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Translating antibiotic prescribing into antibiotic resistance in the environment: A hazard characterisation case study

https://doi.org/10.1371/journal.pone.0221568
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Worldwide estimation of river concentrations of any chemical originating from sewage-treatment plants using dilution factors
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Occurrence and Fate of Human Pharmaceuticals in the Environment
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The use of minimum selectable concentrations (MSCs) for determining the selection of antimicrobial resistant bacteria
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Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation
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Understanding drivers of antibiotic resistance genes in High Arctic soil ecosystems
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Sub-inhibitory concentrations of heavy metals facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes in water environment
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Wild small mammals as sentinels for the environmental transmission of antimicrobial resistance
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Genetic basis of chromosomally-encoded mcr-1 gene
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The impact of on-site hospital wastewater treatment on the downstream communal wastewater system in terms of antibiotics and antibiotic resistance genes
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Prevalence of antibiotics and antibiotic resistance genes in a wastewater effluent-receiving river in the Netherlands
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Selection of resistance at lethal and non-lethal antibiotic concentrations
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The occurrence of antibiotics in an urban watershed: From wastewater to drinking water
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Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance
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Human pharmaceuticals in surface waters
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Removal of antibiotics in conventional and advanced wastewater treatment: Implications for environmental discharge and wastewater recycling
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Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment
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Occurrence and fate of quinolone and fluoroquinolone antibiotics in a municipal sewage treatment plant
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Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: A review
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Occurrence and removal of organic micropollutants: An overview of the watch list of EU Decision 2015/495
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Trace levels of sewage effluent are sufficient to increase class 1 integron prevalence in freshwater biofilms without changing the core community
inferredcites →https://doi.org/10.1016/s0140-6736(13)60604-2openalex-snapshot
Annual Report of the Chief Medical Officer: infection and the rise of antimicrobial resistance
inferredcites →https://doi.org/10.1021/acs.accounts.8b00643openalex-snapshot
Differential Drivers of Antimicrobial Resistance across the World
inferredcites →https://doi.org/10.1021/acs.est.5b00729openalex-snapshot
Comprehensive Evaluation of Antibiotics Emission and Fate in the River Basins of China: Source Analysis, Multimedia Modeling, and Linkage to Bacterial Resistance
inferredcites →https://doi.org/10.1021/es035342uopenalex-snapshot
A Model To Estimate Influent and Effluent Concentrations of Estradiol, Estrone, and Ethinylestradiol at Sewage Treatment Works
inferredcites →https://doi.org/10.1021/es048143zopenalex-snapshot
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inferredcites →https://doi.org/10.1021/es060413lopenalex-snapshot
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inferredcites →https://doi.org/10.1021/es0627693openalex-snapshot
Screening Method for Ecotoxicological Hazard Assessment of 42 Pharmaceuticals Considering Human Metabolism and Excretory Routes
inferredcites →https://doi.org/10.1021/es4030035openalex-snapshot
Do Concentrations of Ethinylestradiol, Estradiol, and Diclofenac in European Rivers Exceed Proposed EU Environmental Quality Standards?
inferredcites →https://doi.org/10.1038/485441aopenalex-snapshot
The hidden costs of flexible fertility
inferredcites →https://doi.org/10.1038/ismej.2014.237openalex-snapshot
Validated predictive modelling of the environmental resistome
inferredcites →https://doi.org/10.1038/ncomms10333openalex-snapshot
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inferredcites →https://doi.org/10.1038/nrmicro3270openalex-snapshot
Microbiological effects of sublethal levels of antibiotics
inferredcites →https://doi.org/10.1038/s41396-017-0030-8openalex-snapshot
