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Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both In Vitro and In Vivo

https://doi.org/10.1371/journal.pone.0108444
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/14651858.cd002967.pub3openalex-snapshot
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
inferredcites →https://doi.org/10.1002/14651858.cd002967.pub4openalex-snapshot
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
inferredcites →https://doi.org/10.1002/cncr.25868openalex-snapshot
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells
inferredcites →https://doi.org/10.1002/iub.1213openalex-snapshot
The multifaceted activities of AMPK in tumor progression-why the “one size fits all” definition does not fit at all?
inferredcites →https://doi.org/10.1002/path.3978openalex-snapshot
Central role of lactic acidosis in cancer cell resistance to glucose deprivation‐induced cell death
inferredcites →https://doi.org/10.1007/s10863-006-9003-8openalex-snapshot
The ROS Production Induced by a Reverse-Electron Flux at Respiratory-Chain Complex 1 is Hampered by Metformin
inferredcites →https://doi.org/10.1016/j.bbabio.2010.08.009openalex-snapshot
Metabolic management of brain cancer
inferredcites →https://doi.org/10.1016/j.bbadis.2011.09.014openalex-snapshot
AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases
inferredcites →https://doi.org/10.1016/j.bbrc.2012.11.010openalex-snapshot
Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: Dependence on glucose concentration and role of AMPK
inferredcites →https://doi.org/10.1016/j.ccr.2012.12.008openalex-snapshot
LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
inferredcites →https://doi.org/10.1016/j.mehy.2011.04.001openalex-snapshot
The complete control of glucose level utilizing the composition of ketogenic diet with the gluconeogenesis inhibitor, the anti-diabetic drug metformin, as a potential anti-cancer therapy
inferredcites →https://doi.org/10.1016/j.nucmedbio.2013.05.006openalex-snapshot
Hypoxia stimulates 18F-Fluorodeoxyglucose uptake in breast cancer cells via Hypoxia inducible Factor-1 and AMP-activated protein kinase
inferredcites →https://doi.org/10.1016/j.ygyno.2008.04.008openalex-snapshot
In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
inferredcites →https://doi.org/10.1016/s0021-9258(17)30124-2openalex-snapshot
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
inferredcites →https://doi.org/10.1016/s0960-9822(00)00742-9openalex-snapshot
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
inferredcites →https://doi.org/10.1038/ncomms3192openalex-snapshot
Metformin improves healthspan and lifespan in mice
inferredcites →https://doi.org/10.1038/onc.2011.91openalex-snapshot
Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients
inferredcites →https://doi.org/10.1042/bj3480607openalex-snapshot
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
inferredcites →https://doi.org/10.1056/nejm199508313330902openalex-snapshot
Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus
inferredcites →https://doi.org/10.1056/nejmoa012512openalex-snapshot
Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin
inferredcites →https://doi.org/10.1074/jbc.275.1.223openalex-snapshot
Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I
inferredcites →https://doi.org/10.1089/thy.2012.0041openalex-snapshot
AMP-Activated Protein Kinase Upregulates Glucose Uptake in Thyroid PCCL3 Cells Independent of Thyrotropin
inferredcites →https://doi.org/10.1093/carcin/bgr107openalex-snapshot
Caloric restriction reduces growth of mammary tumors and metastases
inferredcites →https://doi.org/10.1093/toxsci/kfm052openalex-snapshot
Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants
inferredcites →https://doi.org/10.1136/bmj.38415.708634.f7openalex-snapshot
Metformin and reduced risk of cancer in diabetic patients
inferredcites →https://doi.org/10.1158/0008-5472.can-06-4447openalex-snapshot
Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth
inferredcites →https://doi.org/10.1158/0008-5472.can-08-2689openalex-snapshot
Chemical Genomics Identifies the Unfolded Protein Response as a Target for Selective Cancer Cell Killing during Glucose Deprivation
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2782openalex-snapshot
Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2994openalex-snapshot
Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
inferredcites →https://doi.org/10.1158/0008-5472.can-12-2907openalex-snapshot
Carbon Source and Myc Expression Influence the Antiproliferative Actions of Metformin
inferredcites →https://doi.org/10.1158/1535-7163.mct-11-0871openalex-snapshot
Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation
inferredcites →https://doi.org/10.1158/1541-7786.mcr-10-0343openalex-snapshot
Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells
inferredcites →https://doi.org/10.1186/1743-7075-4-5openalex-snapshot
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
inferredcites →https://doi.org/10.1186/1750-2187-3-18openalex-snapshot
Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
inferredcites →https://doi.org/10.1371/journal.pone.0027074openalex-snapshot
High Glucose Promotes Pancreatic Cancer Cell Proliferation via the Induction of EGF Expression and Transactivation of EGFR
inferredcites →https://doi.org/10.2967/jnumed.112.107011openalex-snapshot
Metformin—an Adjunct Antineoplastic Therapy—Divergently Modulates Tumor Metabolism and Proliferation, Interfering with Early Response Prediction by 18F-FDG PET Imaging
