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The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds

https://doi.org/10.1371/journal.pone.0113300
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00432-012-1283-2openalex-snapshot
Effects of CDC7 gene silencing and Rituximab on apoptosis in diffuse large B cell lymphoma cells
inferredcites →https://doi.org/10.1007/s12032-012-0223-yopenalex-snapshot
High expression of cell division cycle 7 protein correlates with poor prognosis in patients with diffuse large B-cell lymphoma
inferredcites →https://doi.org/10.1016/j.bmcl.2008.11.093openalex-snapshot
Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2012.04.024openalex-snapshot
Discovery of XL413, a potent and selective CDC7 inhibitor
inferredcites →https://doi.org/10.1016/j.bmcl.2012.04.025openalex-snapshot
The design, synthesis, and biological evaluation of PIM kinase inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2013.02.007openalex-snapshot
N-substituted azaindoles as potent inhibitors of Cdc7 kinase
inferredcites →https://doi.org/10.1016/j.canlet.2013.05.008openalex-snapshot
Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents
inferredcites →https://doi.org/10.1016/j.cell.2008.10.026openalex-snapshot
Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomes in Meiosis I
inferredcites →https://doi.org/10.1016/j.chembiol.2010.05.013openalex-snapshot
Probing the Probes: Fitness Factors For Small Molecule Tools
inferredcites →https://doi.org/10.1016/j.ddtec.2004.11.007openalex-snapshot
Lead- and drug-like compounds: the rule-of-five revolution
inferredcites →https://doi.org/10.1016/j.humpath.2009.08.008openalex-snapshot
Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer
inferredcites →https://doi.org/10.1016/s0006-291x(03)01318-4openalex-snapshot
Small molecule inhibitors of the RNA-dependent protein kinase
inferredcites →https://doi.org/10.1016/s0092-8674(02)00741-9openalex-snapshot
The Conformational Plasticity of Protein Kinases
inferredcites →https://doi.org/10.1021/jm0611004openalex-snapshot
Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2)
inferredcites →https://doi.org/10.1021/jm100504dopenalex-snapshot
Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding
inferredcites →https://doi.org/10.1021/jm700956ropenalex-snapshot
Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships
inferredcites →https://doi.org/10.1021/jm800977qopenalex-snapshot
First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery
inferredcites →https://doi.org/10.1021/jm900248gopenalex-snapshot
Cell Division Cycle 7 Kinase Inhibitors: 1H-Pyrrolo[2,3-b]pyridines, Synthesis and Structure−Activity Relationships
inferredcites →https://doi.org/10.1038/emboj.2010.201openalex-snapshot
Molecular architecture of the DNA replication origin activation checkpoint
inferredcites →https://doi.org/10.1038/nchembio.90openalex-snapshot
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
inferredcites →https://doi.org/10.1038/nchembio1207-739openalex-snapshot
Recognizing and exploiting differences between RNAi and small-molecule inhibitors
inferredcites →https://doi.org/10.1038/nprot.2007.321openalex-snapshot
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
inferredcites →https://doi.org/10.1038/nrc2559openalex-snapshot
Targeting cancer with small molecule kinase inhibitors
inferredcites →https://doi.org/10.1038/nsmb.2404openalex-snapshot
Crystal structure of human CDC7 kinase in complex with its activator DBF4
inferredcites →https://doi.org/10.1038/sj.onc.1205910openalex-snapshot
Cell type-specific responses of human cells to inhibition of replication licensing
inferredcites →https://doi.org/10.1046/j.1365-2443.2003.00647.xopenalex-snapshot
Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7‐ASK kinase complex
inferredcites →https://doi.org/10.1073/pnas.0604990103openalex-snapshot
CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein
inferredcites →https://doi.org/10.1073/pnas.94.7.3151openalex-snapshot
mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
inferredcites →https://doi.org/10.1074/jbc.275.8.5600openalex-snapshot
The Chk1 Protein Kinase and the Cdc25C Regulatory Pathways Are Targets of the Anticancer Agent UCN-01
inferredcites →https://doi.org/10.1074/jbc.m102197200openalex-snapshot
Bipartite Binding of a Kinase Activator Activates Cdc7-related Kinase Essential for S Phase
inferredcites →https://doi.org/10.1074/jbc.m111.243311openalex-snapshot
Molecular Mechanism of Activation of Human Cdc7 Kinase
