic dyslipidemia on cardiovascular outcome across different stages of diabetic nephropathy
inferredcites →https://doi.org/10.1615/jenvpathtoxoncol.v22.i1.20openalex-snapshot
Reactive Oxygen Species, Antioxidant Mechanisms, and Serum Cytokine Levels in Cancer Patients: Impact of an Antioxidant Treatment
inferredcites →https://doi.org/10.1667/rr0640.1openalex-snapshot
Adaptive Responses to Low-Dose/Low-Dose-Rate γ Rays in Normal Human Fibroblasts: The Role of Growth Architecture and Oxidative Metabolism
inferredcites →https://doi.org/10.1667/rr0746.1openalex-snapshot
Radiation-Induced DNA Damage as a Predictor of Long-Term Toxicity in Locally Advanced Breast Cancer Patients Treated with High-Dose Hyperfractionated Radical Radiotherapy
inferredcites →https://doi.org/10.1681/asn.2007091048openalex-snapshot
The Role of Inflammatory Cytokines in Diabetic Nephropathy
inferredcites →https://doi.org/10.1900/rds.2011.8.392openalex-snapshot
The Kidney in Type 2 Diabetes Therapy
inferredcites →https://doi.org/10.2169/internalmedicine.47.0906openalex-snapshot
Chronic Kidney Disease in Japan
inferredcites →https://doi.org/10.2215/cjn.04071206openalex-snapshot
Obesity and Obesity-Initiated Metabolic Syndrome
inferredcites →https://doi.org/10.2215/cjn.08160910openalex-snapshot
Lipotoxicity in Diabetic Nephropathy
inferredcites →https://doi.org/10.2337/db08-0057openalex-snapshot
Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes
inferredcites →https://doi.org/10.2337/db10-1164openalex-snapshot
Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo
inferredcites →https://doi.org/10.2337/dc08-0277openalex-snapshot
Inflammation and Progressive Nephropathy in Type 1 Diabetes in the Diabetes Control and Complications Trial
inferredcites →https://doi.org/10.2337/diabetes.52.1.21openalex-snapshot
Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice
inferredcites →https://doi.org/10.3164/jcbn.2008044openalex-snapshot
Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index
inferredcites →https://doi.org/10.4103/1119-3077.84009openalex-snapshot
Prevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state South-East Nigeria
inferredcites →https://doi.org/10.7326/0003-4819-131-5-199909070-00009openalex-snapshot
Potential New Cardiovascular Risk Factors: Left Ventricular Hypertrophy, Homocysteine, Lipoprotein(a), Triglycerides, Oxidative Stress, and Fibrinogen

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Low-dose radiation pretreatment improves survival of human ceiling culture-derived proliferative adipocytes (ccdPAs) under hypoxia via HIF-1 alpha and MMP-2 induction
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C1q/tumor necrosis factor-related protein-3 improves microvascular endothelial function in diabetes through the AMPK/eNOS/NO· signaling pathway
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Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway
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c-Abl contributes to glucose-promoted apoptosis via p53 signaling pathway in podocytes
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Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway
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X-ray irradiation has positive effects for the recovery of peripheral nerve injury maybe through the vascular smooth muscle contraction signaling pathway
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Gamma radiation improves AD pathogenesis in APP/PS1 mouse model by potentiating insulin sensitivity
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Antidiabetic activity of polysaccharides from Suillellus luridus in streptozotocin-induced diabetic mice
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Ginsenoside Rb1 exerts therapeutic effects on ulcerative colitis through regulating the Nrf2/PIP2/NLRP3 inflammasome signaling pathway
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HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis
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Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation
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Ionizing radiation biomarkers in epidemiological studies – An update
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Risk and mechanism of metabolic syndrome associated with radiation exposure
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Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis
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Evaluation of antidiabetic activity of Pleurotus pulmonarius against streptozotocin-nicotinamide induced diabetic wistar albino rats
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Effect of low-dose total-body radiotherapy on immune microenvironment
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Distinctive quality control method for solid-state fermented Isaria cicadae from strain Ic-17-7 and application in a rat model of type 2 diabetes
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Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
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Low-dose radiation exaggerates HFD-induced metabolic dysfunction by gut microbiota through PA-PYCR1 axis
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Metformin-decavanadate treatment ameliorates hyperglycemia and redox balance of the liver and muscle in a rat model of alloxan-induced diabetes
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Radon inhalation suppresses nephropathy in streptozotocin-induced type-1 diabetic mice
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The role of gut in type 2 diabetes mellitus during whole body gamma irradiation in high-fat diet Wistar rats
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Celecoxib prevents pressure overload‐induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress
