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Nutrient sensing and TOR signaling in yeast and mammals

https://doi.org/10.15252/embj.201696010

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inferredcites →https://doi.org/10.1006/mcne.2002.1184openalex-snapshot

Tsc2 Null Murine Neuroepithelial Cells Are a Model for Human Tuber Giant Cells, and Show Activation of an mTOR Pathway

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mTOR in health and in sickness

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Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

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Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

inferredcites →https://doi.org/10.1016/0092-8674(94)90570-3openalex-snapshot

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization

inferredcites →https://doi.org/10.1016/j.ccell.2014.09.008openalex-snapshot

Rab1A Is an mTORC1 Activator and a Colorectal Oncogene

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TOR Signaling in Growth and Metabolism

inferredcites →https://doi.org/10.1016/j.cell.2008.06.028openalex-snapshot

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

inferredcites →https://doi.org/10.1016/j.cell.2008.11.044openalex-snapshot

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

inferredcites →https://doi.org/10.1016/j.cell.2010.02.024openalex-snapshot

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

inferredcites →https://doi.org/10.1016/j.cell.2012.02.044openalex-snapshot

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

inferredcites →https://doi.org/10.1016/j.cell.2012.03.017openalex-snapshot

mTOR Signaling in Growth Control and Disease

inferredcites →https://doi.org/10.1016/j.cell.2012.07.032openalex-snapshot

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

inferredcites →https://doi.org/10.1016/j.cell.2013.06.041openalex-snapshot

Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A

inferredcites →https://doi.org/10.1016/j.cell.2013.11.049openalex-snapshot

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

inferredcites →https://doi.org/10.1016/j.cell.2014.01.024openalex-snapshot

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

inferredcites →https://doi.org/10.1016/j.cell.2014.08.038openalex-snapshot

Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling

inferredcites →https://doi.org/10.1016/j.cell.2016.02.035openalex-snapshot

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

inferredcites →https://doi.org/10.1016/j.celrep.2014.09.014openalex-snapshot

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

inferredcites →https://doi.org/10.1016/j.celrep.2014.10.019openalex-snapshot

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

inferredcites →https://doi.org/10.1016/j.celrep.2015.08.059openalex-snapshot

Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2

inferredcites →https://doi.org/10.1016/j.celrep.2016.07.008openalex-snapshot

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

inferredcites →https://doi.org/10.1016/j.cmet.2013.08.018openalex-snapshot

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

inferredcites →https://doi.org/10.1016/j.cmet.2013.09.005openalex-snapshot

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation

inferredcites →https://doi.org/10.1016/j.cmet.2014.06.014openalex-snapshot

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

inferredcites →https://doi.org/10.1016/j.cmet.2014.09.013openalex-snapshot

AMPK—Sensing Energy while Talking to Other Signaling Pathways

inferredcites →https://doi.org/10.1016/j.cub.2005.02.053openalex-snapshot

Rheb Binds and Regulates the mTOR Kinase

inferredcites →https://doi.org/10.1016/j.devcel.2014.03.017openalex-snapshot

RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice

inferredcites →https://doi.org/10.1016/j.devcel.2015.02.010openalex-snapshot

MCRS1 Binds and Couples Rheb to Amino Acid-Dependent mTORC1 Activation

inferredcites →https://doi.org/10.1016/j.immuni.2014.08.011openalex-snapshot

The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production

inferredcites →https://doi.org/10.1016/j.jmb.2010.07.034openalex-snapshot

Structural Conservation of Components in the Amino Acid Sensing Branch of the TOR Pathway in Yeast and Mammals

inferredcites →https://doi.org/10.1016/j.molcel.2008.03.003openalex-snapshot

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

inferredcites →https://doi.org/10.1016/j.molcel.2009.06.033openalex-snapshot

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

inferredcites →https://doi.org/10.1016/j.molcel.2012.02.009openalex-snapshot

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

inferredcites →https://doi.org/10.1016/j.molcel.2012.05.043openalex-snapshot

Glutaminolysis Activates Rag-mTORC1 Signaling

inferredcites →https://doi.org/10.1016/j.molcel.2012.06.009openalex-snapshot

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

inferredcites →https://doi.org/10.1016/j.molcel.2012.08.001openalex-snapshot

The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy

inferredcites →https://doi.org/10.1016/j.molcel.2013.09.016openalex-snapshot

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

inferredcites →https://doi.org/10.1016/j.molcel.2015.03.033openalex-snapshot

The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation

inferredcites →https://doi.org/10.1016/j.molcel.2015.05.010openalex-snapshot

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1

inferredcites →https://doi.org/10.1016/j.molmed.2012.05.007openalex-snapshot

Amino acids and mTORC1: from lysosomes to disease

inferredcites →https://doi.org/10.1016/j.str.2012.09.019openalex-snapshot

Ego3 Functions as a Homodimer to Mediate the Interaction between Gtr1-Gtr2 and Ego1 in the EGO Complex to Activate TORC1

