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VEGF‐C is required for intestinal lymphatic vessel maintenance and lipid absorption

https://doi.org/10.15252/emmm.201505731
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/dvdy.21200openalex-snapshot
Lymphatic development in mouse small intestine
inferredcites →https://doi.org/10.1007/s00429-005-0011-yopenalex-snapshot
Structural and mechanical architecture of the intestinal villi and crypts in the rat intestine: integrative reevaluation from ultrastructural analysis
inferredcites →https://doi.org/10.1016/j.tem.2010.04.003openalex-snapshot
Lymphatic lipid transport: sewer or subway?
inferredcites →https://doi.org/10.1038/376062a0openalex-snapshot
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
inferredcites →https://doi.org/10.1038/jid.2013.83openalex-snapshot
Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics in the Dermis
inferredcites →https://doi.org/10.1038/nature05541openalex-snapshot
Restoration of p53 function leads to tumour regression in vivo
inferredcites →https://doi.org/10.1038/ni1013openalex-snapshot
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
inferredcites →https://doi.org/10.1038/nm.2545openalex-snapshot
The lymphatic vasculature in disease
inferredcites →https://doi.org/10.1038/nrd2380openalex-snapshot
Molecular basis for sunitinib efficacy and future clinical development
inferredcites →https://doi.org/10.1073/pnas.221449198openalex-snapshot
A model for gene therapy of human hereditary lymphedema
inferredcites →https://doi.org/10.1089/lrb.2008.1008openalex-snapshot
The Lymphatic System in Health and Disease
inferredcites →https://doi.org/10.1093/emboj/20.17.4762openalex-snapshot
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3
inferredcites →https://doi.org/10.1093/emboj/20.6.1223openalex-snapshot
Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice
inferredcites →https://doi.org/10.1096/fj.99-1049comopenalex-snapshot
VEGF‐C and VEGF‐D expression in neuroendocrine cells and their receptor, VEGFR‐3, in fenestrated blood vessels in human tissues
inferredcites →https://doi.org/10.1113/jphysiol.1967.sp008210openalex-snapshot
The effect of a non‐ionic detergent (Triton WR 1339) on the removal of triglyceride fatty acids from the blood of the rat
inferredcites →https://doi.org/10.1126/science.282.5390.946openalex-snapshot
Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3
inferredcites →https://doi.org/10.1128/mcb.02214-07openalex-snapshot
Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos
inferredcites →https://doi.org/10.1128/mcb.25.6.2441-2449.2005openalex-snapshot
Vascular Endothelial Growth Factor D Is Dispensable for Development of the Lymphatic System
inferredcites →https://doi.org/10.1152/ajpheart.00102.2007openalex-snapshot
Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism
inferredcites →https://doi.org/10.1152/ajpheart.00133.2005openalex-snapshot
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
inferredcites →https://doi.org/10.1158/0008-5472.can-07-5809openalex-snapshot
The Tyrosine Kinase Inhibitor Cediranib Blocks Ligand-Induced Vascular Endothelial Growth Factor Receptor-3 Activity and Lymphangiogenesis
inferredcites →https://doi.org/10.1161/01.res.0000073584.46059.e3openalex-snapshot
VEGF-D Is the Strongest Angiogenic and Lymphangiogenic Effector Among VEGFs Delivered Into Skeletal Muscle via Adenoviruses
inferredcites →https://doi.org/10.1172/jci200522037openalex-snapshot
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
inferredcites →https://doi.org/10.1172/jci75395openalex-snapshot
The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel
inferredcites →https://doi.org/10.1242/dev.089565openalex-snapshot
Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature
inferredcites →https://doi.org/10.1242/dev.106591openalex-snapshot
Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting
inferredcites →https://doi.org/10.1371/journal.pone.0068755openalex-snapshot
Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis
inferredcites →https://doi.org/10.1679/aohc.70.107openalex-snapshot
