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Molekularne mechanizmy działania genisteiny w świetle terapii chorób genetycznych i immunologicznych

https://doi.org/10.18388/pb.2018_140

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non‐obese diabetic (NOD) mice

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Dietary intake of isoflavones and polyunsaturated fatty acids associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease: Possible protective effect of traditional Japanese diet

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Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways

inferredcites →https://doi.org/10.1002/ptr.2564openalex-snapshot

Neuroprotective effect of genistein in 6‐hydroxydopamine Hemi‐parkinsonian rat model

inferredcites →https://doi.org/10.1006/bbrc.1999.0577openalex-snapshot

Genistein Is Neuroprotective in Murine Models of Familial Amyotrophic Lateral Sclerosis and Stroke

inferredcites →https://doi.org/10.1006/bbrc.1999.1905openalex-snapshot

A Specific Inhibitor of Janus Kinase-3 Increases Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

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The Use of Elevated Doses of Genistein-Rich Soy Extract in the Gene Expression-Targeted Isoflavone Therapy for Sanfilippo Disease Patients

inferredcites →https://doi.org/10.1007/8904_2015_432openalex-snapshot

Adverse Effects of Genistein in a Mucopolysaccharidosis Type I Mouse Model

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Binding site of activators of the cystic fibrosis transmembrane conductance regulator in the nucleotide binding domains

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In utero and postnatal exposure to a phytoestrogen-enriched diet increases parameters of acute inflammation in a rat model of TNBS-induced colitis

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Direct action of genistein on CFTR

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Tyrosine-kinase-dependent regulation of the nitric oxide synthase gene by endothelin-1 in human endothelial cells

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New therapeutic options for lysosomal storage disorders: enzyme replacement, small molecules and gene therapy

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Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

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Involvement of Nitric Oxide in Maneb- and Paraquat-Induced Parkinson’s Disease Phenotype in Mouse: Is There Any Link with Lipid Peroxidation?

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Role of Secondary Mediators in Caffeine-Mediated Neuroprotection in Maneb- and Paraquat-Induced Parkinson’s Disease Phenotype in the Mouse

inferredcites →https://doi.org/10.1007/s12017-018-8482-1openalex-snapshot

Correction of Huntington’s Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model

inferredcites →https://doi.org/10.1007/s12026-012-8331-5openalex-snapshot

Regulation of the immune response by soybean isoflavones

inferredcites →https://doi.org/10.1007/s12035-012-8377-3openalex-snapshot

Brain Endogenous Estrogen Levels Determine Responses to Estrogen Replacement Therapy via Regulation of BACE1 and NEP in Female Alzheimer’s Transgenic Mice

inferredcites →https://doi.org/10.1016/0090-1229(91)90033-7openalex-snapshot

Genistein, a selective protein tyrosine kinase inhibitor, inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells

inferredcites →https://doi.org/10.1016/j.biopha.2015.10.026openalex-snapshot

Bioactivity of genistein: A review of in vitro and in vivo studies

inferredcites →https://doi.org/10.1016/j.biopha.2016.05.023openalex-snapshot

Genistein as antioxidant and antibrowning agents in in vivo and in vitro: A review

inferredcites →https://doi.org/10.1016/j.bmcl.2010.05.038openalex-snapshot

Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos

inferredcites →https://doi.org/10.1016/j.coph.2008.04.006openalex-snapshot

Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis

inferredcites →https://doi.org/10.1016/j.critrevonc.2017.09.004openalex-snapshot

Genistein: Its role in metabolic diseases and cancer

inferredcites →https://doi.org/10.1016/j.curtheres.2008.04.002openalex-snapshot

Genistin-rich soy isoflavone extract in substrate reduction therapy for Sanfilippo syndrome: An open-label, pilot study in 10 pediatric patients

inferredcites →https://doi.org/10.1016/j.ejmech.2017.09.001openalex-snapshot

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

inferredcites →https://doi.org/10.1016/j.foodchem.2015.09.085openalex-snapshot

Understanding genistein in cancer: The “good” and the “bad” effects: A review

inferredcites →https://doi.org/10.1016/j.imbio.2016.10.004openalex-snapshot

Genistein improves thyroid function in Hashimoto’s thyroiditis patients through regulating Th1 cytokines