inferredcites →https://doi.org/10.1016/j.tcb.2014.03.003openalex-snapshot

Regulation of mTORC1 by amino acids

inferredcites →https://doi.org/10.1016/j.tcb.2015.06.002openalex-snapshot

Regulation of mTORC1 by PI3K signaling

inferredcites →https://doi.org/10.1016/j.tem.2009.05.008openalex-snapshot

ATF4-dependent transcription mediates signaling of amino acid limitation

inferredcites →https://doi.org/10.1016/s0092-8674(00)80324-4openalex-snapshot

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

inferredcites →https://doi.org/10.1016/s0092-8674(02)00808-5openalex-snapshot

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

inferredcites →https://doi.org/10.1016/s0092-8674(02)00833-4openalex-snapshot

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

inferredcites →https://doi.org/10.1016/s0092-8674(03)00929-2openalex-snapshot

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

inferredcites →https://doi.org/10.1016/s1097-2765(00)00028-9openalex-snapshot

Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain

inferredcites →https://doi.org/10.1016/s1097-2765(00)00108-8openalex-snapshot

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

inferredcites →https://doi.org/10.1016/s1097-2765(02)00568-3openalex-snapshot

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

inferredcites →https://doi.org/10.1016/s1097-2765(02)00636-6openalex-snapshot

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

inferredcites →https://doi.org/10.1016/s1097-2765(03)00220-xopenalex-snapshot

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

inferredcites →https://doi.org/10.1038/35007072openalex-snapshot

A family of candidate taste receptors in human and mouse

inferredcites →https://doi.org/10.1038/369756a0openalex-snapshot

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

inferredcites →https://doi.org/10.1038/celldisc.2015.49openalex-snapshot

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling

inferredcites →https://doi.org/10.1038/celldisc.2016.35openalex-snapshot

Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling

inferredcites →https://doi.org/10.1038/cr.2015.146openalex-snapshot

Multiple amino acid sensing inputs to mTORC1

inferredcites →https://doi.org/10.1038/cr.2015.86openalex-snapshot

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

inferredcites →https://doi.org/10.1038/nature14107openalex-snapshot

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

inferredcites →https://doi.org/10.1038/nature19079openalex-snapshot

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

inferredcites →https://doi.org/10.1038/nature726openalex-snapshot

An amino-acid taste receptor

inferredcites →https://doi.org/10.1038/ncb1753openalex-snapshot

Regulation of TORC1 by Rag GTPases in nutrient response

inferredcites →https://doi.org/10.1038/ncb839openalex-snapshot

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

inferredcites →https://doi.org/10.1038/ncb847openalex-snapshot

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

inferredcites →https://doi.org/10.1038/ncomms10025openalex-snapshot

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

inferredcites →https://doi.org/10.1038/ncomms10662openalex-snapshot

Lysosomal recruitment of TSC2 is a universal response to cellular stress

inferredcites →https://doi.org/10.1038/ncomms8250openalex-snapshot

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

inferredcites →https://doi.org/10.1038/nrm2249openalex-snapshot

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

inferredcites →https://doi.org/10.1038/nrm2822openalex-snapshot

The nuts and bolts of AGC protein kinases

inferredcites →https://doi.org/10.1038/nrm3311openalex-snapshot

AMPK: a nutrient and energy sensor that maintains energy homeostasis

inferredcites →https://doi.org/10.1038/nrm3522openalex-snapshot

Amino acid signalling upstream of mTOR

inferredcites →https://doi.org/10.1038/nrm3757openalex-snapshot

Making new contacts: the mTOR network in metabolism and signalling crosstalk

inferredcites →https://doi.org/10.1038/onc.2010.177openalex-snapshot

Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation

inferredcites →https://doi.org/10.1038/onc.2012.465openalex-snapshot

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

inferredcites →https://doi.org/10.1038/onc.2015.363openalex-snapshot

PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer

inferredcites →https://doi.org/10.1038/onc.2015.381openalex-snapshot

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

inferredcites →https://doi.org/10.1038/srep09502openalex-snapshot

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

inferredcites →https://doi.org/10.1038/srep13828openalex-snapshot

TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1

inferredcites →https://doi.org/10.1038/srep27698openalex-snapshot

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

inferredcites →https://doi.org/10.1042/bst0370242openalex-snapshot

Amino-acid-induced signalling via the SPS-sensing pathway in yeast

inferredcites →https://doi.org/10.1042/bst20130041openalex-snapshot

A growing role for mTOR in promoting anabolic metabolism

inferredcites →https://doi.org/10.1046/j.1365-2958.1998.00714.xopenalex-snapshot

The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1073/pnas.0400541101openalex-snapshot

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

inferredcites →https://doi.org/10.1073/pnas.202476899openalex-snapshot

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

inferredcites →https://doi.org/10.1073/pnas.81.20.6442openalex-snapshot

Evidence for translational regulation of the activator of general amino acid control in yeast.

inferredcites →https://doi.org/10.1073/pnas.86.12.4579openalex-snapshot

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.

inferredcites →https://doi.org/10.1073/pnas.91.26.12574openalex-snapshot

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

inferredcites →https://doi.org/10.1074/jbc.270.2.815openalex-snapshot

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

inferredcites →https://doi.org/10.1074/jbc.270.48.28982openalex-snapshot

Cloning of a Novel Family of Mammalian GTP-binding Proteins (RagA, RagBs, RagB1) with Remote Similarity to the Ras-related GTPases

inferredcites →https://doi.org/10.1074/jbc.273.23.14484openalex-snapshot

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

inferredcites →https://doi.org/10.1074/jbc.275.15.11198openalex-snapshot

The Saccharomyces cerevisiae Rheb G-protein Is Involved in Regulating Canavanine Resistance and Arginine Uptake

inferredcites →https://doi.org/10.1074/jbc.c300133200openalex-snapshot

Rapamycin-induced Translational Derepression of GCN4 mRNA Involves a Novel Mechanism for Activation of the eIF2α Kinase GCN2

inferredcites →https://doi.org/10.1074/jbc.m004389200openalex-snapshot

Novel G Proteins, Rag C and Rag D, Interact with GTP-binding Proteins, Rag A and Rag B

inferredcites →https://doi.org/10.1074/jbc.m008028200openalex-snapshot

A Family of Yeast Proteins Mediating Bidirectional Vacuolar Amino Acid Transport

inferredcites →https://doi.org/10.1074/jbc.m110.106864openalex-snapshot

Structural and Functional Insights into Saccharomyces cerevisiae Tpa1, a Putative Prolylhydroxylase Influencing Translation Termination and Transcription

inferredcites →https://doi.org/10.1074/jbc.m110.121947openalex-snapshot

Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast

inferredcites →https://doi.org/10.1074/jbc.m114.574335openalex-snapshot

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

inferredcites →https://doi.org/10.1074/jbc.m201959200openalex-snapshot

ATF4 Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene

inferredcites →https://doi.org/10.1074/jbc.m311862200openalex-snapshot

Induction of CHOP Expression by Amino Acid Limitation Requires Both ATF4 Expression and ATF2 Phosphorylation

inferredcites →https://doi.org/10.1074/jbc.m402228200openalex-snapshot

Dimerization Is Required for Activation of eIF2 Kinase Gcn2 in Response to Diverse Environmental Stress Conditions

inferredcites →https://doi.org/10.1074/jbc.m404559200openalex-snapshot

Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2

inferredcites →https://doi.org/10.1080/21541248.2016.1211070openalex-snapshot

Unsolved mysteries of Rag GTPase signaling in yeast

inferredcites →https://doi.org/10.1083/jcb.201107033openalex-snapshot

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

inferredcites →https://doi.org/10.1083/jcb.201307084openalex-snapshot

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

inferredcites →https://doi.org/10.1091/mbc.7.1.25openalex-snapshot

TOR controls translation initiation and early G1 progression in yeast.

