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Characterizing inhibitors of human AP endonuclease 1

https://doi.org/10.1371/journal.pone.0280526

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/emmm.200900041openalex-snapshot

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

inferredcites →https://doi.org/10.1002/ijc.25900openalex-snapshot

Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma

inferredcites →https://doi.org/10.1002/ijc.27512openalex-snapshot

Synthetic lethal targeting of DNA double‐strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

inferredcites →https://doi.org/10.1006/jmbi.2001.4529openalex-snapshot

Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, ape1: implications for the catalytic mechanism 1 1Edited by I. A. Wilson

inferredcites →https://doi.org/10.1007/bf00197809openalex-snapshot

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

inferredcites →https://doi.org/10.1007/s12104-009-9196-yopenalex-snapshot

Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1

inferredcites →https://doi.org/10.1007/s12154-015-0131-7openalex-snapshot

Design and activity of AP endonuclease-1 inhibitors

inferredcites →https://doi.org/10.1016/b978-0-12-387665-2.00006-7openalex-snapshot

Oxidized Base Damage and Single-Strand Break Repair in Mammalian Genomes

inferredcites →https://doi.org/10.1016/j.cell.2011.03.022openalex-snapshot

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

inferredcites →https://doi.org/10.1016/j.dnarep.2007.09.008openalex-snapshot

Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth

inferredcites →https://doi.org/10.1016/j.nantod.2018.02.011openalex-snapshot

Colloidal aggregation: From screening nuisance to formulation nuance

inferredcites →https://doi.org/10.1016/j.pbiomolbio.2020.10.005openalex-snapshot

Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

inferredcites →https://doi.org/10.1016/s0021-9258(19)69623-7openalex-snapshot

Purification and characterization of an apurinic/apyrimidinic endonuclease from HeLa cells.

inferredcites →https://doi.org/10.1021/acs.chemrev.6b00191openalex-snapshot

Role of Base Excision “Repair” Enzymes in Erasing Epigenetic Marks from DNA

inferredcites →https://doi.org/10.1021/acs.jmedchem.1c01547openalex-snapshot

Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens

inferredcites →https://doi.org/10.1021/acs.jmedchem.8b01529openalex-snapshot

Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1

inferredcites →https://doi.org/10.1021/acs.jmedchem.9b01019openalex-snapshot

Protein Stability Effects in Aggregate-Based Enzyme Inhibition

inferredcites →https://doi.org/10.1021/bi201071gopenalex-snapshot

NMR Studies Reveal an Unexpected Binding Site for a Redox Inhibitor of AP Endonuclease 1

inferredcites →https://doi.org/10.1021/bi500676popenalex-snapshot

High-Resolution Crystal Structures Reveal Plasticity in the Metal Binding Site of Apurinic/Apyrimidinic Endonuclease I

inferredcites →https://doi.org/10.1021/jm010533yopenalex-snapshot

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

inferredcites →https://doi.org/10.1021/jm030266ropenalex-snapshot

A Specific Mechanism of Nonspecific Inhibition

inferredcites →https://doi.org/10.1021/jm0340896openalex-snapshot

Effect of Detergent on “Promiscuous” Inhibitors

inferredcites →https://doi.org/10.1021/jm201537dopenalex-snapshot

Synthesis, Biological Evaluation, and Structure–Activity Relationships of a Novel Class of Apurinic/Apyrimidinic Endonuclease 1 Inhibitors

inferredcites →https://doi.org/10.1038/35000249openalex-snapshot

DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

inferredcites →https://doi.org/10.1038/362709a0openalex-snapshot

Instability and decay of the primary structure of DNA

inferredcites →https://doi.org/10.1038/nature03443openalex-snapshot

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

inferredcites →https://doi.org/10.1038/nature03445openalex-snapshot

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

inferredcites →https://doi.org/10.1038/nprot.2006.77openalex-snapshot

A detergent-based assay for the detection of promiscuous inhibitors

inferredcites →https://doi.org/10.1038/nsmb.3105openalex-snapshot

Capturing snapshots of APE1 processing DNA damage

inferredcites →https://doi.org/10.1038/sj.bjc.6605541openalex-snapshot

Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers

inferredcites →https://doi.org/10.1038/sj.bjc.6606058openalex-snapshot

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

inferredcites →https://doi.org/10.1039/b616314aopenalex-snapshot

Stability and equilibria of promiscuous aggregates in high protein milieus

inferredcites →https://doi.org/10.1074/jbc.272.2.1302openalex-snapshot

Substrate Binding by Human Apurinic/Apyrimidinic Endonuclease Indicates a Briggs-Haldane Mechanism

