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Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/9780470942390.mo110173openalex-snapshot
The Mouse as Model System to Study Host‐Pathogen Interactions in Influenza A Infections
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An endoprotease homologous to the blood clotting factor X as a determinant of viral tropism in chick embryo.
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Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin‐like endoprotease.
inferredcites →https://doi.org/10.1002/jmv.1890210208openalex-snapshot
High protection of animals lethally infected with influenza virus by aprotinin‐rimantadine combination
inferredcites →https://doi.org/10.1002/rmv.657openalex-snapshot
Novel insights into proteolytic cleavage of influenza virus hemagglutinin
inferredcites →https://doi.org/10.1016/0014-5793(92)80303-xopenalex-snapshot
Isolation of factor Xa from chick embryo as the amniotic endoprotease responsible for paramyxovirus activation
inferredcites →https://doi.org/10.1016/0042-6822(75)90284-6openalex-snapshot
Activation of influenza A viruses by trypsin treatment
inferredcites →https://doi.org/10.1016/0042-6822(75)90285-8openalex-snapshot
Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide
inferredcites →https://doi.org/10.1016/0166-3542(94)90038-8openalex-snapshot
Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice
inferredcites →https://doi.org/10.1016/j.antiviral.2011.07.014openalex-snapshot
Aprotinin and similar protease inhibitors as drugs against influenza
inferredcites →https://doi.org/10.1016/j.jviromet.2010.02.009openalex-snapshot
Characterization of lentiviral pseudotypes with influenza H5N1 hemagglutinin and their performance in neutralization assays
inferredcites →https://doi.org/10.1016/j.vaccine.2012.09.078openalex-snapshot
Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus
inferredcites →https://doi.org/10.1016/j.virol.2010.12.047openalex-snapshot
Pathogenicity of different PR8 influenza A virus variants in mice is determined by both viral and host factors
inferredcites →https://doi.org/10.1016/s0021-9258(18)42250-8openalex-snapshot
Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein.
inferredcites →https://doi.org/10.1016/s1473-3099(11)70318-8openalex-snapshot
Antiviral resistance during the 2009 influenza A H1N1 pandemic: public health, laboratory, and clinical perspectives
inferredcites →https://doi.org/10.1046/j.1432-1327.2001.02166.xopenalex-snapshot
Mini‐plasmin found in the epithelial cells of bronchioles triggers infection by broad‐spectrum influenza A viruses and Sendai virus
inferredcites →https://doi.org/10.1073/pnas.0507415102openalex-snapshot
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host
inferredcites →https://doi.org/10.1073/pnas.0701849104openalex-snapshot
Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene
inferredcites →https://doi.org/10.1074/jbc.m112.440362openalex-snapshot
Cleavage Activation of Human-adapted Influenza Virus Subtypes by Kallikrein-related Peptidases 5 and 12
inferredcites →https://doi.org/10.1084/jem.150.1.117openalex-snapshot
Natural, genetically determined resistance toward influenza virus in hemopoietic mouse chimeras. Role of mononuclear phagocytes.
inferredcites →https://doi.org/10.1099/0022-1317-65-1-191openalex-snapshot
Suppression of Influenza Virus Replication in Infected Mice by Protease Inhibitors
inferredcites →https://doi.org/10.1128/jvi.00128-13openalex-snapshot
The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies
inferredcites →https://doi.org/10.1128/jvi.00239-10openalex-snapshot
TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells
inferredcites →https://doi.org/10.1128/jvi.00306-12openalex-snapshot
Cleavage Activation of the Human-Adapted Influenza Virus Subtypes by Matriptase Reveals both Subtype and Strain Specificities
inferredcites →https://doi.org/10.1128/jvi.00676-08openalex-snapshot
Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2
inferredcites →https://doi.org/10.1128/jvi.01118-06openalex-snapshot
Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium
inferredcites →https://doi.org/10.1128/jvi.01294-10openalex-snapshot
Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2
inferredcites →https://doi.org/10.1128/jvi.01542-10openalex-snapshot
Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2
inferredcites →https://doi.org/10.1128/jvi.01890-13openalex-snapshot
Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2
inferredcites →https://doi.org/10.1128/jvi.02062-10openalex-snapshot
A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
inferredcites →https://doi.org/10.1128/jvi.02205-08openalex-snapshot
Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin
inferredcites →https://doi.org/10.1128/jvi.02232-10openalex-snapshot
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
inferredcites →https://doi.org/10.1128/jvi.74.14.6309-6315.2000openalex-snapshot
Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?
