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Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens

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1 of the 38 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1056/nejmoa2007621 (notice 2020-06-04).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2020.4683openalex-snapshot
Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy
inferredcites →https://doi.org/10.1001/jama.2020.4812openalex-snapshot
COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers
inferredcites →https://doi.org/10.1001/jamacardio.2020.1282openalex-snapshot
Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers
inferredcites →https://doi.org/10.1001/jamacardio.2020.1624openalex-snapshot
Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China
inferredcites →https://doi.org/10.1001/jamacardio.2020.1855openalex-snapshot
Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19)
inferredcites →https://doi.org/10.1016/j.bbrc.2003.11.054openalex-snapshot
The SARS-CoV S glycoprotein: expression and functional characterization
inferredcites →https://doi.org/10.1016/j.cell.2020.02.052openalex-snapshot
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
inferredcites →https://doi.org/10.1016/j.phrs.2017.06.005openalex-snapshot
The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases
inferredcites →https://doi.org/10.1016/s2213-2600(20)30079-5openalex-snapshot
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study
inferredcites →https://doi.org/10.1016/s2213-2600(20)30116-8openalex-snapshot
Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
inferredcites →https://doi.org/10.1038/nature02145openalex-snapshot
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
inferredcites →https://doi.org/10.1038/nm1267openalex-snapshot
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
inferredcites →https://doi.org/10.1038/s41569-020-0360-5openalex-snapshot
COVID-19 and the cardiovascular system
inferredcites →https://doi.org/10.1038/s41586-020-2521-4openalex-snapshot
Factors associated with COVID-19-related death using OpenSAFELY
inferredcites →https://doi.org/10.1056/nejme2012924openalex-snapshot
Inhibitors of the Renin–Angiotensin–Aldosterone System and Covid-19
inferredcites →https://doi.org/10.1056/nejmoa2002032openalex-snapshot
Clinical Characteristics of Coronavirus Disease 2019 in China
inferredcites →https://doi.org/10.1056/nejmoa2006923openalex-snapshot
Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19
inferredcites →https://doi.org/10.1056/nejmoa2007621openalex-snapshot
RETRACTED: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19
inferredcites →https://doi.org/10.1056/nejmoa2008975openalex-snapshot
Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19
inferredcites →https://doi.org/10.1056/nejmsr2005760openalex-snapshot
Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
inferredcites →https://doi.org/10.1093/ajh/hpu086openalex-snapshot
Urinary Angiotensin-Converting Enzyme 2 in Hypertensive Patients May Be Increased by Olmesartan, an Angiotensin II Receptor Blocker
inferredcites →https://doi.org/10.1093/eurheartj/ehaa235openalex-snapshot
SARS-CoV2: should inhibitors of the renin–angiotensin system be withdrawn in patients with COVID-19?
inferredcites →https://doi.org/10.1093/eurheartj/ehaa335openalex-snapshot
Switching antihypertensive therapy in times of COVID-19: why we should wait for the evidence
inferredcites →https://doi.org/10.1097/00004872-199606000-00017openalex-snapshot
Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension
inferredcites →https://doi.org/10.1097/hjh.0000000000002450openalex-snapshot
Can angiotensin receptor-blocking drugs perhaps be harmful in the COVID-19 pandemic?
inferredcites →https://doi.org/10.1111/all.14238openalex-snapshot
Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China
inferredcites →https://doi.org/10.1136/bmj.m1198openalex-snapshot
Covid-19: risk factors for severe disease and death
inferredcites →https://doi.org/10.1136/bmj.m1313openalex-snapshot
Drugs and the renin-angiotensin system in covid-19
inferredcites →https://doi.org/10.1136/bmj.m810openalex-snapshot
Preventing a covid-19 pandemic
inferredcites →https://doi.org/10.1152/ajpcell.00145.2008openalex-snapshot
MAP kinase/phosphatase pathway mediates the regulation of ACE2 by angiotensin peptides
inferredcites →https://doi.org/10.1152/ajpheart.00068.2005openalex-snapshot
Angiotensin II AT1 receptors regulate ACE2 and angiotensin-(1–7) expression in the aorta of spontaneously hypertensive rats
inferredcites →https://doi.org/10.1152/ajprenal.90488.2008openalex-snapshot
Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan
inferredcites →https://doi.org/10.1161/01.cir.0000094734.67990.99openalex-snapshot
Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles
inferredcites →https://doi.org/10.1161/01.hyp.0000124667.34652.1aopenalex-snapshot
Upregulation of Angiotensin-Converting Enzyme 2 After Myocardial Infarction by Blockade of Angiotensin II Receptors
inferredcites →https://doi.org/10.1161/circresaha.120.317134openalex-snapshot
Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19
inferredcites →https://doi.org/10.1161/circulationaha.104.510461openalex-snapshot
Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2
inferredcites →https://doi.org/10.1161/hypertensionaha.120.15082openalex-snapshot
Renin-Angiotensin System Blockers and the COVID-19 Pandemic
inferredcites →https://doi.org/10.2807/1560-7917.es.2020.25.3.2000045openalex-snapshot
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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RAAS Blockers and Region-Specific Variations in COVID-19 Outcomes: Findings from a Systematic Review and Meta-Analysis
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Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19
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Association Between Renin-Angiotensin-Aldosterone System Inhibitors and Clinical Outcomes in Patients With COVID-19
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COVID-19 and its cardiovascular effects: a systematic review of prevalence studies
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Is it all in the heart? Myocardial injury as major predictor of mortality among hospitalized COVID‐19 patients
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A systematic review and meta‐analysis of the use of renin‐angiotensin system drugs and COVID‐19 clinical outcomes: What is the evidence so far?