inferredcites →https://doi.org/10.1074/jbc.m110.146498openalex-snapshot

Distinct Roles of Ape1 Protein in the Repair of DNA Damage Induced by Ionizing Radiation or Bleomycin

inferredcites →https://doi.org/10.1074/jbc.m704253200openalex-snapshot

Excision of 5-Halogenated Uracils by Human Thymine DNA Glycosylase

inferredcites →https://doi.org/10.1074/jbc.m805504200openalex-snapshot

Coordinating the Initial Steps of Base Excision Repair

inferredcites →https://doi.org/10.1089/ars.2013.5492openalex-snapshot

Human Apurinic/Apyrimidinic Endonuclease 1

inferredcites →https://doi.org/10.1093/bioinformatics/btu830openalex-snapshot

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

inferredcites →https://doi.org/10.1093/carcin/21.5.329openalex-snapshot

Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species

inferredcites →https://doi.org/10.1093/emboj/16.21.6548openalex-snapshot

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites

inferredcites →https://doi.org/10.1093/nar/gkh676openalex-snapshot

APE1 is the major 3'-phosphoglycolate activity in human cell extracts

inferredcites →https://doi.org/10.1093/nar/gki781openalex-snapshot

Isolation of a small molecule inhibitor of DNA base excision repair

inferredcites →https://doi.org/10.1093/nar/gkv890openalex-snapshot

Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA

inferredcites →https://doi.org/10.1093/nar/gkw768openalex-snapshot

Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues

inferredcites →https://doi.org/10.1107/s0021889805038987openalex-snapshot

TLSMDweb server for the generation of multi-group TLS models

inferredcites →https://doi.org/10.1107/s0021889892009944openalex-snapshot

PROCHECK: a program to check the stereochemical quality of protein structures

inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot

Coot : model-building tools for molecular graphics

inferredcites →https://doi.org/10.1107/s0907444905001617openalex-snapshot

Likelihood-enhanced fast translation functions

inferredcites →https://doi.org/10.1107/s0907444906005270openalex-snapshot

Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

inferredcites →https://doi.org/10.1107/s0907444909047337openalex-snapshot

XDS

inferredcites →https://doi.org/10.1107/s090744491003982xopenalex-snapshot

An introduction to data reduction: space-group determination, scaling and intensity statistics

inferredcites →https://doi.org/10.1107/s0907444910045749openalex-snapshot

Overview of the CCP 4 suite and current developments

inferredcites →https://doi.org/10.1107/s0907444912001308openalex-snapshot

Towards automated crystallographic structure refinement with phenix.refine

inferredcites →https://doi.org/10.1107/s0907444913027042openalex-snapshot

Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+cofactor

inferredcites →https://doi.org/10.1124/jpet.110.169128openalex-snapshot

Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells

inferredcites →https://doi.org/10.1124/mol.107.042622openalex-snapshot

Potent Inhibition of Human Apurinic/Apyrimidinic Endonuclease 1 by Arylstibonic Acids

inferredcites →https://doi.org/10.1126/science.1187945openalex-snapshot

Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway

inferredcites →https://doi.org/10.1126/science.1218231openalex-snapshot

Linking Crystallographic Model and Data Quality

inferredcites →https://doi.org/10.1126/science.abc6506openalex-snapshot

A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions

inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-1161openalex-snapshot

Apurinic Endonuclease Activity in Adult Gliomas and Time to Tumor Progression after Alkylating Agent-Based Chemotherapy and after Radiotherapy

inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-1068openalex-snapshot

Apurinic/Apyrimidinic Endonuclease Activity Is Associated with Response to Radiation and Chemotherapy in Medulloblastoma and Primitive Neuroectodermal Tumors

