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Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archinte.165.5.500openalex-snapshot
Leukocyte Count as a Predictor of Cardiovascular Events and Mortality in Postmenopausal Women
inferredcites →https://doi.org/10.1001/archinte.166.2.188openalex-snapshot
Association Between Circulating White Blood Cell Count and Cancer Mortality
inferredcites →https://doi.org/10.1002/ijc.27942openalex-snapshot
Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers
inferredcites →https://doi.org/10.1007/978-1-4899-3242-6openalex-snapshot
Generalized Linear Models
inferredcites →https://doi.org/10.1007/s00125-013-3080-0openalex-snapshot
Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study
inferredcites →https://doi.org/10.1016/j.amjcard.2011.09.049openalex-snapshot
White Blood Cell Count and Risk of Incident Atrial Fibrillation (From the Framingham Heart Study)
inferredcites →https://doi.org/10.1016/j.amjhyper.2003.11.005openalex-snapshot
Relationship between white blood cell count and incident hypertension
inferredcites →https://doi.org/10.1016/j.amjhyper.2004.05.021openalex-snapshot
Relationship between white blood cell count and incident hypertension
inferredcites →https://doi.org/10.1016/j.cct.2011.07.002openalex-snapshot
The CALERIE Study: Design and methods of an innovative 25% caloric restriction intervention
inferredcites →https://doi.org/10.1016/j.cct.2012.08.011openalex-snapshot
Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE Phase 2) screening and recruitment: Methods and results
inferredcites →https://doi.org/10.1016/j.cell.2008.01.007openalex-snapshot
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
inferredcites →https://doi.org/10.1016/j.exger.2008.04.005openalex-snapshot
Neuroendocrine factors in the regulation of inflammation: Excessive adiposity and calorie restriction
inferredcites →https://doi.org/10.1016/j.ijcard.2013.07.113openalex-snapshot
High-sensitivity C-reactive protein and atherosclerotic disease: From improved risk prediction to risk-guided therapy
inferredcites →https://doi.org/10.1016/j.jacc.2005.08.069openalex-snapshot
Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans
inferredcites →https://doi.org/10.1016/j.nutres.2013.01.005openalex-snapshot
Mild weight loss reduces inflammatory cytokines, leukocyte count, and oxidative stress in overweight and moderately obese participants treated for 3 years with dietary modification
inferredcites →https://doi.org/10.1038/nri2449openalex-snapshot
Nutrient sensing and inflammation in metabolic diseases
inferredcites →https://doi.org/10.1038/nrm1616openalex-snapshot
Calorie restriction, SIRT1 and metabolism: understanding longevity
inferredcites →https://doi.org/10.1038/sj.ijo.0801398openalex-snapshot
Serum concentrations of TNF-α and soluble TNF-α receptors in obesity
inferredcites →https://doi.org/10.1046/j.1467-9884.2003.t01-4-00383_6.xopenalex-snapshot
Analysis of Longitudinal Data,
inferredcites →https://doi.org/10.1073/pnas.0606661103openalex-snapshot
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
inferredcites →https://doi.org/10.1093/aje/kwh090openalex-snapshot
A Modified Poisson Regression Approach to Prospective Studies with Binary Data
inferredcites →https://doi.org/10.1093/biomet/73.1.13openalex-snapshot
Longitudinal Data Analysis Using Generalized Linear Models
inferredcites →https://doi.org/10.1093/gerona/51a.4.b276openalex-snapshot
Reduced Immune Responses in Rhesus Monkeys Subjected to Dietary Restriction
inferredcites →https://doi.org/10.1093/gerona/60.6.688openalex-snapshot
Caloric Restriction Decreases Survival of Aged Mice in Response to Primary Influenza Infection
inferredcites →https://doi.org/10.1093/gerona/glp101openalex-snapshot
Calorie Restriction Enhances T-Cell-Mediated Immune Response in Adult Overweight Men and Women
inferredcites →https://doi.org/10.1093/gerona/glq168openalex-snapshot
Design and Conduct of the CALERIE Study: Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy
inferredcites →https://doi.org/10.1093/gerona/glu057openalex-snapshot
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
inferredcites →https://doi.org/10.1093/gerona/glv057openalex-snapshot
A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity
inferredcites →https://doi.org/10.1096/fasebj.12.1.57openalex-snapshot
Leptin regulates proinflammatory immune responses
inferredcites →https://doi.org/10.1097/maj.0b013e3181c61b66openalex-snapshot
C-Reactive Protein and Cardiovascular Diseases—Is it Ready for Primetime?
