On the public citation graph

The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways

https://doi.org/10.1515/hsz-2015-0171

0 signed · 92 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cncr.23354openalex-snapshot

Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

inferredcites →https://doi.org/10.1002/dvdy.20569openalex-snapshot

Importin α mRNAs have distinct expression profiles during spermatogenesis

inferredcites →https://doi.org/10.1006/abio.1976.9999openalex-snapshot

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

inferredcites →https://doi.org/10.1006/jmbi.2000.3642openalex-snapshot

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-α11Edited by K. Nagai

inferredcites →https://doi.org/10.1007/0-306-46825-5_12openalex-snapshot

Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases

inferredcites →https://doi.org/10.1007/978-1-4939-0348-1_19openalex-snapshot

Investigating Dengue Virus Nonstructural Protein 5 (NS5) Nuclear Import

inferredcites →https://doi.org/10.1007/s00109-015-1276-0openalex-snapshot

Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing

inferredcites →https://doi.org/10.1016/j.antiviral.2013.06.002openalex-snapshot

Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

inferredcites →https://doi.org/10.1016/j.antiviral.2013.10.004openalex-snapshot

Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication

inferredcites →https://doi.org/10.1016/j.bbamcr.2007.12.006openalex-snapshot

Nuclear translocation of hypoxia-inducible factors (HIFs): Involvement of the classical importin α/β pathway

inferredcites →https://doi.org/10.1016/j.bbrc.2009.07.090openalex-snapshot

Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2

inferredcites →https://doi.org/10.1016/j.bbrc.2009.09.093openalex-snapshot

Transport of hypoxia-inducible factor HIF-1α into the nucleus involves importins 4 and 7

inferredcites →https://doi.org/10.1016/j.biochi.2014.03.001openalex-snapshot

Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase

inferredcites →https://doi.org/10.1016/j.bmc.2010.08.038openalex-snapshot

Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport

inferredcites →https://doi.org/10.1016/s0014-4827(03)00100-9openalex-snapshot

Ratjadones inhibit nuclear export by blocking CRM1/exportin 1

inferredcites →https://doi.org/10.1016/s0014-5793(02)02247-0openalex-snapshot

Normoxic induction of the hypoxia‐inducible factor 1α by insulin and interleukin‐1β involves the phosphatidylinositol 3‐kinase pathway

inferredcites →https://doi.org/10.1016/s0968-0004(96)80182-4openalex-snapshot

Regulation of transcription factor localization: fine-tuning of gene expression

inferredcites →https://doi.org/10.1021/cb100094kopenalex-snapshot

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries

inferredcites →https://doi.org/10.1034/j.1600-0854.2001.21002.xopenalex-snapshot

Protein Export from the Nucleus

inferredcites →https://doi.org/10.1038/cddis.2013.521openalex-snapshot

Plasmodium falciparum signal recognition particle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP

inferredcites →https://doi.org/10.1038/srep05500openalex-snapshot

HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation

inferredcites →https://doi.org/10.1042/bj20120150openalex-snapshot

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

inferredcites →https://doi.org/10.1056/nejm200003023420904openalex-snapshot

Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction

inferredcites →https://doi.org/10.1073/pnas.92.12.5510openalex-snapshot

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

inferredcites →https://doi.org/10.1073/pnas.96.16.9112openalex-snapshot

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

inferredcites →https://doi.org/10.1074/jbc.m110.186809openalex-snapshot

Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury

inferredcites →https://doi.org/10.1074/jbc.m406026200openalex-snapshot

Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

inferredcites →https://doi.org/10.1093/emboj/18.6.1660openalex-snapshot

A leucine‐rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

inferredcites →https://doi.org/10.1113/jphysiol.2013.251470openalex-snapshot

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

inferredcites →https://doi.org/10.1128/jvi.00508-10openalex-snapshot

Importin α3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and Replication

inferredcites →https://doi.org/10.1128/mcb.02335-06openalex-snapshot

Shuttling Imbalance of MLF1 Results in p53 Instability and Increases Susceptibility to Oncogenic Transformation

inferredcites →https://doi.org/10.1146/annurev.cellbio.15.1.607openalex-snapshot

Transport Between the Cell Nucleus and the Cytoplasm

inferredcites →https://doi.org/10.1172/jci67230openalex-snapshot

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

inferredcites →https://doi.org/10.1177/1087057110390360openalex-snapshot

An AlphaScreen®-Based Assay for High-Throughput Screening for Specific Inhibitors of Nuclear Import

inferredcites →https://doi.org/10.1182/blood-2012-04-423160openalex-snapshot

Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

inferredcites →https://doi.org/10.1182/blood.v94.5.1561openalex-snapshot

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

inferredcites →https://doi.org/10.1186/1475-2875-12-153openalex-snapshot

Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination

inferredcites →https://doi.org/10.1242/jcs.109041openalex-snapshot

Oxygen sensing by Prolyl-4-Hydroxylase PHD2 within the nuclear compartment and the influence of compartimentalisation on HIF-1 signalling

inferredcites →https://doi.org/10.1385/mo:18:4:243openalex-snapshot

Treatment Resistance of Solid Tumors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3759166openalex-extracted