inferredcites →https://doi.org/10.1091/mbc.e11-04-0282openalex-snapshot

A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5

inferredcites →https://doi.org/10.1091/mbc.e15-07-0470openalex-snapshot

Dynamic relocation of the TORC1–Gtr1/2–Ego1/2/3 complex is regulated by Gtr1 and Gtr2

inferredcites →https://doi.org/10.1091/mbc.e15-08-0581openalex-snapshot

A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress

inferredcites →https://doi.org/10.1093/genetics/152.3.853openalex-snapshot

Saccharomyces cerevisiae Putative G Protein, Gtr1p, Which Forms Complexes With Itself and a Novel Protein Designated as Gtr2p, Negatively Regulates the Ran/Gsp1p G Protein Cycle Through Gtr2p

inferredcites →https://doi.org/10.1093/hmg/11.5.525openalex-snapshot

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

inferredcites →https://doi.org/10.1093/nar/gkt563openalex-snapshot

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

inferredcites →https://doi.org/10.1101/cshperspect.a019141openalex-snapshot

The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control

inferredcites →https://doi.org/10.1101/gad.1069003openalex-snapshot

Translational control by TOR and TAP42 through dephosphorylation of eIF2α kinase GCN2

inferredcites →https://doi.org/10.1101/gad.1110003openalex-snapshot

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

inferredcites →https://doi.org/10.1101/gad.239202openalex-snapshot

Receptor-mediated endoproteolytic activation of two transcription factors in yeast

inferredcites →https://doi.org/10.1101/gad.269324.115openalex-snapshot

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

inferredcites →https://doi.org/10.1101/gad.374206openalex-snapshot

Regulation of transcription factor latency by receptor-activated proteolysis

inferredcites →https://doi.org/10.1126/science.1157535openalex-snapshot

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

inferredcites →https://doi.org/10.1126/science.1207056openalex-snapshot

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase

inferredcites →https://doi.org/10.1126/science.1232044openalex-snapshot

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

inferredcites →https://doi.org/10.1126/science.1257132openalex-snapshot

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

inferredcites →https://doi.org/10.1126/science.1259472openalex-snapshot

Differential regulation of mTORC1 by leucine and glutamine

inferredcites →https://doi.org/10.1126/science.1715094openalex-snapshot

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

inferredcites →https://doi.org/10.1126/science.aab2674openalex-snapshot

Sestrin2 is a leucine sensor for the mTORC1 pathway

inferredcites →https://doi.org/10.1126/science.aad0489openalex-snapshot

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

inferredcites →https://doi.org/10.1126/science.aad2087openalex-snapshot

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

inferredcites →https://doi.org/10.1126/scisignal.2004112openalex-snapshot

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

inferredcites →https://doi.org/10.1126/scisignal.aaf2885openalex-snapshot

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

inferredcites →https://doi.org/10.1126/scisignal.aah4497openalex-snapshot

The apo-structure of the leucine sensor Sestrin2 is still elusive

inferredcites →https://doi.org/10.1128/ec.01.1.22-32.2002openalex-snapshot

Gcn4p, a Master Regulator of Gene Expression, Is Controlled at Multiple Levels by Diverse Signals of Starvation and Stress

inferredcites →https://doi.org/10.1128/ec.5.3.601-608.2006openalex-snapshot

Mapping of an Internal Protease Cleavage Site in the Ssy5p Component of the Amino Acid Sensor of Saccharomyces cerevisiae and Functional Characterization of the Resulting Pro- and Protease Domains by Gain-of-Function Genetics

inferredcites →https://doi.org/10.1128/mcb.00125-15openalex-snapshot

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

inferredcites →https://doi.org/10.1128/mcb.00323-10openalex-snapshot

The Prodomain of Ssy5 Protease Controls Receptor-Activated Proteolysis of Transcription Factor Stp1

inferredcites →https://doi.org/10.1128/mcb.01084-06openalex-snapshot

Effect of 21 Different Nitrogen Sources on Global Gene Expression in the Yeast Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1128/mcb.15.8.4497openalex-snapshot

The Histidyl-tRNA Synthetase-Related Sequence in the eIF-2α Protein Kinase GCN2 Interacts with tRNA and Is Required for Activation in Response to Starvation for Different Amino Acids

inferredcites →https://doi.org/10.1128/mcb.19.2.989openalex-snapshot

Amino Acid Signaling in Saccharomyces cerevisiae : a Permease-Like Sensor of External Amino Acids and F-Box Protein Grr1p Are Required for Transcriptional Induction of the AGP1 Gene, Which Encodes a Broad-Specificity Amino Acid Permease

inferredcites →https://doi.org/10.1128/mcb.19.8.5405openalex-snapshot

Ssy1p and Ptr3p Are Plasma Membrane Components of a Yeast System That Senses Extracellular Amino Acids

inferredcites →https://doi.org/10.1128/mcb.21.3.814-826.2001openalex-snapshot

Genetic and Biochemical Analysis of the Yeast Plasma Membrane Ssy1p-Ptr3p-Ssy5p Sensor of Extracellular Amino Acids

inferredcites →https://doi.org/10.1128/mcb.24.22.9771-9785.2004openalex-snapshot

Amino Acid Signaling in Yeast: Casein Kinase I and the Ssy5 Endoprotease Are Key Determinants of Endoproteolytic Activation of the Membrane-Bound Stp1 Transcription Factor

inferredcites →https://doi.org/10.1128/mcb.25.21.9435-9446.2005openalex-snapshot

Divergence of Stp1 and Stp2 Transcription Factors in Candida albicans Places Virulence Factors Required for Proper Nutrient Acquisition under Amino Acid Control

inferredcites →https://doi.org/10.1146/annurev.micro.59.031805.133833openalex-snapshot

TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST

inferredcites →https://doi.org/10.1242/jcs.047191openalex-snapshot

TORC1 controls degradation of the transcription factor Stp1, a key effector of the SPS amino-acid-sensing pathway in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1242/jcs.111.1.11openalex-snapshot

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway

inferredcites →https://doi.org/10.1242/jcs.168922openalex-snapshot

SEA you later alli-GATOR – a dynamic regulator of the TORC1 stress response pathway

inferredcites →https://doi.org/10.1371/journal.pone.0036616openalex-snapshot

Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

inferredcites →https://doi.org/10.1534/genetics.107.075077openalex-snapshot

Dal81 Enhances Stp1- and Stp2-Dependent Transcription Necessitating Negative Modulation by Inner Nuclear Membrane Protein Asi1 in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1534/genetics.111.133306openalex-snapshot

Regulation of Amino Acid, Nucleotide, and Phosphate Metabolism in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1534/genetics.111.133363openalex-snapshot

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

inferredcites →https://doi.org/10.1534/genetics.114.168369openalex-snapshot

State Transitions in the TORC1 Signaling Pathway and Information Processing in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1534/genetics.166.4.1727openalex-snapshot

The External Amino Acid Signaling Pathway Promotes Activation of Stp1 and Uga35/Dal81 Transcription Factors for Induction of the AGP1 Gene in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.2337/db10-1246openalex-snapshot

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

inferredcites →https://doi.org/10.3945/ajcn.113.070086openalex-snapshot

Role of amino acid transporters in amino acid sensing

inferredcites →https://doi.org/10.4161/auto.29397openalex-snapshot

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

inferredcites →https://doi.org/10.4161/cc.26000openalex-snapshot

SEACing the GAP that nEGOCiates TORC1 activation

inferredcites →https://doi.org/10.4161/sgtp.24262openalex-snapshot

Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II

inferredcites →https://doi.org/10.7554/elife.09181openalex-snapshot

Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

inferredcites →https://doi.org/10.7554/elife.11058openalex-snapshot

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Sphingolipid-mTORC1 Nutrient-Sensing Machinery Enables Animal Development by Suppression of the Intestinal Peroxisome Relocation, Hormone Secretion and the Gut-Brain Crosstalk

inferred← citeshttps://doi.org/10.1002/1873-3468.12882openalex-snapshot

Ecm33 is a novel factor involved in efficient glucose uptake for nutrition‐responsive TORC 1 signaling in yeast

inferred← citeshttps://doi.org/10.1002/1873-3468.13661openalex-snapshot

The activation mechanism of plant S6 kinase (S6K), a substrate of TOR kinase, is different from that of mammalian S6K

inferred← citeshttps://doi.org/10.1002/1873-3468.13722openalex-snapshot

Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1002/1873-3468.13888openalex-snapshot

TOR kinase activity in Chlamydomonas reinhardtii is modulated by cellular metabolic states

inferred← citeshttps://doi.org/10.1002/1873-3468.14741openalex-snapshot

Nutrient‐dependent signaling pathways that control autophagy in yeast

inferred← citeshttps://doi.org/10.1002/1873-3468.14980openalex-snapshot

Fission yeast Pib2 localizes to vacuolar membranes and regulates TOR complex 1 through evolutionarily conserved domains

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The critical function of metabolic reprogramming in cancer metastasis

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KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy‐lysosome defect

inferred← citeshttps://doi.org/10.1002/bies.201900194openalex-snapshot

Nutrient Sensing and Response Drive Developmental Progression in Caenorhabditis elegans

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The molecular mechanisms regulating the assembly of the autophagy initiation complex

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AMPK Activates Cellulase Secretion in Penicillium funiculosum by Downregulating P‐HOG1 MAPK Levels

inferred← citeshttps://doi.org/10.1002/mbo3.1176openalex-snapshot

Magnesium depletion extends fission yeast lifespan via general amino acid control activation

inferred← citeshttps://doi.org/10.1002/mbo3.730openalex-snapshot

Yeast transformation efficiency is enhanced by TORC 1‐ and eisosome‐dependent signaling

inferred← citeshttps://doi.org/10.1002/pld3.184openalex-snapshot

Reciprocal regulation of photosynthesis and mitochondrial respiration by TOR kinase in Chlamydomonas reinhardtii

inferred← citeshttps://doi.org/10.1002/wrna.1480openalex-snapshot

LARP1 on TOP of ribosome production

inferred← citeshttps://doi.org/10.1002/yea.3351openalex-snapshot

Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains

inferred← citeshttps://doi.org/10.1002/yea.3849openalex-snapshot

TorC1 and nitrogen catabolite repression control of integrated GABA shunt and retrograde pathway gene expression

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High nitrogen concentration causes G2/M arrest in Hanseniaspora vineae

inferred← citeshttps://doi.org/10.1002/yea.3939openalex-snapshot

Yeast Crf1p is an activator with different roles in regulation of target genes

inferred← citeshttps://doi.org/10.1002/yea.70008openalex-snapshot

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1007/978-1-0716-4284-9_7openalex-snapshot

Visualization of Subcellular mTOR Complex 1 Activity with a FRET-Based Sensor (TORCAR)

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Quantitative Coarse-Grained Modeling of Microbial Metabolism: Uncovering Growth Laws, Environmental Responses, and Host-Circuit Coupling

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The Yeast Prefoldin Bud27

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Signaling Pathways that Regulate Macropinocytosis in Mammalian Cells

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Hyperlipidemias and Obesity

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Autophagy in Drosophila and Zebrafish

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Autophagy in hypoxic ovary

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Anhydrobiosis as a Model of Aging and Longevity: The Role of Autophagy and Metabolism in Yeast Cells