inferredcites →https://doi.org/10.1111/acel.12280openalex-snapshot
Lifespan‐extending caloric restriction or m TOR inhibition impair adaptive immunity of old mice by distinct mechanisms
inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00345.xopenalex-snapshot
Chronic calorie restriction increases susceptibility of laboratory mice ( Mus musculus ) to a primary intestinal parasite infection
inferredcites →https://doi.org/10.1126/science.1172539openalex-snapshot
Extending Healthy Life Span—From Yeast to Humans
inferredcites →https://doi.org/10.1126/science.7678183openalex-snapshot
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
inferredcites →https://doi.org/10.1128/cdli.8.5.1003-1011.2001openalex-snapshot
Effects of Calorie Restriction on Polymicrobial Peritonitis Induced by Cecum Ligation and Puncture in Young C57BL/6 Mice
inferredcites →https://doi.org/10.1152/ajpheart.00907.2011openalex-snapshot
Inflammation and metabolic dysfunction: links to cardiovascular diseases
inferredcites →https://doi.org/10.1172/jci117899openalex-snapshot
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.
inferredcites →https://doi.org/10.1177/1740774511398369openalex-snapshot
Development of adherence metrics for caloric restriction interventions
inferredcites →https://doi.org/10.1198/jasa.2005.s24openalex-snapshot
Applied Longitudinal Analysis
inferredcites →https://doi.org/10.1198/tech.2003.s767openalex-snapshot
Statistical Models and Methods for Lifetime Data
inferredcites →https://doi.org/10.1371/journal.pmed.0040115openalex-snapshot
Malnutrition and Infection: Complex Mechanisms and Global Impacts
inferredcites →https://doi.org/10.1371/journal.pone.0052774openalex-snapshot
Magnetic Resonance Imaging Determined Visceral Fat Reduction Associates with Enhanced IL-10 Plasma Levels in Calorie Restricted Obese Subjects
inferredcites →https://doi.org/10.18632/aging.100531openalex-snapshot
The role of inflammation in age-related disease
inferredcites →https://doi.org/10.21430/m33e7tcyxtopenalex-snapshot
Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms.
inferredcites →https://doi.org/10.2307/2530695openalex-snapshot
Unbalanced Repeated-Measures Models with Structured Covariance Matrices
inferredcites →https://doi.org/10.2307/2532694openalex-snapshot
Adjusted P-Values for Simultaneous Inference
inferredcites →https://doi.org/10.2337/db06-1656openalex-snapshot
Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans
inferredcites →https://doi.org/10.2337/db11-1300openalex-snapshot
The Critical Role of Metabolic Pathways in Aging
inferredcites →https://doi.org/10.3945/jn.108.093633openalex-snapshot
Energy Restriction Impairs Natural Killer Cell Function and Increases the Severity of Influenza Infection in Young Adult Male C57BL/6 Mice
inferredcites →https://doi.org/10.3945/jn.110.122408openalex-snapshot
Short-Term Re-Feeding of Previously Energy-Restricted C57BL/6 Male Mice Restores Body Weight and Body Fat and Attenuates the Decline in Natural Killer Cell Function after Primary Influenza Infection , ,
inferredcites →https://doi.org/10.4049/jimmunol.0900562openalex-snapshot
Inhibition of Thymic Adipogenesis by Caloric Restriction Is Coupled with Reduction in Age-Related Thymic Involution

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Dietary patterns and the neoplastic‐prone tissue landscape of old age
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Fasting and calorie restriction modulate age‐associated immunosenescence and inflammaging
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Dietary protein source matters for changes in inflammation measured by urinary C‐reactive protein in rural polish women
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Physiological Systems in Promoting Frailty
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Is muscle and protein loss relevant in long‐term fasting in healthy men? A prospective trial on physiological adaptations
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Calorie Restriction Enhanced Glycogen Metabolism to Compensate for Lipid Insufficiency
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Optimized RNA sequencing deconvolution illustrates the impact of obesity and weight loss on cell composition of human adipose tissue
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Molecular and Biological Factors in Aging
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Molecular and Biological Factors in Aging
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Fasting for Cardiovascular Health
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Caloric Restriction and Biomarkers of Aging
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Cell-to-Cell Communication in Aging: Mechanisms, Impact and Therapeutic Prospects
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Inflammaging
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Inflammaging
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Immunmodulation durch Ernährung bei kritisch kranken Patienten
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Healthy ageing: the natural consequences of good nutrition—a conference report
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Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial
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Genetic background, epigenetic factors and dietary interventions which influence human longevity
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Aging and age‐related diseases: from mechanisms to therapeutic strategies
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Precision nutrition for targeting pathophysiology of cardiometabolic phenotypes
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Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges
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Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution
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Bench to bedside: is rapamycin headed for the docTOR?
