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Ziziphus spina-christi leaf extract ameliorates schistosomiasis liver granuloma, fibrosis, and oxidative stress through downregulation of fibrinogenic signaling in mice

https://doi.org/10.1371/journal.pone.0204923
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.21922openalex-snapshot
Metalloproteinase-9 deficiency protects against hepatic ischemia/reperfusion injury
inferredcites →https://doi.org/10.1002/hep.26429openalex-snapshot
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
inferredcites →https://doi.org/10.1007/s00441-011-1246-yopenalex-snapshot
TGF-β in progression of liver disease
inferredcites →https://doi.org/10.1007/s10787-017-0439-8openalex-snapshot
Ziziphus spina-christi leaf extract pretreatment inhibits liver and spleen injury in a mouse model of sepsis via anti-oxidant and anti-inflammatory effects
inferredcites →https://doi.org/10.1016/0003-2697(79)90738-3openalex-snapshot
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
inferredcites →https://doi.org/10.1016/0003-2697(82)90118-xopenalex-snapshot
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
inferredcites →https://doi.org/10.1016/0003-9861(59)90090-6openalex-snapshot
Tissue sulfhydryl groups
inferredcites →https://doi.org/10.1016/j.biopha.2018.03.032openalex-snapshot
Ziziphus spina-christi (L.) leaf extract alleviates myocardial and renal dysfunction associated with sepsis in mice
inferredcites →https://doi.org/10.1016/j.bjid.2014.11.004openalex-snapshot
Impact of human schistosomiasis in sub-Saharan Africa
inferredcites →https://doi.org/10.1016/j.exppara.2018.01.013openalex-snapshot
Impact of treatment with a Protein Tyrosine Kinase Inhibitor (Genistein) on acute and chronic experimental Schistosoma mansoni infection
inferredcites →https://doi.org/10.1016/j.fct.2009.05.038openalex-snapshot
Zizyphus spina-christi protects against carbon tetrachloride-induced liver fibrosis in rats
inferredcites →https://doi.org/10.1016/j.fct.2018.03.002openalex-snapshot
Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2014.03.015openalex-snapshot
Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: Role of NADPH oxidase
inferredcites →https://doi.org/10.1016/j.ijpara.2012.12.006openalex-snapshot
Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice
inferredcites →https://doi.org/10.1016/j.jep.2010.09.001openalex-snapshot
Anti-diabetic activity and stability study of the formulated leaf extract of Zizyphus spina-christi (L.) Willd with the influence of seasonal variation
inferredcites →https://doi.org/10.1016/j.matbio.2015.01.004openalex-snapshot
Matrix metalloproteinases in liver injury, repair and fibrosis
inferredcites →https://doi.org/10.1016/j.parint.2012.09.008openalex-snapshot
Apoptosis phenomenon in the schistosomulum and adult worm life cycle stages of Schistosoma japonicum
inferredcites →https://doi.org/10.1016/j.parint.2013.04.002openalex-snapshot
Efficiency of ginger (Zingbar officinale) against Schistosoma mansoni infection during host–parasite association
inferredcites →https://doi.org/10.1016/j.phymed.2016.01.004openalex-snapshot
Evaluating ancient Egyptian prescriptions today: Anti-inflammatory activity of Ziziphus spina-christi
inferredcites →https://doi.org/10.1016/j.pt.2013.12.005openalex-snapshot
Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis
inferredcites →https://doi.org/10.1016/s0006-291x(72)80218-3openalex-snapshot
The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen
inferredcites →https://doi.org/10.1016/s0021-9258(19)52451-6openalex-snapshot
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
inferredcites →https://doi.org/10.1016/s0076-6879(84)05016-3openalex-snapshot
[13] Catalase in vitro
inferredcites →https://doi.org/10.1016/s0168-8278(01)00142-8openalex-snapshot
Oxidative stress-related molecules and liver fibrosis
inferredcites →https://doi.org/10.1017/s0031182014001115openalex-snapshot
Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis
inferredcites →https://doi.org/10.1038/labinvest.2008.75openalex-snapshot
The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
inferredcites →https://doi.org/10.1038/s41598-017-00377-4openalex-snapshot
Enhanced Wnt Signalling in Hepatocytes is Associated with Schistosoma japonicum Infection and Contributes to Liver Fibrosis