inferredcites →https://doi.org/10.1074/jbc.m112.392910openalex-snapshot
Dbf4 and Cdc7 Proteins Promote DNA Replication through Interactions with Distinct Mcm2–7 Protein Subunits
inferredcites →https://doi.org/10.1074/jbc.m512921200openalex-snapshot
Identification of Mcm2 Phosphorylation Sites by S-phase-regulating Kinases
inferredcites →https://doi.org/10.1074/jbc.m608935200openalex-snapshot
Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin
inferredcites →https://doi.org/10.1074/jbc.m802851200openalex-snapshot
ATR-dependent Activation of p38 MAP Kinase Is Responsible for Apoptotic Cell Death in Cells Depleted of Cdc7
inferredcites →https://doi.org/10.1083/jcb.201006043openalex-snapshot
Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication
inferredcites →https://doi.org/10.1089/thy.2006.16.161openalex-snapshot
Gene Expression in Poorly Differentiated Papillary Thyroid Carcinomas
inferredcites →https://doi.org/10.1093/emboj/18.19.5334openalex-snapshot
Cdc7p–Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway
inferredcites →https://doi.org/10.1093/emboj/18.20.5703openalex-snapshot
Mammalian Cdc7–Dbf4 protein kinase complex is essential for initiation of DNA replication
inferredcites →https://doi.org/10.1096/fj.13-248294openalex-snapshot
The impact of PKR activation: from neurodegeneration to cancer
inferredcites →https://doi.org/10.1101/gad.1626408openalex-snapshot
Cdc28–Clb5 (CDK-S) and Cdc7–Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast
inferredcites →https://doi.org/10.1101/gad.1626608openalex-snapshot
Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination
inferredcites →https://doi.org/10.1101/gad.1683308openalex-snapshot
Cdc7–Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts
inferredcites →https://doi.org/10.1101/gad.1933010openalex-snapshot
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?
inferredcites →https://doi.org/10.1101/gad.224568.113openalex-snapshot
ATR–Chk1–APC/CCdh1-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
inferredcites →https://doi.org/10.1128/mcb.00997-07openalex-snapshot
Structural Changes in Mcm5 Protein Bypass Cdc7-Dbf4 Function and Reduce Replication Origin Efficiency in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1128/mcb.19.7.4888openalex-snapshot
Cell Cycle Control of Cdc7p Kinase Activity through Regulation of Dbf4p Stability
inferredcites →https://doi.org/10.1128/mcb.19.7.5083openalex-snapshot
A Novel Growth- and Cell Cycle-Regulated Protein, ASK, Activates Human Cdc7-Related Kinase and Is Essential for G1/S Transition in Mammalian Cells
inferredcites →https://doi.org/10.1128/mcb.20.1.242-248.2000openalex-snapshot
Dbf4p, an Essential S Phase-Promoting Factor, Is Targeted for Degradation by the Anaphase-Promoting Complex
inferredcites →https://doi.org/10.1128/mcb.22.13.4477-4490.2002openalex-snapshot
A Conserved Domain of Schizosaccharomyces pombe dfp1 + Is Uniquely Required for Chromosome Stability following Alkylation Damage during S Phase
inferredcites →https://doi.org/10.1152/physrev.00025.2010openalex-snapshot
Physiological Relevance of Cell Cycle Kinases
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1547openalex-snapshot
Cdc7 Inhibition Reveals a p53-Dependent Replication Checkpoint That Is Defective in Cancer Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-1276openalex-snapshot
Cdc7 Kinase Is a Predictor of Survival and a Novel Therapeutic Target in Epithelial Ovarian Carcinoma
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-0185openalex-snapshot
Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy
inferredcites →https://doi.org/10.1158/1535-7163.mct-10-1119openalex-snapshot
Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells
inferredcites →https://doi.org/10.1371/journal.pone.0036372openalex-snapshot
Mechanism of Cancer Cell Death Induced by Depletion of an Essential Replication Regulator
inferredcites →https://doi.org/10.1534/genetics.109.110155openalex-snapshot
Budding Yeast Dbf4 Sequences Required for Cdc7 Kinase Activation and Identification of a Functional Relationship Between the Dbf4 and Rev1 BRCT Domains
inferredcites →https://doi.org/10.1593/neo.08216openalex-snapshot
Cdc7-Dbf4 Kinase Overexpression in Multiple Cancers and Tumor Cell Lines Is Correlated with p53 Inactivation
inferredcites →https://doi.org/10.3390/cancers5030901openalex-snapshot
Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models
inferredcites →https://doi.org/10.3748/wjg.v19.i20.3130openalex-snapshot
Expression of huCdc7 in colorectal cancer
