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Persistent STAT3 Activation in Colon Cancer Is Associated with Enhanced Cell Proliferation and Tumor Growth
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1521-1878(199912)22:1<1021::aid-bies6>3.0.co;2-popenalex-snapshot
β-catenin signaling and cancer
inferredcites →https://doi.org/10.1002/pros.10079openalex-snapshot
Stat3 activation in prostatic carcinomas
inferredcites →https://doi.org/10.1002/pros.1080openalex-snapshot
Anti‐interleukin‐6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice
inferredcites →https://doi.org/10.1007/bf02981979openalex-snapshot
Constitutive Activation of Stat1 and Stat3 in Primary Erythroleukemia Cells
inferredcites →https://doi.org/10.1016/0092-8674(94)90235-6openalex-snapshot
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
inferredcites →https://doi.org/10.1016/s0002-9440(10)63067-2openalex-snapshot
Interleukin-6 Is an Autocrine Growth Factor in Human Prostate Cancer
inferredcites →https://doi.org/10.1016/s0003-3995(02)01115-2openalex-snapshot
Genetic instability in human mismatch repair deficient cancers
inferredcites →https://doi.org/10.1016/s0022-5347(05)64741-6openalex-snapshot
Activation of Signal Transducer and Activator of Transcription 3 in Renal Cell Carcinoma: A Study of Incidence and Its Association With Pathological Features and Clinical Outcome
inferredcites →https://doi.org/10.1016/s0092-8674(02)00701-8openalex-snapshot
Cytokine Signaling in 2002
inferredcites →https://doi.org/10.1016/s0940-9602(03)80002-xopenalex-snapshot
Modern laser scanning microscopy in biology, biotechnology and medicine
inferredcites →https://doi.org/10.1016/s0959-8049(99)00305-6openalex-snapshot
Truncated adenomatous polyposis coli (APC) tumour suppressor protein can undergo tyrosine phosphorylation
inferredcites →https://doi.org/10.1016/s0960-7404(99)00034-1openalex-snapshot
Colorectal cancer screening and follow-up
inferredcites →https://doi.org/10.1016/s1534-5807(02)00126-0openalex-snapshot
Stat3 Controls Cell Movements during Zebrafish Gastrulation
inferredcites →https://doi.org/10.1038/ng1045openalex-snapshot
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
inferredcites →https://doi.org/10.1038/sj.onc.1202708openalex-snapshot
Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1
inferredcites →https://doi.org/10.1038/sj.onc.1203568openalex-snapshot
Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability
inferredcites →https://doi.org/10.1038/sj.onc.1204349openalex-snapshot
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
inferredcites →https://doi.org/10.1038/sj.onc.1204990openalex-snapshot
Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
inferredcites →https://doi.org/10.1038/sj.onc.1205263openalex-snapshot
Constitutive activation of Stat3α in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2)
inferredcites →https://doi.org/10.1038/sj.onc.1205385openalex-snapshot
Differential function of STAT5 isoforms in head and neck cancer growth control
inferredcites →https://doi.org/10.1038/sj.onc.1205577openalex-snapshot
Novel colon cancer cell lines leading to better understanding of the diversity of respective primary cancers
inferredcites →https://doi.org/10.1038/sj.onc.1205859openalex-snapshot
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
inferredcites →https://doi.org/10.1038/sj.onc.1206004openalex-snapshot
Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells
inferredcites →https://doi.org/10.1038/sj.onc.1206047openalex-snapshot
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
inferredcites →https://doi.org/10.1046/j.1365-2141.2002.03236.xopenalex-snapshot
CELLULAR SIGNALLING PATHWAYS: NEW TARGETS IN LEUKAEMIA THERAPY
inferredcites →https://doi.org/10.1046/j.1365-2362.2002.01004.xopenalex-snapshot
Molecular causes of colon cancer
inferredcites →https://doi.org/10.1073/pnas.93.21.11400openalex-snapshot
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.