inferredcites →https://doi.org/10.1073/pnas.1100652108openalex-snapshot
Discovery and molecular characterization of a Bcl-2–regulated cell death pathway in schistosomes
inferredcites →https://doi.org/10.1074/jbc.273.25.15846openalex-snapshot
Disruption of Redox Homeostasis in the Transforming Growth Factor-α/c-myc Transgenic Mouse Model of Accelerated Hepatocarcinogenesis
inferredcites →https://doi.org/10.1080/14786419.2016.1226830openalex-snapshot
Phenolic profile, antioxidant capacity of five Ziziphus spina-christi (L.) Willd provenances and their allelopathic effects on Trigonella foenum-graecum L. and Lens culinaris L. seeds
inferredcites →https://doi.org/10.1093/ajcp/28.1.56openalex-snapshot
A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases
inferredcites →https://doi.org/10.1093/infdis/jiq099openalex-snapshot
Tissue Inhibitor of Matrix-Metalloprotease–1 Predicts Risk of Hepatic Fibrosis in Human Schistosoma japonicum Infection
inferredcites →https://doi.org/10.1111/j.0019-2805.2004.01817.xopenalex-snapshot
Expression of matrix metalloproteinases and their inhibitors during the resorption of schistosome egg‐induced fibrosis in praziquantel‐treated mice
inferredcites →https://doi.org/10.1111/j.1365-3024.2005.00765.xopenalex-snapshot
Priming of the immune response by schistosome eggs
inferredcites →https://doi.org/10.1111/j.1478-3231.2007.01463.xopenalex-snapshot
Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride‐induced liver injury in rodents
inferredcites →https://doi.org/10.1126/scisignal.127re6openalex-snapshot
Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities
inferredcites →https://doi.org/10.1128/iai.69.1.271-280.2001openalex-snapshot
Soluble Egg Antigen-Stimulated T Helper Lymphocyte Apoptosis and Evidence for Cell Death Mediated by FasL+T and B Cells during MurineSchistosoma mansoniInfection
inferredcites →https://doi.org/10.1155/2014/381413openalex-snapshot
The Potential Protective Effect ofPhysalis peruvianaL. against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Is Mediated by Suppression of Oxidative Stress and Downregulation of MMP-9 Expression
inferredcites →https://doi.org/10.1155/2016/9521349openalex-snapshot
Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms
inferredcites →https://doi.org/10.1186/1472-6882-10-54openalex-snapshot
Zizyphus lotus L. (Desf.) modulates antioxidant activity and human T-cell proliferation
inferredcites →https://doi.org/10.1186/1756-3305-5-9openalex-snapshot
Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis
inferredcites →https://doi.org/10.1186/s12906-016-1389-1openalex-snapshot
Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress
inferredcites →https://doi.org/10.1186/s13071-015-0640-9openalex-snapshot
Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment
inferredcites →https://doi.org/10.1189/jlb.0805468openalex-snapshot
Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver
inferredcites →https://doi.org/10.1371/journal.pone.0020247openalex-snapshot
New Insight into the Antifibrotic Effects of Praziquantel on Mice in Infection with Schistosoma japonicum
inferredcites →https://doi.org/10.1371/journal.pone.0068479openalex-snapshot
Schistosoma japonicum Eggs Induce a Proinflammatory, Anti-Fibrogenic Phenotype in Hepatic Stellate Cells
inferredcites →https://doi.org/10.1371/journal.pone.0158965openalex-snapshot
Indigofera oblongifolia Prevents Lead Acetate-Induced Hepatotoxicity, Oxidative Stress, Fibrosis and Apoptosis in Rats
inferredcites →https://doi.org/10.1371/journal.pone.0167135openalex-snapshot
Curcumin Generates Oxidative Stress and Induces Apoptosis in Adult Schistosoma mansoni Worms
inferredcites →https://doi.org/10.14218/jcth.2014.00018openalex-snapshot
Hepatobiliary Schistosomiasis
inferredcites →https://doi.org/10.2174/18715273113129990081openalex-snapshot
The Neuroprotective Effects of Purslane (Portulaca oleracea) on Rotenone- Induced Biochemical Changes and Apoptosis in Brain of Rat
inferredcites →https://doi.org/10.3109/10408363.2015.1129530openalex-snapshot
Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy
inferredcites →https://doi.org/10.3389/fimmu.2012.00116openalex-snapshot
IL-13 Signaling in Liver Fibrogenesis
inferredcites →https://doi.org/10.3389/fimmu.2013.00089openalex-snapshot
The Schistosoma Granuloma: Friend or Foe?