inferredcites →https://doi.org/10.1016/j.intimp.2011.02.001openalex-snapshot

Inhibition of airway inflammation, hyperresponsiveness and remodeling by soy isoflavone in a murine model of allergic asthma

inferredcites →https://doi.org/10.1016/j.intimp.2011.12.025openalex-snapshot

Immunomodulatory effects and improved prognosis of experimental autoimmune encephalomyelitis after O-tetradecanoyl-genistein treatment

inferredcites →https://doi.org/10.1016/j.jaci.2011.05.009openalex-snapshot

Soybean isoflavones regulate dendritic cell function and suppress allergic sensitization to peanut

inferredcites →https://doi.org/10.1016/j.jmb.2006.10.086openalex-snapshot

Domain Interdependence in the Biosynthetic Assembly of CFTR

inferredcites →https://doi.org/10.1016/j.maturitas.2008.04.003openalex-snapshot

Genistein modulate immune responses in collagen-induced rheumatoid arthritis model

inferredcites →https://doi.org/10.1016/j.maturitas.2010.08.003openalex-snapshot

Menopause and aging: Changes in the immune system—A review

inferredcites →https://doi.org/10.1016/j.mrfmmm.2006.05.024openalex-snapshot

Genetic analysis of the anti-mutagenic effect of genistein in Escherichia coli

inferredcites →https://doi.org/10.1016/j.nutres.2016.04.002openalex-snapshot

Soy isoflavone intake is associated with risk of Kawasaki disease

inferredcites →https://doi.org/10.1016/j.taap.2007.06.022openalex-snapshot

Genistein genotoxicity: Critical considerations of in vitro exposure dose

inferredcites →https://doi.org/10.1016/j.ymgme.2009.06.013openalex-snapshot

Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice

inferredcites →https://doi.org/10.1016/j.ymgme.2013.06.012openalex-snapshot

High dose genistein aglycone therapy is safe in patients with mucopolysaccharidoses involving the central nervous system

inferredcites →https://doi.org/10.1016/j.ymgme.2013.11.011openalex-snapshot

In vitro effect of genistein on DNA damage in leukocytes from mucopolysaccharidosis IVA patients

inferredcites →https://doi.org/10.1016/j.ymthe.2018.02.029openalex-snapshot

Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production

inferredcites →https://doi.org/10.1016/s0021-9258(18)45614-1openalex-snapshot

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

inferredcites →https://doi.org/10.1016/s0021-9258(19)49564-1openalex-snapshot

Genistein inhibits protein histidine kinase.

inferredcites →https://doi.org/10.1016/s0192-0561(00)00041-2openalex-snapshot

Inhibition of basophil histamine release by tyrosine kinase and phosphatidylinositol 3-kinase inhibitors

inferredcites →https://doi.org/10.1016/s1474-4422(10)70245-3openalex-snapshot

Huntington's disease: from molecular pathogenesis to clinical treatment

inferredcites →https://doi.org/10.1038/mt.2008.84openalex-snapshot

Mannose 6-Phosphate Receptor–mediated Transport of Sulfamidase Across the Blood–brain Barrier in the Newborn Mouse

inferredcites →https://doi.org/10.1038/nature04712openalex-snapshot

The ABC protein turned chloride channel whose failure causes cystic fibrosis

inferredcites →https://doi.org/10.1038/nrneurol.2012.263openalex-snapshot

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

inferredcites →https://doi.org/10.1038/sj.bjp.0707663openalex-snapshot

Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator

inferredcites →https://doi.org/10.1038/sj.ejhg.5201623openalex-snapshot

Genistein-mediated inhibition of glycosaminoglycan synthesis as a basis for gene expression-targeted isoflavone therapy for mucopolysaccharidoses

inferredcites →https://doi.org/10.1038/srep09378openalex-snapshot

Modulation of expression of genes involved in glycosaminoglycan metabolism and lysosome biogenesis by flavonoids

