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Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants

https://doi.org/10.1371/journal.pone.0161526

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mitochondrial Quality Control and Parkinson’s Disease: A Pathway Unfolds

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Temperature-induced changes of HtrA2(Omi) protease activity and structure

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The structural basis of mode of activation and functional diversity: A case study with HtrA family of serine proteases

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Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer

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Allosteric Activation of DegS, a Stress Sensor PDZ Protease

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Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages

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The Wilms' Tumor Suppressor Protein WT1 Is Processed by the Serine Protease HtrA2/Omi

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Association of Omi/HtrA2 with γ-secretase in mitochondria

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Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi

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A Conserved Activation Cluster Is Required for Allosteric Communication in HtrA-Family Proteases

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Crystal Structure of the DegS Stress Sensor

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

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Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

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HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

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Substrate-induced remodeling of the active site regulates human HTRA1 activity

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A smooth particle mesh Ewald method

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Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease

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Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins

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The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies

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Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold

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Allostery Is an Intrinsic Property of the Protease Domain of DegS

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Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

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Crystal Structure of the Protease Domain of a Heat-shock Protein HtrA from Thermotoga maritima

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The C-terminal Tail of Presenilin Regulates Omi/HtrA2 Protease Activity

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Phaser crystallographic software

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The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase

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Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

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HtrA Serine Proteases as Potential Therapeutic Targets in Cancer

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Inter-Subunit Crosstalk via PDZ Synergistically Governs Allosteric Activation of Proapoptotic HtrA2

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Structural insights into the activation mechanisms of human HtrA serine proteases

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Role of conserved regulatory loop residues in allosteric propagation of serine protease HtrA2

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Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2

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Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2

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Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR

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The crystal structure of an essential high-temperature requirement protein HtrA1 (Rv1223) from Mycobacterium tuberculosis reveals its unique features

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Dual role of an essential HtrA2/Omi protease in the human malaria parasite: Maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress

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Progress in research on the role of Omi/HtrA2 in neurological diseases

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Asymmetry in Biological Homochirality

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Identification and Characterization of an HtrA Sheddase Produced by Coxiella burnetii

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Chiral Interface of Amyloid Beta (Aβ): Relevance to Protein Aging, Aggregation and Neurodegeneration

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