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Hindlimb Unloading in C57bl/6j Mice Induces Bone Loss at Thermoneutrality Without Change in Osteocyte and Lacuno-Canalicular Network
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jbm4.10035openalex-snapshot
Cx43 Overexpression in Osteocytes Prevents Osteocyte Apoptosis and Preserves Cortical Bone Quality in Aging Mice
inferredcites →https://doi.org/10.1002/jbmr.1646openalex-snapshot
Matrix metalloproteinase–13 is required for osteocytic perilacunar remodeling and maintains bone fracture resistance
inferredcites →https://doi.org/10.1002/jbmr.1807openalex-snapshot
Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading
inferredcites →https://doi.org/10.1002/jbmr.2807openalex-snapshot
Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs
inferredcites →https://doi.org/10.1002/jbmr.3044openalex-snapshot
Lactation-Induced Changes in the Volume of Osteocyte Lacunar-Canalicular Space Alter Mechanical Properties in Cortical Bone Tissue
inferredcites →https://doi.org/10.1002/jbmr.3188openalex-snapshot
Cortical and Trabecular Bone Microstructure Did Not Recover at Weight-Bearing Skeletal Sites and Progressively Deteriorated at Non-Weight-Bearing Sites During the Year Following International Space Station Missions
inferredcites →https://doi.org/10.1007/bf00582901openalex-snapshot
Thermoregulation in the diabetic-obese (db/db) mouse
inferredcites →https://doi.org/10.1007/s00198-016-3634-3openalex-snapshot
Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss
inferredcites →https://doi.org/10.1007/s00223-018-0463-8openalex-snapshot
Mechanical Loading Differentially Affects Osteocytes in Fibulae from Lactating Mice Compared to Osteocytes in Virgin Mice: Possible Role for Lacuna Size
inferredcites →https://doi.org/10.1007/s00223-020-00708-0openalex-snapshot
Unloading-Induced Cortical Bone Loss is Exacerbated by Low-Dose Irradiation During a Simulated Deep Space Exploration Mission
inferredcites →https://doi.org/10.1007/s00774-003-0432-8openalex-snapshot
Lower bone cellular activities in male and female mature C3H/HeJ mice are associated with higher bone mass and different pyridinium crosslink profiles compared to C57BL/6J mice
inferredcites →https://doi.org/10.1007/s00774-010-0201-4openalex-snapshot
Modeled microgravity and hindlimb unloading sensitize osteoclast precursors to RANKL-mediated osteoclastogenesis
inferredcites →https://doi.org/10.1016/0021-9290(92)90089-jopenalex-snapshot
The physical and mechanical effects of suspension-induced osteopenia on mouse long bones
inferredcites →https://doi.org/10.1016/j.bone.2006.04.014openalex-snapshot
Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes
inferredcites →https://doi.org/10.1016/j.bone.2009.01.376openalex-snapshot
An effective histological staining process to visualize bone interstitial fluid space using confocal microscopy
inferredcites →https://doi.org/10.1016/j.bone.2009.11.006openalex-snapshot
Osteocyte apoptosis and control of bone resorption following ovariectomy in mice
inferredcites →https://doi.org/10.1016/j.bone.2012.01.025openalex-snapshot
Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations
inferredcites →https://doi.org/10.1016/j.bone.2012.05.014openalex-snapshot
Alterations in the osteocyte lacunar–canalicular microenvironment due to estrogen deficiency
inferredcites →https://doi.org/10.1016/j.bone.2014.03.049openalex-snapshot
Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo
inferredcites →https://doi.org/10.1016/j.bone.2015.02.011openalex-snapshot
Novel approaches for two and three dimensional multiplexed imaging of osteocytes
inferredcites →https://doi.org/10.1016/j.bone.2016.07.005openalex-snapshot
Immobilization and long-term recovery results in large changes in bone structure and strength but no corresponding alterations of osteocyte lacunar properties
inferredcites →https://doi.org/10.1016/j.bone.2017.08.002openalex-snapshot
Differential responses of mechanosensitive osteocyte proteins in fore- and hindlimbs of hindlimb-unloaded rats
inferredcites →https://doi.org/10.1016/j.bone.2018.01.018openalex-snapshot
A new open-source tool for measuring 3D osteocyte lacunar geometries from confocal laser scanning microscopy reveals age-related changes to lacunar size and shape in cortical mouse bone
inferredcites →https://doi.org/10.1016/j.bone.2019.04.019openalex-snapshot
Chronic kidney disease and aging differentially diminish bone material and microarchitecture in C57Bl/6 mice
inferredcites →https://doi.org/10.1016/j.bone.2020.115328openalex-snapshot
Multiscale finite element modeling of mechanical strains and fluid flow in osteocyte lacunocanalicular system
inferredcites →https://doi.org/10.1016/j.celrep.2017.10.115openalex-snapshot
Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling
inferredcites →https://doi.org/10.1016/j.cmet.2020.08.012openalex-snapshot
Warmth Prevents Bone Loss Through the Gut Microbiota
inferredcites →https://doi.org/10.1016/j.molmet.2017.10.009openalex-snapshot
Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study
inferredcites →https://doi.org/10.1016/j.molmet.2019.05.006openalex-snapshot
The answer to the question “What is the best housing temperature to translate mouse experiments to humans?” is: thermoneutrality
inferredcites →https://doi.org/10.1016/s0140-6736(00)02217-0openalex-snapshot
Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts
inferredcites →https://doi.org/10.1016/s8756-3282(98)00019-2openalex-snapshot
Hindlimb Unloading of Growing Rats: A Model for Predicting Skeletal Changes During Space Flight
inferredcites →https://doi.org/10.1038/nrrheum.2018.37openalex-snapshot
Skeletal changes during and after spaceflight
inferredcites →https://doi.org/10.1038/s41598-017-03014-2openalex-snapshot
One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons
inferredcites →https://doi.org/10.1038/srep44618openalex-snapshot
Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis
inferredcites →https://doi.org/10.1073/pnas.2023999118openalex-snapshot
Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
inferredcites →https://doi.org/10.1074/jbc.m115.642090openalex-snapshot
Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading
inferredcites →https://doi.org/10.1080/10520290500159253openalex-snapshot
The effects of different decalcification protocols on TUNEL and general cartilage staining
inferredcites →https://doi.org/10.1111/acel.12586openalex-snapshot
Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging
inferredcites →https://doi.org/10.1111/jmi.12973openalex-snapshot
Quantification of the bone lacunocanalicular network from 3D X‐ray phase nanotomography images
inferredcites →https://doi.org/10.1111/nyas.13991openalex-snapshot
Retention of osteocytic micromorphology by sclerostin antibody in a concurrent ovariectomy and functional disuse model
inferredcites →https://doi.org/10.1136/mp.51.4.204openalex-snapshot
False positive staining in the TUNEL assay to detect apoptosis in liver and intestine is caused by endogenous nucleases and inhibited by diethyl pyrocarbonate.
