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AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation

https://doi.org/10.1371/journal.pone.0148213
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s12223-011-0058-5openalex-snapshot
The abc1 − /coq8 − respiratory-deficient mutant of Schizosaccharomyces pombe suffers from glutathione underproduction and hyperaccumulates Cd2+
inferredcites →https://doi.org/10.1016/0003-2697(87)90587-2openalex-snapshot
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
inferredcites →https://doi.org/10.1016/0003-2697(91)90094-aopenalex-snapshot
Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form
inferredcites →https://doi.org/10.1016/j.abb.2007.02.016openalex-snapshot
Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex
inferredcites →https://doi.org/10.1016/j.ajhg.2007.12.022openalex-snapshot
CABC1 Gene Mutations Cause Ubiquinone Deficiency with Cerebellar Ataxia and Seizures
inferredcites →https://doi.org/10.1016/j.ajhg.2007.12.024openalex-snapshot
ADCK3, an Ancestral Kinase, Is Mutated in a Form of Recessive Ataxia Associated with Coenzyme Q10 Deficiency
inferredcites →https://doi.org/10.1016/j.ajhg.2009.03.018openalex-snapshot
A Nonsense Mutation in COQ9 Causes Autosomal-Recessive Neonatal-Onset Primary Coenzyme Q10 Deficiency: A Potentially Treatable Form of Mitochondrial Disease
inferredcites →https://doi.org/10.1016/j.bbagrm.2011.11.007openalex-snapshot
Processing of mitochondrial presequences
inferredcites →https://doi.org/10.1016/j.bbalip.2011.01.009openalex-snapshot
Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants
inferredcites →https://doi.org/10.1016/j.bbamem.2003.11.012openalex-snapshot
Metabolism and function of coenzyme Q
inferredcites →https://doi.org/10.1016/j.bbrc.2010.02.147openalex-snapshot
Coenzyme Q – Biosynthesis and functions
inferredcites →https://doi.org/10.1016/j.cell.2010.12.015openalex-snapshot
Regulation of Mitochondrial Protein Import by Cytosolic Kinases
inferredcites →https://doi.org/10.1016/j.cell.2013.01.013openalex-snapshot
Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis
inferredcites →https://doi.org/10.1016/j.cellsig.2008.01.017openalex-snapshot
cAMP-dependent protein kinase regulates the mitochondrial import of the nuclear encoded NDUFS4 subunit of complex I
inferredcites →https://doi.org/10.1016/j.cub.2011.11.057openalex-snapshot
A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes
inferredcites →https://doi.org/10.1016/j.mad.2003.10.002openalex-snapshot
Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress
inferredcites →https://doi.org/10.1016/j.mito.2007.02.006openalex-snapshot
The antioxidant role of coenzyme Q
inferredcites →https://doi.org/10.1016/j.mito.2007.03.007openalex-snapshot
Endogenous synthesis of coenzyme Q in eukaryotes
inferredcites →https://doi.org/10.1016/j.mito.2010.05.008openalex-snapshot
Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy
inferredcites →https://doi.org/10.1016/s0021-9258(19)40172-5openalex-snapshot
Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver.
inferredcites →https://doi.org/10.1016/s0021-9258(19)49428-3openalex-snapshot
Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.
inferredcites →https://doi.org/10.1016/s0076-6879(07)38008-7openalex-snapshot
Characterization of Rab18, a Lipid Droplet–Associated Small GTPase
inferredcites →https://doi.org/10.1016/s0076-6879(08)04418-2openalex-snapshot
Chapter 18 Analysis of Respiratory Chain Complex Assembly with Radiolabeled Nuclear‐ and Mitochondrial‐Encoded Subunits
inferredcites →https://doi.org/10.1016/s0076-6879(94)33053-0openalex-snapshot
[50] Rapid isolation of lipoproteins and assessment of their peroxidation by high-performance liquid chromatography postcolumn chemiluminescence
inferredcites →https://doi.org/10.1016/s0167-4889(02)00265-3openalex-snapshot
Mitochondrial processing peptidases
inferredcites →https://doi.org/10.1016/s1097-2765(01)00335-5openalex-snapshot
Phosphorylation of Bid by Casein Kinases I and II Regulates Its Cleavage by Caspase 8
inferredcites →https://doi.org/10.1038/274484a0openalex-snapshot
Identification of ataxia telangiectasia heterozygotes, a cancer prone population
inferredcites →https://doi.org/10.1038/emboj.2011.198openalex-snapshot
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
inferredcites →https://doi.org/10.1073/pnas.97.2.871openalex-snapshot
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
inferredcites →https://doi.org/10.1074/jbc.m100952200openalex-snapshot
A Defect in Coenzyme Q Biosynthesis Is Responsible for the Respiratory Deficiency in Saccharomyces cerevisiae abc1Mutants
inferredcites →https://doi.org/10.1074/jbc.m108980200openalex-snapshot
Ubiquinone Is Necessary for Mouse Embryonic Development but Is Not Essential for Mitochondrial Respiration