Mechanical components of rat intestinal villi as revealed by ultrastructural analysis with special reference to the axial smooth muscle cells in the villi

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Specialized Mesenteric Lymphatic Capillaries By-Pass Mesenteric Lymph Nodes To Transport Peritoneal Antigens Directly into Mediastinal Lymph Nodes
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Association of Lymphangiogenic Factors With Pulmonary Arterial Hypertension in Systemic Sclerosis
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Lymphatic Vessel Network Structure and Physiology
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inferred← citeshttps://doi.org/10.1007/978-1-4939-8712-2_8openalex-snapshot
Morphological Analysis of Lacteal Structure in the Small Intestine of Adult Mice
inferred← citeshttps://doi.org/10.1007/978-3-030-22009-9_1071openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00204-016-1906-5openalex-snapshot
In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
inferred← citeshttps://doi.org/10.1007/s11655-021-3342-5openalex-snapshot
Chinese Herbal Medicine Adjusting Brain Microenvironment via Mediating Central Nervous System Lymphatic Drainage in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-822546-2.00009-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-822546-2.24001-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-824371-8.00002-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-323-87763-3.00010-1openalex-snapshot
Development and structure of the lymphoid system
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2016.10.001openalex-snapshot
VEGF Receptor Tyrosine Kinases
inferred← citeshttps://doi.org/10.1016/j.addr.2020.12.005openalex-snapshot
Development and aging of the lymphatic vascular system
inferred← citeshttps://doi.org/10.1016/j.ajpath.2020.08.018openalex-snapshot
Lymphatic Proliferation Ameliorates Pulmonary Fibrosis after Lung Injury
inferred← citeshttps://doi.org/10.1016/j.bbalip.2022.159194openalex-snapshot
Glucagon-like peptide-2 mobilization of intestinal lipid does not require canonical enterocyte chylomicron synthetic machinery
inferred← citeshttps://doi.org/10.1016/j.bbalip.2022.159207openalex-snapshot
Vascular and lymphatic regulation of gastrointestinal function and disease risk
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.118009openalex-snapshot
Naringin affects VEGFC/TGF-β1 to mediate intercellular communication in MASH through coordinated Src and p38 MAPK pathways
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121483openalex-snapshot
Synthetic hydrogels engineered to promote collecting lymphatic vessel sprouting
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.116032openalex-snapshot
CCBE1 regulates the development and prevents the age-dependent regression of meningeal lymphatics
inferred← citeshttps://doi.org/10.1016/j.ccell.2025.12.019openalex-snapshot
IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma
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Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1
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The asymmetric Pitx2 gene regulates gut muscular-lacteal development and protects against fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.07.020openalex-snapshot
The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity
inferred← citeshttps://doi.org/10.1016/j.coi.2018.04.008openalex-snapshot
The evolving role of lymphatics in cancer metastasis
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Emerging Concepts in Organ-Specific Lymphatic Vessels and Metabolic Regulation of Lymphatic Development
inferred← citeshttps://doi.org/10.1016/j.devcel.2024.03.005openalex-snapshot
Villus myofibroblasts are developmental and adult progenitors of mammalian gut lymphatic musculature
inferred← citeshttps://doi.org/10.1016/j.dld.2021.05.013openalex-snapshot
Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.178443openalex-snapshot
Cardiac lymphatic system and coronary heart disease: associations, mechanisms and therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.ejps.2021.105812openalex-snapshot
Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e34490openalex-snapshot