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Low‐dose radiation prevents type 1 diabetes‐induced cardiomyopathy via activation of AKT mediated anti‐apoptotic and anti‐oxidant effects
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Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
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ANRIL regulates production of extracellular matrix proteins and vasoactive factors in diabetic complications
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Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
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Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection
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Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps militaris Fruit Body in Diet‐Streptozotocin‐Induced Diabetic Sprague Dawley Rats
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Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes
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Zinc Supplementation Prevented Type 2 Diabetes-Induced Liver Injury Mediated by the Nrf2-MT Antioxidative Pathway
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Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues
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Research Progress on the Biological Effects of Low-Dose Radiation in China
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Radon Therapy for Autoimmune Diseases Pemphigus and Diabetes: 2 Case Reports
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Apigenin and Exposure to Low Dose Gamma Radiation Ameliorate Acetic Acid-Induced Ulcerative Colitis in Rats
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CXCL8 Antagonist Improves Diabetic Nephropathy in Male Mice With Diabetes and Attenuates High Glucose–Induced Mesangial Injury
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Chronic Internal Exposure to Low Dose 137Cs Induces Positive Impact on the Stability of Atherosclerotic Plaques by Reducing Inflammation in ApoE-/- Mice
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Mouse Models of Diabetes, Obesity and Related Kidney Disease
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The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet
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Endothelial derived miRNA-9 mediated cardiac fibrosis in diabetes and its regulation by ZFAS1
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Expression of Concern: Multiple Low-Dose Radiation Prevents Type 2 Diabetes-Induced Renal Damage through Attenuation of Dyslipidemia and Insulin Resistance and Subsequent Renal Inflammation and Oxidative Stress
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Inhibition of 11β-HSD1 by LG13 improves glucose metabolism in type 2 diabetic mice
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Chronic Exposure to External Low-Dose Gamma Radiation Induces an Increase in Anti-inflammatory and Anti-oxidative Parameters Resulting in Atherosclerotic Plaque Size Reduction in ApoE–/–Mice
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Oxidative Stress, a Bridge that Links Radioadaptive Responses Induced by Ionizing Radiation to Those Induced by Non-Ionizing Radiation
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The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice
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Dysregulation of phosphatidylethanolamine metabolism associated with upregulation of PNPLA6 in high-fat diet/streptozotocin mice
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Low Dose Ionising Radiation-Induced Hormesis: Therapeutic Implications to Human Health
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Radiotherapy Advances in Renal Disease—Focus on Renal Ischemic Preconditioning
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High-Fat Diet and Altered Radiation Response
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C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood–Retinal Barrier Tight Junctions
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Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice
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Anti-Diabetic Nephropathy Activities of Polysaccharides Obtained from Termitornyces albuminosus via Regulation of NF-κB Signaling in db/db Mice
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Metabolomics in Radiation Biodosimetry: Current Approaches and Advances
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Systemic therapy of inflammatory breast cancer with type 2 diabetes mellitus – Prevention of high risk of radiation-induced progression of tumor tissue cancer
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Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
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Molecular description of fibroblast growth factor and mechanisms by which fibroblast growth factor-21 mediating biological actions and acting as a biologic biomarker of cardiovascular diseases
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Étude de la réponse adaptative rénale et des mécanismes sous-jacents après exposition chronique à de faibles concentrations d'uranium ou de fluor
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Effets d’une exposition chronique au césium 137 à faibles doses sur la progression de l’athérosclérose
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Targeting FGF21 in cardiovascular and metabolic diseases: from mechanism to medicine
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Profile of the bile acid FXR-FGF15 pathway in the glucolipid metabolism disorder of diabetic mice suffering from chronic stress
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