inferredcites →https://doi.org/10.7164/antibiotics.39.1059openalex-snapshot
K-252a, a potent inhibitor of protein kinase C from microbial origin.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Preparation for DNA replication: the key to a successful S phase
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Molecular Modeling Studies of Trisubstituted Thiazoles as Cdc7 Kinase Inhibitors through 3D‐QSAR and Molecular Docking Simulation
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Role of DDK in Replication Initiation
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O Cdc7 kinase where art thou?
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CDC7 as a novel biomarker and druggable target in cancer
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Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108096openalex-snapshot
ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
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A new horizon for the old antibacterial drug clofoctol
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Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis
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Current therapy in amyotrophic lateral sclerosis (ALS): A review on past and future therapeutic strategies
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Recent advances in CDC7 kinase inhibitors: Novel strategies for the treatment of cancers and neurodegenerative diseases
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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways
inferred← citeshttps://doi.org/10.1016/j.neo.2018.08.001openalex-snapshot
DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling
inferred← citeshttps://doi.org/10.1016/j.tranon.2018.01.003openalex-snapshot
CDC7-dependent transcriptional regulation of RAD54L is essential for tumorigenicity and radio-resistance of glioblastoma
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01180openalex-snapshot
Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00883openalex-snapshot
Discovery and Structure–Activity-Relationship Study of N -Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β- d -ribose 2′-Oxidase
inferred← citeshttps://doi.org/10.1021/acschembio.7b00117openalex-snapshot
DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors
inferred← citeshttps://doi.org/10.1021/acsptsci.9b00001openalex-snapshot
Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38
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The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer
inferred← citeshttps://doi.org/10.1038/s41467-020-15845-1openalex-snapshot
Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair
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The prognostic significance and potential mechanism of DBF4 zinc finger in hepatocellular carcinoma
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Identifying TP53RK as a key regulator of colorectal cancer survival and a potential therapeutic target
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Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives
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miR-30d-5p represses the proliferation, migration, and invasion of lung squamous cell carcinoma via targeting DBF4
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Interplay between BET Proteins and the Pre-Replication Complex Unveils Therapeutic Vulnerabilities in Cancer
inferred← citeshttps://doi.org/10.1111/febs.17127openalex-snapshot
CDC 7 inhibition drives an inflammatory response and a p53‐dependent senescent‐like state in breast epithelial cells
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Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness
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USP48 promotes tumour progression through the deubiquitination and stabilization of DBF4 in clear cell renal carcinoma
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Role of MCM2–7 protein phosphorylation in human cancer cells
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Evaluation of CIZ1 as a biomarker for neurological tumours
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A Dual Inhibitor of Cdc7/Cdk9 Potently Suppresses T Cell Activation
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Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway
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Multi-Pathway Study for Oxaliplatin Resistance Reduction
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