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The Effect of Oral Magnesium Supplementation on Inflammatory Biomarkers in Adults: A Comprehensive Systematic Review and Dose–response Meta-analysis of Randomized Clinical Trials
inferred← citeshttps://doi.org/10.1007/s12603-022-1815-7openalex-snapshot
Modestly Increased Incidence of Ketosis in Caloric Restriction Does not Significantly Alter the Effects of Caloric Restriction
inferred← citeshttps://doi.org/10.1007/s40263-023-00986-wopenalex-snapshot
The Role of Gut Dysbiosis and Potential Approaches to Target the Gut Microbiota in Multiple Sclerosis
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Nutrition and Athlete Immune Health: New Perspectives on an Old Paradigm
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The Path Towards Progress: A Critical Review to Advance the Science of the Female and Male Athlete Triad and Relative Energy Deficiency in Sport
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Does Relative Energy Deficiency in Sport (REDs) Syndrome Exist?
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Leptin
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Moving from reactive to preventive medicine
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Rejuvenation of mitochondrial function by time-controlled fasting
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Exploring promising pharmaceutical candidates for antiaging
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Nutrigenetics and nutrigenomics—A personalized approach to nutrition
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Fasting and cancer responses to therapy
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How does bariatric surgery remodel adipose tissue?
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Fasting affects the intestine and bacterial flora in mudskippers (Boleophthalmus pectinirostris) in semiaquatic and underwater conditions
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Ribosomal DNA instability: An evolutionary conserved fuel for inflammaging
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Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment
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Targeting immune dysfunction in aging
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The role of dietary strategies in the modulation of hallmarks of aging
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Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review
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Nutrition and dietary restrictions in cancer prevention
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Comparison of the lymphocyte response to interval exercise versus continuous exercise in recreationally trained men
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A systems-approach to NAD+ restoration
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Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
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Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits
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Effects of dietary restriction on gut microbiota and CNS autoimmunity
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Weight loss is a critical factor to reduce inflammation
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Effect of caloric restriction on organ-specific biological aging in a randomized clinical trial
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Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota
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Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity
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Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans
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Bone Marrow: An Immunometabolic Refuge during Energy Depletion
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IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2
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Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience
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When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
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Restricting lipid accumulation in tumor-infiltrating neutrophils mediates caloric restriction-induced anti-cancer effects
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The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?