O-GlcNAc modification in endothelial cells modulates adiposity via fat absorption from the intestine in mice
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.109066openalex-snapshot
Exosomes derived from human umbilical cord mesenchymal stem cells regulate lymphangiogenesis via the miR-302d-3p/VEGFR3/AKT axis to ameliorate inflammatory bowel disease
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.117287openalex-snapshot
Lymphatic vessel regulates tertiary lymphoid structure formation and inflammatory intensity in peripheral nerve allografts
inferred← citeshttps://doi.org/10.1016/j.jare.2025.05.026openalex-snapshot
Fish oil reduces intestinal fat absorption by promoting lacteal junction zippering via GPR120-VEGFR3-MLCK pathway
inferred← citeshttps://doi.org/10.1016/j.jchemneu.2023.102357openalex-snapshot
Lymphatic vessels accompanying dorsal and basal dural sinuses in the human brain
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2018.10.015openalex-snapshot
Regulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2018.12.002openalex-snapshot
The Intestinal Lymphatic System: Functions and Metabolic Implications
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2026.101849openalex-snapshot
Single-Cell Transcriptome Profiles of Foxl1-Lineage Cells Along the Intestinal Crypt–Villus Axis
inferred← citeshttps://doi.org/10.1016/j.jcpa.2018.02.005openalex-snapshot
Small Intestinal Lymphatic Hypoplasia in Three Dogs with Clinical Signs of Protein-losing Enteropathy
inferred← citeshttps://doi.org/10.1016/j.jhepr.2023.100816openalex-snapshot
Recombinant VEGF-C (Cys156Ser) improves mesenteric lymphatic drainage and gut immune surveillance in experimental cirrhosis
inferred← citeshttps://doi.org/10.1016/j.jlr.2023.100387openalex-snapshot
Cytarabine induces cachexia with lipid malabsorption via zippering the junctions of lacteal in murine small intestine
inferred← citeshttps://doi.org/10.1016/j.jpedsurg.2019.02.026openalex-snapshot
Lymphatic network remodeling after small bowel resection
inferred← citeshttps://doi.org/10.1016/j.jtos.2022.07.002openalex-snapshot
Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.03.026openalex-snapshot
Pro-angiogenic activity of isoliquiritin on HUVECs in vitro and zebrafish in vivo through Raf/MEK signaling pathway
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122563openalex-snapshot
VEGF/VEGFR axis and its signaling in melanoma: Current knowledge toward therapeutic targeting agents and future perspectives
inferred← citeshttps://doi.org/10.1016/j.mad.2024.111975openalex-snapshot
The emerging importance of lymphangiogenesis in aging and aging-associated diseases
inferred← citeshttps://doi.org/10.1016/j.molmed.2021.07.003openalex-snapshot
Homeostatic maintenance of the lymphatic vasculature
inferred← citeshttps://doi.org/10.1016/j.molmet.2020.101081openalex-snapshot
Regulation of lymphatic function and injury by nitrosative stress in obese mice
inferred← citeshttps://doi.org/10.1016/j.neuron.2026.09.005openalex-snapshot
Cervical lymphadenectomy impairs brain lymphatic clearance and synaptic proteostasis
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155268openalex-snapshot
Berberine promotes lacteal junction zippering and ameliorates diet-induced obesity through the RhoA/ROCK signaling pathway
inferred← citeshttps://doi.org/10.1016/j.tem.2016.12.002openalex-snapshot
Cardiac Lymphatics – A New Avenue for Therapeutics?
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2019.06.002openalex-snapshot
Lymphatic system identification, pathophysiology and therapy in the cardiovascular diseases
inferred← citeshttps://doi.org/10.1021/acsptsci.8b00061openalex-snapshot
Calcitonin-Receptor-Like Receptor Signaling Governs Intestinal Lymphatic Innervation and Lipid Uptake
inferred← citeshttps://doi.org/10.1038/labinvest.2017.77openalex-snapshot
Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction
inferred← citeshttps://doi.org/10.1038/nprot.2016.092openalex-snapshot
High-resolution 3D analysis of mouse small-intestinal stroma
inferred← citeshttps://doi.org/10.1038/nrgastro.2017.79openalex-snapshot
