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T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Ketamine Affects the Neurogenesis of Rat Fetal Neural Stem Progenitor Cells via the PI3K/Akt‐p27 Signaling Pathway

inferredcites →https://doi.org/10.1002/cmdc.201100126openalex-snapshot

Design and Synthesis of Novel Dual‐Action Compounds Targeting the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection

inferredcites →https://doi.org/10.1002/dneu.20802openalex-snapshot

The A2Aadenosine receptor rescues neuritogenesis impaired by p53 blockage via KIF2A, a kinesin family member

inferredcites →https://doi.org/10.1007/978-3-540-89615-9_8openalex-snapshot

Adenosine Receptors and Inflammation

inferredcites →https://doi.org/10.1007/s00259-004-1688-5openalex-snapshot

In vivo imaging of adenosine A2A receptors in rat and primate brain using [11C]SCH442416

inferredcites →https://doi.org/10.1007/s10522-010-9287-2openalex-snapshot

Aging, frailty and age-related diseases

inferredcites →https://doi.org/10.1007/s11064-013-1146-5openalex-snapshot

Expression of Nucleoside Transporter in Freshly Isolated Neurons and Astrocytes from Mouse Brain

inferredcites →https://doi.org/10.1007/s12035-018-1030-zopenalex-snapshot

Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

inferredcites →https://doi.org/10.1016/0169-328x(93)90058-wopenalex-snapshot

A2a adenosine receptor gene expression in developing rat brain

inferredcites →https://doi.org/10.1016/j.bbi.2014.02.002openalex-snapshot

Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning

inferredcites →https://doi.org/10.1016/j.bcp.2012.06.031openalex-snapshot

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence

inferredcites →https://doi.org/10.1016/j.exger.2009.04.006openalex-snapshot

Age-related expression of adenosine receptors in brain from the senescence-accelerated mouse

inferredcites →https://doi.org/10.1016/j.exger.2017.10.029openalex-snapshot

Role of D-galactose-induced brain aging and its potential used for therapeutic interventions

inferredcites →https://doi.org/10.1016/j.jep.2016.06.057openalex-snapshot

The rhizome of Gastrodia elata Blume – An ethnopharmacological review

inferredcites →https://doi.org/10.1016/j.nbd.2017.10.013openalex-snapshot

The adenosine A2A receptor agonist T1–11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease

inferredcites →https://doi.org/10.1016/j.neuint.2012.12.010openalex-snapshot

Hydrogen sulfide protects SH-SY5Y neuronal cells against d-galactose induced cell injury by suppression of advanced glycation end products formation and oxidative stress

inferredcites →https://doi.org/10.1016/j.neuropharm.2017.08.027openalex-snapshot

Cognitive impairments associated with alterations in synaptic proteins induced by the genetic loss of adenosine A 2A receptors in mice

inferredcites →https://doi.org/10.1016/j.tins.2015.10.003openalex-snapshot

Neurocognitive Aging and the Hippocampus across Species

inferredcites →https://doi.org/10.1016/s0026-895x(25)13292-6openalex-snapshot

Multiple mechanisms for desensitization of A2a adenosine receptor-mediated cAMP elevation in rat pheochromocytoma PC12 cells.

inferredcites →https://doi.org/10.1016/s0047-6374(99)00022-6openalex-snapshot

Advanced glycation in d-galactose induced mouse aging model

inferredcites →https://doi.org/10.1016/s0074-7742(05)63007-3openalex-snapshot

Adenosine and Brain Function

inferredcites →https://doi.org/10.1021/np0605182openalex-snapshot

Neuroprotective Principles from Gastrodia elata

inferredcites →https://doi.org/10.1023/a:1022417102206openalex-snapshot

Establishment of the mimetic aging effect in mice caused by D-galactose

inferredcites →https://doi.org/10.1038/nprot.2006.170openalex-snapshot

Assessing nest building in mice

inferredcites →https://doi.org/10.1038/nprot.2006.19openalex-snapshot

Burrowing in rodents: a sensitive method for detecting behavioral dysfunction

inferredcites →https://doi.org/10.1038/nrn1928openalex-snapshot

Purinergic signalling in neuron–glia interactions

inferredcites →https://doi.org/10.1073/pnas.061020198openalex-snapshot

Activation of Trk neurotrophin receptors in the absence of neurotrophins

inferredcites →https://doi.org/10.1074/jbc.m201206200openalex-snapshot

Essential Role of cAMP-response Element-binding Protein Activation by A2A Adenosine Receptors in Rescuing the Nerve Growth Factor-induced Neurite Outgrowth Impaired by Blockage of the MAPK Cascade

inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00157.xopenalex-snapshot

Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection

inferredcites →https://doi.org/10.1111/jnc.14037openalex-snapshot

Brain aging and neurodegeneration: from a mitochondrial point of view

inferredcites →https://doi.org/10.1124/jpet.106.118018openalex-snapshot

Beryllium Induces Premature Senescence in Human Fibroblasts

inferredcites →https://doi.org/10.1124/mol.105.021261openalex-snapshot

Rescue of p53 Blockage by the A2A Adenosine Receptor via a Novel Interacting Protein, Translin-Associated Protein X

inferredcites →https://doi.org/10.1126/science.1088417openalex-snapshot

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

inferredcites →https://doi.org/10.1146/annurev-physiol-030212-183653openalex-snapshot