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Effect of whey protein consumption on IL-6 and TNF-α: A systematic review and meta-analysis of randomized controlled trials
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Skeletal muscle as potential central link between sarcopenia and immune senescence
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Dietary Regulation of Immunity
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Control of immunity via nutritional interventions
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The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging
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Randomized controlled trial for time-restricted eating in overweight and obese young adults
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Caloric restriction attenuates NLRP3 inflammasome activation and oxidative stress in leukocytes of patients with obesity
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Dietary intervention & immunity: underlying mechanisms and future directions
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Insights into the interplay among zinc, biological aging, fasting, energy intake, and inflammation: A cross-sectional analysis using 2015-2018 NHANES participants
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Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets
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Inflammaging and human longevity in the omics era
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Caloric restriction and cellular senescence
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Changes of the coronary arteries and cardiac microvasculature with aging: Implications for translational research and clinical practice
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A novel nutritional supplement prevents muscle loss and accelerates muscle mass recovery in caloric-restricted mice
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Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected role in gut homeostasis
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Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study
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The role of hypoleptinemia in the psychological and behavioral adaptation to starvation: Implications for anorexia nervosa
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Peripheral interleukin-6 levels and working memory in non-obese adults: A post-hoc analysis from the CALERIE study
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Vías de estrés redox e inflamación en la enfermedad ocular: dianas para la modulación nutricional
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Redox-inflammation pathways in ocular disease: Targets for nutritional modulation
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Cardioprotective effects of calorie restriction against inflammation and apoptosis in ovariectomized obese rats: Role of classical estrogen receptors and SIRT1
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Immunomodulatory effects of calorie restriction and its mimetics: A new potential therapeutic approach for autoimmune diseases
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Germline cell de novo mutations and potential effects of inflammation on germline cell genome stability
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Function and treatment strategies of β-hydroxybutyrate in aging
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Inflammaging and ‘Garb-aging’
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Dietary and pharmacological energy restriction and exercise for healthspan extension
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Integration of immune-metabolic signals to preserve healthy aging
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Hyperplasie bénigne de la prostate et incontinence urinaire
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Nutrition Management in COVID-19 Quarantine: Hospital-Based Study
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Skin immunity: dissecting the complex biology of our body's outer barrier
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Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion
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Interventions to promote cardiometabolic health and slow cardiovascular ageing
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
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Hallmarks of cardiovascular ageing
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DNA damage and repair in age-related inflammation
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Fasting-activated ventrolateral medulla neurons regulate T cell homing and suppress autoimmune disease in mice
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Fasting-induced FOXO4 blunts human CD4+ T helper cell responsiveness
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Metabolic regulation of immunological aging
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Understanding and improving vaccine efficacy in older adults
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Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease
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The road ahead of dietary restriction on anti-aging: focusing on personalized nutrition
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Sirtuin 1 as a potential biomarker of undernutrition in the elderly: a narrative review
inferred← citeshttps://doi.org/10.1080/17446651.2021.1922077openalex-snapshot
Beyond weight loss: current perspectives on the impact of calorie restriction on healthspan and lifespan
inferred← citeshttps://doi.org/10.1080/17461391.2022.2157336openalex-snapshot
Signs of low energy availability in elite male volleyball athletes but no association with risk of bone stress injury and patellar tendinopathy
inferred← citeshttps://doi.org/10.1084/jem.20190086openalex-snapshot
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
inferred← citeshttps://doi.org/10.1084/jem.20221839openalex-snapshot
Nutrients: Signal 4 in T cell immunity
inferred← citeshttps://doi.org/10.1089/jmf.2018.0063openalex-snapshot
A Low-Glycemic, Mediterranean Diet and Lifestyle Modification Program with Targeted Nutraceuticals Reduces Body Weight, Improves Cardiometabolic Variables and Longevity Biomarkers in Overweight Subjects: A 13-Week Observational Trial
inferred← citeshttps://doi.org/10.1093/advances/nmy129openalex-snapshot
Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction
inferred← citeshttps://doi.org/10.1093/eurheartj/ehaf314openalex-snapshot
Clinical staging to guide management of metabolic disorders and their sequelae: a European Atherosclerosis Society consensus statement
inferred← citeshttps://doi.org/10.1093/eurheartj/ehz961openalex-snapshot
Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease
inferred← citeshttps://doi.org/10.1093/gerona/glab210openalex-snapshot
The Second Annual Symposium of the Midwest Aging Consortium: The Future of Aging Research in the Midwestern United States
inferred← citeshttps://doi.org/10.1093/gerona/glac003openalex-snapshot
Potential of Stem Cell-Based Therapy to Restore Function in Aging Systems: Are We There Yet?
