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IL-1Ra Protects Hematopoietic Stem Cells from Chemotoxicity Through Quiescence Induction Via p53

https://doi.org/10.2139/ssrn.3318930
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/stem.2056openalex-extracted
Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration
inferredcites →https://doi.org/10.1006/excr.1998.4319openalex-extracted
Transcriptional Regulation of the p21(WAF1/CIP1)Gene
inferredcites →https://doi.org/10.1016/0092-8674(93)90500-popenalex-extracted
WAF1, a potential mediator of p53 tumor suppression
inferredcites →https://doi.org/10.1016/j.biopha.2012.11.002openalex-extracted
Recombinant human interleukin-1 receptor antagonist reduces acute lethal toxicity and protects hematopoiesis from chemotoxicity in vivo
inferredcites →https://doi.org/10.1016/j.ceb.2013.07.010openalex-extracted
Start and the restriction point
inferredcites →https://doi.org/10.1016/j.cell.2008.07.001openalex-extracted
TGFβ in Cancer
inferredcites →https://doi.org/10.1016/j.cell.2013.08.062openalex-extracted
The Proliferation-Quiescence Decision Is Controlled by a Bifurcation in CDK2 Activity at Mitotic Exit
inferredcites →https://doi.org/10.1016/j.dld.2015.11.025openalex-extracted
A phase III study evaluating oral glutamine and transforming growth factor-beta 2 on chemotherapy-induced toxicity in patients with digestive neoplasm
inferredcites →https://doi.org/10.1016/j.dnarep.2016.04.008openalex-extracted
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
inferredcites →https://doi.org/10.1016/j.smim.2013.10.023openalex-extracted
The interleukin-1 receptor family
inferredcites →https://doi.org/10.1016/j.stem.2008.11.006openalex-extracted
p53 Regulates Hematopoietic Stem Cell Quiescence
inferredcites →https://doi.org/10.1016/s0092-8674(00)00121-5openalex-extracted
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
inferredcites →https://doi.org/10.1038/358015a0openalex-extracted
p53, guardian of the genome
inferredcites →https://doi.org/10.1038/81335openalex-extracted
Stem cell repopulation efficiency but not pool size is governed by p27kip1
inferredcites →https://doi.org/10.1038/bjc.2013.702openalex-extracted
p53-Based cyclotherapy: exploiting the ‘guardian of the genome’ to protect normal cells from cytotoxic therapy
inferredcites →https://doi.org/10.1038/ng2033openalex-extracted
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
inferredcites →https://doi.org/10.1038/nrc2604openalex-extracted
The ups and downs of p53: understanding protein dynamics in single cells
inferredcites →https://doi.org/10.1038/nrclinonc.2010.174openalex-extracted
Translating p53 into the clinic
inferredcites →https://doi.org/10.1038/nrd3800openalex-extracted
Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
inferredcites →https://doi.org/10.1038/nrd4236openalex-extracted
Drugging the p53 pathway: understanding the route to clinical efficacy
inferredcites →https://doi.org/10.1038/nrm3591openalex-extracted
Molecular regulation of stem cell quiescence
inferredcites →https://doi.org/10.1042/bj20100323openalex-extracted
Mechanisms and functions of p38 MAPK signalling
inferredcites →https://doi.org/10.1073/pnas.0813333106openalex-extracted
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
inferredcites →https://doi.org/10.1073/pnas.1019059108openalex-extracted
RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation
inferredcites →https://doi.org/10.1084/jem.180.3.1047openalex-extracted
Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin.
inferredcites →https://doi.org/10.1126/science.287.5459.1804openalex-extracted
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
inferredcites →https://doi.org/10.1126/scitranslmed.aal3986openalex-extracted
Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion
inferredcites →https://doi.org/10.1146/annurev.immunol.021908.132612openalex-extracted
Immunological and Inflammatory Functions of the Interleukin-1 Family
inferredcites →https://doi.org/10.1182/blood.v45.3.321.321openalex-extracted
Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome
inferredcites →https://doi.org/10.1182/blood.v45.3.321.bloodjournal453321openalex-extracted
Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome
inferredcites →https://doi.org/10.1182/blood.v54.3.713.713openalex-extracted
Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia
inferredcites →https://doi.org/10.1182/blood.v87.6.2095.bloodjournal8762095openalex-extracted
Biologic basis for interleukin-1 in disease
inferredcites →https://doi.org/10.4161/cc.1.6.259openalex-extracted
Cyclotherapy: Protection of Normal Cells and Unshielding of Cancer Cells
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