On the public citation graph

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

https://doi.org/10.18632/oncotarget.3701

0 signed · 92 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/mnfr.200700491openalex-snapshot

Betulinic acid: A natural product with anticancer activity

inferredcites →https://doi.org/10.1007/s00018-011-0735-1openalex-snapshot

Vimentin in cancer and its potential as a molecular target for cancer therapy

inferredcites →https://doi.org/10.1007/s40265-013-0142-zopenalex-snapshot

Crizotinib: A Review of Its Use in the Treatment of Anaplastic Lymphoma Kinase-Positive, Advanced Non-Small Cell Lung Cancer

inferredcites →https://doi.org/10.1016/j.bbrc.2010.10.068openalex-snapshot

4′-Acetoamido-4-hydroxychalcone, a chalcone derivative, inhibits glioma growth and invasion through regulation of the tropomyosin 1 gene

inferredcites →https://doi.org/10.1016/j.bmc.2009.07.050openalex-snapshot

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

inferredcites →https://doi.org/10.1016/j.bmcl.2011.07.072openalex-snapshot

New betulinic acid derivatives as potent proteasome inhibitors

inferredcites →https://doi.org/10.1016/j.bmcl.2011.12.102openalex-snapshot

New ionic derivatives of betulinic acid as highly potent anti-cancer agents

inferredcites →https://doi.org/10.1016/j.canlet.2010.07.016openalex-snapshot

Targeting ER stress induced apoptosis and inflammation in cancer

inferredcites →https://doi.org/10.1016/j.ceb.2006.06.005openalex-snapshot

Endoplasmic reticulum stress in health and disease

inferredcites →https://doi.org/10.1016/j.cellsig.2012.09.012openalex-snapshot

Ursolic acid induces ER stress response to activate ASK1–JNK signaling and induce apoptosis in human bladder cancer T24 cells

inferredcites →https://doi.org/10.1016/j.cellsig.2013.04.009openalex-snapshot

Signaling networks of Rho GTPases in cell motility

inferredcites →https://doi.org/10.1016/j.ejmech.2013.03.028openalex-snapshot

Synthesis of 3-O-propargylated betulinic acid and its 1,2,3-triazoles as potential apoptotic agents

inferredcites →https://doi.org/10.1016/j.ejmech.2013.07.012openalex-snapshot

Preparation of betulinic acid derivatives by chemical and biotransformation methods and determination of cytotoxicity against selected cancer cell lines

inferredcites →https://doi.org/10.1016/j.tcb.2014.12.006openalex-snapshot

Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance

inferredcites →https://doi.org/10.1038/36285openalex-snapshot

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

inferredcites →https://doi.org/10.1038/cdd.2012.10openalex-snapshot

Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process

inferredcites →https://doi.org/10.1038/cddis.2014.169openalex-snapshot

Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa

inferredcites →https://doi.org/10.1038/mt.2012.45openalex-snapshot

A Tubulin Binding Peptide Targets Glioma Cells Disrupting Their Microtubules, Blocking Migration, and Inducing Apoptosis

inferredcites →https://doi.org/10.1038/ncb1400openalex-snapshot

Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling

inferredcites →https://doi.org/10.1038/nrc3701openalex-snapshot

Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

inferredcites →https://doi.org/10.1038/nrd2755openalex-snapshot

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

inferredcites →https://doi.org/10.1038/onc.2008.137openalex-snapshot

Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

inferredcites →https://doi.org/10.1038/onc.2011.568openalex-snapshot

Sp1 expression regulates lung tumor progression

inferredcites →https://doi.org/10.1038/onc.2013.393openalex-snapshot

Invading one step at a time: the role of invadopodia in tumor metastasis

inferredcites →https://doi.org/10.1073/pnas.0914203107openalex-snapshot

MYC regulation of a “poor-prognosis” metastatic cancer cell state

inferredcites →https://doi.org/10.1073/pnas.1213677110openalex-snapshot

Synaptopodin regulates denervation-induced homeostatic synaptic plasticity

inferredcites →https://doi.org/10.1073/pnas.1400749111openalex-snapshot

Control of MT1-MMP transport by atypical PKC during breast-cancer progression

inferredcites →https://doi.org/10.1074/jbc.m112.432716openalex-snapshot

ARHGAP21 Protein, a New Partner of α-Tubulin Involved in Cell-Cell Adhesion Formation and Essential for Epithelial-Mesenchymal Transition