inferredcites →https://doi.org/10.1152/ajpendo.00330.2012openalex-snapshot
Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice
inferredcites →https://doi.org/10.1152/ajpregu.00731.2003openalex-snapshot
Effect of ambient temperature on cardiovascular parameters in rats and mice: a comparative approach
inferredcites →https://doi.org/10.1152/jappl.2000.89.3.1046openalex-snapshot
Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling
inferredcites →https://doi.org/10.1359/jbmr.051103openalex-snapshot
Glucocorticoid-Treated Mice Have Localized Changes in Trabecular Bone Material Properties and Osteocyte Lacunar Size That Are Not Observed in Placebo-Treated or Estrogen-Deficient Mice
inferredcites →https://doi.org/10.1359/jbmr.060107openalex-snapshot
Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss
inferredcites →https://doi.org/10.1359/jbmr.070507openalex-snapshot
Age-Related Changes in Trabecular Architecture Differ in Female and Male C57BL/6J Mice
inferredcites →https://doi.org/10.1359/jbmr.081210openalex-snapshot
Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue
inferredcites →https://doi.org/10.1371/journal.pone.0023516openalex-snapshot
Enhanced Osteoclastic Resorption and Responsiveness to Mechanical Load in Gap Junction Deficient Bone
inferredcites →https://doi.org/10.1371/journal.pone.0040143openalex-snapshot
Osteocyte Network; a Negative Regulatory System for Bone Mass Augmented by the Induction of Rankl in Osteoblasts and Sost in Osteocytes at Unloading
inferredcites →https://doi.org/10.1371/journal.pone.0061372openalex-snapshot
Microgravity Induces Pelvic Bone Loss through Osteoclastic Activity, Osteocytic Osteolysis, and Osteoblastic Cell Cycle Inhibition by CDKN1a/p21
inferredcites →https://doi.org/10.1371/journal.pone.0106904openalex-snapshot
Beta-1 Adrenergic Agonist Treatment Mitigates Negative Changes in Cancellous Bone Microarchitecture and Inhibits Osteocyte Apoptosis during Disuse
inferredcites →https://doi.org/10.1371/journal.pone.0189121openalex-snapshot
Model of hindlimb unloading in adult female rats: Characterizing bone physicochemical, microstructural, and biomechanical properties
inferredcites →https://doi.org/10.1530/ec-19-0359openalex-snapshot
Thermoneutral housing attenuates premature cancellous bone loss in male C57BL/6J mice
inferredcites →https://doi.org/10.18632/aging.101308openalex-snapshot
Degeneration of the osteocyte network in the C57BL/6 mouse model of aging
inferredcites →https://doi.org/10.22203/ecm.v042a16openalex-snapshot
Bone loss recovery in mice following microgravity with concurrent bone-compartment-specific osteocyte characteristics
inferredcites →https://doi.org/10.3389/fbioe.2021.733582openalex-snapshot
Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss
inferredcites →https://doi.org/10.3389/fphys.2020.00299openalex-snapshot
Connexin 43 Channels in Osteocytes Regulate Bone Responses to Mechanical Unloading
inferredcites →https://doi.org/10.7150/ijms.11078openalex-snapshot
Paradoxical Response to Mechanical Unloading in Bone Loss, Microarchitecture, and Bone Turnover Markers
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/jor.25643openalex-snapshot
Tibial bone strength is negatively affected by volumetric muscle loss injury to the adjacent muscle in male mice
inferred← citeshttps://doi.org/10.1016/j.bonr.2026.101917openalex-snapshot
Spaceflight and the rodent skeleton: A perspective
inferred← citeshttps://doi.org/10.1016/j.lssr.2026.04.009openalex-snapshot
Decoupling musculoskeletal integrity in microgravity: Molecular drivers and therapeutic horizons
inferred← citeshttps://doi.org/10.1093/jbmr/zjaf057openalex-snapshot
Botulinum toxin (A)-induced bone loss is associated with increased blood velocity and reduced vascular bone porosity
inferred← citeshttps://doi.org/10.1093/jbmrpl/ziaf157openalex-snapshot
Therapeutic potential of FGF19 in combatting osteosarcopenia: effects on muscle strength and bone health in aged male mice
inferred← citeshttps://doi.org/10.1096/fj.202501128ropenalex-snapshot
Resistance and Aerobic Preconditioning Delays Unloading‐Induced Multisystemic Physiological Changes: The NEBULA Project
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