inferredcites →https://doi.org/10.1042/bst0380695openalex-snapshot

Genistein: a natural isoflavone with a potential for treatment of genetic diseases

inferredcites →https://doi.org/10.1056/nejm199809033391002openalex-snapshot

Relation between Mutations of the Cystic Fibrosis Gene and Idiopathic Pancreatitis

inferredcites →https://doi.org/10.1074/jbc.m110.139881openalex-snapshot

c-Cbl Facilitates Endocytosis and Lysosomal Degradation of Cystic Fibrosis Transmembrane Conductance Regulator in Human Airway Epithelial Cells

inferredcites →https://doi.org/10.1074/jbc.m114.555300openalex-snapshot

The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation

inferredcites →https://doi.org/10.1074/jbc.r116.746032openalex-snapshot

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

inferredcites →https://doi.org/10.1080/13543784.2018.1427729openalex-snapshot

Targeted anti-IL-13 therapies in asthma: current data and future perspectives

inferredcites →https://doi.org/10.1080/14656566.2018.1430140openalex-snapshot

Insights into future therapeutics for atopic dermatitis

inferredcites →https://doi.org/10.1081/jas-200038447openalex-snapshot

Dietary Intake of Soy Genistein is Associated with Lung Function in Patients with Asthma

inferredcites →https://doi.org/10.1089/jmf.2017.4068openalex-snapshot

BACE1 Inhibition by Genistein: Biological Evaluation, Kinetic Analysis, and Molecular Docking Simulation

inferredcites →https://doi.org/10.1093/carcin/20.10.1945openalex-snapshot

Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages

inferredcites →https://doi.org/10.1093/jn/136.3.704openalex-snapshot

Genistein, Estrogen Receptors, and the Acquired Immune Response

inferredcites →https://doi.org/10.1093/nutrit/nux021openalex-snapshot

Association of isoflavone biomarkers with risk of chronic disease and mortality: a systematic review and meta-analysis of observational studies

inferredcites →https://doi.org/10.1101/glycobiology.3e.044openalex-snapshot

Genetic Disorders of Glycan Degradation

inferredcites →https://doi.org/10.1111/imm.12922openalex-snapshot

Inflammation in CNS neurodegenerative diseases

inferredcites →https://doi.org/10.1111/j.1365-2222.2007.02862.xopenalex-snapshot

A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38‐dependent leukotriene synthesis

inferredcites →https://doi.org/10.1111/j.1460-9568.2008.06522.xopenalex-snapshot

Mechanisms of neurodegeneration in Huntington’s disease

inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00565.xopenalex-snapshot

Genistein reduces glycosaminoglycan levels in a mouse model of mucopolysaccharidosis type II

inferredcites →https://doi.org/10.1136/medethics-2016-103666openalex-snapshot

Everything in moderation, even hype: learning from vaccine controversies to strike a balance with CRISPR

inferredcites →https://doi.org/10.1152/ajpcell.1999.277.4.c833openalex-snapshot

Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein

inferredcites →https://doi.org/10.1152/ajplung.00134.2016openalex-snapshot

Personalized medicine in cystic fibrosis: genistein supplementation as a treatment option for patients with a rare S1045Y-CFTR mutation

inferredcites →https://doi.org/10.1152/physrev.1999.79.1.s23openalex-snapshot

Structure and Function of the CFTR Chloride Channel

inferredcites →https://doi.org/10.1159/000236252openalex-snapshot

Role of Tyrosine Kinases in IgE-Mediated Signal Transduction in Human Lung Mast Cells and Basophils

inferredcites →https://doi.org/10.1159/000430497openalex-snapshot

Dietary Elimination of Soybean Components Enhances Allergic Immune Response to Peanuts in BALB/c Mice

inferredcites →https://doi.org/10.1172/jci40598openalex-snapshot

Pass the bicarb: the importance of HCO3– for mucin release

inferredcites →https://doi.org/10.1177/0961203308091287openalex-snapshot

Soy isoflavones supplementation alleviates disease severity in autoimmune-prone MRL-lpr/lpr mice