inferred← citeshttps://doi.org/10.1093/gerona/glac168openalex-snapshot
Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis
inferred← citeshttps://doi.org/10.1093/gerona/glad121openalex-snapshot
Sebacic Acid as a Potential Age-Related Biomarker of Liver Aging: Evidence Linking Mice and Human
inferred← citeshttps://doi.org/10.1093/gerona/glae299openalex-snapshot
Effects of Graded Levels of Calorie Restriction XXI: Impact of Short-term Graded Restriction on Gene Expression Profiles of Stomach and Skeletal Muscle
inferred← citeshttps://doi.org/10.1093/gerona/gly192openalex-snapshot
Effect of Intentional Weight Loss on Mortality Biomarkers in Older Adults With Obesity
inferred← citeshttps://doi.org/10.1093/jleuko/qiae006openalex-snapshot
Propionate functions as a feeding state–dependent regulatory metabolite to counter proinflammatory signaling linked to nutrient load and obesity
inferred← citeshttps://doi.org/10.1093/nutrit/nuaa085openalex-snapshot
Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2
inferred← citeshttps://doi.org/10.1093/nutrit/nuae062openalex-snapshot
Intermittent fasting as a dietary intervention with potential sexually dimorphic health benefits
inferred← citeshttps://doi.org/10.1093/pm/pnaa378openalex-snapshot
Dietary Interventions Are Beneficial for Patients with Chronic Pain: A Systematic Review with Meta-Analysis
inferred← citeshttps://doi.org/10.1097/j.pbj.0000000000000120openalex-snapshot
Ageing, cellular senescence and the impact of diet: an overview
inferred← citeshttps://doi.org/10.1098/rsos.241659openalex-snapshot
Costs and constraints of cellular immune activity during development in an arboreal primate
inferred← citeshttps://doi.org/10.1101/2022.06.03.494722openalex-snapshot
Epigenome-wide association study analysis of calorie restriction in humans, CALERIE™ Trial analysis
inferred← citeshttps://doi.org/10.1101/2023.06.12.544352openalex-snapshot
Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer’s Disease, healthspan and lifespan- Aging as a consequence of glycolysis
inferred← citeshttps://doi.org/10.1101/2024.01.28.24301860openalex-snapshot
RANDOMIZED CONTROLLED TRIAL OF INTERMITTENT CALORIE RESTRICTION IN PEOPLE WITH MULTIPLE SCLEROSIS
inferred← citeshttps://doi.org/10.1101/2024.09.23.614489openalex-snapshot
An optimized pipeline for high-throughput bulk RNA-Seq deconvolution illustrates the impact of obesity and weight loss on cell composition of human adipose tissue
inferred← citeshttps://doi.org/10.1101/2025.08.30.673138openalex-snapshot
Systemic multi-omic remodelling underlies health benefits of intermittent fasting
inferred← citeshttps://doi.org/10.1111/1750-3841.70170openalex-snapshot
Intermittent fasting applied in combination with astaxanthin alleviates D‐galactose‐induced aging in rats: Comparison in oxidative stress, immune response, and metabolomics
inferred← citeshttps://doi.org/10.1111/acel.12746openalex-snapshot
The effects of graded caloric restriction: XII . Comparison of mouse to human impact on cellular senescence in the colon
inferred← citeshttps://doi.org/10.1111/acel.14149openalex-snapshot
Effect of long‐term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
inferred← citeshttps://doi.org/10.1111/acel.14442openalex-snapshot
Multi‐omic analysis of biological aging biomarkers in long‐term calorie restriction and endurance exercise practitioners: A cross‐sectional study
inferred← citeshttps://doi.org/10.1111/exd.14429openalex-snapshot
Novel mechanisms of microbial crosstalk with skin innate immunity
inferred← citeshttps://doi.org/10.1111/ijlh.13590openalex-snapshot
Effects of circadian variation, lifestyle and environment on hematological parameters: A narrative review
inferred← citeshttps://doi.org/10.1111/imr.12732openalex-snapshot
Plasma cells: You are what you eat
inferred← citeshttps://doi.org/10.1111/imr.13153openalex-snapshot
Neutrophils in aging and aging‐related pathologies
inferred← citeshttps://doi.org/10.1111/jhn.70137openalex-snapshot
Impact of Achieved Weight Loss by Intermittent Fasting Plus Early Time‐Restricted Eating and Calorie Restriction on Systemic and Adipose Tissue Markers of Inflammation in Adults at Risk of Type 2 Diabetes: An Exploratory Sub‐Study
inferred← citeshttps://doi.org/10.1126/science.abg7292openalex-snapshot
Caloric restriction in humans reveals immunometabolic regulators of health span
inferred← citeshttps://doi.org/10.1128/msystems.00348-19openalex-snapshot
Timing of Calorie Restriction in Mice Impacts Host Metabolic Phenotype with Correlative Changes in Gut Microbiota
inferred← citeshttps://doi.org/10.1136/jnnp-2024-333465openalex-snapshot
Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis
inferred← citeshttps://doi.org/10.1146/annurev-nutr-082117-051637openalex-snapshot
Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?