inferredcites →https://doi.org/10.1073/pnas.94.8.3801openalex-snapshot
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
inferredcites →https://doi.org/10.1073/pnas.98.4.1543openalex-snapshot
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
inferredcites →https://doi.org/10.1074/jbc.271.39.23634openalex-snapshot
Homodimerization of Interleukin-4 Receptor α Chain Can Induce Intracellular Signaling
inferredcites →https://doi.org/10.1074/jbc.273.47.31222openalex-snapshot
The Interleukin-4 Receptor Activates STAT5 by a Mechanism That Relies upon Common γ-Chain
inferredcites →https://doi.org/10.1074/jbc.m109962200openalex-snapshot
Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines
inferredcites →https://doi.org/10.1074/jbc.m304307200openalex-snapshot
Inhibition of Transcription Factor Stat5 Induces Cell Death of Human Prostate Cancer Cells
inferredcites →https://doi.org/10.1093/carcin/20.11.2045openalex-snapshot
Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level
inferredcites →https://doi.org/10.1093/emboj/18.17.4657openalex-snapshot
Keratinocyte‐specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
inferredcites →https://doi.org/10.1146/annurev.genom.3.022502.103043openalex-snapshot
GENETIC AND EPIGENETIC ALTERATIONS IN COLON CANCER
inferredcites →https://doi.org/10.1159/000066755openalex-snapshot
Wnt/Beta-Catenin/Tcf Signaling: A Critical Pathway in Gastrointestinal Tumorigenesis
inferredcites →https://doi.org/10.1172/jci3785openalex-snapshot
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.
inferredcites →https://doi.org/10.1172/jci9940openalex-snapshot
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
inferredcites →https://doi.org/10.1182/blood.v95.12.3765openalex-snapshot
Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6
inferredcites →https://doi.org/10.1182/blood.v99.1.252openalex-snapshot
Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival
inferredcites →https://doi.org/10.3892/ijmm.10.5.589openalex-snapshot
Evaluation of telomerase in the development and progression of colon cancer
inferredcites →https://doi.org/10.4049/jimmunol.166.12.7486openalex-snapshot
Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4617358openalex-extracted
The Characteristics Of Tumor Microenvironment In Colorectal Cancer With Different Msi Status And Current Therapeutic Strategies
inferred← citeshttps://doi.org/10.1002/1873-3468.12655openalex-snapshot
Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS 3
inferred← citeshttps://doi.org/10.1002/2211-5463.12642openalex-snapshot
Retracted: High‐intensity focused ultrasound inhibits invasion and metastasis of colon cancer cells by enhancing microRNA‐124‐mediated suppression of STAT3
inferred← citeshttps://doi.org/10.1002/advs.202405332openalex-snapshot
SNORA28 Promotes Proliferation and Radioresistance in Colorectal Cancer Cells through the STAT3 Pathway by Increasing H3K9 Acetylation in the LIFR Promoter
inferred← citeshttps://doi.org/10.1002/cac2.12235openalex-snapshot
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells
inferred← citeshttps://doi.org/10.1002/cac2.12295openalex-snapshot
Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
inferred← citeshttps://doi.org/10.1002/cbin.11397openalex-snapshot
Reduced expression of CYLD promotes cell survival and inflammation in gefitinib‐treated NSCLC PC‐9 cells: Targeting CYLD may be beneficial for acquired resistance to gefitinib therapy
inferred← citeshttps://doi.org/10.1002/cncr.22293openalex-snapshot
The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis
inferred← citeshttps://doi.org/10.1002/hep.24595openalex-snapshot
Primate-specific microRNA-637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting signal transducer and activator of transcription 3 signaling
inferred← citeshttps://doi.org/10.1002/ijc.23436openalex-snapshot
Adiponectin blocks multiple signaling cascades associated with leptin‐induced cell proliferation in ApcMin/+ colon epithelial cells
inferred← citeshttps://doi.org/10.1002/ijc.25992openalex-snapshot
Inactivation of the vitamin D receptor in APCmin/+ mice reveals a critical role for the vitamin D receptor in intestinal tumor growth
inferred← citeshttps://doi.org/10.1002/ijc.28429openalex-snapshot
STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo
inferred← citeshttps://doi.org/10.1002/ijc.31064openalex-snapshot
CRHR2/Ucn2 signaling is a novel regulator of miR‐7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas‐mediated apoptosis
inferred← citeshttps://doi.org/10.1002/jcb.21475openalex-snapshot
STAT‐mediated EGFR signaling in cancer
inferred← citeshttps://doi.org/10.1002/jcb.30078openalex-snapshot
Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors
inferred← citeshttps://doi.org/10.1002/mc.22271openalex-snapshot