Intestinal lymphatic vasculature: structure, mechanisms and functions
inferred← citeshttps://doi.org/10.1038/nrm.2017.36openalex-snapshot
Vascular heterogeneity and specialization in development and disease
inferred← citeshttps://doi.org/10.1038/s41366-026-02178-0openalex-snapshot
Bidirectional crosstalk between obesity and the lymphatic system: a novel pathway in obesity pathogenesis and treatment
inferred← citeshttps://doi.org/10.1038/s41385-020-0308-4openalex-snapshot
Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation
inferred← citeshttps://doi.org/10.1038/s41392-023-01723-xopenalex-snapshot
Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets
inferred← citeshttps://doi.org/10.1038/s41392-025-02177-zopenalex-snapshot
Meningeal lymphatic drainage: novel insights into central nervous system disease
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Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms
inferred← citeshttps://doi.org/10.1038/s41467-020-17886-yopenalex-snapshot
Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
inferred← citeshttps://doi.org/10.1038/s41467-021-23808-3openalex-snapshot
Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
inferred← citeshttps://doi.org/10.1038/s41467-025-64047-0openalex-snapshot
Artery formation in the intestinal wall and mesentery by intestine-derived Esm1+ endothelial cells
inferred← citeshttps://doi.org/10.1038/s41568-024-00681-yopenalex-snapshot
Lymphatic vessels in the age of cancer immunotherapy
inferred← citeshttps://doi.org/10.1038/s41569-018-0087-8openalex-snapshot
Cardiac lymphatics in health and disease
inferred← citeshttps://doi.org/10.1038/s41569-020-00489-xopenalex-snapshot
The evolving cardiac lymphatic vasculature in development, repair and regeneration
inferred← citeshttps://doi.org/10.1038/s41574-026-01243-yopenalex-snapshot
Dysfunctional adipose tissue–lymphatic crosstalk in obesity
inferred← citeshttps://doi.org/10.1038/s41575-024-00996-zopenalex-snapshot
Transport functions of intestinal lymphatic vessels
inferred← citeshttps://doi.org/10.1038/s41581-020-0260-2openalex-snapshot
Targeting angiogenesis and lymphangiogenesis in kidney disease
inferred← citeshttps://doi.org/10.1038/s41598-020-71812-2openalex-snapshot
Defective development and microcirculation of intestine in Npr2 mutant mice
inferred← citeshttps://doi.org/10.1038/s41598-022-15848-6openalex-snapshot
Lipid absorption and overall intestinal lymphatic transport are impaired following partial small bowel resection in mice
inferred← citeshttps://doi.org/10.1038/s41598-022-22156-6openalex-snapshot
Claudin-3 inhibits tumor-induced lymphangiogenesis via regulating the PI3K signaling pathway in lymphatic endothelial cells
inferred← citeshttps://doi.org/10.1038/s44161-024-00570-5openalex-snapshot
Direct specification of lymphatic endothelium from mesenchymal progenitors
inferred← citeshttps://doi.org/10.1038/s44161-026-00872-wopenalex-snapshot
Lymphatic rarefaction drives cardiac inflammaging
inferred← citeshttps://doi.org/10.1038/s44319-025-00431-7openalex-snapshot
Epicardial VEGFC/D signaling is essential for coronary lymphangiogenesis
inferred← citeshttps://doi.org/10.1038/srep31566openalex-snapshot
Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice
inferred← citeshttps://doi.org/10.1080/21623945.2022.2028372openalex-snapshot
Adipose endothelial cells mastering adipose tissues metabolic fate
inferred← citeshttps://doi.org/10.1083/jcb.202207049openalex-snapshot
Mechanosensitive mTORC1 signaling maintains lymphatic valves
inferred← citeshttps://doi.org/10.1083/jcb.202505012openalex-snapshot
Eosinophils promote a second wave of postnatal smooth muscle differentiation in intestinal villi
inferred← citeshttps://doi.org/10.1084/jem.20170391openalex-snapshot
Development and plasticity of meningeal lymphatic vessels
inferred← citeshttps://doi.org/10.1084/jem.20171868openalex-snapshot
Organ-specific lymphatic vasculature: From development to pathophysiology
inferred← citeshttps://doi.org/10.1084/jem.20172031openalex-snapshot
The amazing brain drain
inferred← citeshttps://doi.org/10.1084/jem.20222008openalex-snapshot
Mechanisms and functions of intestinal vascular specialization