inferred← citeshttps://doi.org/10.1152/ajprenal.00122.2026openalex-snapshot
Caloric restriction decreases autoimmune disease activity and lowers blood pressure in an experimental model of systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1152/physiol.00002.2021openalex-snapshot
Caloric Restriction and Cardiovascular Health: the Good, the Bad, and the Renin-Angiotensin System
inferred← citeshttps://doi.org/10.1172/jci169173openalex-snapshot
Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity
inferred← citeshttps://doi.org/10.1177/1535370219900185openalex-snapshot
The immune remodel: Weight loss-mediated inflammatory changes to obesity
inferred← citeshttps://doi.org/10.1177/27683192251376656openalex-snapshot
Food as Medicine in Hidradenitis Suppurativa: A Review of Dietary Effects on Hidradenitis Suppurativa Pathogenesis
inferred← citeshttps://doi.org/10.1186/s12916-026-04621-5openalex-snapshot
CardioMetAge estimates cardiometabolic aging and predicts disease outcomes
inferred← citeshttps://doi.org/10.1186/s12929-025-01188-wopenalex-snapshot
The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans
inferred← citeshttps://doi.org/10.1186/s12979-023-00361-9openalex-snapshot
Obesity accelerates age defects in B cells, and weight loss improves B cell function
inferred← citeshttps://doi.org/10.1186/s12979-023-00374-4openalex-snapshot
Towards a better preclinical cancer model – human immune aging in humanized mice
inferred← citeshttps://doi.org/10.1186/s13104-018-3996-zopenalex-snapshot
A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging
inferred← citeshttps://doi.org/10.1186/s13148-017-0365-zopenalex-snapshot
Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders
inferred← citeshttps://doi.org/10.1186/s40035-025-00517-1openalex-snapshot
Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications
inferred← citeshttps://doi.org/10.1186/s40168-018-0440-5openalex-snapshot
Predominant gut Lactobacillus murinus strain mediates anti-inflammaging effects in calorie-restricted mice
inferred← citeshttps://doi.org/10.12688/f1000research.12724.2openalex-snapshot
The sedentary (r)evolution: Have we lost our metabolic flexibility?
inferred← citeshttps://doi.org/10.15252/emmm.202114418openalex-snapshot
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
inferred← citeshttps://doi.org/10.17554/j.issn.2224-3992.2017.06.669openalex-snapshot
Gut Microbiota: Influence of Aloe vera gel and Calorie Restriction
inferred← citeshttps://doi.org/10.18632/aging.101731openalex-snapshot
Calorie restriction protects neural stem cells from age-related deficits in the subventricular zone
inferred← citeshttps://doi.org/10.2174/0115665240268180231113045836openalex-snapshot
The Effect of Selenium, Zinc, and their Combined Supplementation on Cardiometabolic Biomarkers-comparing their Effects in the Energy Restriction and High-fat Diet Methods in Obese Rats
inferred← citeshttps://doi.org/10.31080/asnh.2022.06.1108openalex-snapshot
Impact of Diet and Nutrition on Memory T Cell Development, Maintenance and Function in the Context of Healthy Immune System
inferred← citeshttps://doi.org/10.3177/jnsv.65.132openalex-snapshot
Expression of MHC-I and II by Microglia and Lymphocytes in the Brain of Diet-Restricted Mice
inferred← citeshttps://doi.org/10.3233/nha-160017openalex-snapshot
Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study
inferred← citeshttps://doi.org/10.3322/caac.21694openalex-snapshot
Intermittent fasting in the prevention and treatment of cancer
inferred← citeshttps://doi.org/10.3389/fendo.2019.00027openalex-snapshot
ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective
inferred← citeshttps://doi.org/10.3389/fendo.2023.1141906openalex-snapshot
Exercise training modifies the bone and endocrine response to graded reductions in energy availability in skeletally mature female rodents
inferred← citeshttps://doi.org/10.3389/fimmu.2022.952398openalex-snapshot
Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases
inferred← citeshttps://doi.org/10.3389/fnagi.2019.00296openalex-snapshot
Effect of Systemic Inflammation on Rat Attentional Function and Neuroinflammation: Possible Protective Role for Food Restriction
inferred← citeshttps://doi.org/10.3389/fnut.2022.1006747openalex-snapshot
The microbiota composition drives personalized nutrition: Gut microbes as predictive biomarkers for the success of weight loss diets
inferred← citeshttps://doi.org/10.3389/fnut.2026.1736969openalex-snapshot
Intermittent fasting and immune aging: implications for immunosenescence, inflammaging, neuroinflammation, and frailty
inferred← citeshttps://doi.org/10.3389/fphar.2019.00033openalex-snapshot
Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders
inferred← citeshttps://doi.org/10.3389/fragi.2024.1495029openalex-snapshot
Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity
inferred← citeshttps://doi.org/10.3389/fvets.2025.1639055openalex-snapshot
Age-related obesity and inflammaging in cats
inferred← citeshttps://doi.org/10.3390/biomedicines11030766openalex-snapshot
Training vs. Tolerance: The Yin/Yang of the Innate Immune System
inferred← citeshttps://doi.org/10.3390/cancers12092338openalex-snapshot
Is Host Metabolism the Missing Link to Improving Cancer Outcomes?
