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A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent

https://doi.org/10.1371/journal.pone.0118926
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Pediatric brain stem gliomas
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Expression of an IGF‐I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells
inferredcites →https://doi.org/10.1002/pbc.22741openalex-snapshot
Initial testing (stage 1) of the IGF‐1 receptor inhibitor BMS‐754807 by the pediatric preclinical testing program
inferredcites →https://doi.org/10.1002/pbc.24060openalex-snapshot
Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma
inferredcites →https://doi.org/10.1007/s00401-012-0998-0openalex-snapshot
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
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Gliomas in Children
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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
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Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma
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Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
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Pediatric brain stem gliomas: A review
inferredcites →https://doi.org/10.1016/s1470-2045(06)70615-5openalex-snapshot
Diffuse brainstem glioma in children: critical review of clinical trials
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Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975-1995
inferredcites →https://doi.org/10.1038/nature10833openalex-snapshot
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
inferredcites →https://doi.org/10.1038/ng.1102openalex-snapshot
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
inferredcites →https://doi.org/10.1038/ng.2925openalex-snapshot
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
inferredcites →https://doi.org/10.1038/ng.2936openalex-snapshot
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
inferredcites →https://doi.org/10.1038/ng.2938openalex-snapshot
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
inferredcites →https://doi.org/10.1038/ng.2950openalex-snapshot
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
inferredcites →https://doi.org/10.1073/pnas.1101657108openalex-snapshot
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
inferredcites →https://doi.org/10.1073/pnas.95.3.1218openalex-snapshot
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
inferredcites →https://doi.org/10.1093/jnci/djr077openalex-snapshot
Annual Report to the Nation on the Status of Cancer, 1975-2007, Featuring Tumors of the Brain and Other Nervous System
inferredcites →https://doi.org/10.1093/neuonc/nop008openalex-snapshot
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma
inferredcites →https://doi.org/10.1097/00006123-199312000-00010openalex-snapshot
Magnetic Resonance Scans Should Replace Biopsies for the Diagnosis of Diffuse Brain Stem Gliomas
inferredcites →https://doi.org/10.1101/gad.217778.113openalex-snapshot
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
inferredcites →https://doi.org/10.1111/j.1750-3639.2012.00633.xopenalex-snapshot
A urora Kinase B Is a Potential Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma
inferredcites →https://doi.org/10.1126/science.1232245openalex-snapshot
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2503openalex-snapshot
Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma
inferredcites →https://doi.org/10.1158/0008-5472.can-10-0391openalex-snapshot
Differential Mechanisms of Acquired Resistance to Insulin-like Growth Factor-I Receptor Antibody Therapy or to a Small-Molecule Inhibitor, BMS-754807, in a Human Rhabdomyosarcoma Model
inferredcites →https://doi.org/10.1158/0008-5472.can-11-1080openalex-snapshot
Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-13-1491openalex-snapshot
Novel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
inferredcites →https://doi.org/10.1158/1535-7163.mct-09-0499openalex-snapshot
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
inferredcites →https://doi.org/10.1158/1535-7163.mct-12-0447openalex-snapshot
BMS-754807, a Small-Molecule Inhibitor of Insulin-like Growth Factor-1 Receptor/Insulin Receptor, Enhances Gemcitabine Response in Pancreatic Cancer
inferredcites →https://doi.org/10.1200/jco.2009.25.5463openalex-snapshot
Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor α and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets
inferredcites →https://doi.org/10.1200/jco.2011.35.5677openalex-snapshot
Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma
inferredcites →https://doi.org/10.1227/00006123-198303000-00008openalex-snapshot
Pediatric Brain Stem Tumors: Radiographic, Pathological, and Clinical Correlations
inferredcites →https://doi.org/10.1371/journal.pone.0030313openalex-snapshot
Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas
inferredcites →https://doi.org/10.1371/journal.pone.0047109openalex-snapshot
Novel Agents Targeting the IGF-1R/PI3K Pathway Impair Cell Proliferation and Survival in Subsets of Medulloblastoma and Neuroblastoma
inferredcites →https://doi.org/10.1371/journal.pone.0077639openalex-snapshot
PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma
inferredcites →https://doi.org/10.3171/ped-07/07/001openalex-snapshot
Stereotactic biopsy of diffuse pontine lesions in children

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Tumor location, but not H3.3K27M, significantly influences the blood–brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma
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A novel CDK4/6 inhibitor combined with irradiation demonstrates potent anti-tumor efficacy in diffuse midline glioma
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IGF-binding protein 2 is a candidate target of therapeutic potential in cancer
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Animal models of primary brain tumors
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In vivo evaluation of IGF1R/IR PET ligand [18F]BMS-754807 in rodents
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Shared ACVR1 mutations in FOP and DIPG: Opportunities and challenges in extending biological and clinical implications across rare diseases
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The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma
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Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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Unveiling the therapeutic role of penfluridol and BMS-754,807: NUDT5 inhibition in breast cancer
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Preclinical therapeutic targets in diffuse midline glioma
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Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations
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Targeting the CD40 costimulatory receptor to improve virotherapy efficacy in diffuse midline gliomas
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Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies
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Small Molecule Kinase Inhibitors for the Treatment of Brain Cancer
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Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant
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Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas
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The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models
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ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma
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Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations
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Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1 -Mutant Diffuse Intrinsic Pontine Glioma
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