inferredcites →https://doi.org/10.4103/1477-3163.83043openalex-snapshot
Metformin as an energy restriction mimetic agent for breast cancer prevention
inferredcites →https://doi.org/10.4161/cc.20948openalex-snapshot
Metformin is synthetically lethal with glucose withdrawal in cancer cells
inferredcites →https://doi.org/10.4161/cc.8.1.7499openalex-snapshot
The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Hnf4a Functions as an Hcc Oncogene or Tumor Suppressor Depending Upon the Ampk Pathway Activity Status
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Caveolin‐1 in oncogenic metabolic symbiosis
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The common diabetes drug metformin can diminish the action of citral against Rhabdomyosarcoma cells in vitro
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Risk-Reducing (Chemopreventive) Agents in Breast Cancer Prevention
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Hierarchical F-actin microstructures and multi-passage viscoelasticity evolution in living cancer cells under varying glucose environment
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Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside
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Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice
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Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells
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Do MCF7 cells cope with metformin treatment under energetic stress in low glucose conditions?
inferred← citeshttps://doi.org/10.1007/s11033-024-09501-wopenalex-snapshot
Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition
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A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma
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Identification of glucose-independent and reversible metabolic pathways associated with anti-proliferative effect of metformin in liver cancer cells
inferred← citeshttps://doi.org/10.1007/s11523-016-0423-zopenalex-snapshot
The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development
inferred← citeshttps://doi.org/10.1007/s12010-021-03723-5openalex-snapshot
Enhanced Antiproliferation Potency of Electrical Pulse-Mediated Metformin and Cisplatin Combination Therapy on MDA-MB-231 Cells
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Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation
inferred← citeshttps://doi.org/10.1007/s40495-023-00336-wopenalex-snapshot
Anti-cancer Efficacy of Metformin: Recent Updates on Breast and Other Cancers
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Cancer
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Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalents in vitro
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Targeting HIF-1α is a prerequisite for cell sensitivity to dichloroacetate (DCA) and metformin
inferred← citeshttps://doi.org/10.1016/j.bbrc.2019.05.090openalex-snapshot
Comparison of the effects of metformin on MDA-MB-231 breast cancer cells in a monolayer culture and in tumor spheroids as a function of nutrient concentrations
inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.07.029openalex-snapshot
Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response
inferred← citeshttps://doi.org/10.1016/j.canlet.2025.217732openalex-snapshot
HNF4A functions as a hepatocellular carcinoma oncogene or tumor suppressor depending upon the AMPK pathway activity status
inferred← citeshttps://doi.org/10.1016/j.ccell.2019.03.007openalex-snapshot
Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
inferred← citeshttps://doi.org/10.1016/j.clnu.2026.106670openalex-snapshot
Precision nutrition in breast cancer: Towards patient- and tumour-informed dietary strategies
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Novel cytotoxic amphiphilic nitro-compounds derived from a synthetic route for paraconic acids
inferred← citeshttps://doi.org/10.1016/j.currproblcancer.2019.06.003openalex-snapshot
Metformin in breast cancer: preclinical and clinical evidence
inferred← citeshttps://doi.org/10.1016/j.diabres.2020.108232openalex-snapshot
Use of metformin and risk of breast and colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.ejphar.2016.06.036openalex-snapshot
The effects of metformin and simvastatin on the growth of LNCaP and RWPE-1 prostate epithelial cell lines
inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174605openalex-snapshot
Metformin inhibits tumor growth and affects intestinal flora in diabetic tumor-bearing mice
inferred← citeshttps://doi.org/10.1016/j.ejphar.2026.178857openalex-snapshot
Studying synergistic anticancer effects of repurposed AT1B losartan with antidiabetics metformin, rosiglitazone in triple-negative breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.exer.2024.110163openalex-snapshot
Increased glucose concentration modifies TGF-β1 and NFκB signaling pathways in aniridia limbal fibroblasts, in vitro
inferred← citeshttps://doi.org/10.1016/j.fct.2022.113129openalex-snapshot
High-dose metformin induces a low-glucose dependent genotoxic stress
inferred← citeshttps://doi.org/10.1016/j.leukres.2016.10.004openalex-snapshot
Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine
inferred← citeshttps://doi.org/10.1016/j.mehy.2018.06.014openalex-snapshot
A hypothetical method for controlling highly glycolytic cancers and metastases
inferred← citeshttps://doi.org/10.1016/j.molmet.2019.06.026openalex-snapshot
Ketogenic diet in the treatment of cancer – Where do we stand?