PAC exhibits potent anti‐colon cancer properties through targeting cyclin D1 and suppressing epithelial‐to‐mesenchymal transition
inferred← citeshttps://doi.org/10.1002/mc.22353openalex-snapshot
Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
inferred← citeshttps://doi.org/10.1002/mc.22447openalex-snapshot
Interleukin‐6 increases expression of serine protease inhibitor Kazal type 1 through STAT3 in colorectal adenocarcinoma
inferred← citeshttps://doi.org/10.1002/mc.22691openalex-snapshot
CRH promotes human colon cancer cell proliferation via IL‐6/JAK2/STAT3 signaling pathway and VEGF‐induced tumor angiogenesis
inferred← citeshttps://doi.org/10.1002/med.21761openalex-snapshot
The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy
inferred← citeshttps://doi.org/10.1002/mnfr.201300120openalex-snapshot
The role of cancer stem cells in the anti‐carcinogenicity of curcumin
inferred← citeshttps://doi.org/10.1002/mog2.70063openalex-snapshot
The JAK/STAT Pathway in Cancer: From Molecular Mechanisms to Clinical Applications
inferred← citeshttps://doi.org/10.1002/path.2218openalex-snapshot
Augmented gp130‐mediated cytokine signalling accompanies human gastric cancer progression
inferred← citeshttps://doi.org/10.1002/path.2818openalex-snapshot
The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target
inferred← citeshttps://doi.org/10.1002/slct.202502456openalex-snapshot
Design, Synthesis, and In‐Silico Molecular Docking Studies of 1,2,3‐Triazole‐Bearing Oxepinopyridine Derivatives as Potent Anticancer Agents
inferred← citeshttps://doi.org/10.1002/stem.2320openalex-snapshot
IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4939-0706-9_15openalex-snapshot
Epigenetic Mechanisms of Colon Cancer Prevention: What Can Nutrition Do?
inferred← citeshttps://doi.org/10.1007/978-1-59745-337-0_7openalex-snapshot
Molecular Targeting of Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/978-3-7091-0891-8_16openalex-snapshot
STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer
inferred← citeshttps://doi.org/10.1007/978-3-7091-0891-8_17openalex-snapshot
Universal and Specific Functions of STAT3 in Solid Tumours
inferred← citeshttps://doi.org/10.1007/978-981-10-6728-0_15openalex-snapshot
Transcription Factors and Colorectal Cancer: An Overview
inferred← citeshttps://doi.org/10.1007/978-981-99-4657-0_5openalex-snapshot
The Role of Interleukin (IL)-6/IL-6 Receptor Axis in Cancer
inferred← citeshttps://doi.org/10.1007/s00011-009-2015-1openalex-snapshot
Th17 in sensitized human lymphocytes ex vivo ?
inferred← citeshttps://doi.org/10.1007/s00011-021-01486-7openalex-snapshot
MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer
inferred← citeshttps://doi.org/10.1007/s00018-017-2477-1openalex-snapshot
Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis
inferred← citeshttps://doi.org/10.1007/s00210-025-04893-3openalex-snapshot
Targeting STAT3 by SH-4–54 suppresses the occurrence and inactivates oxidative phosphorylation in small-cell lung cancer via the SRC signaling
inferred← citeshttps://doi.org/10.1007/s00210-026-05523-2openalex-snapshot
Enhanced antitumor efficacy of sulfasalazine and mesalazine in colorectal cancer through modulatory action of Lacticaseibacillus rhamnosus GG
inferred← citeshttps://doi.org/10.1007/s00384-010-1060-0openalex-snapshot
Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6–STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1007/s00432-007-0318-6openalex-snapshot
Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells
inferred← citeshttps://doi.org/10.1007/s00432-010-0943-3openalex-snapshot
Cell–cell contacts induce STAT3 activity in colon carcinoma cells through an autocrine stimulation loop
inferred← citeshttps://doi.org/10.1007/s00432-022-04029-7openalex-snapshot
Inflammation suppresses DLG2 expression decreasing inflammasome formation
inferred← citeshttps://doi.org/10.1007/s00535-013-0885-zopenalex-snapshot
Functions and regulation of MUC13 mucin in colon cancer cells
inferred← citeshttps://doi.org/10.1007/s10238-024-01532-8openalex-snapshot
Long non-coding RNAs (lncRNAs) in cancer development: new insight from STAT3 signaling pathway to immune evasion
inferred← citeshttps://doi.org/10.1007/s10555-022-10028-4openalex-snapshot
Inflammatory bowel disease and carcinogenesis
inferred← citeshttps://doi.org/10.1007/s10620-019-05971-2openalex-snapshot
Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation
inferred← citeshttps://doi.org/10.1007/s11010-015-2424-0openalex-snapshot
Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro
inferred← citeshttps://doi.org/10.1007/s11010-020-03719-5openalex-snapshot
Ceramide and palmitic acid inhibit macrophage-mediated epithelial–mesenchymal transition in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s11010-020-03893-6openalex-snapshot