inferredcites →https://doi.org/10.1074/jbc.m204758200openalex-snapshot
Development and Fertility in Caenorhabditis elegans clk-1 Mutants Depend upon Transport of Dietary Coenzyme Q8 to Mitochondria
inferredcites →https://doi.org/10.1074/jbc.m205613200openalex-snapshot
Insertion and Assembly of Human Tom7 into the Preprotein Translocase Complex of the Outer Mitochondrial Membrane
inferredcites →https://doi.org/10.1074/jbc.m301807200openalex-snapshot
Phosphorylation Enhances Mitochondrial Targeting of GSTA4-4 through Increased Affinity for Binding to Cytoplasmic Hsp70
inferredcites →https://doi.org/10.1074/jbc.m501315200openalex-snapshot
Coq3 and Coq4 Define a Polypeptide Complex in Yeast Mitochondria for the Biosynthesis of Coenzyme Q
inferredcites →https://doi.org/10.1074/jbc.m513267200openalex-snapshot
Complementation of Saccharomyces cerevisiae coq7 Mutants by Mitochondrial Targeting of the Escherichia coli UbiF Polypeptide
inferredcites →https://doi.org/10.1074/jbc.m807797200openalex-snapshot
hNOA1 Interacts with Complex I and DAP3 and Regulates Mitochondrial Respiration and Apoptosis
inferredcites →https://doi.org/10.1080/10715760290021252openalex-snapshot
Regulation of the Mitochondrial Permeability Transition Pore by Ubiquinone Analogs. A Progress Report
inferredcites →https://doi.org/10.1083/jcb.200809125openalex-snapshot
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
inferredcites →https://doi.org/10.1086/500092openalex-snapshot
A Mutation in Para-Hydroxybenzoate-Polyprenyl Transferase (COQ2) Causes Primary Coenzyme Q10 Deficiency
inferredcites →https://doi.org/10.1086/510023openalex-snapshot
Leigh Syndrome with Nephropathy and CoQ10 Deficiency Due to decaprenyl diphosphate synthase subunit 2 (PDSS2) Mutations
inferredcites →https://doi.org/10.1093/emboj/19.21.5720openalex-snapshot
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
inferredcites →https://doi.org/10.1093/nar/gkh377openalex-snapshot
The PredictProtein server
inferredcites →https://doi.org/10.1096/fj.07-100149openalex-snapshot
Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ 10 deficiency
inferredcites →https://doi.org/10.1111/j.1567-1364.2008.00436.xopenalex-snapshot
Ubiquinone biosynthesis inSaccharomyces cerevisiae: the molecular organization ofO-methylase Coq3p depends on Abc1p/Coq8p
inferredcites →https://doi.org/10.1126/science.1064653openalex-snapshot
Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q
inferredcites →https://doi.org/10.1126/science.1075762openalex-snapshot
The Protein Kinase Complement of the Human Genome
inferredcites →https://doi.org/10.1126/science.1230381openalex-snapshot
Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain
inferredcites →https://doi.org/10.1146/annurev.biochem.76.052705.163409openalex-snapshot
Translocation of Proteins into Mitochondria
inferredcites →https://doi.org/10.1172/jci29089openalex-snapshot
Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders
inferredcites →https://doi.org/10.1172/jci45693openalex-snapshot
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
inferredcites →https://doi.org/10.1179/135100005x70170openalex-snapshot
Lysosomal ROS formation
inferredcites →https://doi.org/10.1371/journal.pone.0011792openalex-snapshot
Ubiquinone Analogs: A Mitochondrial Permeability Transition Pore-Dependent Pathway to Selective Cell Death
inferredcites →https://doi.org/10.1371/journal.pone.0016054openalex-snapshot
Possible Existence of Lysosome-Like Organella within Mitochondria and Its Role in Mitochondrial Quality Control
inferredcites →https://doi.org/10.1371/journal.pone.0052830openalex-snapshot
Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo
inferredcites →https://doi.org/10.1385/0-89603-353-8:17openalex-snapshot
SDS Polyacrylamide Gel Electrophoresis for N-Terminal Protein Sequencing
inferredcites →https://doi.org/10.1385/1-59259-342-9:19openalex-snapshot
SDS Polyacrylamide Gel Electrophoresis for N-Terminal Protein Sequencing
inferredcites →https://doi.org/10.1681/asn.2006080833openalex-snapshot
COQ2 Nephropathy
inferredcites →https://doi.org/10.4161/auto.21211openalex-snapshot
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy
inferredcites →https://doi.org/10.4161/auto.5.1.7174openalex-snapshot
Coenzyme Q deficiency triggers mitochondria degradation by mitophagy

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Additional file 1 of Loss of Drosophila Coq8 results in impaired survival, locomotor deficits and photoreceptor degeneration
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Additional file 2 of Loss of Drosophila Coq8 results in impaired survival, locomotor deficits and photoreceptor degeneration
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