The widespread dissemination of integrons throughout bacterial communities in a riverine system
inferredcites →https://doi.org/10.1038/s41396-018-0275-xopenalex-snapshot
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inferredcites →https://doi.org/10.1038/s41467-018-07992-3openalex-snapshot
Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments
inferredcites →https://doi.org/10.1038/s41540-018-0069-9openalex-snapshot
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inferredcites →https://doi.org/10.1038/s41586-018-0278-9openalex-snapshot
Species-specific activity of antibacterial drug combinations
inferredcites →https://doi.org/10.1038/s41598-017-16898-xopenalex-snapshot
Raman-Deuterium Isotope Probing for in-situ identification of antimicrobial resistant bacteria in Thames River
inferredcites →https://doi.org/10.1039/c2em10916fopenalex-snapshot
Occurrence, distribution and bioaccumulation of antibiotics in the Haihe River in China
inferredcites →https://doi.org/10.1039/c3em00567dopenalex-snapshot
Occurrence, distribution and bioaccumulation of antibiotics in the Liao River Basin in China
inferredcites →https://doi.org/10.1042/ebc20160057openalex-snapshot
Fitness costs associated with the acquisition of antibiotic resistance
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Impact of antibiotics on conjugational resistance gene transfer in Staphylococcus aureus in sewage
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Exposure Assessment of Pharmaceuticals and Their Metabolites in the Aquatic Environment: Application to the French Situation and Preliminary Prioritization
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inferredcites →https://doi.org/10.1093/jac/dkr041openalex-snapshot
Variation in the genetic environments of blaCTX-M-15 in Escherichia coli from the faeces of travellers returning to the United Kingdom
inferredcites →https://doi.org/10.1093/jac/dku079openalex-snapshot
Waste water effluent contributes to the dissemination of CTX-M-15 in the natural environment
inferredcites →https://doi.org/10.1093/jac/dkv387openalex-snapshot
Predictors of bacterial resistance usingin vitrodynamic models: area under the concentration–time curve related to either the minimum inhibitory or mutant prevention antibiotic concentration
inferredcites →https://doi.org/10.1093/jac/dkx500openalex-snapshot
Potential for reducing inappropriate antibiotic prescribing in English primary care
inferredcites →https://doi.org/10.1093/jac/dkx502openalex-snapshot
Actual versus ‘ideal’ antibiotic prescribing for common conditions in English primary care
inferredcites →https://doi.org/10.1093/jac/dkx535openalex-snapshot
Reducing inappropriate prescribing of antibiotics in English primary care: evidence and outlook
inferredcites →https://doi.org/10.1093/jac/dky007openalex-snapshot
CTX-M ESBL-producing Enterobacteriaceae: estimated prevalence in adults in England in 2014
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Herbicide ingredients change Salmonella enterica sv. Typhimurium and Escherichia coli antibiotic responses
inferredcites →https://doi.org/10.1101/gr.232629.117openalex-snapshot
Detection of vancomycin-resistant Enterococcus faecium hospital-adapted lineages in municipal wastewater treatment plants indicates widespread distribution and release into the environment
inferredcites →https://doi.org/10.1111/1462-2920.13942openalex-snapshot
Strong impact of anthropogenic contamination on the co‐occurrence patterns of a riverine microbial community
inferredcites →https://doi.org/10.1111/j.1469-0691.2003.00739.xopenalex-snapshot
Promoting resistance by the emission of antibiotics from hospitals and households into effluent
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Environmental Escherichia coli : ecology and public health implications-a review
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Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence
inferredcites →https://doi.org/10.1128/aac.01182-10openalex-snapshot
Selective Advantage of Resistant Strains at Trace Levels of Antibiotics: a Simple and Ultrasensitive Color Test for Detection of Antibiotics and Genotoxic Agents
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Spread of bla CTX-M-14 Is Driven Mainly by IncK Plasmids Disseminated among Escherichia coli Phylogroups A, B1, and D in Spain
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Sublethal Exposure to Commercial Formulations of the Herbicides Dicamba, 2,4-Dichlorophenoxyacetic Acid, and Glyphosate Cause Changes in Antibiotic Susceptibility in Escherichia coli and Salmonella enterica serovar Typhimurium
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inferredcites →https://doi.org/10.1371/journal.pone.0078906openalex-snapshot
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Low Flows 2000: a national water resources assessment and decision support tool
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ECDC/EFSA/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food‐producing animals