Targeting STAT proteins via computational analysis in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s11033-021-06610-8openalex-snapshot
Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway
inferred← citeshttps://doi.org/10.1007/s11888-014-0248-zopenalex-snapshot
Role of Prolactin and Its Receptor in Colorectal Cancer
inferred← citeshttps://doi.org/10.1007/s12032-022-01854-1openalex-snapshot
Investigation of molecular mechanisms underlying JAK/STAT signaling pathway in HPV-induced cervical carcinogenesis using ‘omics’ approach
inferred← citeshttps://doi.org/10.1007/s12032-024-02404-7openalex-snapshot
From bench to bedside: the past, present and future of IL-21 immunotherapy
inferred← citeshttps://doi.org/10.1007/s12253-010-9321-3openalex-snapshot
PHOSPHO-STAT5 Expression is Associated with Poor Prognosis of Human Colonic Adenocarcinoma
inferred← citeshttps://doi.org/10.1007/s13402-013-0124-xopenalex-snapshot
Abrogation of galectin-4 expression promotes tumorigenesis in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s40199-020-00326-zopenalex-snapshot
STAT3 inhibitory stattic enhances immunogenic cell death induced by chemotherapy in cancer cells
inferred← citeshttps://doi.org/10.1007/s43152-023-00044-zopenalex-snapshot
Application of Nano-Antibodies for Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-415847-4.00091-4openalex-snapshot
Intestinal Inflammation and Cancer of the Gastrointestinal Tract
inferred← citeshttps://doi.org/10.1016/b978-0-12-811785-9.00018-1openalex-snapshot
Resistance to EGFR Targeting Treatments in Colorectal Cancer
inferred← citeshttps://doi.org/10.1016/j.ajpath.2012.11.026openalex-snapshot
RETRACTED: Death-Associated Protein Kinase Controls STAT3 Activity in Intestinal Epithelial Cells
inferred← citeshttps://doi.org/10.1016/j.ajpath.2015.09.013openalex-snapshot
Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis
inferred← citeshttps://doi.org/10.1016/j.amjsurg.2026.116941openalex-snapshot
Uncovering molecular pathways in appendiceal cancer: A comprehensive characterization for precision oncology
inferred← citeshttps://doi.org/10.1016/j.arcmed.2010.02.009openalex-snapshot
Elevated Serum Level of IL-23 Correlates with Expression of VEGF in Human Colorectal Carcinoma
inferred← citeshttps://doi.org/10.1016/j.bbagen.2021.130058openalex-snapshot
Structural and utational nalysis of ember-pecific STAT unctions
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2009.07.009openalex-snapshot
Cytokine signalling via gp130 in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2010.12.010openalex-snapshot
Cytokine disbalance in common human cancers
inferred← citeshttps://doi.org/10.1016/j.bbcan.2013.12.005openalex-snapshot
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.08.067openalex-snapshot
Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas
inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.10.112openalex-snapshot
STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+/CD133+ stem cell-like human colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2012.10.037openalex-snapshot
Opposing roles of STAT-1 and STAT-3 in regulating vascular endothelial growth factor expression in vascular smooth muscle cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.07.105openalex-snapshot
JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein–protein interaction in human colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.10.054openalex-snapshot
microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.12.042openalex-snapshot
STAT3 stimulates adipogenic stem cell proliferation and cooperates with HMGA2 during the early stage of differentiation to promote adipogenesis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.02.084openalex-snapshot
Activated STAT3 may participate in tumor progression through increasing CD133/survivin expression in early stage of colon cancer
inferred← citeshttps://doi.org/10.1016/j.bcp.2011.12.024openalex-snapshot
The many faces of Janus kinase
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.05.089openalex-snapshot
Lactobacillus rhamnosus ATCC 7469 exopolysaccharides synergizes with low level ionizing radiation to modulate signaling molecular targets in colorectal carcinogenesis in rats
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.09.138openalex-snapshot
MiR-146a functions as a small silent player in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.117930openalex-snapshot
Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.115089openalex-snapshot
Natural product pectolinarigenin exhibits potent anti-metastatic activity in colorectal carcinoma cells in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.01.030openalex-snapshot
