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Inflammatory PAF Receptor Signaling Initiates Hedgehog Signaling and Kidney Fibrogenesis During Ethanol Consumption

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1 of the 60 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1371/journal.pone.0016068 (notice 2018-10-02).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamapsychiatry.2015.0584openalex-snapshot
Epidemiology of DSM-5 Alcohol Use Disorder
inferredcites →https://doi.org/10.1002/hep.22776openalex-snapshot
An early complement-dependent and TLR-4–independent phase in the pathogenesis of ethanol-induced liver injury in mice #
inferredcites →https://doi.org/10.1002/hep.23258openalex-snapshot
Alcoholic Liver Disease
inferredcites →https://doi.org/10.1002/hep.23652openalex-snapshot
Comments on Aasld Practice Guidelines for Alcoholic Liver Disease
inferredcites →https://doi.org/10.1007/s11095-010-0246-zopenalex-snapshot
Inhibition of Endogenous Hedgehog Signaling Protects Against Acute Liver Injury After Ischemia Reperfusion
inferredcites →https://doi.org/10.1007/s40139-013-0026-7openalex-snapshot
Matrix-Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation
inferredcites →https://doi.org/10.1016/0006-2952(94)90524-xopenalex-snapshot
Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics
inferredcites →https://doi.org/10.1016/j.ajpath.2011.12.039openalex-snapshot
Hedgehog-Gli Pathway Activation during Kidney Fibrosis
inferredcites →https://doi.org/10.1016/j.bbamem.2012.03.004openalex-snapshot
Bioactive oxidatively truncated phospholipids in inflammation and apoptosis: Formation, targets, and inactivation
inferredcites →https://doi.org/10.1016/j.biocel.2010.10.015openalex-snapshot
The role of Hedgehog signaling in fibrogenic liver repair
inferredcites →https://doi.org/10.1016/j.cgh.2011.09.011openalex-snapshot
Acute Kidney Injury Is an Early Predictor of Mortality for Patients With Alcoholic Hepatitis
inferredcites →https://doi.org/10.1016/j.febslet.2012.05.011openalex-snapshot
Crosstalk between TGF‐β and hedgehog signaling in cancer
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2007.11.004openalex-snapshot
CYP2E1 and oxidative liver injury by alcohol
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2010.07.026openalex-snapshot
Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2014.01.001openalex-snapshot
Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2015.05.020openalex-snapshot
Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption
inferredcites →https://doi.org/10.1016/j.mrfmmm.2004.04.021openalex-snapshot
Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1
inferredcites →https://doi.org/10.1016/j.semnephrol.2014.06.004openalex-snapshot
Kidney Pericytes: Roles in Regeneration and Fibrosis
inferredcites →https://doi.org/10.1016/j.stem.2014.11.004openalex-snapshot
Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
inferredcites →https://doi.org/10.1016/j.urology.2010.08.032openalex-snapshot
Urothelial Cell Platelet-activating Factor Production Mediated by Calcium-independent Phospholipase A2γ
inferredcites →https://doi.org/10.1016/s0006-2952(97)00381-xopenalex-snapshot
Expression and Distribution of Cytochrome P450 Enzymes in Male Rat Kidney: Effects of Ethanol, Acetone and Dietary Conditions
inferredcites →https://doi.org/10.1016/s0021-9258(18)99133-7openalex-snapshot
Oxidatively fragmented phosphatidylcholines activate human neutrophils through the receptor for platelet-activating factor
inferredcites →https://doi.org/10.1016/s0076-6879(94)33061-1openalex-snapshot
[58] Animal models of chronic ethanol toxicity
inferredcites →https://doi.org/10.1016/s0090-6980(02)00058-8openalex-snapshot
Platelet-activating factor receptor
inferredcites →https://doi.org/10.1016/s0090-9556(24)11826-0openalex-snapshot
Cellular Distribution of Cytochromes P-450 in the Rat Kidney
inferredcites →https://doi.org/10.1016/s1537-1891(02)00169-6openalex-snapshot
Activation of vascular cells by PAF-like lipids in oxidized LDL
