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Prediction of Liquid-Liquid Phase Separation Proteins Using Machine Learning
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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A Phase Separation Model for Transcriptional Control
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A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
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Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
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A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression
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Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm
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Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
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Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
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RNA Controls PolyQ Protein Phase Transitions
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Properties of Stress Granule and P-Body Proteomes
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Liquid–liquid phase separation in cellular signaling systems
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First-generation predictors of biological protein phase separation
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ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain
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Biomolecular condensates: organizers of cellular biochemistry
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Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
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Three archetypical classes of macromolecular regulators of protein liquid–liquid phase separation
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Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
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HLA class I binding prediction via convolutional neural networks
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Computational identification of prion-like RNA-binding proteins that form liquid phase-separated condensates
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DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists
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DisProt 7.0: a major update of the database of disordered proteins
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MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins
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RCSB Protein Data Bank: biological macromolecular structures enabling research and education in fundamental biology, biomedicine, biotechnology and energy
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DrLLPS: a data resource of liquid–liquid phase separation in eukaryotes
inferredcites →https://doi.org/10.1093/nar/gkz778openalex-snapshot
LLPSDB: a database of proteins undergoing liquid–liquid phase separation in vitro
inferredcites →https://doi.org/10.1093/nar/gkz847openalex-snapshot
PhaSepDB: a database of liquid–liquid phase separation related proteins
inferredcites →https://doi.org/10.1093/nar/gkz848openalex-snapshot
PhaSePro: the database of proteins driving liquid–liquid phase separation
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Drug2Vec: Knowledge-aware Feature-driven Method for Drug Representation Learning
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Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
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Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks
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BLAST+: architecture and applications
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Comparing sequences without using alignments: application to HIV/SIV subtyping
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Prediction of potential drug targets based on simple sequence properties
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Software Framework for Topic Modelling with Large Corpora
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M6AMRFS: Robust Prediction of N6-Methyladenosine Sites With Sequence-Based Features in Multiple Species
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Distributed Representations of Words and Phrases and their Compositionality
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Pi-Pi contacts are an overlooked protein feature relevant to phase separation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Phase separation of FG-nucleoporins in nuclear pore complexes
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Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics
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Machine learning for biochemical engineering: A review
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Advances in targeting the WNT/β-catenin signaling pathway in cancer
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Prevalence and functionality of intrinsic disorder in human FG-nucleoporins
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Liquid-liquid phase separation of the intrinsically disordered AB region of hRXRγ is driven by hydrophobic interactions
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A protein pre-trained model-based approach for the identification of the liquid-liquid phase separation (LLPS) proteins
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Beta turn propensity and a model polymer scaling exponent identify intrinsically disordered phase-separating proteins
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Cauliflower mosaic virus P6 inclusion body formation: A dynamic and intricate process
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A variational graph-partitioning approach to modeling protein liquid-liquid phase separation
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GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein
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JMJD3 intrinsically disordered region links the 3D-genome structure to TGFβ-dependent transcription activation
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PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms
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Proteomic analysis of heat-stable proteins revealed an increased proportion of proteins with compositionally biased regions
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Computational resources for identifying and describing proteins driving liquid–liquid phase separation
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In silico prediction of in vitro protein liquid–liquid phase separation experiments outcomes with multi-head neural attention
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LLPSDB v2.0: an updated database of proteins undergoing liquid–liquid phase separation in vitro
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PlantGSAD: a comprehensive gene set annotation database for plant species
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Cingulin unfolds ZO-1 and organizes myosin-2B and γ-actin to mechanoregulate apical and tight junction membranes
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Beta turn propensity and a model polymer scaling exponent identify disordered proteins that phase separate
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Machine learning models for predicting protein condensate formation from sequence determinants and embeddings
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Identification of Phase Separating Proteins With Distributed Reduced Alphabet Representations of Sequences
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New technologies to analyse protein function: an intrinsic disorder perspective
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Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis
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Phase separation in synthetic biology
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Protein Databases Related to Liquid–Liquid Phase Separation
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Studying Peptide-Metal Ion Complex Structures by Solution-State NMR
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Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments
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