inferredcites →https://doi.org/10.1128/jvi.76.17.8682-8689.2002openalex-snapshot
Cleavage of Influenza A Virus Hemagglutinin in Human Respiratory Epithelium Is Cell Associated and Sensitive to Exogenous Antiproteases
inferredcites →https://doi.org/10.1128/mcb.26.3.965-975.2006openalex-snapshot
Phenotypic Analysis of Mice Lacking the Tmprss2 -Encoded Protease
inferredcites →https://doi.org/10.1186/1743-422x-8-27openalex-snapshot
Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection
inferredcites →https://doi.org/10.1371/journal.pone.0035876openalex-snapshot
Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts
inferredcites →https://doi.org/10.1371/journal.ppat.1003151openalex-snapshot
Influenza HA Subtypes Demonstrate Divergent Phenotypes for Cleavage Activation and pH of Fusion: Implications for Host Range and Adaptation
inferredcites →https://doi.org/10.2174/138161207780162971openalex-snapshot
Proteases Essential for Human Influenza Virus Entry into Cells and Their Inhibitors as Potential Therapeutic Agents
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Tmprss2-Specific Antisense Oligonucleotides Inhibit Emerging Viruses Entry
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Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication
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Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection
inferred← citeshttps://doi.org/10.1002/jmv.28124openalex-snapshot
Native and activated antithrombin inhibits TMPRSS2 activity and SARS‐CoV‐2 infection
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Spike protein mediated membrane fusion during SARS‐CoV‐2 infection
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Broad antiviral and anti‐inflammatory efficacy of nafamostat against SARS‐CoV‐2 and seasonal coronaviruses in primary human bronchiolar epithelia
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Strategies for the Development of Influenza Drugs: Basis for New Efficient Combination Therapies
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The Hemagglutinin: A Determinant of Pathogenicity
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Activation of the Hemagglutinin of Influenza Viruses
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The Antiviral Potential of Host Protease Inhibitors
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Priming Time: How Cellular Proteases Arm Coronavirus Spike Proteins
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Membrane-Anchored Serine Proteases: Host Cell Factors in Proteolytic Activation of Viral Glycoproteins
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Antiviral strategies against influenza virus: towards new therapeutic approaches
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Kallikreins emerge as new regulators of viral infections
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Structural modeling and analysis of the SARS-CoV-2 cell entry inhibitor camostat bound to the trypsin-like protease TMPRSS2
inferred← citeshttps://doi.org/10.1007/s00228-023-03517-0openalex-snapshot
Translatability scoring in prospective and retrospective COVID drug development cases
inferred← citeshttps://doi.org/10.1007/s11224-022-01921-3openalex-snapshot
Identification of novel TMPRSS2 inhibitors against SARS-CoV-2 infection: a structure-based virtual screening and molecular dynamics study
inferred← citeshttps://doi.org/10.1007/s11224-022-01991-3openalex-snapshot
Identification, virtual screening and molecular dynamic analysis of novel TMPRSS2 inhibitors from natural compound database as potential entry-blocking agents in SARS-CoV-2 therapy
inferred← citeshttps://doi.org/10.1007/s11248-016-9989-6openalex-snapshot
Zygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs
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Antiviral peptides against SARS-CoV-2: therapeutic targets, mechanistic antiviral activity, and efficient delivery
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Extracellular: Plasma Membrane Proteases – Serine Proteases
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Extracellular: Plasma Membrane Proteases – Serine Proteases
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Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals
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Anti-Influenza Treatment: Drugs Currently Used and Under Development
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Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches
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Current state of vaccine development and targeted therapies for COVID-19: impact of basic science discoveries
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A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
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Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins
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Host genetics of severe influenza: from mouse Mx1 to human IRF7
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Host genes and influenza pathogenesis in humans: an emerging paradigm
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Airway proteases: an emerging drug target for influenza and other respiratory virus infections
inferred← citeshttps://doi.org/10.1016/j.coviro.2023.101303openalex-snapshot
The role of influenza-A virus and coronavirus viral glycoprotein cleavage in host adaptation
inferred← citeshttps://doi.org/10.1016/j.ebiom.2021.103255openalex-snapshot
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
inferred← citeshttps://doi.org/10.1016/j.ejcb.2015.05.013openalex-snapshot
Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114437openalex-snapshot
Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors
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Structural insights into frog skin-derived cyclic peptides as selective matriptase inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118385openalex-snapshot
Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1
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Design and identification of novel annomontine analogues against SARS-CoV-2: An in-silico approach
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Restriction of influenza A virus replication via serine protease targeting in chicken cells and organ cultures