inferredcites →https://doi.org/10.1083/jcb.139.1.193openalex-snapshot

Synaptopodin: An Actin-associated Protein in Telencephalic Dendrites and Renal Podocytes

inferredcites →https://doi.org/10.1083/jcb.153.5.1011openalex-snapshot

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

inferredcites →https://doi.org/10.1091/mbc.e13-12-0749openalex-snapshot

Capping protein is essential for cell migration in vivo and for filopodial morphology and dynamics

inferredcites →https://doi.org/10.1093/carcin/bgm189openalex-snapshot

2-Cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor in colon and pancreatic cancer cells

inferredcites →https://doi.org/10.1093/carcin/bgs109openalex-snapshot

Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells

inferredcites →https://doi.org/10.1093/jnci/djs648openalex-snapshot

PKB/Akt-Dependent Regulation of Cell Motility

inferredcites →https://doi.org/10.1096/fj.08-106187openalex-snapshot

Intermediate filament protein synemin contributes to the migratory properties of astrocytoma cells by influencing the dynamics of the actin cytoskeleton

inferredcites →https://doi.org/10.1124/mol.112.078485openalex-snapshot

Betulinic Acid Decreases Specificity Protein 1 (Sp1) Level via Increasing the Sumoylation of Sp1 to Inhibit Lung Cancer Growth

inferredcites →https://doi.org/10.1126/science.1101902openalex-snapshot

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

inferredcites →https://doi.org/10.1128/mcb.24.18.8113-8133.2004openalex-snapshot

Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling

inferredcites →https://doi.org/10.1152/ajprenal.00206.2010openalex-snapshot

Regulation of podocyte BKCachannels by synaptopodin, Rho, and actin microfilaments

inferredcites →https://doi.org/10.1158/0008-5472.can-06-3735openalex-snapshot

Betulinic Acid Inhibits Prostate Cancer Growth through Inhibition of Specificity Protein Transcription Factors

inferredcites →https://doi.org/10.1158/0008-5472.can-13-1275openalex-snapshot

LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-3630openalex-snapshot

Lamin B1 Is a Novel Therapeutic Target of Betulinic Acid in Pancreatic Cancer

inferredcites →https://doi.org/10.1158/1535-7163.mct-12-0026openalex-snapshot

Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

inferredcites →https://doi.org/10.1158/1541-7786.mcr-11-0616openalex-snapshot

Cdc42 and the Guanine Nucleotide Exchange Factors Ect2 and Trio Mediate Fn14-Induced Migration and Invasion of Glioblastoma Cells

inferredcites →https://doi.org/10.1164/rccm.201301-0189ppopenalex-snapshot

Targeted Therapy for Non–Small Cell Lung Cancer

inferredcites →https://doi.org/10.1172/jci26373openalex-snapshot

Endoplasmic reticulum stress: cell life and death decisions

inferredcites →https://doi.org/10.1172/jci44871openalex-snapshot

Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium

inferredcites →https://doi.org/10.1186/1471-2407-11-371openalex-snapshot

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

inferredcites →https://doi.org/10.1242/jcs.104018openalex-snapshot

Filamin A controls matrix metalloprotease activity and regulates cell invasion in human fibrosarcoma cells.