inferred← citeshttps://doi.org/10.1084/jem.20250506openalex-snapshot
Aquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironments
inferred← citeshttps://doi.org/10.1089/lrb.2021.0026openalex-snapshot
The Role of Lymphangiogenesis in Coronary Atherosclerosis
inferred← citeshttps://doi.org/10.1093/cvr/cvw175openalex-snapshot
Heterogeneity in the lymphatic vascular system and its origin
inferred← citeshttps://doi.org/10.1093/hmg/ddz132openalex-snapshot
Recent advances in novel therapies for lipid disorders
inferred← citeshttps://doi.org/10.1093/lifemeta/loaf014openalex-snapshot
DHHC5 regulates lacteal function and intestinal lipid absorption by maintaining VEGFR2 localization in lipid rafts
inferred← citeshttps://doi.org/10.1096/fj.201600887ropenalex-snapshot
Hyperglycemia‐ and hyperinsulinemia‐induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle
inferred← citeshttps://doi.org/10.1097/mol.0000000000000626openalex-snapshot
Intestinal lymphatic vessels and their role in chylomicron absorption and lipid homeostasis
inferred← citeshttps://doi.org/10.1097/mol.0000000000000821openalex-snapshot
Lymphatics - not just a chylomicron conduit
inferred← citeshttps://doi.org/10.1101/2020.12.24.20248815openalex-snapshot
Recombinant VEGF-C (Cys156Ser) protein restores mesenteric lymphatic drainage and improves gut immune surveillance in experimental liver cirrhosis
inferred← citeshttps://doi.org/10.1101/2023.02.10.528007openalex-snapshot
Control of coronary lymphangiogenesis by epicardial VEGFC/D
inferred← citeshttps://doi.org/10.1101/2023.07.11.548304openalex-snapshot
Specialized mesenteric lymphatic capillaries by-pass the mesenteric lymph node chain to transport peritoneal antigens directly into mediastinal lymph nodes
inferred← citeshttps://doi.org/10.1101/2025.03.05.641652openalex-snapshot
Aquaporin-1 sustains lymphangiogenic responses in inflammatory microenvironments
inferred← citeshttps://doi.org/10.1101/cshperspect.a041178openalex-snapshot
Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels
inferred← citeshttps://doi.org/10.1101/gad.303776.117openalex-snapshot
Lymphangiogenesis guidance by paracrine and pericellular factors
inferred← citeshttps://doi.org/10.1111/brv.13114openalex-snapshot
The relationship between the secondary vascular system and the lymphatic vascular system in fish
inferred← citeshttps://doi.org/10.1111/iju.13567openalex-snapshot
Pazopanib‐induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma
inferred← citeshttps://doi.org/10.1111/jvim.15406openalex-snapshot
Comparative pathophysiology and management of protein-losing enteropathy
inferred← citeshttps://doi.org/10.1111/obr.13922openalex-snapshot
Defective lymphatic vasculature in obesity
inferred← citeshttps://doi.org/10.1113/jp273061openalex-snapshot
Obesity‐induced lymphatic dysfunction is reversible with weight loss
inferred← citeshttps://doi.org/10.1113/jp273253openalex-snapshot
Obesity causes lymphatic vascular injury: time for clinical translation
inferred← citeshttps://doi.org/10.1124/pharmrev.123.001159openalex-snapshot
Intestinal Lymphatic Biology, Drug Delivery, and Therapeutics: Current Status and Future Directions
inferred← citeshttps://doi.org/10.1126/sciadv.abf4335openalex-snapshot
FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
inferred← citeshttps://doi.org/10.1126/science.aap9331openalex-snapshot
Lacteal junction zippering protects against diet-induced obesity
inferred← citeshttps://doi.org/10.1126/science.aau5583openalex-snapshot
Tighter lymphatic junctions prevent obesity
inferred← citeshttps://doi.org/10.1126/science.aax4063openalex-snapshot
Biological functions of lymphatic vessels
inferred← citeshttps://doi.org/10.1146/annurev-physiol-022516-034008openalex-snapshot
Lymphatic Dysfunction, Leukotrienes, and Lymphedema
inferred← citeshttps://doi.org/10.1152/ajpheart.00208.2016openalex-snapshot
Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D
inferred← citeshttps://doi.org/10.1152/ajprenal.00120.2024openalex-snapshot
Acute kidney injury results in long-term alterations of kidney lymphatics in mice
inferred← citeshttps://doi.org/10.1152/physrev.00006.2020openalex-snapshot
Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema
inferred← citeshttps://doi.org/10.1152/physrev.00029.2017openalex-snapshot
Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds
inferred← citeshttps://doi.org/10.1152/physrev.00039.2021openalex-snapshot
Lymphatic vessels in cancer
inferred← citeshttps://doi.org/10.1152/physrev.00052.2021openalex-snapshot
The ebb and flow of cardiac lymphatics: a tidal wave of new discoveries
inferred← citeshttps://doi.org/10.1161/atvbaha.121.317093openalex-snapshot
Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice
inferred← citeshttps://doi.org/10.1161/atvbaha.122.318406openalex-snapshot
Promoting Lymphangiogenesis and Lymphatic Growth and Remodeling to Treat Cardiovascular and Metabolic Diseases
inferred← citeshttps://doi.org/10.1161/circresaha.115.306544openalex-snapshot
Lymphatic System in Cardiovascular Medicine
inferred← citeshttps://doi.org/10.1161/circresaha.121.318142openalex-snapshot
Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies
inferred← citeshttps://doi.org/10.1161/circresaha.121.318852openalex-snapshot
VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling
inferred← citeshttps://doi.org/10.1161/circresaha.122.321671openalex-snapshot
Intestinal Lymphatic Dysfunction in Kidney Disease
inferred← citeshttps://doi.org/10.1161/circresaha.123.322607openalex-snapshot
Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption
inferred← citeshttps://doi.org/10.1161/jaha.118.010355openalex-snapshot
VEGF‐C and Mortality in Patients With Suspected or Known Coronary Artery Disease
inferred← citeshttps://doi.org/10.1172/jci.insight.137652openalex-snapshot
S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress–dependent VEGF-C signaling
inferred← citeshttps://doi.org/10.1172/jci.insight.172062openalex-snapshot
Single-cell transcriptomics analysis of proliferative diabetic retinopathy fibrovascular membranes reveals AEBP1 as fibrogenesis modulator
inferred← citeshttps://doi.org/10.1172/jci.insight.90103openalex-snapshot
Rapamycin reversal of VEGF-C–driven lymphatic anomalies in the respiratory tract
inferred← citeshttps://doi.org/10.1172/jci.insight.92465openalex-snapshot
Lymphatic deletion of calcitonin receptor–like receptor exacerbates intestinal inflammation
inferred← citeshttps://doi.org/10.1172/jci147070openalex-snapshot
Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction
inferred← citeshttps://doi.org/10.1172/jci153448openalex-snapshot
Lymphatics in the broken heart
inferred← citeshttps://doi.org/10.1172/jci155478openalex-snapshot
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression
inferred← citeshttps://doi.org/10.1172/jci83967openalex-snapshot
Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD
inferred← citeshttps://doi.org/10.1177/1535370217697385openalex-snapshot
Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation’s fire?
inferred← citeshttps://doi.org/10.1182/blood.2019001736openalex-snapshot
Hemostasis stimulates lymphangiogenesis through release and activation of VEGFC
inferred← citeshttps://doi.org/10.1182/blood.2020005699openalex-snapshot
VEGF-C protects the integrity of the bone marrow perivascular niche in mice
inferred← citeshttps://doi.org/10.1186/s12951-025-03759-3openalex-snapshot
Nanobody Immunolabelling and three-dimensional imaging reveals spatially restricted LYVE1 expression by kidney lymphatic vessels in mice
inferred← citeshttps://doi.org/10.1186/s13287-022-03132-3openalex-snapshot
ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome
inferred← citeshttps://doi.org/10.1186/s13578-022-00898-0openalex-snapshot
The lymphatic vascular system: much more than just a sewer
inferred← citeshttps://doi.org/10.1210/clinem/dgac690openalex-snapshot
Glucagon-like Peptide-2 Acutely Enhances Chylomicron Secretion in Humans Without Mobilizing Cytoplasmic Lipid Droplets
inferred← citeshttps://doi.org/10.1242/dev.151019openalex-snapshot
Vascular endothelial growth factor signaling in development and disease
inferred← citeshttps://doi.org/10.1242/dev.167098openalex-snapshot
When form meets function: the cells and signals that shape the lymphatic vasculature during development