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IAV inhibits the host antiviral defense mediated by LncRNA-LRIR to enhance viral replication
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Monoclonal antibodies against human TMPRSS2 prevent infection by any SARS-CoV-2 variant
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.102643openalex-snapshot
Transmembrane serine protease TMPRSS2 implicated in SARS-CoV-2 infection is autoactivated intracellularly and requires N-glycosylation for regulation
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.105201openalex-snapshot
The endoplasmic reticulum–localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
inferred← citeshttps://doi.org/10.1016/j.job.2025.100619openalex-snapshot
TMPRSS2 expression in oral mucosal cells induced by transfected double-stranded RNA and IL-1β
inferred← citeshttps://doi.org/10.1016/j.mehy.2020.109773openalex-snapshot
Covid-19, TMPRSS2, and whether android regulation affects pandemic virus gender incidence and age distribution of disease
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Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2)
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SARS-CoV-2 and cancer: the intriguing and informative cross-talk
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Influenza A pathway analysis of highly pathogenic avian influenza virus (H5N1) infection in genetically disparate Ri chicken lines
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Modification of the hemagglutinin cleavage site allows indirect activation of avian influenza virus H9N2 by bacterial staphylokinase
inferred← citeshttps://doi.org/10.1016/j.virol.2018.08.011openalex-snapshot
Selection of influenza virus resistant to the novel camphor-based antiviral camphecene results in loss of pathogenicity
inferred← citeshttps://doi.org/10.1016/j.virol.2020.01.004openalex-snapshot
SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses
inferred← citeshttps://doi.org/10.1016/j.virol.2024.110218openalex-snapshot
TMPRSS2-specific antisense oligonucleotides inhibit host cell entry of emerging viruses
inferred← citeshttps://doi.org/10.1016/j.virusres.2014.12.024openalex-snapshot
Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus
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A tricompartmental model of lung oxygenation disruption to explain pulmonary and systemic pathology in severe COVID-19
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Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors
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TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform
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The oncogene ERG: a key factor in prostate cancer
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Crosstalk between COVID-19 and prostate cancer
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Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
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Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1038/s41467-025-59677-3openalex-snapshot
Structural basis of TMPRSS11D specificity and autocleavage activation
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The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies
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Simulations and active learning enable efficient identification of an experimentally-validated broad coronavirus inhibitor
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Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID
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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
inferred← citeshttps://doi.org/10.1038/s41598-022-04906-8openalex-snapshot
Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s42003-022-03613-4openalex-snapshot
Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
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Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents
inferred← citeshttps://doi.org/10.1038/srep29430openalex-snapshot
TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus
inferred← citeshttps://doi.org/10.1039/d0sc05064dopenalex-snapshot
Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat
inferred← citeshttps://doi.org/10.1042/bcj20250335openalex-snapshot
Towards broad-spectrum antiviral drugs: inhibition of transmembrane serine proteases
inferred← citeshttps://doi.org/10.1042/bst20190675openalex-snapshot
Membrane-anchored serine proteases as regulators of epithelial function
inferred← citeshttps://doi.org/10.1056/evidoa2300132openalex-snapshot
A Randomized Trial of Nafamostat for Covid-19
inferred← citeshttps://doi.org/10.1073/pnas.2021450118openalex-snapshot
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2
inferred← citeshttps://doi.org/10.1073/pnas.2108728118openalex-snapshot
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
inferred← citeshttps://doi.org/10.1074/jbc.h120.015153openalex-snapshot
Finding proteases that make cells go viral
inferred← citeshttps://doi.org/10.1074/jbc.ra118.001273openalex-snapshot
TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1
inferred← citeshttps://doi.org/10.1074/jbc.ra120.012635openalex-snapshot
Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways
inferred← citeshttps://doi.org/10.1080/07391102.2020.1798813openalex-snapshot
Identification of potential anti-TMPRSS2 natural products through homology modelling, virtual screening and molecular dynamics simulation studies
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Type II transmembrane serine proteases as potential target for anti-influenza drug discovery
inferred← citeshttps://doi.org/10.1080/17460441.2022.2029843openalex-snapshot
The discovery and development of transmembrane serine protease 2 (TMPRSS2) inhibitors as candidate drugs for the treatment of COVID-19
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Ultrapure and potent tannic acid as a pluripotent protease and influenza HA inhibitor against influenza virus infection
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Gene editing of pigs to control influenza A virus infections
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TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection
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Placental Expression of ACE2 and TMPRSS2 in Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Are Placental Defenses Mediated by Fetal Sex?