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Water, Water Everywhere, but Every Drop Unique: Challenges in the Science to Understand the Role of Contaminants of Emerging Concern in the Management of Drinking Water Supplies
inferred← citeshttps://doi.org/10.1038/s41598-021-98300-5openalex-snapshot
Quantifying and predicting antimicrobials and antimicrobial resistance genes in waterbodies through a holistic approach: a study in Minnesota, United States
inferred← citeshttps://doi.org/10.1038/s44259-025-00149-5openalex-snapshot
Environmental hazards from pollution of antibiotics and resistance-driving chemicals in an urban river network from Malawi
inferred← citeshttps://doi.org/10.1039/d2ew00637eopenalex-snapshot
Combined sewer overflows: relating event duration monitoring data to wastewater systems' capacity in England
inferred← citeshttps://doi.org/10.1080/10934529.2021.1923311openalex-snapshot
Antibiotic residues in the aquatic environment – current perspective and risk considerations
inferred← citeshttps://doi.org/10.1080/27658511.2025.2479897openalex-snapshot
Antibiotic resistance genes in E. coli strains isolated from Bagua drinking water, under the One Health approach
inferred← citeshttps://doi.org/10.1101/2020.06.05.133348openalex-snapshot
Impact of trimethoprim on the river microbiome and antimicrobial resistance
inferred← citeshttps://doi.org/10.1101/2025.04.15.25325896openalex-snapshot
Environmental hazards from pollution of antibiotics and resistance-driving chemicals in urban river networks of Malawi
inferred← citeshttps://doi.org/10.1108/ijphm-12-2020-0104openalex-snapshot
The relationship among corporate social responsibility, sustainability and organizational performance in pharmaceutical sector: a literature review
inferred← citeshttps://doi.org/10.1128/aac.00997-24openalex-snapshot
Insights into antibiotic resistance promoted by quinolone exposure
inferred← citeshttps://doi.org/10.1136/bmjopen-2019-035502openalex-snapshot
Chinese physicians’ attitudes toward eco-directed sustainable prescribing from the perspective of ecopharmacovigilance: a cross-sectional study
inferred← citeshttps://doi.org/10.1146/annurev-animal-072020-080638openalex-snapshot
Beyond Antimicrobial Use: A Framework for Prioritizing Antimicrobial Resistance Interventions
inferred← citeshttps://doi.org/10.1186/s12302-025-01180-zopenalex-snapshot
Continuous improvement towards environmental protection for pharmaceuticals: advancing a strategy for Europe
inferred← citeshttps://doi.org/10.1186/s12911-021-01727-zopenalex-snapshot
PrAna: an R package to calculate and visualize England NHS primary care prescribing data
inferred← citeshttps://doi.org/10.1186/s12982-025-00557-yopenalex-snapshot
Climate change and antimicrobial resistance: application of one health approach to mitigating dual global threats
inferred← citeshttps://doi.org/10.1186/s42523-025-00434-8openalex-snapshot
Impacts of environmentally relevant concentrations of antibiotic cocktails on the skin microbiome of Eurasian carp (Cyprinus carpio)
inferred← citeshttps://doi.org/10.2174/0118742858416239250822063901openalex-snapshot
Artemia, Probiotics, And Immunostimulant: Essential Elements For Optimal Litopenaeus vannamei Shrimp Production
inferred← citeshttps://doi.org/10.32920/25260832openalex-snapshot
Impact of zinc and copper on antibiotic resistance and conjugative plasmid transfer in bacteria isolated from wastewater treatment plants
inferred← citeshttps://doi.org/10.32920/25260832.v1openalex-snapshot
Impact of zinc and copper on antibiotic resistance and conjugative plasmid transfer in bacteria isolated from wastewater treatment plants
inferred← citeshttps://doi.org/10.3390/antibiotics10111428openalex-snapshot
Quantifying the Gap between Expected and Actual Rates of Antibiotic Prescribing in British Columbia, Canada
inferred← citeshttps://doi.org/10.3390/antibiotics13060565openalex-snapshot
Non-Canonical Aspects of Antibiotics and Antibiotic Resistance
inferred← citeshttps://doi.org/10.3390/antibiotics15010082openalex-snapshot
Antimicrobial Resistance: How Can We Overcome the Problem?
inferred← citeshttps://doi.org/10.3390/chemistry7060197openalex-snapshot
Electron Interaction-Enhanced Photocatalytic Degradation of Tetracycline over Fe/UIO-66
inferred← citeshttps://doi.org/10.3390/ijerph22030353openalex-snapshot
Detection of Antibiotic-Resistance Genes in Drinking Water: A Study at a University in the Peruvian Amazon
inferred← citeshttps://doi.org/10.3390/w13162225openalex-snapshot
Targeted Hydrolysis of β-Lactam Antibiotics in Dry Suspension Residue: A Proposed Method to Reduce Ecological Toxicity and Bacterial Resistance
inferred← citeshttps://doi.org/10.38126/jspg180209openalex-snapshot
Phytoremediation Strategies for United Kingdom River Health in the Flood of Climate Change
inferred← citeshttps://doi.org/10.3934/environsci.2021002openalex-snapshot
Antibiotic resistance from, and to the environment
inferred← citeshttps://doi.org/10.5713/ab.24.0685openalex-snapshot
— Invited Review — Challenges and constraints to the sustainability of poultry farming in Thailand
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.