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Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The Gene Expression Omnibus Database
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Integrated analysis of single-cell and bulk RNA-sequencing identifies a signature based on B cell marker genes to predict prognosis and immunotherapy response in lung adenocarcinoma
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Human natural killer cell development and biology
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Notch Signaling in the Tumor Microenvironment
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Molecular control of monocyte development
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The Molecular Signatures Database Hallmark Gene Set Collection
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Mast cell progenitors: Origin, development and migration to tissues
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clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
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Gene Ontology: tool for the unification of biology
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Comprehensive genomic characterization of squamous cell lung cancers
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PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
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The Cancer Genome Atlas Pan-Cancer analysis project
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SCENIC: single-cell regulatory network inference and clustering
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Protective and pathogenic functions of macrophage subsets
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Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations
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Regenerative lineages and immune-mediated pruning in lung cancer metastasis
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Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions
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GSEA-InContext: identifying novel and common patterns in expression experiments
inferredcites →https://doi.org/10.1093/nar/27.1.29openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
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KEGG: Kyoto Encyclopedia of Genes and Genomes
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The UCSC Genome Browser database: 2021 update
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CellMarker: a manually curated resource of cell markers in human and mouse
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The expression of POSTN and immune cell infiltration are prognostic factors of lung adenocarcinoma
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Single-cell transcriptomics to explore the immune system in health and disease
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Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma
inferredcites →https://doi.org/10.1146/annurev.immunol.24.021605.090612openalex-snapshot
DEVELOPMENT OF HUMAN LYMPHOID CELLS
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The Non–Small Cell Lung Cancer Immune Contexture. A Major Determinant of Tumor Characteristics and Patient Outcome
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GSVA: gene set variation analysis for microarray and RNA-Seq data
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Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer
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Identification and Validation of a Novel Signature Based on NK Cell Marker Genes to Predict Prognosis and Immunotherapy Response in Lung Adenocarcinoma by Integrated Analysis of Single-Cell and Bulk RNA-Sequencing
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Identification of OTUD6B as a new biomarker for prognosis and immunotherapy by pan-cancer analysis
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Identification and Verification of Immune-Related Gene Prognostic Signature Based on ssGSEA for Osteosarcoma
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Three Differential Expression Analysis Methods for RNA Sequencing: limma, EdgeR, DESeq2
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CCL20 promotes lung adenocarcinoma progression by driving epithelial-mesenchymal transition

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Multi-Omics Reveals Tumor Cell Heterogeneity Effects on the Immunosuppression in ccRCC and Facilitates Prognostic Model Construction
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inferred← citeshttps://doi.org/10.1007/s12026-025-09595-9openalex-snapshot
Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in lung adenocarcinoma
inferred← citeshttps://doi.org/10.1007/s12672-024-01286-5openalex-snapshot
Single-cell RNA sequencing explored potential therapeutic targets by revealing the tumor microenvironment of neuroblastoma and its expression in cell death
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Discovering the Potential Role of the C2 DUSP2+ MCs Subgroup in Lung Adenocarcinoma
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inferred← citeshttps://doi.org/10.1136/jitc-2024-010008openalex-snapshot
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FTO/m6A mediates miR-138-5p maturation and regulates gefitinib resistance of lung adenocarcinoma cells by miR-138-5p/LCN2 axis
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METTL16 accelerates lung adenocarcinoma progression by inducing N6-methyladenosine modification of GTSE1 to regulate p53 pathway and cell cycle
inferred← citeshttps://doi.org/10.2174/0115734110370974250117074604openalex-snapshot
Classification of Molecular Subtypes and Establishment of a Mitophagy-related Gene Signature to Predict the Prognostic Outcomes for Lung Adenocarcinoma Patients
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Glioma Pathogenesis and Treatment Modality: Novel Insights From Midkine Research
inferred← citeshttps://doi.org/10.3389/fphar.2024.1426033openalex-snapshot
Pericytes: jack-of-all-trades in cancer-related inflammation
inferred← citeshttps://doi.org/10.61958/ncoc5630openalex-snapshot
Being associated with multiple diseases, CD79a, as a B-cell marker plays an important role in disease treatment and prognosis
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