Synthetic derivatives of the natural product 13-amino 2-desoxy-4-epi-pulchellin inhibit STAT3 signaling and induce G2/M arrest and death of colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.canlet.2013.08.009openalex-snapshot
Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro
inferred← citeshttps://doi.org/10.1016/j.canlet.2014.07.044openalex-snapshot
Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression
inferred← citeshttps://doi.org/10.1016/j.canlet.2014.12.047openalex-snapshot
The role of IL-21 in immunity and cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2016.08.023openalex-snapshot
Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade
inferred← citeshttps://doi.org/10.1016/j.ccell.2016.03.014openalex-snapshot
IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.05.032openalex-snapshot
ADAM17-Dependent c-MET-STAT3 Signaling Mediates Resistance to MEK Inhibitors in KRAS Mutant Colorectal Cancer
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.02.064openalex-snapshot
The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals
inferred← citeshttps://doi.org/10.1016/j.clcc.2022.11.002openalex-snapshot
Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study
inferred← citeshttps://doi.org/10.1016/j.clim.2010.06.017openalex-snapshot
Alternatively activated alveolar macrophages in pulmonary fibrosis—mediator production and intracellular signal transduction
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2021.104780openalex-snapshot
Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2012.09.014openalex-snapshot
Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis
inferred← citeshttps://doi.org/10.1016/j.crtox.2023.100139openalex-snapshot
Network pharmacology and bioinformatics to identify the molecular mechanisms of Gleditsiae Spina against colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.ddmec.2012.02.003openalex-snapshot
SIGIRR, a negative regulator of colon tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.ejca.2006.07.006openalex-snapshot
JAK/STAT signalling pathway in colorectal cancer: A new biological target with therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116448openalex-snapshot
Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117308openalex-snapshot
Identification of Thieno[3,2-d]pyrimidine derivatives as potent and selective Janus Kinase 1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejphar.2019.172620openalex-snapshot
Novel repair mechanisms in a renal ischaemia/reperfusion model: Subsequent saxagliptin treatment modulates the pro-angiogenic GLP-1/cAMP/VEGF, ANP/eNOS/NO, SDF-1α/CXCR4, and Kim-1/STAT3/HIF-1α/VEGF/eNOS pathways
inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173107openalex-snapshot
Targeting STAT3 in cancer and autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177294openalex-snapshot
Beyond chemotherapy: Exploring 5-FU resistance and stemness in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.febslet.2015.11.013openalex-snapshot
MgcRacGAP inhibition stimulates JAK‐dependent STAT3 activity
inferred← citeshttps://doi.org/10.1016/j.gene.2023.147357openalex-snapshot
Association between the methylation of CpG islands in JAK-STAT pathway-related genes and colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2018.05.121openalex-snapshot
STAT3 and apoptosis challenges in cancer
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.117452openalex-snapshot
Gut microbiota regulation of the IL-6/STAT3 pathway: Linking hematopoiesis to colorectal cancer progression
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2015.08.001openalex-snapshot
Diminished Expression of Corticotropin-Releasing Hormone Receptor 2 in Human Colon Cancer Promotes Tumor Growth and Epithelial-to-Mesenchymal Transition via Persistent Interleukin-6/Stat3 Signaling
inferred← citeshttps://doi.org/10.1016/j.jep.2016.08.039openalex-snapshot
Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through targeting IL-6-induced JAK2/STAT3 pathway in human colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.jff.2015.03.020openalex-snapshot
Sorghum polyphenol suppresses the growth as well as metastasis of colon cancer xenografts through co-targeting jak2/STAT3 and PI3K/Akt/mTOR pathways
inferred← citeshttps://doi.org/10.1016/j.jff.2023.105977openalex-snapshot
Tea polyphenol EGC suppresses colorectal cancer cell proliferation both in vitro and in vivo via downregulation of STAT3
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2017.06.002openalex-snapshot
Recent development of transition metal complexes with in vivo antitumor activity
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2015.07.024openalex-snapshot
Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.116626openalex-snapshot
Suppressor of activator protein-1 regulated by interferon expression in prostate cancer tissues and cells
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118522openalex-snapshot
Repurposing of niclosamide as a STAT3 inhibitor to enhance the anticancer effect of chemotherapeutic drugs in treating colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.mce.2010.06.013openalex-snapshot
Regulation of translocator protein 18kDa (TSPO) expression in health and disease states☆
inferred← citeshttps://doi.org/10.1016/j.mtnano.2021.100155openalex-snapshot
Synergistic nanoassemblies constructed from a STAT3 inhibitor and a cabazitaxel prodrug with enhanced cancer chemo-immunotherapy
inferred← citeshttps://doi.org/10.1016/j.nano.2021.102373openalex-snapshot
Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2015.10.004openalex-snapshot
Targeting transcription factor STAT3 for cancer prevention and therapy
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2018.06.006openalex-snapshot
Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.105412openalex-snapshot
Posttranslational modifications as therapeutic targets for intestinal disorders
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154526openalex-snapshot
Gracillin exerts anti-melanoma effects in vitro and in vivo: role of DNA damage, apoptosis and autophagy
inferred← citeshttps://doi.org/10.1016/j.prp.2015.01.007openalex-snapshot
Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway
inferred← citeshttps://doi.org/10.1016/j.semcancer.2017.06.009openalex-snapshot
Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk
inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.02.022openalex-snapshot
Re-establishing the comprehension of phytomedicine and nanomedicine in inflammation-mediated cancer signaling
inferred← citeshttps://doi.org/10.1016/j.semcancer.2023.01.001openalex-snapshot
The complex network of transcription factors, immune checkpoint inhibitors and stemness features in colorectal cancer: A recent update
inferred← citeshttps://doi.org/10.1016/j.semcdb.2008.06.004openalex-snapshot
Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling
inferred← citeshttps://doi.org/10.1016/j.smim.2013.12.003openalex-snapshot
Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development
inferred← citeshttps://doi.org/10.1016/j.tranon.2015.02.002openalex-snapshot
Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation
inferred← citeshttps://doi.org/10.1016/j.tranon.2020.100996openalex-snapshot
Phosphorylated transducer and activator of transcription-3 (pSTAT3) immunohistochemical expression in paired primary and metastatic colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.trecan.2019.10.013openalex-snapshot
Unmasking the Many Faces of Tumor-Associated Neutrophils and Macrophages: Considerations for Targeting Innate Immune Cells in Cancer
inferred← citeshttps://doi.org/10.1016/j.trsl.2018.02.002openalex-snapshot
NF-κB pathways in the development and progression of colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.ydbio.2008.11.016openalex-snapshot
miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation
inferred← citeshttps://doi.org/10.1016/j.yexcr.2009.12.005openalex-snapshot
Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00076openalex-snapshot
Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01392openalex-snapshot
Discovery of (2 R )‑ N ‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1 H ‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor
inferred← citeshttps://doi.org/10.1021/jm300207sopenalex-snapshot
Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein
inferred← citeshttps://doi.org/10.1038/bjc.2011.200openalex-snapshot
Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030
inferred← citeshttps://doi.org/10.1038/bjc.2013.274openalex-snapshot
Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma
inferred← citeshttps://doi.org/10.1038/cddis.2016.452openalex-snapshot
Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis
inferred← citeshttps://doi.org/10.1038/cr.2013.101openalex-snapshot
Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration
inferred← citeshttps://doi.org/10.1038/leu.2014.245openalex-snapshot
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia
inferred← citeshttps://doi.org/10.1038/nature04846openalex-snapshot
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
inferred← citeshttps://doi.org/10.1038/ncomms5715openalex-snapshot
Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis
inferred← citeshttps://doi.org/10.1038/onc.2013.80openalex-snapshot
The regulatory roles of phosphatases in cancer
inferred← citeshttps://doi.org/10.1038/s41388-020-01587-3openalex-snapshot