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Is Spironolactone the Preferred Renin–Angiotensin–Aldosterone Inhibitor for Protection Against COVID-19?
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Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice
inferred← citeshttps://doi.org/10.1099/jgv.0.001274openalex-snapshot
Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis
inferred← citeshttps://doi.org/10.1101/2020.04.15.042085openalex-snapshot
TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
inferred← citeshttps://doi.org/10.1101/2020.08.14.248880openalex-snapshot
Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis
inferred← citeshttps://doi.org/10.1101/2020.09.16.297366openalex-snapshot
Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells
inferred← citeshttps://doi.org/10.1101/2021.04.01.438089openalex-snapshot
Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex?
inferred← citeshttps://doi.org/10.1101/2021.05.03.442520openalex-snapshot
A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice
inferred← citeshttps://doi.org/10.1101/2021.06.15.448583openalex-snapshot
Structural Modeling of the TMPRSS Subfamily of Host Cell Proteases Reveals Potential Binding Sites
inferred← citeshttps://doi.org/10.1101/736678openalex-snapshot
Evidence for influenza B virus hemagglutinin adaptation to the human host: high cleavability, acid-stability and preference for cool temperature
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Proteolytic activation of SARS‐CoV‐2 spike protein
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A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development: IUPHAR Review 29
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Bromhexine Hydrochloride Tablets for the Treatment of Moderate COVID‐19: An Open‐Label Randomized Controlled Pilot Study
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Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay
inferred← citeshttps://doi.org/10.1128/jvi.00124-15openalex-snapshot
A Mutant H3N2 Influenza Virus Uses an Alternative Activation Mechanism in TMPRSS2 Knockout Mice by Loss of an Oligosaccharide in the Hemagglutinin Stalk Region
inferred← citeshttps://doi.org/10.1128/jvi.00398-21openalex-snapshot
Host Serine Proteases TMPRSS2 and TMPRSS11D Mediate Proteolytic Activation and Trypsin-Independent Infection in Group A Rotaviruses
inferred← citeshttps://doi.org/10.1128/jvi.00421-17openalex-snapshot
Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs
inferred← citeshttps://doi.org/10.1128/jvi.00543-15openalex-snapshot
Coronavirus and Influenza Virus Proteolytic Priming Takes Place in Tetraspanin-Enriched Membrane Microdomains
inferred← citeshttps://doi.org/10.1128/jvi.00615-15openalex-snapshot
Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase
inferred← citeshttps://doi.org/10.1128/jvi.00649-19openalex-snapshot
TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes
inferred← citeshttps://doi.org/10.1128/jvi.00685-25openalex-snapshot
Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin
inferred← citeshttps://doi.org/10.1128/jvi.00807-25openalex-snapshot
Lock out: targeting TMPRSS2 to block influenza and coronaviruses
inferred← citeshttps://doi.org/10.1128/jvi.00820-25openalex-snapshot
Genetic resilience or resistance in poultry against avian influenza virus: mirage or reality?