inferredcites →https://doi.org/10.3748/wjg.v5.i5.397openalex-snapshot
Dynamic changes of type I, III and IV collagen synthesis and distribution of collagen-producing cells in carbon tetrachloride-induced rat liver fibrosis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3690091openalex-extracted
Drug Development for Schistosomiasis
inferred← citeshttps://doi.org/10.1007/s11356-019-07237-wopenalex-snapshot
Ziziphus spina-christi leaf extract attenuates mercury chloride-induced testicular dysfunction in rats
inferred← citeshttps://doi.org/10.1007/s11356-020-12160-6openalex-snapshot
Ziziphus spina-christi leaf extract attenuates mercuric chloride-induced liver injury in male rats via inhibition of oxidative damage
inferred← citeshttps://doi.org/10.1007/s11356-022-23098-2openalex-snapshot
Parasitological and histopathological studies to the effect of aqueous extract of Moringa oleifera Lam. leaves combined with praziquantel therapy in modulating the liver and spleen damage induced by Schistosoma mansoni to male mice
inferred← citeshttps://doi.org/10.1007/s11686-026-01274-5openalex-snapshot
Therapeutic and Prophylactic Effects of the Surfactant Protein D Mimetic CGSPS18 Against Schistosoma mansoni in Biomphalaria alexandrina and Mice
inferred← citeshttps://doi.org/10.1007/s43450-023-00442-2openalex-snapshot
Immunomodulating and Anti-parasitary Mechanisms of Plant Products in the Treatment of Schistosomiasis
inferred← citeshttps://doi.org/10.1016/b978-0-443-29044-2.00010-2openalex-snapshot
Natural products with activity against Schistosoma species
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111831openalex-snapshot
Lycopene corrects metabolic syndrome and liver injury induced by high fat diet in obese rats through antioxidant, anti-inflammatory, antifibrotic pathways
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116848openalex-snapshot
Progress of mesenchymal stem cells (MSCs) & MSC-Exosomes combined with drugs intervention in liver fibrosis
inferred← citeshttps://doi.org/10.1016/j.exppara.2022.108260openalex-snapshot
Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.07.038openalex-snapshot
Mutual antagonism between indoleamine 2,3-dioxygenase 1 and nuclear factor E2-related factor 2 regulates the maturation status of DCs in liver fibrosis
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e32459openalex-snapshot
The role of Nrf2 signaling in parasitic diseases and its therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e33070openalex-snapshot
A comprehensive exploration of schistosomiasis: Global impact, molecular characterization, drug discovery, artificial intelligence and future prospects
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.116811openalex-snapshot
Biosynthesized selenium nanoparticles as a promising antischistosomal agent: modulation of oxidative stress and pro-inflammatory cytokines in mice
inferred← citeshttps://doi.org/10.1016/j.jmii.2022.04.013openalex-snapshot
Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis
inferred← citeshttps://doi.org/10.1016/j.prenap.2026.100874openalex-snapshot
Evaluation of the nephroprotective potential of Ziziphus Spina Christi methanolic leaf extract against gentamicin toxicity in rats
inferred← citeshttps://doi.org/10.1016/j.sjbs.2021.07.076openalex-snapshot
Genus Ziziphus for the treatment of chronic inflammatory diseases
inferred← citeshttps://doi.org/10.1038/s41598-024-68957-9openalex-snapshot
The synergistic effect of Ficus carica nanoparticles and Praziquantel on mice infected by Schistosoma mansoni cercariae
inferred← citeshttps://doi.org/10.1038/s41598-025-14037-5openalex-snapshot
Optimizing the therapeutic benefits of synriam combined with praziquantel in mice harbouring juvenile and mature Schistosoma mansoni
inferred← citeshttps://doi.org/10.1038/s41598-025-91955-4openalex-snapshot
The antifibrotic effect of Vildagliptin and Diaminodiphenyl Sulfone in murine schistosomiasis mansoni
inferred← citeshttps://doi.org/10.1038/s41598-026-47325-9openalex-snapshot
Antiviral activity and chemical characterization of Egyptian Ziziphus spina-christi against human respiratory viruses
inferred← citeshttps://doi.org/10.1042/bsr20190379openalex-snapshot
Anti- Toxoplasma activity of silver nanoparticles green synthesized with Phoenix dactylifera and Ziziphus spina-christi extracts which inhibits inflammation through liver regulation of cytokines in Balb/c mice
inferred← citeshttps://doi.org/10.1079/cabicompendium.57569openalex-snapshot
Ziziphus spina-christi (Christ's thorn jujube)
inferred← citeshttps://doi.org/10.1080/20477724.2023.2240085openalex-snapshot
Stem cell-derived exosomes as a potential therapy for schistosomal hepatic fibrosis in experimental animals
inferred← citeshttps://doi.org/10.1101/755959openalex-snapshot
Immunoinformatics Prediction of Epitope Based Peptide Vaccine Against Schistosoma Mansoni Fructose Bisphosphate Aldolase Protein