Transcription factors in colorectal cancer: molecular mechanism and therapeutic implications
inferred← citeshttps://doi.org/10.1038/s41389-019-0130-6openalex-snapshot
Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
inferred← citeshttps://doi.org/10.1038/s41389-023-00492-0openalex-snapshot
Molecular mechanisms in colitis-associated colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41392-021-00677-2openalex-snapshot
CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression
inferred← citeshttps://doi.org/10.1038/s41419-025-07566-4openalex-snapshot
Molecular mechanisms underlying TXNIP’s anti-tumor role in breast cancer, including interaction with a novel, pro-tumor partner: CAST
inferred← citeshttps://doi.org/10.1038/s41420-024-01990-9openalex-snapshot
CEBPB-mediated upregulation of SERPINA1 promotes colorectal cancer progression by enhancing STAT3 signaling
inferred← citeshttps://doi.org/10.1038/s41467-022-33377-8openalex-snapshot
A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma
inferred← citeshttps://doi.org/10.1038/s41598-017-12934-yopenalex-snapshot
SRVF, a novel herbal formula including Scrophulariae Radix and Viticis Fructus, disrupts focal adhesion and causes detachment-induced apoptosis in malignant cancer cells
inferred← citeshttps://doi.org/10.1038/s41598-021-86941-5openalex-snapshot
Key biomarkers within the colorectal cancer related inflammatory microenvironment
inferred← citeshttps://doi.org/10.1038/sj.onc.1210065openalex-snapshot
Wnt signalling in the mouse intestine
inferred← citeshttps://doi.org/10.1039/c3mb25518bopenalex-snapshot
Topological patterns in microRNA–gene regulatory network: studies in colorectal and breast cancer
inferred← citeshttps://doi.org/10.1039/c5fo00260eopenalex-snapshot
Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation
inferred← citeshttps://doi.org/10.1039/c6ra21533eopenalex-snapshot
Niclosamide induces colorectal cancer apoptosis, impairs metastasis and reduces immunosuppressive cells in vivo
inferred← citeshttps://doi.org/10.1039/d2fo02208gopenalex-snapshot
Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives
inferred← citeshttps://doi.org/10.1042/bst20180136openalex-snapshot
The role of the interleukin (IL)-6/IL-6 receptor axis in cancer
inferred← citeshttps://doi.org/10.1049/iet-syb.2009.0060openalex-snapshot
Investigation of IL-6 and IL-10 signalling via mathematical modelling
inferred← citeshttps://doi.org/10.1053/j.gastro.2009.11.049openalex-snapshot
Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice
inferred← citeshttps://doi.org/10.1073/pnas.0611665104openalex-snapshot
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
inferred← citeshttps://doi.org/10.1073/pnas.2105747118openalex-snapshot
cGAS restricts colon cancer development by protecting intestinal barrier integrity
inferred← citeshttps://doi.org/10.1074/jbc.m611040200openalex-snapshot
The Interleukin-22/STAT3 Pathway Potentiates Expression of Inducible Nitric-oxide Synthase in Human Colon Carcinoma Cells
inferred← citeshttps://doi.org/10.1074/mcp.ra120.002152openalex-snapshot
Novel Proteome Extraction Method Illustrates a Conserved Immunological Signature of MSI-H Colorectal Tumors
inferred← citeshttps://doi.org/10.1080/01635581.2021.1968444openalex-snapshot
Root Bark ofMorus Alba L.Induced p53-Independent Apoptosis in Human Colorectal Cancer Cells by Suppression of STAT3 Activity
inferred← citeshttps://doi.org/10.1080/07357907.2016.1247166openalex-snapshot
Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies
inferred← citeshttps://doi.org/10.1080/07357907.2022.2055050openalex-snapshot
Signaling Pathways Involved in 5-FU Drug Resistance in Cancer
inferred← citeshttps://doi.org/10.1080/08958378.2022.2086651openalex-snapshot
Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation
inferred← citeshttps://doi.org/10.1080/09674845.2004.11732661openalex-snapshot
Reduction in neutrophil elastase concentration by recombinant α1-antitrypsin (recAAT) does not alter bacterial loading in the sputum of cystic fibrosis patients
inferred← citeshttps://doi.org/10.1080/10408398.2016.1203755openalex-snapshot
Ursolic acid, a potential anticancer compound for breast cancer therapy
inferred← citeshttps://doi.org/10.1080/10408398.2020.1829541openalex-snapshot
The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
inferred← citeshttps://doi.org/10.1080/14728222.2017.1306055openalex-snapshot
Signaling pathways as therapeutic targets in biliary tract cancer
inferred← citeshttps://doi.org/10.1080/14728222.2023.2199924openalex-snapshot
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells
inferred← citeshttps://doi.org/10.1089/jir.2012.0154openalex-snapshot