inferredcites →https://doi.org/10.1038/ki.2011.208openalex-snapshot
Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis
inferredcites →https://doi.org/10.1038/nbt.1623openalex-snapshot
Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
inferredcites →https://doi.org/10.1038/ni.2477openalex-snapshot
Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs
inferredcites →https://doi.org/10.1046/j.1523-1755.2002.00433.xopenalex-snapshot
Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury
inferredcites →https://doi.org/10.1046/j.1523-1755.2003.00908.xopenalex-snapshot
Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis
inferredcites →https://doi.org/10.1053/j.gastro.2011.09.002openalex-snapshot
Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
inferredcites →https://doi.org/10.1053/j.gastro.2015.06.009openalex-snapshot
Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans
inferredcites →https://doi.org/10.1055/s-0035-1550065openalex-snapshot
Fibrosis in Nonalcoholic Fatty Liver Disease: Mechanisms and Clinical Implications
inferredcites →https://doi.org/10.1056/nejmra0805786openalex-snapshot
Alcoholic Hepatitis
inferredcites →https://doi.org/10.1074/jbc.274.40.28395openalex-snapshot
Inflammatory Platelet-activating Factor-like Phospholipids in Oxidized Low Density Lipoproteins Are Fragmented Alkyl Phosphatidylcholines
inferredcites →https://doi.org/10.1074/jbc.m109.018978openalex-snapshot
Suppression of Mitochondrial Function by Oxidatively Truncated Phospholipids Is Reversible, Aided by Bid, and Suppressed by Bcl-XL
inferredcites →https://doi.org/10.1074/jbc.m111.300012openalex-snapshot
Oxidatively Truncated Phospholipids Are Required Agents of Tumor Necrosis Factor α (TNFα)-induced Apoptosis
inferredcites →https://doi.org/10.1074/jbc.m200562200openalex-snapshot
Shedding of Kidney Injury Molecule-1, a Putative Adhesion Protein Involved in Renal Regeneration
inferredcites →https://doi.org/10.1074/jbc.m702865200openalex-snapshot
Cytotoxic Phospholipid Oxidation Products
inferredcites →https://doi.org/10.1093/ndt/13.4.886openalex-snapshot
Overexpression of extracellular matrix proteins in renal tubulointerstitial cells by platelet-activating factor stimulation
inferredcites →https://doi.org/10.1093/ndt/gfs134openalex-snapshot
Biology of the renal pericyte
inferredcites →https://doi.org/10.1093/oxfordjournals.alcalc.a045740openalex-snapshot
CYTOCHROME P-450 2E1 IN RAT LIVER, KIDNEY AND LUNG MICROSOMES AFTER CHRONIC ADMINISTRATION OF ETHANOL EITHER ORALLY OR BY INHALATION
inferredcites →https://doi.org/10.1097/mnh.0b013e328344c3d4openalex-snapshot
Mechanisms of fibrosis: the role of the pericyte
inferredcites →https://doi.org/10.1111/acer.12157openalex-snapshot
Genetic Resistance to Liver Fibrosis on A/J Mouse Chromosome 17
inferredcites →https://doi.org/10.1136/annrheumdis-2011-200883openalex-snapshot
Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis
inferredcites →https://doi.org/10.1146/annurev.biochem.69.1.419openalex-snapshot
Platelet-Activating Factor and Related Lipid Mediators
inferredcites →https://doi.org/10.1152/ajpgi.00041.2014openalex-snapshot
Animals Models of Gastrointestinal and Liver Diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges
inferredcites →https://doi.org/10.1152/ajprenal.00117.2002openalex-snapshot
Platelet-activating factor and solute transport processes in the kidney
inferredcites →https://doi.org/10.1158/0008-5472.can-07-0491openalex-snapshot
Induction of Sonic Hedgehog Mediators by Transforming Growth Factor-β: Smad3-Dependent Activation of Gli2 and Gli1 Expression In vitro and In vivo
inferredcites →https://doi.org/10.1159/000168202openalex-snapshot
Role of Platelet-Activating Factor in Renal Immune Injury and Proteinuria
inferredcites →https://doi.org/10.1161/atvbaha.108.178731openalex-snapshot
Platelet Activation by Low Concentrations of Intact Oxidized LDL Particles Involves the PAF Receptor
inferredcites →https://doi.org/10.1194/jlr.r800024-jlr200openalex-snapshot
The emerging roles of PAF acetylhydrolase
