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Amyloid precursor protein regulates 5-fluorouracil resistance in human hepatocellular carcinoma cells by inhibiting the mitochondrial apoptotic pathway

https://doi.org/10.1631/jzus.b1900413
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1 of the 36 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1038/nature07767 (notice 2023-12-18).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1097-0215(200102)9999:9999<::aid-ijc1155>3.0.co;2-hopenalex-snapshot
Amyloid β protein precursor is involved in the growth of human colon carcinoma cellin vitro andin vivo
inferredcites →https://doi.org/10.1007/s11064-016-2147-yopenalex-snapshot
Betulinic Acid Induces Apoptosis in Differentiated PC12 Cells Via ROS-Mediated Mitochondrial Pathway
inferredcites →https://doi.org/10.1007/s11764-017-0630-3openalex-snapshot
A user-centred approach to developing bWell, a mobile app for arm and shoulder exercises after breast cancer treatment
inferredcites →https://doi.org/10.1007/s11764-017-0668-2openalex-snapshot
Development of the Cancer Survivor Profile-Breast Cancer (CSPro-BC) app: patient and nurse perspectives on a new navigation tool
inferredcites →https://doi.org/10.1007/s12035-016-9995-yopenalex-snapshot
Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease
inferredcites →https://doi.org/10.1007/s13277-015-4501-0openalex-snapshot
Quercetin induces apoptosis and enhances 5-FU therapeutic efficacy in hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.bbcan.2017.10.002openalex-snapshot
New insights into sorafenib resistance in hepatocellular carcinoma: Responsible mechanisms and promising strategies
inferredcites →https://doi.org/10.1016/j.bbrc.2014.09.010openalex-snapshot
Amyloid precursor protein regulates migration and metalloproteinase gene expression in prostate cancer cells
inferredcites →https://doi.org/10.1016/j.bbrc.2014.10.004openalex-snapshot
The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells
inferredcites →https://doi.org/10.1016/j.biopha.2018.01.002openalex-snapshot
Baicalein sensitizes hepatocellular carcinoma cells to 5-FU and Epirubicin by activating apoptosis and ameliorating P-glycoprotein activity
inferredcites →https://doi.org/10.1016/j.pneurobio.2017.05.005openalex-snapshot
Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.toxlet.2018.03.011openalex-snapshot
Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines
inferredcites →https://doi.org/10.1016/j.yexmp.2016.06.003openalex-snapshot
Overexpression of DLX2 is associated with poor prognosis and sorafenib resistance in hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/s0140-6736(17)33326-3openalex-snapshot
Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries
inferredcites →https://doi.org/10.1016/s1097-2765(02)00482-3openalex-snapshot
Mechanisms of Caspase Activation and Inhibition during Apoptosis
inferredcites →https://doi.org/10.1038/aps.2017.79openalex-snapshot
Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells
inferredcites →https://doi.org/10.1038/nature07767openalex-snapshot
RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
inferredcites →https://doi.org/10.1038/nature19076openalex-snapshot
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
inferredcites →https://doi.org/10.1038/sj.onc.1204436openalex-snapshot
Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms
inferredcites →https://doi.org/10.1074/jbc.m113.459255openalex-snapshot
Inhibition of Amyloid Precursor Protein Processing Enhances Gemcitabine-mediated Cytotoxicity in Pancreatic Cancer Cells
inferredcites →https://doi.org/10.1093/jjco/hyx180openalex-snapshot
Chemotherapy for hepatocellular carcinoma: current status and future perspectives
inferredcites →https://doi.org/10.1111/febs.14004openalex-snapshot
The discovery of Alzheimer‐causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”
inferredcites →https://doi.org/10.1152/ajpgi.00158.2012openalex-snapshot
Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3633openalex-snapshot
Amyloid Precursor Protein Is a Primary Androgen Target Gene That Promotes Prostate Cancer Growth
inferredcites →https://doi.org/10.1159/000485285openalex-snapshot
Multiple Roles of Autophagy in the Sorafenib Resistance of Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1245/s10434-014-4242-0openalex-snapshot
Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1523/jneurosci.4963-13.2014openalex-snapshot
A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models
inferredcites →https://doi.org/10.18632/oncotarget.15798openalex-snapshot
USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt
inferredcites →https://doi.org/10.2147/dddt.s188505openalex-snapshot
Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway
inferredcites →https://doi.org/10.3322/caac.21442openalex-snapshot
Cancer statistics, 2018
inferredcites →https://doi.org/10.3748/wjg.v21.i13.3843openalex-snapshot
Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma
inferredcites →https://doi.org/10.3748/wjg.v21.i21.6550openalex-snapshot
Alternative splicing ofVEGFA,APPandNUMBgenes in colorectal cancer
inferredcites →https://doi.org/10.3892/mmr.2016.4897openalex-snapshot
Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression
inferredcites →https://doi.org/10.3892/mmr.2018.8615openalex-snapshot
Anti‑cancer effects of a novel Pan‑RAF inhibitor in a hepatocellular carcinoma cell line
inferredcites →https://doi.org/10.3892/or.2014.3033openalex-snapshot
Downregulation of Rap1 promotes 5-fluorouracil-induced apoptosis in hepatocellular carcinoma cell line HepG2
inferredcites →https://doi.org/10.7534/j.issn.1009-2137.2017.03.018openalex-snapshot
[Mechanism of Apoptosis for Resveratrol-mediated Reversing the Drug-resistance of AML HL-60/ADR cells].