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Regulation of eosinophil functions by autophagy

inferred← citeshttps://doi.org/10.1007/s00294-017-0738-zopenalex-snapshot

Control of RNA polymerase II-transcribed genes by direct binding of TOR kinase

inferred← citeshttps://doi.org/10.1007/s00294-018-00929-9openalex-snapshot

Whi2: a new player in amino acid sensing

inferred← citeshttps://doi.org/10.1007/s00294-019-01045-yopenalex-snapshot

tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state

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Ccr4-Not as a mediator of environmental signaling: a jack of all trades and master of all

inferred← citeshttps://doi.org/10.1007/s00294-025-01321-0openalex-snapshot

Possible regulatory network and associated pathways governing the expression of ADH2 in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1007/s00438-019-01592-6openalex-snapshot

Leucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1

inferred← citeshttps://doi.org/10.1007/s00535-026-02437-xopenalex-snapshot

S-adenosylhomocysteine hydrolase-like protein 1 deficiency resulted in stronger inflammation reaction in acute pancreatitis

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Neuroprotective properties of queen bee acid by autophagy induction

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Molecular frontiers of fungal autophagy: from molecular mechanisms to potential targets for antifungal drug discovery

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The PICLS high-throughput screening method for agents extending cellular longevity identifies 2,5-anhydro-D-mannitol as novel anti-aging compound

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Copper and iron engage distinct metabolic programs for cellular survival

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14-3-3β is essential for milk composition stimulated by Leu/IGF-1 via IGF1R signaling pathway in BMECs

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Die Rolle von mTORC1 in der Verstoffwechslung extrazellulärer Proteine

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MicroRNA-mediated autophagy and drug resistance in cancer: mechanisms and therapeutic strategies

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OSW-1 induces apoptosis and cyto-protective autophagy, and synergizes with chemotherapy on triple negative breast cancer metastasis

inferred← citeshttps://doi.org/10.1016/b978-0-12-815962-0.00008-1openalex-snapshot

Yeast as a model organism for aging research

inferred← citeshttps://doi.org/10.1016/b978-0-12-819460-7.00001-3openalex-snapshot

Regulation | mTOR and its Substrates

inferred← citeshttps://doi.org/10.1016/b978-0-12-820528-0.00015-6openalex-snapshot

Retrograde signaling: A novel antifungal drug target

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The Late Endosome

inferred← citeshttps://doi.org/10.1016/b978-0-12-822003-0.00024-3openalex-snapshot

Autophagy in cell plasticity with particular focus on paligenosis

inferred← citeshttps://doi.org/10.1016/b978-0-323-95424-2.00011-xopenalex-snapshot

Carbohydrate and protein metabolism

inferred← citeshttps://doi.org/10.1016/b978-0-323-99606-8.00019-5openalex-snapshot

Advances in metabolic engineering of yeasts

inferred← citeshttps://doi.org/10.1016/bs.mie.2022.07.007openalex-snapshot

Purification and biochemical characterization of the Rag GTPase heterodimer

inferred← citeshttps://doi.org/10.1016/j.algal.2024.103848openalex-snapshot

Dissecting nitrogen starvation signaling in Chlamydomonas: Insights from arginine-fed transcriptome profiling

inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.741473openalex-snapshot

Fasting time after feeding affects the evaluation of metabolic response in abalone Haliotis discus hannai to nutrients using dietary methionine as an example

inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.741849openalex-snapshot

A comprehensive analysis of metabolomics and transcriptomics revealed the mTOR-autophagy pathway is involved in ammonia metabolism of yellow catfish Pelteobagrus fulvidraco

inferred← citeshttps://doi.org/10.1016/j.bbagen.2018.12.011openalex-snapshot

The regulation of TORC1 pathway by the yeast chaperones Hsp31 is mediated by SFP1 and affects proteasomal activity

inferred← citeshttps://doi.org/10.1016/j.bbagen.2025.130810openalex-snapshot

G-quadruplex in cancer energy metabolism: A potential therapeutic target

inferred← citeshttps://doi.org/10.1016/j.bbagrm.2019.194414openalex-snapshot

A genome-wide transcriptional study reveals that iron deficiency inhibits the yeast TORC1 pathway

inferred← citeshttps://doi.org/10.1016/j.bbalip.2019.03.005openalex-snapshot

ER platforms mediating autophagosome generation

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2018.12.008openalex-snapshot

The emerging interrelation between ROCO and related kinases, intracellular Ca2+ signaling, and autophagy

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2020.118926openalex-snapshot

Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2021.119061openalex-snapshot

Cell death as a result of calcium signaling modulation: A cancer-centric prospective

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2025.119957openalex-snapshot

POLR1D, a shared subunit of RNA polymerase I and III, modulates mTORC1 activity

inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.189006openalex-snapshot

Role of stress granules in tumorigenesis and cancer therapy

inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.05.123openalex-snapshot

The TORC1 signaling pathway regulates respiration-induced mitophagy in yeast

inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.10.015openalex-snapshot

Carbon starvation-induced synthesis of GDH2 and PEPCK is essential for the survival of Pichia pastoris

inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.02.063openalex-snapshot

FPR1 is essential for rapamycin-induced lifespan extension in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.149499openalex-snapshot

Interaction between Gtr2p and ribosomal Rps31p affects the incorporation of Rps31p into ribosomes of Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150639openalex-snapshot

TOR2 plays the central role in rapamycin-induced lifespan extension in budding yeast

inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116115openalex-snapshot

Potential role of modulating autophagy levels in sensorineural hearing loss

inferred← citeshttps://doi.org/10.1016/j.biochi.2019.06.016openalex-snapshot

Targeting TOR signaling for enhanced lipid productivity in algae

inferred← citeshttps://doi.org/10.1016/j.biochi.2022.10.004openalex-snapshot

Autophagy: Dual roles and perspective for clinical treatment of colorectal cancer

inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110799openalex-snapshot

microRNA-based autophagy inhibition as targeted therapy in pancreatic cancer

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107740openalex-snapshot

Cultivation processes to select microorganisms with high accumulation ability

inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216178openalex-snapshot

m6A-modification of cyclin D1 and c-myc IRESs in glioblastoma controls ITAF activity and resistance to mTOR inhibition