Aging, Cellular Senescence, and Cancer

inferredcites →https://doi.org/10.1155/2016/1681590openalex-snapshot

A Common Language: How Neuroimmunological Cross Talk Regulates Adult Hippocampal Neurogenesis

inferredcites →https://doi.org/10.1155/2018/8938207openalex-snapshot

Flavonoid‐Rich Ethanol Extract from the Leaves of Diospyros kaki Attenuates D‐Galactose‐Induced Oxidative Stress and Neuroinflammation‐Mediated Brain Aging in Mice

inferredcites →https://doi.org/10.1165/rcmb.2008-0168ocopenalex-snapshot

The Adenosine A2a Receptor Inhibits Matrix-Induced Inflammation in a Novel Fashion

inferredcites →https://doi.org/10.1172/jci95148openalex-snapshot

Mechanisms and functions of cellular senescence

inferredcites →https://doi.org/10.1177/1535370216685432openalex-snapshot

L-carnitine contributes to enhancement of neurogenesis from mesenchymal stem cells through Wnt/β-catenin and PKA pathway

inferredcites →https://doi.org/10.1371/journal.pone.0007901openalex-snapshot

Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

inferredcites →https://doi.org/10.1371/journal.pone.0020934openalex-snapshot

A New Drug Design Targeting the Adenosinergic System for Huntington's Disease

inferredcites →https://doi.org/10.3389/fphar.2014.00069openalex-snapshot

Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb

inferredcites →https://doi.org/10.3390/ijms15022024openalex-snapshot

Adenosine Receptors: Expression, Function and Regulation

inferredcites →https://doi.org/10.3390/ijms19020598openalex-snapshot

The Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer’s Disease-Related Pathologies in APP/PS1 Transgenic Mice

inferredcites →https://doi.org/10.3390/molecules22040676openalex-snapshot

Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration

inferredcites →https://doi.org/10.3945/an.117.016261openalex-snapshot

Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function

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Unconventional Neurogenic Niches and Neurogenesis Modulation by Vitamins

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4485173openalex-extracted

Dendrobium Nobile Lindl. Alkaloids Inhibits D-Galactose-Induced Hippocampal Neuronal Senescence Through the Sirt1-Foxo1-Autophagy Axis

inferred← citeshttps://doi.org/10.1002/fsn3.71737openalex-snapshot

Gastrodia elata –Derived Parishin Extracts Attenuate Aging by Modulating Oxidative Stress, Inflammation, Apoptosis, and Metabolism

inferred← citeshttps://doi.org/10.1002/prp2.70176openalex-snapshot

Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease

inferred← citeshttps://doi.org/10.1007/s00213-022-06079-8openalex-snapshot

N6-substituated adenosine analog J4 attenuates anxiety-like behaviors in mice

inferred← citeshttps://doi.org/10.1007/s11011-022-01049-7openalex-snapshot

RETRACTED ARTICLE: Adenosine protects D-galactose induced alterations in rat model of aging via attenuating neurochemical profile and redox status

inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462405openalex-snapshot

A five-dimensional data collection strategy for multicomponent discovery and characterization in Traditional Chinese Medicine: Gastrodia Rhizoma as a case study

inferred← citeshttps://doi.org/10.1016/j.mseb.2023.116982openalex-snapshot

Design of astaxanthin cold application gel using hydroxy propyl methyl cellulose with superior release and antioxidant properties

inferred← citeshttps://doi.org/10.1016/j.phymed.2021.153576openalex-snapshot

Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation

inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154020openalex-snapshot

Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation

inferred← citeshttps://doi.org/10.1016/j.prmcm.2023.100288openalex-snapshot

Dendrobium nobile Lindl. alkaloids (DNLA) inhibits d-galactose-induced hippocampal neuronal senescence through the SIRT1-FoxO1-autophagy axis

inferred← citeshttps://doi.org/10.1093/toxres/tfab051openalex-snapshot

Proteomic characteristics of beryllium sulfate-induced differentially expressed proteins in rats

inferred← citeshttps://doi.org/10.1111/acel.13686openalex-snapshot

Ganoderic acid D prevents oxidative stress‐induced senescence by targeting 14‐3‐3ε to activate CaM / CaMKII / NRF2 signaling pathway in mesenchymal stem cells

inferred← citeshttps://doi.org/10.1186/s12986-022-00688-yopenalex-snapshot

Glucosamine delays the progression of osteoporosis in senile mice by promoting osteoblast autophagy

inferred← citeshttps://doi.org/10.3389/fnagi.2025.1562453openalex-snapshot

Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies

inferred← citeshttps://doi.org/10.3389/fphar.2023.1191517openalex-snapshot

Mitochondrial homeostasis: a potential target for delaying renal aging

inferred← citeshttps://doi.org/10.3389/fphar.2025.1673532openalex-snapshot

NeuproGemp, a polyphenol-rich botanical formula, ameliorates Alzheimer’s-like pathology in APP/PS1 mice via inhibition of human glutaminyl cyclase

inferred← citeshttps://doi.org/10.3390/ijms242316580openalex-snapshot

Impact of NLRP3 Depletion on Aging-Related Metaflammation, Cognitive Function, and Social Behavior in Mice

inferred← citeshttps://doi.org/10.3390/molecules30173474openalex-snapshot

Comparative Phytochemical Analysis of Gastrodiae Rhizoma Peel and Core and Their Lifespan-Extending Potential in Caenorhabditis elegans

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