inferred← citeshttps://doi.org/10.1111/btp.13152openalex-snapshot
Diversity in habit expands the environmental niche of Ziziphus (Rhamnaceae)
inferred← citeshttps://doi.org/10.1139/bcb-2018-0318openalex-snapshot
Ziziphus spina-christi leaves methanolic extract alleviates diethylnitrosamine-induced hepatocellular carcinoma in rats
inferred← citeshttps://doi.org/10.1155/2021/5545331openalex-snapshot
Antischistosomal Activity of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa Plant Extracts on Hamster Infected with Schistosoma haematobium
inferred← citeshttps://doi.org/10.1155/2021/7202447openalex-snapshot
Comparison between the Antioxidant and Antidiabetic Activity of Fenugreek and Buckthorn in Streptozotocin‐Induced Diabetic Male Rats
inferred← citeshttps://doi.org/10.1155/2022/4495688openalex-snapshot
Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review
inferred← citeshttps://doi.org/10.1155/2024/7551813openalex-snapshot
In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi
inferred← citeshttps://doi.org/10.1186/s12906-018-2406-3openalex-snapshot
Probiotics and yogurt modulate oxidative stress and fibrosis in livers of Schistosoma mansoni-infected mice
inferred← citeshttps://doi.org/10.1371/journal.pntd.0011426openalex-snapshot
Anti-angiogenic and anti-proliferative activity of ziziphus leaf extract as a novel potential therapeutic agent for reducing hepatic injury in experimental hamster schistosomiasis
inferred← citeshttps://doi.org/10.14719/pst.1659openalex-snapshot
Biochemical profile, antioxidant effect and antifungal activity of Saudi Ziziphus spina-christi L. for vaginal lotion formulation
inferred← citeshttps://doi.org/10.21608/ejchem.2021.84043.4114openalex-snapshot
The ameliorative effects of Eremina desertorum snail mucin in combination with Silymarin against experimentally induced liver fibrosis
inferred← citeshttps://doi.org/10.2217/nnm-2023-0185openalex-snapshot
Silver-Cored Ziziphus Spina-Christi Extract-Loaded Antimicrobial Nanosuspension: Overcoming Multidrug Resistance
inferred← citeshttps://doi.org/10.33084/bjop.v3i1.1242openalex-snapshot
Test on the Antioxidant Activities of Methanol Extract of Bidara Leaves (Ziziphus spina-christi L.) using the DPPH Radical Immersion Method
inferred← citeshttps://doi.org/10.3389/fphar.2024.1332027openalex-snapshot
Therapeutic potential of natural products in schistosomiasis-associated liver fibrosis
inferred← citeshttps://doi.org/10.3389/fvets.2025.1646155openalex-snapshot
A comparative parasitological, histopathological, and proteomic analysis of Schistosoma mansoni infected mice treated with ivermectin and praziquantel
inferred← citeshttps://doi.org/10.3390/ijms20040993openalex-snapshot
Myristica fragrans Kernels Prevent Paracetamol-Induced Hepatotoxicity by Inducing Anti-Apoptotic Genes and Nrf2/HO-1 Pathway
inferred← citeshttps://doi.org/10.3390/jox16040120openalex-snapshot
Safranal Enhances the Efficacy of Praziquantel Against Schistosoma mansoni Infection and Alleviates Liver Fibrosis, Inflammation and Oxidative Stress in Mice
inferred← citeshttps://doi.org/10.3390/microorganisms9102113openalex-snapshot
Antileishmanial Activity of Ziziphus spina-christi Leaves Extract and Its Possible Cellular Mechanisms
inferred← citeshttps://doi.org/10.4152/pea.2023410205openalex-snapshot
Ziziphus Spina Christi Leaves Methanol Extract Evaluation as Antifungal, Antibacterial, Antioxidant and Green Inhibitor for Carbon Steel Alloy Corrosion in Hydrochloric Acid
inferred← citeshttps://doi.org/10.4254/wjh.v18.i1.114542openalex-snapshot
Enhanced surgical tolerance of schistosomiasis-induced fibrotic liver following treatment with Ziziphus plant extract
inferred← citeshttps://doi.org/10.47665/tb.38.1.004openalex-snapshot
The potent effect of silymarin combination with Praziquantel or mirazid for Schistosoma mansoni treatment in infected male swiss albino mice
inferred← citeshttps://doi.org/10.47665/tb.39.1.001openalex-snapshot
Potentiality of curcumin on ISHAK scoring system and the expressions of BAX, IL-17A, and EGF in the treatment of Schistosoma mansoni infection using Swiss albino mice
inferred← citeshttps://doi.org/10.54319/jjbs/1602openalex-snapshot
inferred← citeshttps://doi.org/10.54319/jjbs/160208openalex-snapshot
Skin-Cancer Protective Effect of Ziziphus Spina-christi Leaf Extract: In vitro and in Vivo Models
inferred← citeshttps://doi.org/10.62877/40-ijcbs-24-25-19-40openalex-snapshot
The Effect of Adding Chitosan Nanoparticles Loaded with Sidr Leaf Extract (Ziziphus spina-christi) (CPNs SLE) in Diet on Pangasius sp. Infected Aeromonas hydrophila
inferred← citeshttps://doi.org/10.9734/jpri/2021/v33i54b33783openalex-snapshot
'Silymarin' a Potential Treatment Targeting Hepatic Fibrosis of Schistosomiasis
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