inferred← citeshttps://doi.org/10.1016/j.nut.2020.110748openalex-snapshot
In vitro quantification: Long-term effect of glucose deprivation on various cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.nut.2024.112427openalex-snapshot
Ketogenic diet as a treatment and prevention strategy for cancer: A therapeutic alternative
inferred← citeshttps://doi.org/10.1016/j.nutres.2016.08.002openalex-snapshot
Nutrient restriction of glucose or serum results in similar proteomic expression changes in 3D colon cancer cell cultures
inferred← citeshttps://doi.org/10.1016/j.phanu.2023.100340openalex-snapshot
From antiepileptic therapy to promising adjuvant in medical oncology: A historical view of the ketogenic diet
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2023.108413openalex-snapshot
Metabolic dependencies and targets in ovarian cancer
inferred← citeshttps://doi.org/10.1016/j.phrs.2015.06.014openalex-snapshot
Metformin and cancer: Between the bioenergetic disturbances and the antifolate activity
inferred← citeshttps://doi.org/10.1016/j.semcancer.2017.12.011openalex-snapshot
Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma
inferred← citeshttps://doi.org/10.1016/j.semcancer.2025.09.001openalex-snapshot
Ketogenic diets: Dietary therapeutic potential on breast cancer
inferred← citeshttps://doi.org/10.1016/j.taap.2016.08.018openalex-snapshot
Destabilization of mitochondrial functions as a target against breast cancer progression: Role of TPP + -linked-polyhydroxybenzoates
inferred← citeshttps://doi.org/10.1016/j.taap.2021.115523openalex-snapshot
Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.taap.2023.116630openalex-snapshot
Mebendazole targets essential proteins in glucose metabolism leading gastric cancer cells to death
inferred← citeshttps://doi.org/10.1016/j.tiv.2022.105357openalex-snapshot
Differences in glucose concentration shows new perspectives in gastric cancer metabolism
inferred← citeshttps://doi.org/10.1017/s0031182021001633openalex-snapshot
Metformin improves the therapeutic efficacy of low-dose albendazole against experimental alveolar echinococcosis
inferred← citeshttps://doi.org/10.1038/s41416-019-0627-yopenalex-snapshot
Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin
inferred← citeshttps://doi.org/10.1038/s41598-017-01801-5openalex-snapshot
Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro
inferred← citeshttps://doi.org/10.1038/s41598-023-28558-4openalex-snapshot
Monocarboxylate transporter 4 involves in energy metabolism and drug sensitivity in hypoxia
inferred← citeshttps://doi.org/10.1038/s42255-020-00317-zopenalex-snapshot
Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism
inferred← citeshttps://doi.org/10.1042/bj20150122openalex-snapshot
Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis
inferred← citeshttps://doi.org/10.1080/01635581.2018.1421677openalex-snapshot
Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3
inferred← citeshttps://doi.org/10.1080/01635581.2021.1942081openalex-snapshot
The Effect of Ketogenic Diet on Weight Loss in Adult Patients with Cancer: A Systematic Review and Meta-Analysis of Controlled Clinical Trials
inferred← citeshttps://doi.org/10.1080/08982104.2019.1610434openalex-snapshot
Design, optimization, characterization, and in vivo evaluation of sterosomes as a carrier of metformin for treatment of lung cancer
inferred← citeshttps://doi.org/10.1080/09553002.2017.1380330openalex-snapshot
The influence of ketogenic therapy on the 5 R’s of radiobiology
inferred← citeshttps://doi.org/10.1080/09553002.2018.1409443openalex-snapshot
Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma
inferred← citeshttps://doi.org/10.1088/1361-6463/ab938aopenalex-snapshot
Non-thermal plasma with metformin synergistically induces cell death via upregulating AMPK to suppress energy metabolism
inferred← citeshttps://doi.org/10.1093/carcin/bgab106openalex-snapshot
A low-carbohydrate diet containing soy protein and fish oil reduces breast but not prostate cancer in C3(1)/Tag mice
inferred← citeshttps://doi.org/10.1093/med/9780190497996.003.0012openalex-snapshot
Metabolism-Based Treatments to Counter Cancer
inferred← citeshttps://doi.org/10.1093/med/9780197501207.003.0014openalex-snapshot
Metabolism-Based Treatments for Managing Cancer
inferred← citeshttps://doi.org/10.1096/fj.202202078rropenalex-snapshot