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Impact of cardiovascular disease on clinical outcomes in hospitalized patients with Covid-19: a systematic review and meta-analysis
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Renin–angiotensin system modulation and outcomes in patients hospitalized for interstitial SARS-CoV2 pneumonia: a cohort study
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Renin–Angiotensin–Aldosterone Inhibitors and COVID-19 Infection
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Safety and Efficacy of Renin–Angiotensin–Aldosterone System Inhibitors in COVID-19 Population
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The association of diabetes with COVID-19 disease severity: evidence from adjusted effect estimates
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Discontinuing vs continuing ACEIs and ARBs in hospitalized patients with COVID-19 according to disease severity: Insights from the BRACE CORONA trial
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Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis
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Hypertension, Diabetes and Obesity, Major Risk Factors for Death in Patients with COVID-19 in Mexico
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Is Cancer an Independent Risk Factor for Fatal Outcomes of Coronavirus Disease 2019 Patients?
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Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs
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Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors in COVID-19: Meta-analysis/Meta-regression Adjusted for Confounding Factors
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Prediction of death status on the course of treatment in SARS-COV-2 patients with deep learning and machine learning methods
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COPD and the risk of poor outcomes in COVID-19: A systematic review and meta-analysis
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Lack of association of antihypertensive drugs with the risk and severity of COVID-19: A meta-analysis
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A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
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Risk Factors and Clinical Phenotypes Associated with Severity in Patients with COVID-19 in Northeast Mexico
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The Effect of Prior Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Treatment on Coronavirus Disease 2019 (COVID-19) Susceptibility and Outcome: A Systematic Review and Meta-analysis
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Association between renin–angiotensin–aldosterone system blockers and outcome in coronavirus disease 2019: analysing in-hospital exposure generates a biased seemingly protective effect of treatment
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Determinants of healing among patients with coronavirus disease 2019: the results of the SARS-RAS study of the Italian Society of Hypertension
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Renin–angiotensin-system inhibitors and all-cause mortality in patients with COVID-19: a systematic review and meta-analysis of observational studies
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Mortality and use of angiotensin-converting enzyme inhibitors in COVID 19 disease: a systematic review
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Association Between ACEIs or ARBs Use and Clinical Outcomes in COVID-19 Patients: A Systematic Review and Meta-analysis
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Renin Angiotensin System Inhibition and Susceptibility and Outcomes from COVID-19: A Systematic Review and Meta-analysis of 69,200 COVID-19 Patients
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Risk factors associated with severe outcomes of COVID-19: A systematic rapid review to inform national guidance on vaccine prioritization in Canada
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Comparison of infection risks and clinical outcomes in patients with and without SARS‐CoV‐2 lung infection under renin–angiotensin–aldosterone system blockade: Systematic review and meta‐analysis
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Use of inhibitors of the renin‐angiotensin system in hypertensive patients and COVID‐19 severity: A systematic review and meta‐analysis
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Renin‐Angiotensin Aldosterone System Inhibitors and COVID‐19: A Systematic Review and Meta‐Analysis Revealing Critical Bias Across a Body of Observational Research
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Renin–angiotensin–aldosterone system blockers and region-specific variations in COVID-19 outcomes: findings from a systematic review and meta-analysis
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Nicotine treatment and smoking cessation in the era of COVID-19 pandemic: an interesting alliance
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Characteristics of the COVID-19 Epidemiological Situation in the Russian Federation in 2020
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Presenting characteristics, comorbidities, and outcomes among 390 patients hospitalized with COVID-19 pneumonia in a tertiary hospital
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THE RELATIONSHIP BETWEEN COVID-19 SEVERITY AND THE USAGE OF ANGIOTENSIN-II RECEPTOR BLOCKERS IN HYPERTENSIVE PATIENTS
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Associations Between the Use of Renin–Angiotensin System Inhibitors and the Risks of Severe COVID-19 and Mortality in COVID-19 Patients With Hypertension: A Meta-Analysis of Observational Studies
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Mortality and Severity in COVID-19 Patients on ACEIs and ARBs—A Systematic Review, Meta-Analysis, and Meta-Regression Analysis
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Controversial Roles of the Renin Angiotensin System and Its Modulators During the COVID-19 Pandemic
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Low eGFR Is a Strong Predictor of Worse Outcome in Hospitalized COVID-19 Patients
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The Role of Health Preconditions on COVID-19 Deaths in Portugal: Evidence from Surveillance Data of the First 20293 Infection Cases
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Evolution of COVID-19 mortality over time: results from the Swiss hospital surveillance system (CH-SUR)
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Additional file 1 of Comparison of renin–angiotensin–aldosterone system inhibitors with other antihypertensives in association with coronavirus disease-19 clinical outcomes
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Additional file 1 of A meta-analysis on the risk factors adjusted association between cardiovascular disease and COVID-19 severity
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Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19
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Update Alert: Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults
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Update Alert 2: Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults
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Update Alert 7: Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults
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