inferredcites →https://doi.org/10.1186/1423-0127-16-26openalex-snapshot

Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway

inferredcites →https://doi.org/10.12659/msm.881715openalex-snapshot

Two-year follow-up of Sanfilippo Disease patients treated with a genistein-rich isoflavone extract: Assessment of effects on cognitive functions and general status of patients

inferredcites →https://doi.org/10.1371/journal.pone.0014192openalex-snapshot

Genistein Improves Neuropathology and Corrects Behaviour in a Mouse Model of Neurodegenerative Metabolic Disease

inferredcites →https://doi.org/10.1385/endo:21:1:77openalex-snapshot

Estrogens and Parkinson Disease: Novel Approach for Neuroprotection

inferredcites →https://doi.org/10.1385/jmn:23:1-2:041openalex-snapshot

CFTR and Chaperones: Processing and Degradation

inferredcites →https://doi.org/10.1556/030.65.2018.018openalex-snapshot

Effect of endocrine disruptor phytoestrogens on the immune system: Present and future

inferredcites →https://doi.org/10.2174/0929867324666171006143047openalex-snapshot

Effects of Isolated Isoflavones Intake on Health

inferredcites →https://doi.org/10.2174/156652321802180507170539openalex-snapshot

Editorial: Genetics and Gene Therapy of Lysosomial Storage Disorders

inferredcites →https://doi.org/10.2174/1568026618666180116122650openalex-snapshot

Genistein as a Potential Anticancer Agent Against Head and Neck Squamous Cell Carcinoma

inferredcites →https://doi.org/10.3390/ijms17111855openalex-snapshot

Bidirectional Estrogen-Like Effects of Genistein on Murine Experimental Autoimmune Ovarian Disease

inferredcites →https://doi.org/10.3390/molecules15020878openalex-snapshot

3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future

inferredcites →https://doi.org/10.3390/molecules21111489openalex-snapshot

The Cooperative Effect of Genistein and Protein Hydrolysates on the Proliferation and Survival of Osteoblastic Cells (hFOB 1.19)

inferredcites →https://doi.org/10.3390/nu8110692openalex-snapshot

Protective Effect of Genistein against Neuronal Degeneration in ApoE−/− Mice Fed a High-Fat Diet

inferredcites →https://doi.org/10.3945/an.114.008052openalex-snapshot

Genistein and Cancer: Current Status, Challenges, and Future Directions

inferredcites →https://doi.org/10.4049/jimmunol.151.5.2717openalex-snapshot

Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages.

inferredcites →https://doi.org/10.4103/1673-5374.187056openalex-snapshot

Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's disease

inferredcites →https://doi.org/10.4103/1673-5374.215260openalex-snapshot

Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats

inferredcites →https://doi.org/10.5625/lar.2014.30.4.143openalex-snapshot

Chemopreventive and chemotherapeutic effects of genistein, a soy isoflavone, upon cancer development and progression in preclinical animal models

inferredcites →https://doi.org/10.7861/clinmedicine.13-5-482openalex-snapshot

Coming of age in cystic fibrosis – transition from paediatric to adult care

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4786329openalex-extracted

Unlocking Therapeutic Potential of Genistein: Its Hybrids with Selected Nsaids – Synthesis, Characterisation and Dft Study

inferred← citeshttps://doi.org/10.1007/s11224-024-02377-3openalex-snapshot

Molecular insights into genistein-NSAID hybrids—synthesis, characterisation and DFT study

inferred← citeshttps://doi.org/10.1101/2021.12.16.473091openalex-snapshot

The Trypanosoma cruzi kinetoplast DNA minicircle sequences transfer biomarker of the multidrug treatment of Chagas disease

inferred← citeshttps://doi.org/10.3390/cimb46030140openalex-snapshot

Inflammation Factors and Genistein Supplementation in Cancer—Preliminary Research

inferred← citeshttps://doi.org/10.3390/molecules27030815openalex-snapshot

Genistein—Opportunities Related to an Interesting Molecule of Natural Origin

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