STAT Activation in Malignancies: Roles in Tumor Progression and in the Generation of Antineoplastic Effects of IFNs
inferred← citeshttps://doi.org/10.1093/abbs/gmaa069openalex-snapshot
STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1093/carcin/bgm180openalex-snapshot
Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma
inferred← citeshttps://doi.org/10.1093/jb/mvaf040openalex-snapshot
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate suppresses cell proliferation in metastatic melanoma through TC-PTP/PTPN2 and SH-PTP2/PTPN11
inferred← citeshttps://doi.org/10.1096/fj.201801176ropenalex-snapshot
Stat3 is indispensable for damage‐induced crypt regeneration but not for Wnt‐driven intestinal tumorigenesis
inferred← citeshttps://doi.org/10.1096/fj.202002392ropenalex-snapshot
Resolvin D1 suppresses inflammation‐associated tumorigenesis in the colon by inhibiting IL‐6‐induced mitotic spindle abnormality
inferred← citeshttps://doi.org/10.1097/cad.0000000000000605openalex-snapshot
A novel small molecular STAT3 inhibitor, 5Br-6b, induces apoptosis and inhibits migration in colorectal cancer cells
inferred← citeshttps://doi.org/10.1101/2024.06.04.597409openalex-snapshot
Probabilistic graph-based model uncovers previously unseen druggable vulnerabilities in major solid cancers
inferred← citeshttps://doi.org/10.1101/2025.07.22.666143openalex-snapshot
Glucose Metabolism Sustains Aberrant STAT3 Signaling in Colorectal Cancer via Glycosylated Paracrine Factors
inferred← citeshttps://doi.org/10.1101/2025.08.18.670822openalex-snapshot
Integrative network modeling of colorectal cancer reveals diagnostic signatures and therapeutic targets
inferred← citeshttps://doi.org/10.1111/bjd.13922openalex-snapshot
Eruptive squamous cell carcinomas with keratoacanthoma-like features in a patient treated with ruxolitinib
inferred← citeshttps://doi.org/10.1111/cas.12205openalex-snapshot
Tying the knot between cytokine and toll‐like receptor signaling in gastrointestinal tract cancers
inferred← citeshttps://doi.org/10.1111/cas.12359openalex-snapshot
2‐Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor‐κB signaling by inhibiting Janus kinase 2 and IκB kinase
inferred← citeshttps://doi.org/10.1111/cas.12608openalex-snapshot
Ginkgetin inhibits the growth of DU −145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity
inferred← citeshttps://doi.org/10.1111/j.1745-7254.2008.00742.xopenalex-snapshot
Molecular markers and targets for colorectal cancer prevention
inferred← citeshttps://doi.org/10.1111/jgh.70532openalex-snapshot
Preventive Effect of Helicobacter pylori Treatment on Colorectal Cancer Incidence and Mortality
inferred← citeshttps://doi.org/10.1126/scisignal.adz6443openalex-snapshot
Glucose metabolism sustains aberrant STAT3 signaling in colorectal cancer through glycosylated local signaling factors
inferred← citeshttps://doi.org/10.1134/s1990519x23060111openalex-snapshot
The Role of Cytokines in the Pathogenesis of Malignant Neoplasms
inferred← citeshttps://doi.org/10.1136/gut.2009.184176openalex-snapshot
Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis
inferred← citeshttps://doi.org/10.1136/jclinpath-2017-204739openalex-snapshot
Cancer stem cells in colorectal cancer: a review
inferred← citeshttps://doi.org/10.1136/jcp.2005.035113openalex-snapshot
STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation
inferred← citeshttps://doi.org/10.1145/2506583.2506599openalex-snapshot
Reconstructing transcriptional regulatory networks by probabilistic network component analysis
inferred← citeshttps://doi.org/10.1152/ajpgi.00419.2015openalex-snapshot
Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24
inferred← citeshttps://doi.org/10.1155/2012/987239openalex-snapshot
STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of TumorsIn Vitro
inferred← citeshttps://doi.org/10.1155/2014/187105openalex-snapshot
Genome-Wide Uncovering of STAT3-Mediated miRNA Expression Profiles in Colorectal Cancer Cell Lines
inferred← citeshttps://doi.org/10.1155/2017/5180707openalex-snapshot
Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT‐29 Colorectal Cancer Cells via Suppressing NF‐κB and STAT3 Signaling
inferred← citeshttps://doi.org/10.1155/2020/8032187openalex-snapshot
Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin β 6 Upregulation in Colorectal Cancer
inferred← citeshttps://doi.org/10.1155/2021/9918116openalex-snapshot
Colorectal Cancer: From Genetic Landscape to Targeted Therapy
inferred← citeshttps://doi.org/10.11569/wcjd.v28.i21.1084openalex-snapshot
Role of cGAS-STING signaling pathway in colon cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.can-10-4660openalex-snapshot
STAT3 Is Necessary for Proliferation and Survival in Colon Cancer–Initiating Cells
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