inferredcites →https://doi.org/10.1371/journal.pone.0016068openalex-snapshot
Up-Regulation of Sonic Hedgehog Contributes to TGF-β1-Induced Epithelial to Mesenchymal Transition in NSCLC Cells
inferredcites →https://doi.org/10.1371/journal.pone.0044121openalex-snapshot
Autocrine Sonic Hedgehog Attenuates Inflammation in Cerulein-Induced Acute Pancreatitis in Mice via Upregulation of IL-10
inferredcites →https://doi.org/10.1371/journal.pone.0074141openalex-snapshot
Potential Role of Hedgehog Pathway in Liver Response to Radiation
inferredcites →https://doi.org/10.1681/asn.2011060614openalex-snapshot
Sonic Hedgehog Signaling Mediates Epithelial–Mesenchymal Communication and Promotes Renal Fibrosis
inferredcites →https://doi.org/10.2353/ajpath.2008.080433openalex-snapshot
Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney
inferredcites →https://doi.org/10.2353/ajpath.2010.090517openalex-snapshot
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
inferredcites →https://doi.org/10.3109/08860229509037614openalex-snapshot
Real-Time Monitoring of Renal Function During Ischemic Injury in the Rhesus Monkey

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4637498openalex-extracted
inferred← citeshttps://doi.org/10.1016/j.biopha.2016.09.097openalex-snapshot
Ginger extract protects rat’s kidneys against oxidative damage after chronic ethanol administration
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119673openalex-snapshot
10-Dehydrogingerdione ameliorates renal endoplasmic reticulum/oxidative stress and apoptosis in alcoholic nephropathy induced in experimental rats
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103386openalex-snapshot
Chronic alcohol consumption aggravates acute kidney injury through integrin β1/JNK signaling
inferred← citeshttps://doi.org/10.1038/s41401-022-00903-9openalex-snapshot
Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis
inferred← citeshttps://doi.org/10.1038/s41581-019-0248-yopenalex-snapshot
Targeting the progression of chronic kidney disease
inferred← citeshttps://doi.org/10.1038/s44321-025-00194-7openalex-snapshot
An AI-assisted morphoproteomic approach is a supportive tool in esophagitis-related precision medicine
inferred← citeshttps://doi.org/10.1042/cs20191047openalex-snapshot
Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7
inferred← citeshttps://doi.org/10.1111/acer.14415openalex-snapshot
Moderate Alcohol Consumption Targets S100β+ Vascular Stem Cells and Attenuates Injury‐Induced Neointimal Hyperplasia
inferred← citeshttps://doi.org/10.1186/s12882-025-04126-yopenalex-snapshot
Neutrophil extracellular traps-related genes contribute to sepsis-associated acute kidney injury
inferred← citeshttps://doi.org/10.1556/1646.10.2018.23openalex-snapshot
Chronic ethanol ingestion induces glomerular filtration barrier proteins genes expression alteration and increases matrix metalloproteinases activity in the kidney of rats
inferred← citeshttps://doi.org/10.3389/fmed.2026.1948851openalex-snapshot
Divergent outcomes of delayed ureteropelvic junction stenosis after renal cyst sclerotherapy: two case reports
inferred← citeshttps://doi.org/10.3389/fnagi.2022.856628openalex-snapshot
Platelet Activating Factor Receptor Exaggerates Microglia-Mediated Microenvironment by IL10-STAT3 Signaling: A Novel Potential Biomarker and Target for Diagnosis and Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3389/fnut.2024.1458106openalex-snapshot
High fat, high sucrose diet promotes increased expression of ACE2 receptor in the SIV-infected host: implications for SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.3390/cancers10020038openalex-snapshot
Colorectal Cancer and Alcohol Consumption—Populations to Molecules
inferred← citeshttps://doi.org/10.5603/fhc.95685openalex-snapshot
Simvastatin suppresses ethanol effects on the kidney of adolescent mice
inferred← citeshttps://doi.org/10.7150/thno.20846openalex-snapshot
LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d
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