inferredcites →https://doi.org/10.1158/1541-7786.mcr-06-0329openalex-snapshot

A Dominant-Negative Form of the Major Human Abasic Endonuclease Enhances Cellular Sensitivity to Laboratory and Clinical DNA-Damaging Agents

inferredcites →https://doi.org/10.1158/1541-7786.mcr-08-0519openalex-snapshot

Impairment of APE1 Function Enhances Cellular Sensitivity to Clinically Relevant Alkylators and Antimetabolites

inferredcites →https://doi.org/10.1371/journal.pone.0005740openalex-snapshot

Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1

inferredcites →https://doi.org/10.1371/journal.pone.0047974openalex-snapshot

Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection

inferredcites →https://doi.org/10.18632/oncotarget.1926openalex-snapshot

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy

inferredcites →https://doi.org/10.2174/1874467211205010003openalex-snapshot

Overview of Base Excision Repair Biochemistry

inferredcites →https://doi.org/10.2174/1874467211205010014openalex-snapshot

Small-Molecule Inhibitors of APE1 DNA Repair Function: An Overview

inferredcites →https://doi.org/10.3389/fonc.2012.00176openalex-snapshot

Repair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomide

inferredcites →https://doi.org/10.3390/antiox11091817openalex-snapshot

Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene Expression

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4527933openalex-extracted

Chemically Induced Partial Unfolding of the Multifunctional Apurinic/Apyrimidinic Endonuclease 1

inferred← citeshttps://doi.org/10.1002/cplu.202400696openalex-snapshot

Antimicrobial Potential of a Formazanate‐Based Mercury(II) Complex: In Vitro ‐ and In Silico ‐Based Insights

inferred← citeshttps://doi.org/10.1002/pro.70148openalex-snapshot

Chemically induced partial unfolding of the multifunctional apurinic/apyrimidinic endonuclease 1

inferred← citeshttps://doi.org/10.1007/s10456-024-09966-0openalex-snapshot

Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor

inferred← citeshttps://doi.org/10.1007/s11033-023-08946-9openalex-snapshot

The APE1/REF-1 and the hallmarks of cancer

inferred← citeshttps://doi.org/10.1016/j.dnarep.2025.103879openalex-snapshot

Base excision repair in human cancer: Emerging diagnostic and therapeutic target

inferred← citeshttps://doi.org/10.1021/acsabm.5c01172openalex-snapshot

Green Synthesis of Gold Nanoparticles and Their Cytotoxic Effect in Breast Cancer: An Experimental and Theoretical Study

inferred← citeshttps://doi.org/10.1021/acsnano.6c00255openalex-snapshot

Enzymatic Cascade-Powered Urinary Diagnostics for Visual Cancer Monitoring

inferred← citeshttps://doi.org/10.1021/acssensors.5c00730openalex-snapshot

Real-Time, Light-Activated, and Multiplexed Monitoring of Base Excision Repair in Living Cells Using Chimeric d / l -DNA Molecular Beacons

inferred← citeshttps://doi.org/10.1038/s41598-026-51975-0openalex-snapshot

Structure-based virtual screening identifies novel small-molecule inhibitors targeting the endonuclease active site of APE1

inferred← citeshttps://doi.org/10.1039/d4ra01387eopenalex-snapshot

Recent advances on anticancer and antimicrobial activities of directly-fluorinated five-membered heterocycles and their benzo-fused systems

inferred← citeshttps://doi.org/10.1186/s13046-026-03705-7openalex-snapshot

Targeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer

inferred← citeshttps://doi.org/10.2174/0109298665338519241114103223openalex-snapshot

Targeting APE1: Advancements in the Diagnosis and Treatment of Tumors

inferred← citeshttps://doi.org/10.3389/fcell.2024.1436563openalex-snapshot

How to sensitize glioblastomas to temozolomide chemotherapy: a gap-centered view

inferred← citeshttps://doi.org/10.3390/cells12141895openalex-snapshot

Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons

inferred← citeshttps://doi.org/10.3390/ijms242316637openalex-snapshot

A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1

inferred← citeshttps://doi.org/10.3390/ijms26136420openalex-snapshot

Anticancer Activity of Roburic Acid: In Vitro and In Silico Investigation

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