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Variable selection in omics data: A practical evaluation of small sample sizes

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Partial least squares discriminant analysis: taking the magic away
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Toward the integration of Omics data in epidemiological studies: still a “long and winding road”
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High‐throughput direct‐infusion ion trap mass spectrometry: a new method for metabolomics
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A comparative study of variable selection methods in the context of developing psychiatric screening instruments
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The Elements of Statistical Learning: Data Mining, Inference, and Prediction
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Support Vector Machines on Large Data Sets: Simple Parallel Approaches
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Next generation modeling in GWAS: comparing different genetic architectures
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Metabolite identification: are you sure? And how do your peers gauge your confidence?
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Improved experimental data processing for UHPLC–HRMS/MS lipidomics applied to nonalcoholic fatty liver disease
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A computationally fast variable importance test for random forests for high-dimensional data
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A computationally fast variable importance test for random forests for high-dimensional data
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Statistical power analysis for the behavioral sciences
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A tutorial review: Metabolomics and partial least squares-discriminant analysis – a marriage of convenience or a shotgun wedding
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The use of random-effect models for high-dimensional variable selection problems
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Cross-validation and bootstrapping are unreliable in small sample classification
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A systematic statistical linear modeling approach to oligonucleotide array experiments
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The NCBI dbGaP database of genotypes and phenotypes
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The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster
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Preprocessing, classification modeling and feature selection using flow injection electrospray mass spectrometry metabolite fingerprint data
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
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Metabolomics: the apogee of the omics trilogy
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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
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An analysis of ozone damage to historical maize and soybean yields in the United States
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Ridge Regression: Applications to Nonorthogonal Problems
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Statistical Methods for Research Workers
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Evaluation of variable selection methods for random forests and omics data sets
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Is cross-validation valid for small-sample microarray classification?
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MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data
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AmiGO: online access to ontology and annotation data
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Permutation importance: a corrected feature importance measure
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Development of a Metabolic Biosignature for Detection of Early Lyme Disease
inferredcites →https://doi.org/10.1093/nar/gkv1042openalex-snapshot
Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools
inferredcites →https://doi.org/10.1101/gr.217984.116openalex-snapshot
Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes
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The Elements of Statistical Learning: Data Mining, Inference, and Prediction
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Regularization and Variable Selection Via the Elastic Net
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THE USE OF MULTIPLE MEASUREMENTS IN TAXONOMIC PROBLEMS
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
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Regression Shrinkage and Selection Via the Lasso
inferredcites →https://doi.org/10.1126/science.286.5439.531openalex-snapshot
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
inferredcites →https://doi.org/10.1145/2808425.2808430openalex-snapshot
Exploring Privacy Preservation in Outsourced K-Nearest Neighbors with Multiple Data Owners
inferredcites →https://doi.org/10.1155/jbb.2005.147openalex-snapshot
Classification and Selection of Biomarkers in Genomic Data Using LASSO
inferredcites →https://doi.org/10.1186/1471-2105-12-253openalex-snapshot
Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems
inferredcites →https://doi.org/10.1186/1753-6561-3-s7-s25openalex-snapshot
Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis
inferredcites →https://doi.org/10.1186/1756-0500-6-365openalex-snapshot
Variable selection methods for developing a biomarker panel for prediction of dengue hemorrhagic fever
inferredcites →https://doi.org/10.1186/s12864-015-2353-zopenalex-snapshot
Comparison of normalization and differential expression analyses using RNA-Seq data from 726 individual Drosophila melanogaster
inferredcites →https://doi.org/10.1186/s12874-015-0066-2openalex-snapshot
Comparison of subset selection methods in linear regression in the context of health-related quality of life and substance abuse in Russia
inferredcites →https://doi.org/10.1186/s12874-016-0254-8openalex-snapshot
Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application
inferredcites →https://doi.org/10.1186/s13040-016-0087-3openalex-snapshot
r2VIM: A new variable selection method for random forests in genome-wide association studies
inferredcites →https://doi.org/10.1214/009053604000000067openalex-snapshot
Least angle regression
inferredcites →https://doi.org/10.1214/07-aos504openalex-snapshot
High-dimensional classification using features annealed independence rules
inferredcites →https://doi.org/10.1371/journal.pone.0107957openalex-snapshot
Simulation Studies as Designed Experiments: The Comparison of Penalized Regression Models in the “Large p, Small n” Setting
inferredcites →https://doi.org/10.1517/17530059.2012.718329openalex-snapshot
Challenges in biomarker discovery: combining expert insights with statistical analysis of complex omics data
inferredcites →https://doi.org/10.1609/aaai.v29i1.9625openalex-snapshot
A Reduction of the Elastic Net to Support Vector Machines with an Application to GPU Computing
inferredcites →https://doi.org/10.18637/jss.v033.i01openalex-snapshot
Regularization Paths for Generalized Linear Models via Coordinate Descent
inferredcites →https://doi.org/10.18637/jss.v036.i11openalex-snapshot
Feature Selection with the Boruta Package
inferredcites →https://doi.org/10.2307/1270020openalex-snapshot
Statistical Power Analysis for the Behavioral Sciences
inferredcites →https://doi.org/10.2307/2341488openalex-snapshot
Statistical Methods for Research Workers.
inferredcites →https://doi.org/10.3389/fbioe.2015.00023openalex-snapshot
Analytical Methods in Untargeted Metabolomics: State of the Art in 2015
inferredcites →https://doi.org/10.3389/fmolb.2016.00030openalex-snapshot
Feature Selection Methods for Early Predictive Biomarker Discovery Using Untargeted Metabolomic Data
inferredcites →https://doi.org/10.3389/fmolb.2016.00035openalex-snapshot
PLS-Based and Regularization-Based Methods for the Selection of Relevant Variables in Non-targeted Metabolomics Data
inferredcites →https://doi.org/10.3832/ifor1495-008openalex-snapshot
Chemometric technique performances in predicting forest soil chemical and biological properties from UV-Vis-NIR reflectance spectra with small, high dimensional datasets
inferredcites →https://doi.org/10.4137/cin.s13875openalex-snapshot
Overcome Support Vector Machine Diagnosis Overfitting
inferredcites →https://doi.org/10.4155/bio.12.204openalex-snapshot
The Importance of Experimental Design And Qc Samples in Large-Scale And Ms-Driven Untargeted Metabolomic Studies of Humans
inferredcites →https://doi.org/10.4172/2153-0769.1000126openalex-snapshot
Comparison of Regularized Regression Methods for ~Omics Data
inferredcites →https://doi.org/10.48550/arxiv.1606.00930openalex-snapshot
Comparison of 14 different families of classification algorithms on 115 binary datasets

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Additional file 1 of Enhancing data pipelines for forecasting student performance: integrating feature selection with cross-validation
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Additional file 1 of Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients
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Additional file 2 of Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients
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Metabolic consequences of various fruit-based diets in a generalist insect species
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