inferred← citeshttps://doi.org/10.1016/j.cbpa.2024.111799openalex-snapshot

Salinity stress impairs disease resistance in white shrimp, Penaeus vannamei through AMPK pathway, ameliorated by dietary glucose-mediated energy homeostasis

inferred← citeshttps://doi.org/10.1016/j.ceb.2017.10.006openalex-snapshot

Upstairs, downstairs: spatial regulation of Hippo signalling

inferred← citeshttps://doi.org/10.1016/j.cell.2019.10.036openalex-snapshot

Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex

inferred← citeshttps://doi.org/10.1016/j.cell.2020.10.016openalex-snapshot

Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.10.029openalex-snapshot

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

inferred← citeshttps://doi.org/10.1016/j.celrep.2019.03.022openalex-snapshot

Mitochondrial Protein Synthesis and mtDNA Levels Coordinated through an Aminoacyl-tRNA Synthetase Subunit

inferred← citeshttps://doi.org/10.1016/j.celrep.2020.02.058openalex-snapshot

The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1

inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108024openalex-snapshot

Phosphoproteomic Analysis across the Yeast Life Cycle Reveals Control of Fatty Acyl Chain Length by Phosphorylation of the Fatty Acid Synthase Complex

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.108830openalex-snapshot

Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109490openalex-snapshot

Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.110149openalex-snapshot

Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110534openalex-snapshot

The mTOR chromatin-bound interactome in prostate cancer

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110554openalex-snapshot

Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110631openalex-snapshot

A negative feedback loop of TOR signaling balances growth and stress-response trade-offs in plants

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111140openalex-snapshot

A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113205openalex-snapshot

Metabolism of glucose activates TORC1 through multiple mechanisms in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114281openalex-snapshot

Sch9S6K controls DNA repair and DNA damage response efficiency in aging cells

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115282openalex-snapshot

Selective clearance of aberrant membrane proteins by TORC1-mediated micro-ER-phagy

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115683openalex-snapshot

TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89

inferred← citeshttps://doi.org/10.1016/j.cels.2018.08.001openalex-snapshot

Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts

inferred← citeshttps://doi.org/10.1016/j.chembiol.2019.05.009openalex-snapshot

Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters

inferred← citeshttps://doi.org/10.1016/j.clindermatol.2017.09.006openalex-snapshot

Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle

inferred← citeshttps://doi.org/10.1016/j.cmet.2018.04.009openalex-snapshot

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity

inferred← citeshttps://doi.org/10.1016/j.cmet.2019.05.002openalex-snapshot

Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass

inferred← citeshttps://doi.org/10.1016/j.cmet.2020.01.015openalex-snapshot

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

inferred← citeshttps://doi.org/10.1016/j.cmet.2023.10.016openalex-snapshot

The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2023.107875openalex-snapshot

Investigation of Macrocyclic mTOR Modulators of Rapamycin Binding Site via Pharmacoinformatics Approaches

inferred← citeshttps://doi.org/10.1016/j.copbio.2019.11.021openalex-snapshot

Yeast systems biology in understanding principles of physiology underlying complex human diseases

inferred← citeshttps://doi.org/10.1016/j.csbj.2021.12.003openalex-snapshot

Yeast Crf1p: An activator in need is an activator indeed

inferred← citeshttps://doi.org/10.1016/j.ctmp.2024.200174openalex-snapshot

Targeting STAT3-mediated autophagy with small molecules in cancer treatment – A comprehensive review

inferred← citeshttps://doi.org/10.1016/j.cub.2017.11.069openalex-snapshot

Cell Size and Growth Rate Are Modulated by TORC2-Dependent Signals

inferred← citeshttps://doi.org/10.1016/j.cub.2019.07.039openalex-snapshot

Leucine-Rich Repeat Extensin Proteins and Their Role in Cell Wall Sensing

inferred← citeshttps://doi.org/10.1016/j.devcel.2020.02.015openalex-snapshot

Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

inferred← citeshttps://doi.org/10.1016/j.engmic.2023.100079openalex-snapshot

Profiling proteomic responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.envpol.2023.121670openalex-snapshot

Nickel nanoparticles induce autophagy and apoptosis via HIF-1α/mTOR signaling in human bronchial epithelial cells

inferred← citeshttps://doi.org/10.1016/j.envpol.2023.123090openalex-snapshot

Inulin alleviates perfluorooctanoic acid-induced intestinal injury in mice by modulating the PI3K/AKT/mTOR signaling pathway

inferred← citeshttps://doi.org/10.1016/j.fbio.2026.110090openalex-snapshot

Fungal nitrogen overflow-driven cross-feeding alleviates bacterial growth limitations and promotes γ-aminobutyric acid and ethyl ester biosynthesis

inferred← citeshttps://doi.org/10.1016/j.fct.2024.114510openalex-snapshot

Rapamycin protects Sertoli cells against BPA-induced autophagy disorders

inferred← citeshttps://doi.org/10.1016/j.foodres.2026.120882openalex-snapshot

Amino acid cross-feeding by Debaryomyces hansenii promotes bacterial growth and flavor metabolite formation in fermented sausages

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2024.10.288openalex-snapshot

A critical role for microglia in regulating metabolic homeostasis and neural repair after spinal cord injury

inferred← citeshttps://doi.org/10.1016/j.funbio.2020.10.009openalex-snapshot

Carbamoyl phosphate synthetase subunit Cpa1 interacting with Dut1, controls development, arginine biosynthesis, and pathogenicity of Colletotrichum gloeosporioides

inferred← citeshttps://doi.org/10.1016/j.hnm.2023.200210openalex-snapshot

Visceral fat: A key mediator of NAFLD development and progression

inferred← citeshttps://doi.org/10.1016/j.ibmb.2021.103667openalex-snapshot

Halofuginone triggers a transcriptional program centered on ribosome biogenesis and function in honey bees

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.09.211openalex-snapshot

Insights into intracellular signaling network in Fusarium species

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.141730openalex-snapshot

The role of the poly(A) binding protein-binding protein MoPbp1 as a regulator of the TOR signaling pathway in growth, autophagy, and pathogenicity of the rice blast fungus