The Current Understanding and Potential Therapeutic Options to Combat COVID-19

inferred← citeshttps://doi.org/10.1002/9781394168033.ch10openalex-snapshot

Antiviral Uses of Ivermectin

inferred← citeshttps://doi.org/10.1002/bit.26870openalex-snapshot

Mechanisms of unprimed and dexamethasone‐primed nonviral gene delivery to human mesenchymal stem cells

inferred← citeshttps://doi.org/10.1002/iub.2773openalex-snapshot

Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy

inferred← citeshttps://doi.org/10.1007/s12602-022-09925-5openalex-snapshot

Could the COVID-19-Driven Increased Use of Ivermectin Lead to Incidents of Imbalanced Gut Microbiota and Dysbiosis?

inferred← citeshttps://doi.org/10.1007/s42250-020-00203-xopenalex-snapshot

Natural and Synthetic Drugs as Potential Treatment for Coronavirus Disease 2019 (COVID-2019)

inferred← citeshttps://doi.org/10.1016/j.antiviral.2020.104760openalex-snapshot

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

inferred← citeshttps://doi.org/10.1016/j.antiviral.2020.104787openalex-snapshot

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.09.035openalex-snapshot

Nuclear transport and subcellular localization of the dystrophin Dp71 and Dp40 isoforms in the PC12 cell line

inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117831openalex-snapshot

Role of nuclear import proteins in maintaining proteostasis and disease pathogenesis

inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115757openalex-snapshot

COVID-19 therapy: What weapons do we bring into battle?

inferred← citeshttps://doi.org/10.1016/j.ceb.2019.01.001openalex-snapshot

Inhibitors of nuclear transport

inferred← citeshttps://doi.org/10.1016/j.cellsig.2026.112558openalex-snapshot

Importin α as a central regulator of nucleocytoplasmic transport: Structural basis, isoform diversification, and disease implications

inferred← citeshttps://doi.org/10.1016/j.ebiom.2017.09.022openalex-snapshot

Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia

inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2020.106054openalex-snapshot

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): a global pandemic and treatment strategies

inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2020.106125openalex-snapshot

Repurposing of host-based therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19): a link between antiviral and anticancer mechanisms?

inferred← citeshttps://doi.org/10.1016/j.jallcom.2021.159627openalex-snapshot

Ivermectin detection using Ag@ B, S co-doped reduced graphene oxide nanohybrid

inferred← citeshttps://doi.org/10.1016/j.jid.2025.03.031openalex-snapshot

Microbe–Host Interaction in Rosacea and Its Modulation through Topical Ivermectin

inferred← citeshttps://doi.org/10.1016/j.metabol.2024.155832openalex-snapshot

Interleukin-6 classic and trans-signaling utilize glucose metabolism reprogramming to achieve anti- or pro-inflammatory effects

inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c00755openalex-snapshot

Synthetic Monopartite Peptide That Enables the Nuclear Import of Genes Delivered by the Neurotensin-Polyplex Vector

inferred← citeshttps://doi.org/10.1021/acsmacrolett.1c00740openalex-snapshot

Design and Synthesis of Shikimoylated-Polypeptides for Nuclear Specific Internalization

inferred← citeshttps://doi.org/10.1021/jacs.7b02801openalex-snapshot

Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags

inferred← citeshttps://doi.org/10.1038/cddis.2016.187openalex-snapshot

A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT

inferred← citeshttps://doi.org/10.1038/ja.2017.11openalex-snapshot

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

inferred← citeshttps://doi.org/10.1038/s41388-019-0989-xopenalex-snapshot

Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region

inferred← citeshttps://doi.org/10.1038/s41419-022-05182-0openalex-snapshot

Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer

inferred← citeshttps://doi.org/10.1038/s41429-020-0336-zopenalex-snapshot

Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen

inferred← citeshttps://doi.org/10.1038/s41598-021-86679-0openalex-snapshot

Ivermectin reduces in vivo coronavirus infection in a mouse experimental model

inferred← citeshttps://doi.org/10.1038/s41598-023-47066-zopenalex-snapshot

The nuclear entry of the aryl hydrocarbon receptor (AHR) relies on the first nuclear localization signal and can be negatively regulated through IMPα/β specific inhibitors