inferred← citeshttps://doi.org/10.1242/dev.195453openalex-snapshot
YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling
inferred← citeshttps://doi.org/10.1242/dev.202901openalex-snapshot
A neuro-lymphatic communication guides lymphatic development by CXCL12 and CXCR4 signaling
inferred← citeshttps://doi.org/10.1253/jjcsc.27.0_49openalex-snapshot
冠動脈疾患疑い患者における VEGF-C レベルと死亡リスクの関連
inferred← citeshttps://doi.org/10.1371/journal.pone.0249256openalex-snapshot
Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities
inferred← citeshttps://doi.org/10.14341/omet12776openalex-snapshot
Lymphatic system and adipose tissue: Crosstalk in health and disease
inferred← citeshttps://doi.org/10.15252/embr.201846927openalex-snapshot
Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages
inferred← citeshttps://doi.org/10.15252/emmm.202114742openalex-snapshot
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease
inferred← citeshttps://doi.org/10.1530/mah-23-0021openalex-snapshot
The impact of gut microbiota on vascularization of the small intestine
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2004077/v1openalex-snapshot
Recombinant VEGF-C restores mesenteric lymphatic drainage and improves gut immune surveillance in experimental cirrhosis
inferred← citeshttps://doi.org/10.2174/1389201023666220506105026openalex-snapshot
The Role of VEGF Family in Lipid Metabolism
inferred← citeshttps://doi.org/10.21873/invivo.13422openalex-snapshot
Deletion of RAMP1 Signaling Enhances Diet-induced Obesity and Fat Absorption via Intestinal Lacteals in Mice
inferred← citeshttps://doi.org/10.3389/fbioe.2018.00007openalex-snapshot
Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels
inferred← citeshttps://doi.org/10.3389/fcell.2020.627647openalex-snapshot
Molecular Mechanisms Controlling Lymphatic Endothelial Junction Integrity
inferred← citeshttps://doi.org/10.3389/fcell.2025.1527971openalex-snapshot
Regulation of VEGFR3 signaling in lymphatic endothelial cells
inferred← citeshttps://doi.org/10.3389/fcvm.2021.738325openalex-snapshot
The Role of the VEGF Family in Coronary Heart Disease
inferred← citeshttps://doi.org/10.3389/fcvm.2023.1240288openalex-snapshot
Variation in VEGFA and risk of cardiovascular disease in the UK Biobank
inferred← citeshttps://doi.org/10.3389/fendo.2022.1007856openalex-snapshot
The role of lacteal integrity and junction transformation in obesity: A promising therapeutic target?
inferred← citeshttps://doi.org/10.3389/fimmu.2019.00720openalex-snapshot
Tumor-Associated Lymphatic Vessel Features and Immunomodulatory Functions
inferred← citeshttps://doi.org/10.3389/fimmu.2019.03043openalex-snapshot
Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels
inferred← citeshttps://doi.org/10.3389/fncel.2021.683676openalex-snapshot
Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases
inferred← citeshttps://doi.org/10.3389/fonc.2021.632189openalex-snapshot
Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
inferred← citeshttps://doi.org/10.3389/fphar.2019.00582openalex-snapshot
Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
inferred← citeshttps://doi.org/10.3389/fphar.2022.848088openalex-snapshot
Lymphatic Collecting Vessel: New Perspectives on Mechanisms of Contractile Regulation and Potential Lymphatic Contractile Pathways to Target in Obesity and Metabolic Diseases
inferred← citeshttps://doi.org/10.3389/fphar.2022.915161openalex-snapshot
Kuoxin Decoction promotes lymphangiogenesis in zebrafish and in vitro based on network analysis
inferred← citeshttps://doi.org/10.3389/fphar.2023.1097835openalex-snapshot
New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases
inferred← citeshttps://doi.org/10.3389/fphys.2018.01783openalex-snapshot
VEGFR-3 Signaling Regulates Triglyceride Retention and Absorption in the Intestine
inferred← citeshttps://doi.org/10.3389/fphys.2019.01579openalex-snapshot
Emerging Roles for Lymphatics in Chronic Liver Disease
inferred← citeshttps://doi.org/10.3389/fphys.2019.01604openalex-snapshot
Emerging Role of Lymphatics in the Regulation of Intestinal Lipid Mobilization
inferred← citeshttps://doi.org/10.3389/fphys.2020.00003openalex-snapshot