inferred← citeshttps://doi.org/10.1128/jvi.00906-21openalex-snapshot
Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells
inferred← citeshttps://doi.org/10.1128/jvi.01296-21openalex-snapshot
TMPRSS2 Activates Hemagglutinin-Esterase Glycoprotein of Influenza C Virus
inferred← citeshttps://doi.org/10.1128/jvi.01427-14openalex-snapshot
DESC1 and MSPL Activate Influenza A Viruses and Emerging Coronaviruses for Host Cell Entry
inferred← citeshttps://doi.org/10.1128/jvi.01430-19openalex-snapshot
Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways
inferred← citeshttps://doi.org/10.1128/jvi.01815-18openalex-snapshot
TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection
inferred← citeshttps://doi.org/10.1128/jvi.01853-24openalex-snapshot
The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids
inferred← citeshttps://doi.org/10.1128/jvi.01903-23openalex-snapshot
Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19
inferred← citeshttps://doi.org/10.1128/jvi.02693-15openalex-snapshot
The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases
inferred← citeshttps://doi.org/10.1128/jvi.03050-13openalex-snapshot
Identification of a Broad-Spectrum Antiviral Small Molecule against Severe Acute Respiratory Syndrome Coronavirus and Ebola, Hendra, and Nipah Viruses by Using a Novel High-Throughput Screening Assay
inferred← citeshttps://doi.org/10.1128/jvi.03677-13openalex-snapshot
The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses
inferred← citeshttps://doi.org/10.1128/jvi.03799-13openalex-snapshot
TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice
inferred← citeshttps://doi.org/10.1152/ajplung.00028.2015openalex-snapshot
Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants
inferred← citeshttps://doi.org/10.1155/2021/2706789openalex-snapshot
A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation
inferred← citeshttps://doi.org/10.1155/sci5/3687892openalex-snapshot
Exploring TMPRSS2 Drug Target to Combat Influenza and Coronavirus Infection
inferred← citeshttps://doi.org/10.1158/2159-8290.cd-20-0451openalex-snapshot
TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
inferred← citeshttps://doi.org/10.1159/000450705openalex-snapshot
Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection
inferred← citeshttps://doi.org/10.1164/rccm.202104-0833leopenalex-snapshot
Therapeutic Application of Alpha-1 Antitrypsin in COVID-19
inferred← citeshttps://doi.org/10.1177/14703203251351110openalex-snapshot
Molecular pathways for targeted therapeutics in the management of COVID-19 and heart failure
inferred← citeshttps://doi.org/10.1183/09031936.00186214openalex-snapshot
Influenza virus-induced lung injury: pathogenesis and implications for treatment
inferred← citeshttps://doi.org/10.1183/13993003.03988-2020openalex-snapshot
Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells
inferred← citeshttps://doi.org/10.1186/s12943-020-01209-2openalex-snapshot
Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1186/s12943-021-01363-1openalex-snapshot
The intersection of COVID-19 and cancer: signaling pathways and treatment implications
inferred← citeshttps://doi.org/10.1186/s12985-020-01323-zopenalex-snapshot
H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice
inferred← citeshttps://doi.org/10.1186/s12985-023-02027-wopenalex-snapshot
Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice
inferred← citeshttps://doi.org/10.1186/s13054-019-2566-7openalex-snapshot
Host susceptibility to severe influenza A virus infection
inferred← citeshttps://doi.org/10.1186/s13063-021-05137-4openalex-snapshot
COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial
inferred← citeshttps://doi.org/10.1186/s43170-022-00111-9openalex-snapshot
Improvements in pig agriculture through gene editing
inferred← citeshttps://doi.org/10.13189/app.2021.090406openalex-snapshot
The Recent Developmental Platforms and Potential Targets of SARS CoV-2 Vaccines: A Comprehensive Review
inferred← citeshttps://doi.org/10.1371/journal.pone.0126849openalex-snapshot
A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway
inferred← citeshttps://doi.org/10.1371/journal.pone.0138380openalex-snapshot
TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0152134openalex-snapshot
The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0164501openalex-snapshot
Cathepsin L Helps to Defend Mice from Infection with Influenza A
inferred← citeshttps://doi.org/10.1371/journal.pone.0176597openalex-snapshot
Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin
inferred← citeshttps://doi.org/10.1371/journal.pone.0179177openalex-snapshot
Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2
inferred← citeshttps://doi.org/10.15420/ecr.2020.28openalex-snapshot
The Coronavirus Disease 2019 Outbreak Highlights the Importance of Sex-sensitive Medicine
inferred← citeshttps://doi.org/10.20411/pai.v6i1.408openalex-snapshot
Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2
inferred← citeshttps://doi.org/10.20944/preprints202101.0266.v1openalex-snapshot
Comparative Study of Epithelial Entry Gene Expression of SARS-Cov-2 and Other Human Viral Species in Asthma: Differences by Sex, Airway Location Aand Disease Endotype
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9889115/v1openalex-snapshot
A reversible broad-spectrum antiviral targets the human V-ATPase VO domain
inferred← citeshttps://doi.org/10.2174/1389450121666200924113243openalex-snapshot
Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion
inferred← citeshttps://doi.org/10.2174/1389450121999201125201112openalex-snapshot
Can Host Cell Proteins Like ACE2, ADAM17, TMPRSS2, Androgen Receptor be the Efficient Targets in SARS-CoV-2 Infection?