inferredcites →https://doi.org/10.1242/jcs.118315openalex-snapshot

A complex containing LPP and α-Actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells

inferredcites →https://doi.org/10.1371/journal.pone.0021492openalex-snapshot

Suppression of STAT3 and HIF-1 Alpha Mediates Anti-Angiogenic Activity of Betulinic Acid in Hypoxic PC-3 Prostate Cancer Cells

inferredcites →https://doi.org/10.1371/journal.pone.0030240openalex-snapshot

Mitochondrial Apoptosis and FAK Signaling Disruption by a Novel Histone Deacetylase Inhibitor, HTPB, in Antitumor and Antimetastatic Mouse Models

inferredcites →https://doi.org/10.1371/journal.pone.0056234openalex-snapshot

Betulinic Acid Selectively Increases Protein Degradation and Enhances Prostate Cancer-Specific Apoptosis: Possible Role for Inhibition of Deubiquitinase Activity

inferredcites →https://doi.org/10.1371/journal.pone.0062171openalex-snapshot

Prognostic Significance of Twist and N-Cadherin Expression in NSCLC

inferredcites →https://doi.org/10.1371/journal.pone.0065463openalex-snapshot

Contactin-1 Reduces E-Cadherin Expression Via Activating AKT in Lung Cancer

inferredcites →https://doi.org/10.2174/138945011795906534openalex-snapshot

Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis

inferredcites →https://doi.org/10.2174/1871520614666140223192148openalex-snapshot

Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview

inferredcites →https://doi.org/10.3390/genes1030440openalex-snapshot

Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase

inferredcites →https://doi.org/10.3724/sp.j.1263.2012.02292openalex-snapshot

Salubrinal protects against tunicamycin and hypoxia induced cardiomyocyte apoptosis via the PERK-eIF2α signaling pathwaySalubrinal protects against tunicamycin and hypoxia induced cardiomyocyte apoptosis via the PERK-eIF2α signaling pathway

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4651625openalex-extracted

inferred← citeshttps://doi.org/10.1002/adma.202007778openalex-snapshot

Mito‐Bomb: Targeting Mitochondria for Cancer Therapy

inferred← citeshttps://doi.org/10.1002/cmdc.202100659openalex-snapshot

Mitochondria‐Targeted Triphenylphosphonium Conjugated C‐3 Modified Betulin: Synthesis, Antitumor Properties and Mechanism of Action

inferred← citeshttps://doi.org/10.1007/s11051-015-3265-1openalex-snapshot

Controlled delivery of Gemcitabine Hydrochloride using mannosylated poly(propyleneimine) dendrimers

inferred← citeshttps://doi.org/10.1007/s11064-016-2147-yopenalex-snapshot

Betulinic Acid Induces Apoptosis in Differentiated PC12 Cells Via ROS-Mediated Mitochondrial Pathway

inferred← citeshttps://doi.org/10.1016/j.apsb.2021.12.008openalex-snapshot

A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

inferred← citeshttps://doi.org/10.1016/j.biopha.2016.10.018openalex-snapshot

Multiple molecular targets in breast cancer therapy by betulinic acid

inferred← citeshttps://doi.org/10.1016/j.bmc.2019.03.033openalex-snapshot

Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo

inferred← citeshttps://doi.org/10.1016/j.cbi.2019.108841openalex-snapshot

Evaluation of the Betulinic Acid–Cisplatin conjugate APC and its precursor DE9B for the treatment of human malignant glioma

inferred← citeshttps://doi.org/10.1016/j.colsurfa.2024.133624openalex-snapshot

Stabilization of weakly associated water forms by the surface of compacted methylsilica and its composites with Betulin

inferred← citeshttps://doi.org/10.1016/j.fitote.2021.104845openalex-snapshot

Natural pentacyclic triterpenoid acids potentially useful as biocompatible nanocarriers

inferred← citeshttps://doi.org/10.1016/j.tiv.2023.105756openalex-snapshot

Betulinic acid inhibits the proliferation of human laryngeal carcinoma cells through reactive oxygen species-mediate mitochondrial apoptotic pathway