Deletion of the tyrosine phosphatase Shp2 in cervical cancer cells promotes reprogramming of glutamine metabolism
inferred← citeshttps://doi.org/10.1101/2025.10.27.684770openalex-snapshot
Nischarin agonist rilmenidine shows antimetastatic potential in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1111/dme.14713openalex-snapshot
Hyperglycaemia‐induced human hepatocellular carcinoma (HepG2) cell proliferation through ROS‐mediated P38 activation is effectively inhibited by a xanthophyll carotenoid, lutein
inferred← citeshttps://doi.org/10.1146/annurev-nutr-013120-041149openalex-snapshot
The Role of Diet in Cancer Prevention and Chemotherapy Efficacy
inferred← citeshttps://doi.org/10.1146/annurev-nutr-062122-021518openalex-snapshot
The Influence of Diet on Cancer Progression and Treatment
inferred← citeshttps://doi.org/10.1155/2024/1094274openalex-snapshot
Metformin as a Potential In Vitro Anticancer Modulator of Adenosine Monophosphate Kinase: A Review
inferred← citeshttps://doi.org/10.1158/0008-5472.can-25-1123openalex-snapshot
Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-15-1021openalex-snapshot
Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-17-0074openalex-snapshot
The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer
inferred← citeshttps://doi.org/10.11605/j.pnrs.201802009openalex-snapshot
Low Sugar Diet: A New Tool in War Against Tumorigenesis
inferred← citeshttps://doi.org/10.1177/11782234241240173openalex-snapshot
Estrogen Receptor Is Required for Metformin-Induced Apoptosis in Breast Cancer Cells Under Hyperglycemic Conditions
inferred← citeshttps://doi.org/10.1177/15347354221150787openalex-snapshot
The Role of Ketogenic Diet in the Treatment of Neuroblastoma
inferred← citeshttps://doi.org/10.1177/1758834016687482openalex-snapshot
Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis
inferred← citeshttps://doi.org/10.1186/s12885-017-3230-8openalex-snapshot
Anti-tumor effects of everolimus and metformin are complementary and glucose-dependent in breast cancer cells
inferred← citeshttps://doi.org/10.1186/s12885-018-4250-8openalex-snapshot
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism
inferred← citeshttps://doi.org/10.1186/s12885-018-4727-5openalex-snapshot
Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes
inferred← citeshttps://doi.org/10.1186/s12885-024-13397-xopenalex-snapshot
Exploring the potential of gemcitabine-metal–organic frameworks in combating pancreatic cancer under ketogenic conditions
inferred← citeshttps://doi.org/10.1186/s12986-017-0178-2openalex-snapshot
Press-pulse: a novel therapeutic strategy for the metabolic management of cancer
inferred← citeshttps://doi.org/10.1186/s12986-025-01055-3openalex-snapshot
Nutritional approaches in combating therapeutic resistance and enhancing treatment efficacy in cancer: the impact of ketogenic diets
inferred← citeshttps://doi.org/10.1186/s13046-019-1090-6openalex-snapshot
Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress-associated pathways
inferred← citeshttps://doi.org/10.1186/s13048-020-00703-xopenalex-snapshot
Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer
inferred← citeshttps://doi.org/10.1186/s13048-023-01196-0openalex-snapshot
Tumor metabolism rewiring in epithelial ovarian cancer
inferred← citeshttps://doi.org/10.1186/s40364-018-0136-9openalex-snapshot
Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose
inferred← citeshttps://doi.org/10.1186/s41231-024-00178-8openalex-snapshot
The combined treatment with ketogenic diet and metformin slows tumor growth in two mouse models of triple negative breast cancer
inferred← citeshttps://doi.org/10.1360/ssv-2024-0297openalex-snapshot
Research on the mechanism of ketogenic diet in radiotherapy of tumors
inferred← citeshttps://doi.org/10.1371/journal.pone.0136250openalex-snapshot
Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions
inferred← citeshttps://doi.org/10.1371/journal.pone.0154747openalex-snapshot
Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0155050openalex-snapshot
Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis
inferred← citeshttps://doi.org/10.1371/journal.pone.0174486openalex-snapshot
Metformin inhibits gastric cancer cells metastatic traits through suppression of epithelial-mesenchymal transition in a glucose-independent manner
inferred← citeshttps://doi.org/10.1371/journal.pone.0180061openalex-snapshot
Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0257403openalex-snapshot
Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line
inferred← citeshttps://doi.org/10.1371/journal.pone.0340117openalex-snapshot
Elevated anti-apoptotic shift in primary human aniridia limbal stromal cells following 48 hours supraphysiological glucose exposure, in vitro
inferred← citeshttps://doi.org/10.14288/1.0377751openalex-snapshot
Examining the markers of vitamin C cytotoxicity in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1530/erc-15-0402openalex-snapshot
Glucose-deprivation increases thyroid cancer cells sensitivity to metformin
inferred← citeshttps://doi.org/10.15761/icst.1000301openalex-snapshot
Phase transitions in tumor growth VII: The effect of periodic glucose pulses and privations in a cancer model
inferred← citeshttps://doi.org/10.1586/14737140.2015.1095095openalex-snapshot
Drugs acting on homeostasis: challenging cancer cell adaptation
inferred← citeshttps://doi.org/10.18632/oncotarget.11759openalex-snapshot
On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer
inferred← citeshttps://doi.org/10.18632/oncotarget.24989openalex-snapshot
Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells
inferred← citeshttps://doi.org/10.18632/oncotarget.26377openalex-snapshot
Targeting the Wnt/β-catenin pathway in human osteosarcoma cells
inferred← citeshttps://doi.org/10.18632/oncotarget.4556openalex-snapshot
Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer
inferred← citeshttps://doi.org/10.18632/oncotarget.7929openalex-snapshot
Combination of metronomic cyclophosphamide and dietary intervention inhibits neuroblastoma growth in a CD1-nu mouse model
inferred← citeshttps://doi.org/10.21203/rs.2.14622/v1openalex-snapshot
Synergistic therapeutic effects of metformin at a clinically relevant dosage in combination with chemotherapy via the AKT/mTOR pathway on ovarian cancer
inferred← citeshttps://doi.org/10.21203/rs.2.14622/v2openalex-snapshot
Synergistic therapeutic effects of metformin at a clinically relevant dosage in combination with chemotherapy via the AKT/mTOR pathway on ovarian cancer
inferred← citeshttps://doi.org/10.2147/bctt.s135665openalex-snapshot
High glucose levels promote the proliferation of breast cancer cells through GTPases
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Ketogenic Diets and their Therapeutic Potential on Breast Cancer: A Systemic Review
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The development and application of a ChIP and MeDIP assay to determine a link between epigenetics and metabolism in ovarian cancer progression
inferred← citeshttps://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-1.12432openalex-snapshot
Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma
inferred← citeshttps://doi.org/10.3389/fendo.2019.00617openalex-snapshot
The Potential Effect of Metformin on Cancer: An Umbrella Review
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Combination of metformin and parthenolide inhibits breast cancer in mice by apoptosis induction and angiogenesis inhibition
inferred← citeshttps://doi.org/10.3389/fnut.2021.594408openalex-snapshot
Cancer Treatment With the Ketogenic Diet: A Systematic Review and Meta-analysis of Animal Studies
inferred← citeshttps://doi.org/10.3389/fonc.2023.1225220openalex-snapshot
Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression
inferred← citeshttps://doi.org/10.3390/antiox10060950openalex-snapshot
Implications of Oxidative Stress in Glioblastoma Multiforme Following Treatment with Purine Derivatives
inferred← citeshttps://doi.org/10.3390/antiox13070873openalex-snapshot
Culture of Bovine Aortic Endothelial Cells in Galactose Media Enhances Mitochondrial Plasticity and Changes Redox Sensing, Altering Nrf2 and FOXO3 Levels
inferred← citeshttps://doi.org/10.3390/app152111576openalex-snapshot
The Dual Role of Metformin: Repurposing an Antidiabetic Drug for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/biom16030413openalex-snapshot
Metformin—A Type 2 Diabetes Mellitus Drug—And Ovarian Cancer: Anticancer Mechanisms and Therapeutic Implications
inferred← citeshttps://doi.org/10.3390/cancers12051329openalex-snapshot
TOM40 Inhibits Ovarian Cancer Cell Growth by Modulating Mitochondrial Function Including Intracellular ATP and ROS Levels
inferred← citeshttps://doi.org/10.3390/cancers14071753openalex-snapshot
