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Substrate-Selective Positive Allosteric Modulation of Ptprd's Phosphatase by Flavonols

https://doi.org/10.2139/ssrn.4065674
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.200461517openalex-snapshot
Inhibitors of Protein Tyrosine Phosphatases: Next‐Generation Drugs?
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Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation.
inferredcites →https://doi.org/10.1002/jcc.21334openalex-snapshot
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
inferredcites →https://doi.org/10.1002/jnr.21523openalex-snapshot
Pharmacological inhibition of GSK‐3 is not strictly correlated with a decrease in tyrosine phosphorylation of residues 216/279
inferredcites →https://doi.org/10.1002/pmic.201200439openalex-snapshot
Comet: An open‐source MS / MS sequence database search tool
inferredcites →https://doi.org/10.1002/prot.22716openalex-snapshot
Sub-angstrom modeling of complexes between flexible peptides and globular proteins
inferredcites →https://doi.org/10.1006/abio.1993.1231openalex-snapshot
A General Peptide Substrate for Protein Tyrosine Phosphatases
inferredcites →https://doi.org/10.1007/s10822-013-9644-8openalex-snapshot
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
inferredcites →https://doi.org/10.1007/s10969-007-9036-1openalex-snapshot
Structural genomics of protein phosphatases
inferredcites →https://doi.org/10.1007/s11064-014-1304-4openalex-snapshot
Dihydromyricetin Ameliorates Behavioral Deficits and Reverses Neuropathology of Transgenic Mouse Models of Alzheimer’s Disease
inferredcites →https://doi.org/10.1007/s13765-016-0217-0openalex-snapshot
Quercetin and quercetin-3-β-d-glucoside improve cognitive and memory function in Alzheimer’s disease mouse
inferredcites →https://doi.org/10.1016/j.bbadis.2013.05.022openalex-snapshot
Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities
inferredcites →https://doi.org/10.1016/j.bcp.2021.114868openalex-snapshot
Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development
inferredcites →https://doi.org/10.1016/j.bmcl.2015.11.026openalex-snapshot
Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension
inferredcites →https://doi.org/10.1016/j.brainres.2016.03.030openalex-snapshot
Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system
inferredcites →https://doi.org/10.1016/j.celrep.2018.02.038openalex-snapshot
Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling
inferredcites →https://doi.org/10.1016/j.molonc.2016.03.003openalex-snapshot
Unbiased identification of substrates of protein tyrosine phosphatase ptp‐3 in C. elegans
inferredcites →https://doi.org/10.1016/j.nbt.2015.08.002openalex-snapshot
Alterations in the phosphoproteomic profile of cells expressing a non-functional form of the SHP2 phosphatase
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2009.07.007openalex-snapshot
c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice
inferredcites →https://doi.org/10.1016/s1474-4422(17)30327-7openalex-snapshot
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
inferredcites →https://doi.org/10.1017/s1368980009992990openalex-snapshot
Flavonoid intake and disability-adjusted life years due to Alzheimer’s and related dementias: a population-based study involving twenty-three developed countries
inferredcites →https://doi.org/10.1021/ac026117iopenalex-snapshot
Stop and Go Extraction Tips for Matrix-Assisted Laser Desorption/Ionization, Nanoelectrospray, and LC/MS Sample Pretreatment in Proteomics
inferredcites →https://doi.org/10.1021/bi401223ropenalex-snapshot
Diverse Levels of Sequence Selectivity and Catalytic Efficiency of Protein-Tyrosine Phosphatases
inferredcites →https://doi.org/10.1021/jm030644sopenalex-snapshot
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening
inferredcites →https://doi.org/10.1021/jm051256oopenalex-snapshot
Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes
inferredcites →https://doi.org/10.1023/a:1007614613771openalex-snapshot
Intake of flavonoids and risk of dementia
inferredcites →https://doi.org/10.1038/35096019openalex-snapshot
A decade of CDK5
inferredcites →https://doi.org/10.1038/mp.2017.20openalex-snapshot
Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies
inferredcites →https://doi.org/10.1038/s41386-021-01097-0openalex-snapshot
Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study
inferredcites →https://doi.org/10.1038/srep15709openalex-snapshot
Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation
inferredcites →https://doi.org/10.1073/pnas.0609836104openalex-snapshot
Large-scale phosphorylation analysis of mouse liver
inferredcites →https://doi.org/10.1073/pnas.1720446115openalex-snapshot
Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist
inferredcites →https://doi.org/10.1074/jbc.275.6.4066openalex-snapshot
Structural Basis for Substrate Specificity of Protein-tyrosine Phosphatase SHP-1
inferredcites →https://doi.org/10.1074/jbc.m113.463984openalex-snapshot
An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease
inferredcites →https://doi.org/10.1074/mcp.m113.028886openalex-snapshot
Phosphatase of Regenerating Liver 3 (PRL3) Provokes a Tyrosine Phosphoproteome to Drive Prometastatic Signal Transduction
inferredcites →https://doi.org/10.1074/mcp.ra119.001716openalex-snapshot
Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2*[S]
inferredcites →https://doi.org/10.1074/mcp.t500030-mcp200openalex-snapshot
Parts per Million Mass Accuracy on an Orbitrap Mass Spectrometer via Lock Mass Injection into a C-trap
inferredcites →https://doi.org/10.1084/jem.20041890openalex-snapshot
Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45
inferredcites →https://doi.org/10.1093/ajcn/nqaa079openalex-snapshot
Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort
inferredcites →https://doi.org/10.1093/bioinformatics/btq054openalex-snapshot
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
inferredcites →https://doi.org/10.1093/emboj/19.12.2775openalex-snapshot
Impaired learning with enhanced hippocampal long‐term potentiation in PTPδ‐deficient mice
inferredcites →https://doi.org/10.1097/jgp.0b013e3181c65250openalex-snapshot
Midlife Fruit and Vegetable Consumption and Risk of Dementia in Later Life in Swedish Twins
inferredcites →https://doi.org/10.1097/wnr.0000000000000594openalex-snapshot
Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer’s disease patients
inferredcites →https://doi.org/10.1111/acel.12873openalex-snapshot
Temporal and regional progression of Alzheimer’s disease‐like pathology in 3xTg‐AD mice
inferredcites →https://doi.org/10.1111/febs.15666openalex-snapshot
Roles of type IIa receptor protein tyrosine phosphatases as synaptic organizers
inferredcites →https://doi.org/10.1111/nyas.14002openalex-snapshot
PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes
inferredcites →https://doi.org/10.1212/wnl.0000000000008981openalex-snapshot
Dietary flavonols and risk of Alzheimer dementia
inferredcites →https://doi.org/10.1242/jcs.147553openalex-snapshot
Cdk5 activity in the brain – multiple paths of regulation
inferredcites →https://doi.org/10.1371/journal.pone.0018934openalex-snapshot
Rosetta FlexPepDock ab-initio: Simultaneous Folding, Docking and Refinement of Peptides onto Their Receptors
inferredcites →https://doi.org/10.15252/embj.2019104150openalex-snapshot
Splice‐dependent trans‐synaptic PTPδ–IL1RAPL1 interaction regulates synapse formation and non‐REM sleep
inferredcites →https://doi.org/10.2119/molmed.2015.00017openalex-snapshot
Mouse Model for Protein Tyrosine Phosphatase D (PTPRD) Associations with Restless Leg Syndrome or Willis-Ekbom Disease and Addiction: Reduced Expression Alters Locomotion, Sleep Behaviors and Cocaine-Conditioned Place Preference
inferredcites →https://doi.org/10.3390/ijms21020493openalex-snapshot
Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies
inferredcites →https://doi.org/10.3390/jcm9010180openalex-snapshot
Genome-Wide Association Study of Opioid Cessation
inferredcites →https://doi.org/10.3390/molecules24122287openalex-snapshot
Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
inferredcites →https://doi.org/10.3390/proteomes3030160openalex-snapshot
Complementary PTM Profiling of Drug Response in Human Gastric Carcinoma by Immunoaffinity and IMAC Methods with Total Proteome Analysis
inferredcites →https://doi.org/10.4049/jimmunol.1401841openalex-snapshot
Protein Tyrosine Phosphatase Receptor Type γ Is a JAK Phosphatase and Negatively Regulates Leukocyte Integrin Activation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.tjpad.2025.100361openalex-snapshot
Alzheimer’s disease prevention by flavonols and their analogs
inferred← citeshttps://doi.org/10.1038/s41368-025-00407-2openalex-snapshot
MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD
inferred← citeshttps://doi.org/10.1097/fbp.0000000000000853openalex-snapshot
Pretreatment with LY2090314, a potent glycogen synthase kinase-3 inhibitor, suppresses methamphetamine-induced stereotyped behavior but not hyperlocomotion in mice
inferred← citeshttps://doi.org/10.1101/2025.07.28.667221openalex-snapshot
Pentilludin reduces rat amphetamine and remifentail self-administration with good pharmacologic and toxicologic profiles
inferred← citeshttps://doi.org/10.1111/jnc.70292openalex-snapshot
Synaptic and Non‐Synaptic Functions of PTPRD : A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism
inferred← citeshttps://doi.org/10.1136/egastro-2024-100159openalex-snapshot
Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease
inferred← citeshttps://doi.org/10.1186/s40659-025-00607-4openalex-snapshot
Ptprd deficiency promotes tau hyperphosphorylation and impairs cognitive function in aged mice
inferred← citeshttps://doi.org/10.1523/jneurosci.2043-25.2026openalex-snapshot
Elaboration of Cortical Pyramidal Dendrites Requires Dephosphorylation of Signal Regulatory Protein α by Protein Tyrosine Phosphatase δ
inferred← citeshttps://doi.org/10.3389/fnins.2026.1803332openalex-snapshot
Altering PTPRD via genetics or pharmacology modulates 3xTg-AD mouse neurofibrillary pathology
inferred← citeshttps://doi.org/10.3389/fpsyt.2023.1031283openalex-snapshot
Selecting the appropriate hurdles and endpoints for pentilludin, a novel antiaddiction pharmacotherapeutic targeting the receptor type protein tyrosine phosphatase D
inferred← citeshttps://doi.org/10.3390/biomedicines14102210openalex-snapshot
Alzheimer’s Disease Neurofibrillary Pathophysiology: PTPRD- and Flavonol-Modified Mechanisms, Prevention and Therapeutics
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