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.149944openalex-snapshot

TSC2 is a positive master regulator of cellulase production by affecting protein secretion in Trichoderma reesei

inferred← citeshttps://doi.org/10.1016/j.ijfoodmicro.2026.111813openalex-snapshot

Effect of nitrogen status on competitive abilities between indigenous and commercial wine strains in alcoholic fermentation

inferred← citeshttps://doi.org/10.1016/j.immuni.2025.06.010openalex-snapshot

More TOR: The expanding role of mTOR in regulating immune responses

inferred← citeshttps://doi.org/10.1016/j.immuni.2026.04.004openalex-snapshot

Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress

inferred← citeshttps://doi.org/10.1016/j.intimp.2026.116902openalex-snapshot

Targeting macrophage metabolism: Ghrelin regulates macrophage polarization via dual modulation of the AMPK/mTOR axis in immune-mediated diseases

inferred← citeshttps://doi.org/10.1016/j.isci.2019.08.002openalex-snapshot

Eukaryotic Adaptation to Years-Long Starvation Resembles that of Bacteria

inferred← citeshttps://doi.org/10.1016/j.isci.2019.09.025openalex-snapshot

Pib2-Dependent Feedback Control of the TORC1 Signaling Network by the Npr1 Kinase

inferred← citeshttps://doi.org/10.1016/j.isci.2020.100858openalex-snapshot

Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration

inferred← citeshttps://doi.org/10.1016/j.isci.2021.102778openalex-snapshot

A novel amino acid signaling process governs glucose-6-phosphatase transcription

inferred← citeshttps://doi.org/10.1016/j.isci.2022.104186openalex-snapshot

The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy

inferred← citeshttps://doi.org/10.1016/j.isci.2022.104238openalex-snapshot

Plasma membrane H+-ATPases promote TORC1 activation in plant suspension cells

inferred← citeshttps://doi.org/10.1016/j.isci.2023.108777openalex-snapshot

Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology

inferred← citeshttps://doi.org/10.1016/j.isci.2024.110814openalex-snapshot

FYVE1/FREE1 is involved in glutamine-responsive TORC1 activation in plants

inferred← citeshttps://doi.org/10.1016/j.jare.2021.10.014openalex-snapshot

Salicylic acid fights against Fusarium wilt by inhibiting target of rapamycin signaling pathway in Fusarium oxysporum

inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100891openalex-snapshot

Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast

inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101100openalex-snapshot

Alkaline intracellular pH (pHi) activates AMPK–mTORC2 signaling to promote cell survival during growth factor limitation

inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101103openalex-snapshot

The yoga of Rag GTPases: Dynamic structural poses confer amino acid sensing by mTORC1

inferred← citeshttps://doi.org/10.1016/j.jbc.2022.102030openalex-snapshot

Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1

inferred← citeshttps://doi.org/10.1016/j.jbc.2023.104644openalex-snapshot

An affinity tool for the isolation of endogenous active mTORC1 from various cellular sources

inferred← citeshttps://doi.org/10.1016/j.jbc.2025.110329openalex-snapshot

Perturbations in L-serine metabolism regulate protein quality control through the sensor of the retrograde response pathway RTG2 in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.jbc.2025.110700openalex-snapshot

TOR signaling regulates GPCR levels on the plasma membrane and suppresses the Saccharomyces cerevisiae mating pathway

inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113107openalex-snapshot

An intricate functional relationship between NuA4 and Sfp1 regulates ribosome biogenesis in response to nutrient availability

inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113228openalex-snapshot

Leucyl-tRNA synthetase as a molecular target of isobutanol-mediated growth inhibition in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113580openalex-snapshot

Medulloblastoma-associated mutations in the RNA helicase DDX3X/DED1 cause defects in the translational response to TORC1 inhibition

inferred← citeshttps://doi.org/10.1016/j.jbior.2017.11.001openalex-snapshot

Dysregulation of mRNA translation and energy metabolism in cancer

inferred← citeshttps://doi.org/10.1016/j.jbior.2017.12.002openalex-snapshot

Disrupting the ‘Warburg effect’ re-routes cancer cells to OXPHOS offering a vulnerability point via ‘ferroptosis’-induced cell death

inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.05.015openalex-snapshot

Control of alcoholic fermentation through modulation of nitrogen metabolism in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1016/j.jgg.2022.05.006openalex-snapshot

Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice

inferred← citeshttps://doi.org/10.1016/j.jgg.2026.01.007openalex-snapshot

Transcriptional, epigenetic, and post-translational regulation of plant autophagy

inferred← citeshttps://doi.org/10.1016/j.jgg.2026.06.002openalex-snapshot

Divergent roles of the Rag GTPases MoGtr1 and MoGtr2 in TOR signaling, autophagy, and pathogenicity of Magnaporthe oryzae

inferred← citeshttps://doi.org/10.1016/j.jmb.2018.10.008openalex-snapshot

Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 Pathway

inferred← citeshttps://doi.org/10.1016/j.jmb.2019.09.005openalex-snapshot

Mechanisms of Autophagy in Metabolic Stress Response

inferred← citeshttps://doi.org/10.1016/j.jmb.2020.01.017openalex-snapshot

Autophagy as a Cellular Stress Response Mechanism in the Nervous System

inferred← citeshttps://doi.org/10.1016/j.jmb.2020.166743openalex-snapshot

Architecture of the Tuberous Sclerosis Protein Complex

inferred← citeshttps://doi.org/10.1016/j.jnutbio.2024.109592openalex-snapshot

Nutrient-epigenome interactions: Implications for personalized nutrition against aging-associated diseases

inferred← citeshttps://doi.org/10.1016/j.jplph.2022.153716openalex-snapshot

Roles of TOR signaling in nutrient deprivation and abiotic stress

inferred← citeshttps://doi.org/10.1016/j.jplph.2024.154186openalex-snapshot

TOR in plants: Multidimensional regulators of plant growth and signaling pathways

inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119312openalex-snapshot

Piperine protects against pancreatic β-cell dysfunction by alleviating macrophage inflammation in obese mice