Reduction of Metastasis via Epigenetic Modulation in a Murine Model of Metastatic Triple Negative Breast Cancer (TNBC)
inferred← citeshttps://doi.org/10.3390/cancers16213671openalex-snapshot
The Role of the Microbiome and of Radiotherapy-Derived Metabolites in Breast Cancer
inferred← citeshttps://doi.org/10.3390/cimb43020042openalex-snapshot
Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities
inferred← citeshttps://doi.org/10.3390/cimb48090934openalex-snapshot
Metformin Attenuates the High-Glucose Effect on MORG1 Expression in HEK293 Cells
inferred← citeshttps://doi.org/10.3390/genes14010144openalex-snapshot
High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes
inferred← citeshttps://doi.org/10.3390/ijms18030674openalex-snapshot
ROS Production and ERK Activity Are Involved in the Effects of d-β-Hydroxybutyrate and Metformin in a Glucose Deficient Condition
inferred← citeshttps://doi.org/10.3390/ijms19092750openalex-snapshot
Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3)
inferred← citeshttps://doi.org/10.3390/ijms19123910openalex-snapshot
Melatonin May Increase Anticancer Potential of Pleiotropic Drugs
inferred← citeshttps://doi.org/10.3390/ijms20010179openalex-snapshot
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases
inferred← citeshttps://doi.org/10.3390/ijms20163873openalex-snapshot
Untargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models
inferred← citeshttps://doi.org/10.3390/ijms21228674openalex-snapshot
Glucose Concentration in Cell Culture Medium Influences the BRCA1-Mediated Regulation of the Lipogenic Action of IGF-I in Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/ijms25052637openalex-snapshot
Metformin and Glucose Concentration as Limiting Factors in Retinal Pigment Epithelial Cell Viability and Proliferation
inferred← citeshttps://doi.org/10.3390/ijms25074083openalex-snapshot
Metformin: A Dual-Role Player in Cancer Treatment and Prevention
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Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines
inferred← citeshttps://doi.org/10.3390/jcm10112297openalex-snapshot
Complex Interplay of Genes Underlies Invasiveness in Fibrosarcoma Progression Model
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Nutrition Intervention and Microbiome Modulation in the Management of Breast Cancer
inferred← citeshttps://doi.org/10.3390/ph13090206openalex-snapshot
Metformin Restores the Drug Sensitivity of MCF-7 Cells Resistant Derivates via the Cooperative Modulation of Growth and Apoptotic-Related Pathways
inferred← citeshttps://doi.org/10.3390/ph16091238openalex-snapshot
Ginsenoside Rb1 Reduces Hyper-Vasoconstriction Induced by High Glucose and Endothelial Dysfunction in Rat Aorta
inferred← citeshttps://doi.org/10.3390/ph17030396openalex-snapshot
Metformin and Breast Cancer: Current Findings and Future Perspectives from Preclinical and Clinical Studies
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An update on the effectiveness of metformin alone and with chemotherapy drugs on tumor cells
inferred← citeshttps://doi.org/10.3892/ijo.2018.4343openalex-snapshot
Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation
inferred← citeshttps://doi.org/10.3892/mmr.2019.10459openalex-snapshot
Inhibitory effects of plasmid small interfering RNA targeting signal transducer and activator of transcription‑3 in C6 glioma cells
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Proliferation and metastatic potential of endometrial cancer cells in response to metformin treatment in a high versus normal glucose environment
inferred← citeshttps://doi.org/10.3906/sag-1908-112openalex-snapshot
Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism
inferred← citeshttps://doi.org/10.4103/2395-3977.189306openalex-snapshot
Metformin in ovarian cancer therapy: A discussion
inferred← citeshttps://doi.org/10.6084/m9.figshare.26085082openalex-snapshot
Additional file 1 of The combined treatment with ketogenic diet and metformin slows tumor growth in two mouse models of triple negative breast cancer
inferred← citeshttps://doi.org/10.7150/jca.31184openalex-snapshot
The risk trajectory between preoperative fasting glucose and common digestive tract cancer-specific mortality in the FIESTA cohort involving 6865 Chinese patients
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