inferred← citeshttps://doi.org/10.2174/1871526521666210322160038openalex-snapshot
Investigation of Structural, Treatment, and Clinical Characteristics of COVID-19 Along with the Challenges Caused by its Prevalence
inferred← citeshttps://doi.org/10.2222/jsv.69.61openalex-snapshot
Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2
inferred← citeshttps://doi.org/10.22541/au.158679935.58510327openalex-snapshot
A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development
inferred← citeshttps://doi.org/10.26508/lsa.202000786openalex-snapshot
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
inferred← citeshttps://doi.org/10.26508/lsa.202201813openalex-snapshot
Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells
inferred← citeshttps://doi.org/10.31219/osf.io/rtfmxopenalex-snapshot
Host signaling and proteolytic pathways in the resolution or the exacerbation of coronavirus (CoV-2) infection in COVID-19 disease: what therapeutic targets?
inferred← citeshttps://doi.org/10.32902/2663-0338-2022-3-5-12openalex-snapshot
Antiviral activity of aminocaproic acid against SARS-CoV-2: review of the literature and results of the first experimental study
inferred← citeshttps://doi.org/10.3389/fchem.2023.1128859openalex-snapshot
Interaction of copper potential metallodrugs with TMPRSS2: A comparative study of docking tools and its implications on COVID-19
inferred← citeshttps://doi.org/10.3389/fcimb.2018.00091openalex-snapshot
Enterokinase Enhances Influenza A Virus Infection by Activating Trypsinogen in Human Cell Lines
inferred← citeshttps://doi.org/10.3389/fcimb.2026.1904701openalex-snapshot
Host cell entry receptors as pharmacological targets in respiratory viral infections: from biology to clinical translation
inferred← citeshttps://doi.org/10.3389/fgeed.2023.1320180openalex-snapshot
Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus
inferred← citeshttps://doi.org/10.3389/fimmu.2020.01229openalex-snapshot
Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?
inferred← citeshttps://doi.org/10.3389/fimmu.2020.552925openalex-snapshot
Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1671173openalex-snapshot
Host proteases: key regulators in viral infection and therapeutic targeting
inferred← citeshttps://doi.org/10.3389/fmolb.2020.00196openalex-snapshot
Molecular Pathogenesis, Immunopathogenesis and Novel Therapeutic Strategy Against COVID-19
inferred← citeshttps://doi.org/10.3389/fmolb.2021.725528openalex-snapshot
Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and Influenza
inferred← citeshttps://doi.org/10.3390/ani15030422openalex-snapshot
Gene Editing for Enhanced Swine Production: Current Advances and Prospects
inferred← citeshttps://doi.org/10.3390/antiox9060518openalex-snapshot
Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
inferred← citeshttps://doi.org/10.3390/biom15010075openalex-snapshot
TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses
inferred← citeshttps://doi.org/10.3390/biomedicines11030682openalex-snapshot
In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes
inferred← citeshttps://doi.org/10.3390/biotech12040061openalex-snapshot
Bacterial Proteases as Potentially Exploitable Modulators of SARS-CoV-2 Infection: Logic from the Literature, Informatics, and Inspiration from the Dog
inferred← citeshttps://doi.org/10.3390/books978-3-03928-818-2openalex-snapshot
Influenza Virus and Vaccination
inferred← citeshttps://doi.org/10.3390/cancers12082186openalex-snapshot
SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities
inferred← citeshttps://doi.org/10.3390/ddc4020025openalex-snapshot
Regulatory T Cell Function Is Not Affected by Antisense Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer (PPMO)-Mediated TMPRSS2 Truncation
inferred← citeshttps://doi.org/10.3390/ijms23031351openalex-snapshot
The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment
inferred← citeshttps://doi.org/10.3390/ijms23042372openalex-snapshot
Identification of Nifurtimox and Chrysin as Anti-Influenza Virus Agents by Clinical Transcriptome Signature Reversion
inferred← citeshttps://doi.org/10.3390/ijms24076253openalex-snapshot
Receptors and Cofactors That Contribute to SARS-CoV-2 Entry: Can Skin Be an Alternative Route of Entry?