inferred← citeshttps://doi.org/10.3390/cancers13061260openalex-snapshot
Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer Immunotherapy
inferred← citeshttps://doi.org/10.3390/cells11030359openalex-snapshot
Interconnections between Inflammageing and Immunosenescence during Ageing
inferred← citeshttps://doi.org/10.3390/cells12131708openalex-snapshot
Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment
inferred← citeshttps://doi.org/10.3390/foods13131960openalex-snapshot
Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen Approach
inferred← citeshttps://doi.org/10.3390/ijms21124363openalex-snapshot
Dietary Regulation of Memory T Cells
inferred← citeshttps://doi.org/10.3390/ijms23126546openalex-snapshot
The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?
inferred← citeshttps://doi.org/10.3390/ijms27125605openalex-snapshot
A Healthy Lifestyle Can Slow Immune System Aging and Reduce Age-Related Chronic Inflammation: A Narrative Review
inferred← citeshttps://doi.org/10.3390/jcm11144119openalex-snapshot
Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases
inferred← citeshttps://doi.org/10.3390/metabo14060341openalex-snapshot
Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications
inferred← citeshttps://doi.org/10.3390/nu12020422openalex-snapshot
Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept
inferred← citeshttps://doi.org/10.3390/nu12030818openalex-snapshot
Nutrition and the Immune System: A Complicated Tango
inferred← citeshttps://doi.org/10.3390/nu12071959openalex-snapshot
Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors?
inferred← citeshttps://doi.org/10.3390/nu12082290openalex-snapshot
Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials
inferred← citeshttps://doi.org/10.3390/nu13051492openalex-snapshot
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness
inferred← citeshttps://doi.org/10.3390/nu13051570openalex-snapshot
Fasting: How to Guide
inferred← citeshttps://doi.org/10.3390/nu13093222openalex-snapshot
Effects of Caloric Restriction and Rope-Skipping Exercise on Cardiometabolic Health: A Pilot Randomized Controlled Trial in Young Adults
inferred← citeshttps://doi.org/10.3390/nu13114089openalex-snapshot
No Significant Effect of the Individual Chronotype on the Result of Moderate Calorie Restriction for Obesity—A Pilot Study
inferred← citeshttps://doi.org/10.3390/nu14193914openalex-snapshot
Anti-Inflammatory Diets in Fertility: An Evidence Review
inferred← citeshttps://doi.org/10.3390/nu14204299openalex-snapshot
Importance of Intermittent Fasting Regimens and Selection of Adequate Therapy on Inflammation and Oxidative Stress in SARS-CoV-2 Infection
inferred← citeshttps://doi.org/10.3390/nu16173007openalex-snapshot
Effects of Different Exercises Combined with Different Dietary Interventions on Body Composition: A Systematic Review and Network Meta-Analysis
inferred← citeshttps://doi.org/10.3390/nu17071130openalex-snapshot
Time-Restricted Eating Versus Daily Calorie Restriction: Effects on Inflammatory Markers over 12 Months in Adults with Obesity
inferred← citeshttps://doi.org/10.3390/quantum4010005openalex-snapshot
Thermodynamics and Inflammation: Insights into Quantum Biology and Ageing
inferred← citeshttps://doi.org/10.3410/f.735381198.793558347openalex-snapshot
Faculty Opinions recommendation of Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity.
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