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.3c00304openalex-snapshot

Bifunctionalized Betulinic Acid Conjugates with C-3-Monodesmoside and C-28-Triphenylphosphonium Moieties with Increased Cancer Cell Targetability

inferred← citeshttps://doi.org/10.1039/d4ra08503eopenalex-snapshot

Monophthalates of betulinic acid and related pentacyclic triterpenes inhibit efficiently the SOS-mediated nucleotide exchange and impact PI3K/AKT signaling in oncogenic K-RAS4B proteins

inferred← citeshttps://doi.org/10.1055/s-0043-113826openalex-snapshot

Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus

inferred← citeshttps://doi.org/10.1055/s-0043-123472openalex-snapshot

New Pharmacological Opportunities for Betulinic Acid

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-17-0527openalex-snapshot

Comparative Transcriptome Profiling Reveals Coding and Noncoding RNA Differences in NSCLC from African Americans and European Americans

inferred← citeshttps://doi.org/10.1186/s13020-026-01424-xopenalex-snapshot

Research advances in the application of betulinic acid for anti-inflammatory and anti-tumour therapy

inferred← citeshttps://doi.org/10.15407/surface.2025.17.413openalex-snapshot

Medical nanocomposites based on hydrophilic and hydrophobic silicas and their properties

inferred← citeshttps://doi.org/10.17179/excli2016-642openalex-snapshot

Lupane-type triterpenes and their anti-cancer activities against most common malignant tumors: a review

inferred← citeshttps://doi.org/10.18632/oncotarget.23376openalex-snapshot

Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models

inferred← citeshttps://doi.org/10.18632/oncotarget.7894openalex-snapshot

Positive feedback regulation between IL10 and EGFR promotes lung cancer formation

inferred← citeshttps://doi.org/10.21203/rs.3.rs-2943757/v1openalex-snapshot

Efficient Sequential Delivery Nanosystem of Betulinic Acid and Celastrol for Inhibition of Tumor- Associated Fibroblast-Induced Resistance and Metastasis

inferred← citeshttps://doi.org/10.2147/ijn.s427783openalex-snapshot

Efficient Sequential Co-Delivery Nanosystem for Inhibition of Tumor and Tumor-Associated Fibroblast-Induced Resistance and Metastasis

inferred← citeshttps://doi.org/10.2174/0127724328295592240419064719openalex-snapshot

Cell-Derived Allograft Models as a Solution to the Obstacles of Preclinical Studies under Limited Resources: A Systematic Review on Experimental Lung Cancer Animal Models

inferred← citeshttps://doi.org/10.2217/nnm-2016-0251openalex-snapshot

Potential Use of Nanocarriers With Pentacyclic Triterpenes in Cancer Treatments

inferred← citeshttps://doi.org/10.26444/jpccr/92743openalex-snapshot

Betulin and betulinic acid in cancer research

inferred← citeshttps://doi.org/10.3390/cancers12040981openalex-snapshot

Betulinic Acid-Mediated Tuning of PERK/CHOP Signaling by Sp1 Inhibition as a Novel Therapeutic Strategy for Glioblastoma

inferred← citeshttps://doi.org/10.3390/ijms242417325openalex-snapshot

The Nexus of Inflammation-Induced Epithelial-Mesenchymal Transition and Lung Cancer Progression: A Roadmap to Pentacyclic Triterpenoid-Based Therapies

inferred← citeshttps://doi.org/10.3390/molecules27154738openalex-snapshot

Synthesis and Biological Evaluation of Novel Allobetulon/Allobetulin–Nucleoside Conjugates as AntitumorAgents

inferred← citeshttps://doi.org/10.3390/molecules28010067openalex-snapshot

Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis

inferred← citeshttps://doi.org/10.3390/pharmaceutics17010022openalex-snapshot

The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential

inferred← citeshttps://doi.org/10.7324/japs.2018.8922openalex-snapshot

Variation of Ursolic and Betulinic Acid in Five Malus χ domestica clones from Southern Brazil

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.