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Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family

https://doi.org/10.1371/journal.pone.0143227

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.950080106openalex-snapshot

The role of the otu Gene in Drosophila oogenesis

inferredcites →https://doi.org/10.1002/dvg.1020070102openalex-snapshot

Complementation between alleles at the ovarian tumor locus of Drosophila melanogaster

inferredcites →https://doi.org/10.1016/0092-8674(95)90150-7openalex-snapshot

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

inferredcites →https://doi.org/10.1016/j.bbrc.2003.12.050openalex-snapshot

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

inferredcites →https://doi.org/10.1016/j.cell.2013.05.046openalex-snapshot

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

inferredcites →https://doi.org/10.1016/j.chom.2007.09.014openalex-snapshot

Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISG15-Dependent Innate Immune Responses

inferredcites →https://doi.org/10.1016/j.devcel.2008.01.003openalex-snapshot

Distinct Mechanisms of Apoptosis-Induced Compensatory Proliferation in Proliferating and Differentiating Tissues in the Drosophila Eye

inferredcites →https://doi.org/10.1016/j.tibs.2013.08.002openalex-snapshot

Tudor: a versatile family of histone methylation ‘readers’

inferredcites →https://doi.org/10.1016/s0925-4773(01)00314-8openalex-snapshot

Distinct domains mediate the early and late functions of the Drosophila ovarian tumor proteins

inferredcites →https://doi.org/10.1016/s0968-0004(96)30049-2openalex-snapshot

Tudor domains in proteins that interact with RNA

inferredcites →https://doi.org/10.1016/s0968-0004(99)01530-3openalex-snapshot

A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

inferredcites →https://doi.org/10.1038/embor.2011.17openalex-snapshot

Polyubiquitin binding and cross‐reactivity in the USP domain deubiquitinase USP21

inferredcites →https://doi.org/10.1038/msb.2011.75openalex-snapshot

Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega

inferredcites →https://doi.org/10.1038/nrg1111openalex-snapshot

Human and mouse proteases: a comparative genomic approach

inferredcites →https://doi.org/10.1038/nrm2731openalex-snapshot

Breaking the chains: structure and function of the deubiquitinases

inferredcites →https://doi.org/10.1038/nrm3478openalex-snapshot

Function and regulation of SUMO proteases

inferredcites →https://doi.org/10.1038/scientificamerican0774-74openalex-snapshot

A Family of Protein-Cutting Proteins

inferredcites →https://doi.org/10.1038/sj.cdd.4401868openalex-snapshot

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery

inferredcites →https://doi.org/10.1038/sj.emboj.7600628openalex-snapshot

Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1

inferredcites →https://doi.org/10.1038/sj.embor.7400201openalex-snapshot

Crystal structure of human otubain 2

inferredcites →https://doi.org/10.1042/bj20071399openalex-snapshot

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

inferredcites →https://doi.org/10.1093/genetics/133.2.253openalex-snapshot

Structure and expression of hybrid dysgenesis-induced alleles of the ovarian tumor (otu) gene in Drosophila melanogaster.

inferredcites →https://doi.org/10.1093/genetics/141.1.191openalex-snapshot

Developmental analysis of the ovarian tumor gene during Drosophila oogenesis.

inferredcites →https://doi.org/10.1093/nar/gkf436openalex-snapshot

MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform

inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a040454openalex-snapshot

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

inferredcites →https://doi.org/10.1101/gad.463208openalex-snapshot

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

inferredcites →https://doi.org/10.1101/gad.9.14.1694openalex-snapshot

The head involution defective gene of Drosophila melanogaster functions in programmed cell death.

inferredcites →https://doi.org/10.1126/science.271.5250.805openalex-snapshot

Cell Killing by the Drosophila Gene reaper

inferredcites →https://doi.org/10.1128/mcb.9.12.5726openalex-snapshot

Sequence and structure of the Drosophila melanogaster ovarian tumor gene and generation of an antibody specific for the ovarian tumor protein.

inferredcites →https://doi.org/10.1128/mcb.9.12.5726-5732.1989openalex-snapshot

Sequence and Structure of the Drosophila melanogaster Ovarian Tumor Gene and Generation of an Antibody Specific for the Ovarian Tumor Protein

inferredcites →https://doi.org/10.1146/annurev-biochem-060310-170328openalex-snapshot

The Ubiquitin Code

inferredcites →https://doi.org/10.1152/physrev.00002.2013openalex-snapshot

Deubiquitylases From Genes to Organism

inferredcites →https://doi.org/10.1186/1756-0500-5-670openalex-snapshot

Whole genome phylogenies for multiple Drosophila species

inferredcites →https://doi.org/10.1242/dev.27.2.353openalex-snapshot

Cell lines derived from late embryonic stages of Drosophila melanogaster

inferredcites →https://doi.org/10.1371/journal.pgen.1004117openalex-snapshot

Loss of Trabid, a New Negative Regulator of the Drosophila Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span

inferredcites →https://doi.org/10.1371/journal.pone.0000679openalex-snapshot

Screen for ISG15-crossreactive Deubiquitinases

inferredcites →https://doi.org/10.15252/embj.201490497openalex-snapshot

Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4185911openalex-extracted

OTUD4-Mediated GSDME Deubiquitination Enhances Radiosensitivity in Nasopharyngeal Carcinoma by Inducing Pyroptosis

inferred← citeshttps://doi.org/10.1002/advs.201902040openalex-snapshot

Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

inferred← citeshttps://doi.org/10.1002/jcp.31104openalex-snapshot

OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1

inferred← citeshttps://doi.org/10.1007/s10495-024-01953-6openalex-snapshot

Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells

inferred← citeshttps://doi.org/10.1016/j.jbc.2025.110784openalex-snapshot

The deubiquitinase OTUD4 suppresses TAK1 kinase–dependent NF-κB signaling and inflammation

inferred← citeshttps://doi.org/10.1016/j.molcel.2019.02.004openalex-snapshot

LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan

inferred← citeshttps://doi.org/10.1042/bcj20230284openalex-snapshot

DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability

inferred← citeshttps://doi.org/10.1042/bst20160268openalex-snapshot

Pseudo-DUBs as allosteric activators and molecular scaffolds of protein complexes

inferred← citeshttps://doi.org/10.1073/pnas.1619188114openalex-snapshot

Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A

inferred← citeshttps://doi.org/10.1073/pnas.2426524122openalex-snapshot

Bourbon and Mycbp function with Otu to promote Sxl protein expression in the Drosophila female germline

inferred← citeshttps://doi.org/10.1186/s12935-022-02463-8openalex-snapshot

DNMT1 facilitates growth of breast cancer by inducing MEG3 hyper-methylation

inferred← citeshttps://doi.org/10.1186/s13046-022-02533-9openalex-snapshot

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

inferred← citeshttps://doi.org/10.21203/rs.3.rs-3772075/v1openalex-snapshot

Mendelian randomization reveals pleiotropic genes between major depression and bowel cancer

inferred← citeshttps://doi.org/10.2147/cmar.s233028openalex-snapshot

OTUD4: A Potential Prognosis Biomarker for Multiple Human Cancers

inferred← citeshttps://doi.org/10.3390/cells11030556openalex-snapshot

Deubiquitinases in Neurodegeneration

inferred← citeshttps://doi.org/10.6084/m9.figshare.19113030openalex-snapshot

Additional file 1 of DNMT1 facilitates growth of breast cancer by inducing MEG3 hyper-methylation

inferred← citeshttps://doi.org/10.6084/m9.figshare.21594003openalex-snapshot

Additional file 1 of OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

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