inferred← citeshttps://doi.org/10.1038/s42003-020-01577-xopenalex-snapshot

Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents

inferred← citeshttps://doi.org/10.1039/d2ew00620kopenalex-snapshot

Antibiotic removal by metal–organic framework and 2D nanomaterial based polyetherimide mixed matrix membranes using a membrane bioreactor

inferred← citeshttps://doi.org/10.1080/07391102.2020.1841028openalex-snapshot

An in-silico analysis of ivermectin interaction with potential SARS-CoV-2 targets and host nuclear importin α

inferred← citeshttps://doi.org/10.1080/07391102.2021.1906750openalex-snapshot

Mechanistic insights into the inhibitory activity of FDA approved ivermectin against SARS-CoV-2: old drug with new implications

inferred← citeshttps://doi.org/10.1080/10837450.2025.2579558openalex-snapshot

Ivermectin-based therapeutics: modern dosage forms and drug delivery innovations

inferred← citeshttps://doi.org/10.1101/2020.07.29.226027openalex-snapshot

Laying Hens Affected By Newcastle Virus And Laryngotracheitis Virus Show Rapid Recovery After Treatment With Ivermectin

inferred← citeshttps://doi.org/10.1111/bcpt.13600openalex-snapshot

An update on emerging therapeutics to combat COVID‐19

inferred← citeshttps://doi.org/10.1111/bpa.12699openalex-snapshot

Brain‐derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer’s disease

inferred← citeshttps://doi.org/10.1186/s12943-019-0968-4openalex-snapshot

mRNA-to-protein translation in hypoxia

inferred← citeshttps://doi.org/10.1186/s13014-015-0539-9openalex-snapshot

The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment

inferred← citeshttps://doi.org/10.1631/jzus.b2200385openalex-snapshot

Suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis

inferred← citeshttps://doi.org/10.2174/1389557521666210629100630openalex-snapshot

Neurological Effects of SARS-CoV-2 and Neurotoxicity of Antiviral Drugs Against COVID-19

inferred← citeshttps://doi.org/10.2174/1567201819666220516163242openalex-snapshot

Forging Ahead the Repositioning of Multitargeted Drug Ivermectin

inferred← citeshttps://doi.org/10.29121/granthaalayah.v9.i3.2021.3769openalex-snapshot

CORONAVIRUS INFECTION AND ITS CONTROL THROUGH VARIOUS APPROACHES: A SHORT REVIEW

inferred← citeshttps://doi.org/10.3389/fimmu.2021.663586openalex-snapshot

Repurposing Ivermectin for COVID-19: Molecular Aspects and Therapeutic Possibilities

inferred← citeshttps://doi.org/10.3389/pore.2022.1610518openalex-snapshot

Decreased Expression of Karyopherin-α 1 is Related to the Malignant Degree of Cervical Cancer and is Critical for the Proliferation of Hela Cells

inferred← citeshttps://doi.org/10.3390/cells7110221openalex-snapshot

Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport

inferred← citeshttps://doi.org/10.3390/cells9122654openalex-snapshot

The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses

inferred← citeshttps://doi.org/10.3390/ijms21155487openalex-snapshot

Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis

inferred← citeshttps://doi.org/10.3390/life12091384openalex-snapshot

Ivermectin: A Controversial Focal Point during the COVID-19 Pandemic

inferred← citeshttps://doi.org/10.3390/ph13050096openalex-snapshot

The Rationale for Potential Pharmacotherapy of COVID-19

inferred← citeshttps://doi.org/10.3390/ph19030407openalex-snapshot

Captivating Synergistic, Dose-Dependent Anticancer Effects of Tumor-Regulation Modulators Chloroquine and Ivermectin Completely Abolished by an Opposing Modulator, Deoxycholic Acid, in Hamster Fibrosarcoma: In Vivo, In Vitro, and Literature Review

inferred← citeshttps://doi.org/10.3892/ijmm.2018.3921openalex-snapshot

Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1α/YAP signaling pathway

inferred← citeshttps://doi.org/10.70675/d56c7569z1192z4fafzb54dzca1d85719b00openalex-snapshot

Étude des mécanismes d’action de nouveaux inhibiteurs de coronavirus humains

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.