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Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism

https://doi.org/10.1371/journal.pone.0251067
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00253-008-1523-1openalex-snapshot
Cloning and functional characterization of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus
inferredcites →https://doi.org/10.1016/j.drudis.2017.04.012openalex-snapshot
Targeting isocitrate lyase for the treatment of latent tuberculosis
inferredcites →https://doi.org/10.1016/j.immuni.2018.11.017openalex-snapshot
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons
inferredcites →https://doi.org/10.1038/35021074openalex-snapshot
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
inferredcites →https://doi.org/10.1038/77964openalex-snapshot
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
inferredcites →https://doi.org/10.1038/nature25986openalex-snapshot
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
inferredcites →https://doi.org/10.1038/nm1252openalex-snapshot
Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
inferredcites →https://doi.org/10.1038/s41467-019-12614-7openalex-snapshot
Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
inferredcites →https://doi.org/10.1038/s41577-019-0128-5openalex-snapshot
Itaconate: the poster child of metabolic reprogramming in macrophage function
inferredcites →https://doi.org/10.1038/s41598-020-75799-8openalex-snapshot
Demystifying the catalytic pathway of Mycobacterium tuberculosis isocitrate lyase
inferredcites →https://doi.org/10.1039/d0md00301hopenalex-snapshot
Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase
inferredcites →https://doi.org/10.1073/pnas.1218599110openalex-snapshot
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
inferredcites →https://doi.org/10.1073/pnas.1400390111openalex-snapshot
Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids
inferredcites →https://doi.org/10.1073/pnas.1705949114openalex-snapshot
CIDE domains form functionally important higher-order assemblies for DNA fragmentation
inferredcites →https://doi.org/10.1073/pnas.1908770116openalex-snapshot
Crystal structure of cis -aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis
inferredcites →https://doi.org/10.1074/jbc.m116.741082openalex-snapshot
ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces
inferredcites →https://doi.org/10.1084/jem.20180118openalex-snapshot
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection
inferredcites →https://doi.org/10.1093/protein/8.2.127openalex-snapshot
LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions
inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot
Coot : model-building tools for molecular graphics
inferredcites →https://doi.org/10.1107/s0907444906045975openalex-snapshot
Solving structures of protein complexes by molecular replacement with Phaser
inferredcites →https://doi.org/10.1107/s0907444909042073openalex-snapshot
MolProbity : all-atom structure validation for macromolecular crystallography
inferredcites →https://doi.org/10.1107/s0907444909052925openalex-snapshot
PHENIX : a comprehensive Python-based system for macromolecular structure solution
inferredcites →https://doi.org/10.1111/j.1365-2958.2006.05297.xopenalex-snapshot
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/iai.37.3.1042-1049.1982openalex-snapshot
Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions
inferredcites →https://doi.org/10.1128/jb.131.1.136-144.1977openalex-snapshot
Itaconate, an isocitrate lyase-directed inhibitor in Pseudomonas indigofera
inferredcites →https://doi.org/10.1155/2015/895453openalex-snapshot
Potential Inhibitors for Isocitrate Lyase ofMycobacterium tuberculosisand Non-M. tuberculosis: A Summary
inferredcites →https://doi.org/10.1172/jci99169openalex-snapshot
Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors
inferredcites →https://doi.org/10.1186/s12929-019-0546-5openalex-snapshot
The glyoxylate cycle and alternative carbon metabolism as metabolic adaptation strategies of Candida glabrata: perspectives from Candida albicans and Saccharomyces cerevisiae
inferredcites →https://doi.org/10.2174/092986712804485782openalex-snapshot
Advances in Mycobacterial Isocitrate Lyase Targeting and Inhibitors
inferredcites →https://doi.org/10.2174/1872213x11307020003openalex-snapshot
Isocitrate Lyase: A Potential Target for Anti-Tubercular Drugs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3897/pharmacia.73.e182414zenodo-depositor-declared
Pharmaceutical development of a medicinal product containing an isocitrate lyase inhibitor
inferred← citeshttps://doi.org/10.1016/j.bbagen.2022.130130openalex-snapshot
Rv1915 and Rv1916 from Mycobacterium tuberculosis H37Rv form in vitro protein-protein complex
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114737openalex-snapshot
In situ chemoproteomic profiling reveals itaconate inhibits de novo purine biosynthesis in pathogens
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.116058openalex-snapshot
The significance of persisters in tuberculosis drug discovery: Exploring the potential of targeting the glyoxylate shunt pathway
inferred← citeshttps://doi.org/10.1016/j.sajb.2025.04.021openalex-snapshot
Plant-based multi-target directed antitubercular ligand identification from Ipomoea sepiaria with application of bioinformatics methodology
inferred← citeshttps://doi.org/10.1021/acs.jproteome.3c00772openalex-snapshot
Unraveling the Mechanisms of Efficient Phosphorus Utilization in Popcorn (Zea mays L. var. everta): Insights from Proteomic and Metabolite Analysis
inferred← citeshttps://doi.org/10.1073/pnas.2423114122openalex-snapshot
Itaconate mechanism of action and dissimilation in Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1080/07391102.2024.2404145openalex-snapshot
Cheminformatics-enhanced discovery of therapeutic agents targeting isocitrate lyase in Mycobacterium tuberculosis infections
inferred← citeshttps://doi.org/10.1093/lambio/ovad044openalex-snapshot
Characterization of a salt-resistant isocitrate lyase gene from mangrove wetland using shotgun metagenomic sequencing
inferred← citeshttps://doi.org/10.1109/icbcb64873.2025.11198064openalex-snapshot
Target Identification of Bio-Inhibitor Against Mycobacterium Tuberculosis by Subtractive Proteomics Approach
inferred← citeshttps://doi.org/10.1186/s40001-025-02443-4openalex-snapshot
Host-directed therapy for tuberculosis
inferred← citeshttps://doi.org/10.2174/0929866529666221006121831openalex-snapshot
Lessons Learnt and the Way Forward for Drug Development Against Isocitrate Lyase from Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.3390/bioengineering9110633openalex-snapshot
Integrated Bioinformatics-Based Subtractive Genomics Approach to Decipher the Therapeutic Drug Target and Its Possible Intervention against Brucellosis
inferred← citeshttps://doi.org/10.3390/molecules26237082openalex-snapshot
An Outline of the Latest Crystallographic Studies on Inhibitor-Enzyme Complexes for the Design and Development of New Therapeutics against Tuberculosis
inferred← citeshttps://doi.org/10.3390/ph19050707openalex-snapshot
Covalent Inhibitors Targeting Mycobacterial Enzymes: Current Status, Challenges and Future Perspectives
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