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4125816openalex-extracted
Curcumin Induces Mitochondrial Apoptosis in Human Hepatoma Cells Through BCLAF1-Mediated Modulation of PI3K/AKT/GSK-3β Signaling
inferred← citeshttps://doi.org/10.1007/s10753-024-02026-1openalex-snapshot
Integrated Single Cell Analysis Reveals An Atlas of Tumor Associated Macrophages in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1007/s12033-025-01494-6openalex-snapshot
GALNT18-Mediated O-Glycosylation Promotes Development of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma Through Activation of EGR1/TGF-β1/Smad Signaling
inferred← citeshttps://doi.org/10.1007/s13205-021-02737-4openalex-snapshot
Integrated analysis and identification of nine-gene signature associated to oral squamous cell carcinoma pathogenesis
inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167449openalex-snapshot
Therapeutic modulation of APP-CD74 axis can activate phagocytosis of TAMs in GBM
inferred← citeshttps://doi.org/10.1016/j.jlr.2024.100660openalex-snapshot
Fatty acid synthase inhibitor cerulenin hinders liver cancer stem cell properties through FASN/APP axis as novel therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120804openalex-snapshot
Curcumin induces mitochondrial apoptosis in human hepatoma cells through BCLAF1-mediated modulation of PI3K/AKT/GSK-3β signaling
inferred← citeshttps://doi.org/10.1038/s41420-025-02836-8openalex-snapshot
Microgravity and cancer cells: from molecular mechanisms to therapeutic strategies
inferred← citeshttps://doi.org/10.1038/s41598-023-50696-yopenalex-snapshot
Network-based pharmacology-based research on the effect and mechanism of the Hedyotis diffusa–Scutellaria Barbata pair in the treatment of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/s41598-024-73143-yopenalex-snapshot
5-Fluorouracil induces apoptosis in nutritional deprived hepatocellular carcinoma through mitochondrial damage
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1493954/v1openalex-snapshot
Curcumin induces Mitochondrial Apoptosis in Human Hepatoma Cells through BCLAF1-mediated Modulation of PI3K/AKT/GSK-3β Signaling
inferred← citeshttps://doi.org/10.3389/fgene.2022.921195openalex-snapshot
Network analysis of hepatocellular carcinoma liquid biopsies augmented by single-cell sequencing data
inferred← citeshttps://doi.org/10.3389/fmed.2024.1437226openalex-snapshot
Advances in hepatocellular carcinoma drug resistance models
inferred← citeshttps://doi.org/10.3390/cells13040342openalex-snapshot
A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/ijms22094999openalex-snapshot
Molecular Characteristics of Amyloid Precursor Protein (APP) and Its Effects in Cancer
inferred← citeshttps://doi.org/10.3390/medsci14010130openalex-snapshot
The Effect of Viniferin on Liver Cancer: Research Based on Network Pharmacology, Molecular Docking and Molecular Dynamics Simulation
inferred← citeshttps://doi.org/10.4103/1673-5374.386406openalex-snapshot
Amyloid-beta and tau protein beyond Alzheimer’s disease
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