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Mesenchymal Stem Cell-Derived Exosomes Attenuate SiO2-Induced Pulmonary Fibrosis by Inhibiting Pulmonary Fibroblast Transdifferentiation Through miR-99a

https://doi.org/10.2139/ssrn.4638311
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miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis
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mTOR Signaling in Growth, Metabolism, and Disease
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A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis
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miR-770–5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1
inferredcites →https://doi.org/10.1016/j.ecoenv.2022.113302openalex-extracted
Exosomal let-7i-5p from three-dimensional cultured human umbilical cord mesenchymal stem cells inhibits fibroblast activation in silicosis through targeting TGFBR1
inferredcites →https://doi.org/10.1016/j.ecoenv.2023.114537openalex-extracted
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223–3p/NLRP3 axis
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Targeting STING-mediated pro-inflammatory and pro-fibrotic effects of alveolar macrophages and fibroblasts blunts silicosis caused by silica particles
inferredcites →https://doi.org/10.1016/j.omtn.2018.10.017openalex-extracted
MicroRNA-29b Mediates Lung Mesenchymal-Epithelial Transition and Prevents Lung Fibrosis in the Silicosis Model
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Pulmonary Silicosis Alters MicroRNA Expression in Rat Lung and miR-411-3p Exerts Anti-fibrotic Effects by Inhibiting MRTF-A/SRF Signaling
inferredcites →https://doi.org/10.1016/j.omtn.2021.07.010openalex-extracted
miR-99a regulates CD4+ T cell differentiation and attenuates experimental autoimmune encephalomyelitis by mTOR-mediated glycolysis
inferredcites →https://doi.org/10.1016/j.stem.2018.05.004openalex-extracted
Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities
inferredcites →https://doi.org/10.1016/s2213-2600(16)30102-3openalex-extracted
Deadly denim: sandblasting-induced silicosis in the jeans industry
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Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance
inferredcites →https://doi.org/10.1038/cddis.2017.544openalex-extracted
miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer
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Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
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miR-29 Inhibits Bleomycin-induced Pulmonary Fibrosis in Mice
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MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
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Mesenchymal stem cell therapy for severe COVID-19
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Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury
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Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer
inferredcites →https://doi.org/10.1038/s41467-020-14344-7openalex-extracted
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
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FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway
inferredcites →https://doi.org/10.1101/2020.03.18.997080openalex-extracted
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Silica‐related diseases in the modern world
inferredcites →https://doi.org/10.1126/scitranslmed.aay3724openalex-extracted
Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models
inferredcites →https://doi.org/10.1126/scitranslmed.aaz5506openalex-extracted
Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis
inferredcites →https://doi.org/10.1136/thoraxjnl-2019-214077openalex-extracted
Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of antifibrotic miR-142-3p
inferredcites →https://doi.org/10.1146/annurev-biochem-060308-103103openalex-extracted
Regulation of mRNA Translation and Stability by microRNAs
inferredcites →https://doi.org/10.1146/annurev-physiol-021014-071641openalex-extracted
Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy
inferredcites →https://doi.org/10.1164/rccm.201705-0925ocopenalex-extracted
Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation
inferredcites →https://doi.org/10.1164/rccm.201802-0356ocopenalex-extracted
Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury
inferredcites →https://doi.org/10.1172/jci.insight.128060openalex-extracted
Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes
inferredcites →https://doi.org/10.1183/13993003.00161-2019openalex-extracted
Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases
inferredcites →https://doi.org/10.1183/13993003.01992-2018openalex-extracted
A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis
inferredcites →https://doi.org/10.1183/16000617.0044-2017openalex-extracted
Cell therapy for lung disease
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Reciprocal regulation of MicroRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells
inferredcites →https://doi.org/10.1186/s11658-022-00329-5openalex-extracted
ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1
inferredcites →https://doi.org/10.1186/s12964-019-0486-4openalex-extracted
FGFR3 signaling and function in triple negative breast cancer
inferredcites →https://doi.org/10.1186/s13046-022-02499-8openalex-extracted
Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis
inferredcites →https://doi.org/10.1186/s13287-020-02023-9openalex-extracted
Exosomes derived from three-dimensional cultured human umbilical cord mesenchymal stem cells ameliorate pulmonary fibrosis in a mouse silicosis model
inferredcites →https://doi.org/10.1371/journal.pone.0138625openalex-extracted
mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis
inferredcites →https://doi.org/10.15252/embr.201439246openalex-extracted
The extracellular matrix modulates the hallmarks of cancer
inferredcites →https://doi.org/10.15585/mmwr.mm6628a2openalex-extracted
Surveillance for Silicosis Deaths Among Persons Aged 15–44 Years — United States, 1999–2015
inferredcites →https://doi.org/10.3389/fphar.2021.719589openalex-extracted
Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway
inferredcites →https://doi.org/10.3390/cells7120226openalex-extracted
Mesenchymal Stem Cell-Derived Exosomes Ameliorated Diabetic Nephropathy by Autophagy Induction through the mTOR Signaling Pathway
inferredcites →https://doi.org/10.3390/ijms241411440openalex-extracted
miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO2-Induced Lung Fibrosis
inferredcites →https://doi.org/10.7150/thno.21945openalex-extracted
Exosome Theranostics: Biology and Translational Medicine
inferredcites →https://doi.org/10.7150/thno.30853openalex-extracted
Design strategies and application progress of therapeutic exosomes
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Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis
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Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2
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Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity
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