inferred← citeshttps://doi.org/10.1016/j.livres.2020.02.004openalex-snapshot

Nutrient mTORC1 signaling contributes to hepatic lipid metabolism in the pathogenesis of non-alcoholic fatty liver disease

inferred← citeshttps://doi.org/10.1016/j.lwt.2024.115732openalex-snapshot

Protective effect of wheat gluten peptides against ethanol-stress damage in yeast cell and identification of anti-ethanol peptides

inferred← citeshttps://doi.org/10.1016/j.mce.2017.09.008openalex-snapshot

Endocrine and physiological regulation of neutral fat storage in Drosophila

inferred← citeshttps://doi.org/10.1016/j.mib.2017.12.012openalex-snapshot

How yeast coordinates metabolism, growth and division

inferred← citeshttps://doi.org/10.1016/j.mib.2021.09.003openalex-snapshot

Arginine sensing in intracellular parasitism of Leishmania

inferred← citeshttps://doi.org/10.1016/j.micres.2023.127361openalex-snapshot

Components of TOR and MAP kinase signaling control chemotropism and pathogenicity in the fungal pathogen Verticillium dahliae

inferred← citeshttps://doi.org/10.1016/j.molcel.2017.09.026openalex-snapshot

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

inferred← citeshttps://doi.org/10.1016/j.molcel.2019.10.009openalex-snapshot

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

inferred← citeshttps://doi.org/10.1016/j.molcel.2021.03.031openalex-snapshot

The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1

inferred← citeshttps://doi.org/10.1016/j.molcel.2021.04.020openalex-snapshot

More writing: mTORC1 promotes m6A mRNA methylation

inferred← citeshttps://doi.org/10.1016/j.molcel.2021.06.017openalex-snapshot

An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

inferred← citeshttps://doi.org/10.1016/j.molcel.2022.12.011openalex-snapshot

GATOR2 rings GATOR1 to speak to mTORC1

inferred← citeshttps://doi.org/10.1016/j.molcel.2023.08.016openalex-snapshot

Regulation of nucleo-cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress

inferred← citeshttps://doi.org/10.1016/j.molcel.2024.04.016openalex-snapshot

eIF4F complex dynamics are important for the activation of the integrated stress response

inferred← citeshttps://doi.org/10.1016/j.molcel.2024.10.008openalex-snapshot

mTORC1 activity licenses its own release from the lysosomal surface

inferred← citeshttps://doi.org/10.1016/j.molcel.2025.09.001openalex-snapshot

A network of P-body and Whi3 condensates adjusts cell fate decisions to cellular context

inferred← citeshttps://doi.org/10.1016/j.molcel.2025.12.018openalex-snapshot

EGO complex at 20: The Rag GTPase-TORC1 nutrient-sensing blueprint

inferred← citeshttps://doi.org/10.1016/j.molcel.2026.06.014openalex-snapshot

LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance

inferred← citeshttps://doi.org/10.1016/j.molp.2026.08.018openalex-snapshot

The TORC–SnRK axis: An integrative signaling framework balancing growth and stress responses in plants

inferred← citeshttps://doi.org/10.1016/j.mycmed.2023.101363openalex-snapshot

In silico-chemogenomic repurposing of new chemical scaffolds for histoplasmosis treatment

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.108012openalex-snapshot

Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery

inferred← citeshttps://doi.org/10.1016/j.plantsci.2019.110220openalex-snapshot

TOR and SnRK1 signaling pathways in plant response to abiotic stresses: Do they always act according to the “yin-yang” model?

inferred← citeshttps://doi.org/10.1016/j.plantsci.2025.112577openalex-snapshot

Research progress on the autophagy gene ATG6 in planta

inferred← citeshttps://doi.org/10.1016/j.plaphy.2023.107641openalex-snapshot

Phosphoproteomics analysis of the effect of target of rapamycin kinase inhibition on Cucumis sativus in response to Podosphaera xanthii

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2017.05.001openalex-snapshot

Augmenting brain metabolism to increase macro- and chaperone-mediated autophagy for decreasing neuronal proteotoxicity and aging

inferred← citeshttps://doi.org/10.1016/j.postharvbio.2024.112904openalex-snapshot

Plumbagin controls fungal postharvest pathogens by affecting metabolism and inducing autophagy

inferred← citeshttps://doi.org/10.1016/j.semcancer.2019.08.020openalex-snapshot

Pro-survival autophagy: An emerging candidate of tumor progression through maintaining hallmarks of cancer

inferred← citeshttps://doi.org/10.1016/j.semcancer.2021.06.019openalex-snapshot

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

inferred← citeshttps://doi.org/10.1016/j.semcdb.2026.103690openalex-snapshot

Nutrient-sensing pathways in adult stem cells: Orchestrating homeostasis, aging, and disease

inferred← citeshttps://doi.org/10.1016/j.tcb.2019.12.006openalex-snapshot

Relevance and Regulation of Cell Density

inferred← citeshttps://doi.org/10.1016/j.tcb.2020.12.003openalex-snapshot

Expanding the View of IKK: New Substrates and New Biology

inferred← citeshttps://doi.org/10.1016/j.tcb.2022.06.008openalex-snapshot

Nutrient availability as an arbiter of cell size

inferred← citeshttps://doi.org/10.1016/j.tem.2023.01.004openalex-snapshot

Regulation of mTOR by phosphatidic acid

inferred← citeshttps://doi.org/10.1016/j.tibs.2020.04.010openalex-snapshot

Coupling of Ribosome Synthesis and Translational Capacity with Cell Growth

inferred← citeshttps://doi.org/10.1016/j.tibs.2020.11.004openalex-snapshot

A Tour of TOR Complex Signaling in Plants

inferred← citeshttps://doi.org/10.1016/j.tim.2021.08.002openalex-snapshot

The phosphate language of fungi

inferred← citeshttps://doi.org/10.1016/j.tips.2017.09.003openalex-snapshot

Leveraging Chemotype-Specific Resistance for Drug Target Identification and Chemical Biology

inferred← citeshttps://doi.org/10.1016/j.tplants.2018.03.010openalex-snapshot

The Plant Target of Rapamycin Kinase: A connecTOR between Sulfur and Growth

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