inferred← citeshttps://doi.org/10.3390/ijms241311173openalex-snapshot
Aprotinin—Drug against Respiratory Diseases
inferred← citeshttps://doi.org/10.3390/inorganics12110282openalex-snapshot
Comparative Study of Docking Tools for Evaluation of Potential Copper Metallodrugs and Their Interaction with TMPRSS2
inferred← citeshttps://doi.org/10.3390/jpm12040622openalex-snapshot
The Predictive Value of Serum ACE2 and TMPRSS2 Concentrations in Patients with COVID-19—A Prospective Pilot Study
inferred← citeshttps://doi.org/10.3390/pathogens8040168openalex-snapshot
Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans
inferred← citeshttps://doi.org/10.3390/v12060589openalex-snapshot
Avian Influenza A Virus Infects Swine Airway Epithelial Cells without Prior Adaptation
inferred← citeshttps://doi.org/10.3390/v12121425openalex-snapshot
Leveraging 3D Model Systems to Understand Viral Interactions with the Respiratory Mucosa
inferred← citeshttps://doi.org/10.3390/v13061011openalex-snapshot
Animal Models for Influenza Research: Strengths and Weaknesses
inferred← citeshttps://doi.org/10.3390/v13061081openalex-snapshot
Comparative Study of SARS-CoV-2, SARS-CoV-1, MERS-CoV, HCoV-229E and Influenza Host Gene Expression in Asthma: Importance of Sex, Disease Severity, and Epithelial Heterogeneity
inferred← citeshttps://doi.org/10.3390/v14071566openalex-snapshot
Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus Genesis
inferred← citeshttps://doi.org/10.3390/v16111798openalex-snapshot
Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells
inferred← citeshttps://doi.org/10.3390/v7102875openalex-snapshot
Modeling Influenza Virus Infection: A Roadmap for Influenza Research
inferred← citeshttps://doi.org/10.3906/biy-2104-67openalex-snapshot
Host variations in SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.52586/4984openalex-snapshot
Identification of key factors shaping integrated levels of ACE2 and TMPRSS2 expression in head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.53846/goediss-4629openalex-snapshot
Bedeutung der ACE2-Spaltung durch Wirtszellproteasen für die SARS-Coronavirus-Infektion
inferred← citeshttps://doi.org/10.53846/goediss-4631openalex-snapshot
Functional analysis of the MERS-coronavirus spike protein
inferred← citeshttps://doi.org/10.53846/goediss-5580openalex-snapshot
Activation of the influenza virus hemagglutinin by type II transmembrane serine proteases
inferred← citeshttps://doi.org/10.53846/goediss-8112openalex-snapshot
Characterization of host cell factors used by emerging coronaviruses for entry into target cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.22688882openalex-snapshot
Additional file 1 of Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice
inferred← citeshttps://doi.org/10.64898/2026.06.17.732908openalex-snapshot
TMPRSS2 regulates ACE2 trafficking and shedding
inferred← citeshttps://doi.org/10.7883/yoken.jjid.2023.353openalex-snapshot
Cleavage-Activation of Respiratory Viruses – Half a Century of History from Sendai Virus to SARS-CoV-2
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