Lymphatic Vasculature in Energy Homeostasis and Obesity
inferred← citeshttps://doi.org/10.3389/fphys.2020.00404openalex-snapshot
The Role of Lymphatic Vascular Function in Metabolic Disorders
inferred← citeshttps://doi.org/10.3389/fphys.2020.00459openalex-snapshot
Regulation of Lymphatic Function in Obesity
inferred← citeshttps://doi.org/10.3389/fphys.2021.672987openalex-snapshot
Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology
inferred← citeshttps://doi.org/10.3390/biology10020167openalex-snapshot
Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs
inferred← citeshttps://doi.org/10.3390/cancers14174225openalex-snapshot
The Role of Periostin in Angiogenesis and Lymphangiogenesis in Tumors
inferred← citeshttps://doi.org/10.3390/cancers16101794openalex-snapshot
Angiogenesis Still Plays a Crucial Role in Human Melanoma Progression
inferred← citeshttps://doi.org/10.3390/cells10102584openalex-snapshot
Interplay between Gut Lymphatic Vessels and Microbiota
inferred← citeshttps://doi.org/10.3390/cells13010068openalex-snapshot
Dysregulation of Lymphatic Endothelial VEGFR3 Signaling in Disease
inferred← citeshttps://doi.org/10.3390/ijms21020565openalex-snapshot
Potential Therapeutic Strategies for Lung and Breast Cancers through Understanding the Anti-Angiogenesis Resistance Mechanisms
inferred← citeshttps://doi.org/10.3390/ijms22083955openalex-snapshot
Mechanosensation and Mechanotransduction by Lymphatic Endothelial Cells Act as Important Regulators of Lymphatic Development and Function
inferred← citeshttps://doi.org/10.3390/ijms22147760openalex-snapshot
Regulation of VEGFR Signalling in Lymphatic Vascular Development and Disease: An Update
inferred← citeshttps://doi.org/10.3390/ijms222011036openalex-snapshot
The Effect of Surface-Modified Gold Nanorods on the Early Stage of Embryonic Development and Angiogenesis: Insight into the Molecular Pathways
inferred← citeshttps://doi.org/10.3390/ijms23020931openalex-snapshot
The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets
inferred← citeshttps://doi.org/10.3390/medsci13030140openalex-snapshot
PROX1 Expression in Resected Non-Small Cell Lung Cancer: Immunohistochemical Profile and Clinicopathological Correlates
inferred← citeshttps://doi.org/10.3390/mi11020147openalex-snapshot
Blood and Lymphatic Vasculatures On-Chip Platforms and Their Applications for Organ-Specific In Vitro Modeling
inferred← citeshttps://doi.org/10.3390/nu13072198openalex-snapshot
The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis
inferred← citeshttps://doi.org/10.3390/nu17091416openalex-snapshot
Glucagon-like Peptide-2 Acts Partially Through Central GLP-2R and MC4R in Mobilizing Stored Lipids from the Intestine
inferred← citeshttps://doi.org/10.3390/photonics9050304openalex-snapshot
Optical Coherence Tomography Angiography and Attenuation Imaging for Label-Free Observation of Functional Changes in the Intestine after Sympathectomy: A Pilot Study
inferred← citeshttps://doi.org/10.3724/zdxbyxb-2025-0549openalex-snapshot
Research progress on vascular endothelial growth factor C in meningeal lymphatic vessel-mediated clearance of amyloid β-protein
inferred← citeshttps://doi.org/10.4049/jimmunol.1700967openalex-snapshot
Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators
inferred← citeshttps://doi.org/10.4103/1673-5374.230299openalex-snapshot
Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease
inferred← citeshttps://doi.org/10.4155/fmc-2019-0337openalex-snapshot
High ELK3 Expression is Associated with the VEGF-C/VEGFR-3 Axis and Gastric Tumorigenesis and Enhances Infiltration of M2 Macrophages
inferred← citeshttps://doi.org/10.6084/m9.figshare.20962366openalex-snapshot
Additional file 1 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome
inferred← citeshttps://doi.org/10.6084/m9.figshare.20962375openalex-snapshot
Additional file 2 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome
inferred← citeshttps://doi.org/10.6084/m9.figshare.20962378openalex-snapshot
Additional file 3 of ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pathway by the secretome
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