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Targeting TLR4/NF-kB and Nrf2/HO-1 Crosstalk Via Trimetazidine Alleviates LPS-Induced Depressive Like Behaviors in Mice

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Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?
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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
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TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
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Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice
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Anxiolytic Properties of Trimetazidine in Experimental Models of Increased Anxiety
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Trans-cinnamaldehyde Modulates Hippocampal Nrf2 Factor and Inhibits Amyloid Beta Aggregation in LPS-Induced Neuroinflammation Mouse Model
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Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway
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Blood–brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone
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Gambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-κB and MAPK activation to reduce inflammation in LPS-activated RAW264.7 cells
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Modeling the blood–brain barrier: Beyond the endothelial cells
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Trimetazidine in conditions other than coronary disease, old drug, new tricks?
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SIRT1/PARP-1/NLRP3 cascade as a potential target for niacin neuroprotective effect in lipopolysaccharide-induced depressive-like behavior in mice
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Cytokines sing the blues: inflammation and the pathogenesis of depression
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“Plurol will not miss the boat”: A new manifesto of galantamine conveyance
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Trimetazidine attenuates cyclophosphamide-induced cystitis by inhibiting TLR4-mediated NFκB signaling in mice
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Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities
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Salidroside attenuates lipopolysaccharide (LPS) induced serum cytokines and depressive-like behavior in mice
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Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice
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Targeting central β2 receptors ameliorates streptozotocin-induced neuroinflammation via inhibition of glycogen synthase kinase3 pathway in mice
inferredcites →https://doi.org/10.1016/j.pnpbp.2022.110583openalex-extracted
Niacin mitigates blood–brain barrier tight junctional proteins dysregulation and cerebral inflammation in ketamine rat model of psychosis: Role of GPR109A receptor
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Nrf2: An all-rounder in depression
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Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats
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Pioglitazone, a PPARγ agonist rescues depression associated with obesity using chronic unpredictable mild stress model in experimental mice
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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Raised levels of plasma interleukin‐1β in major and postviral depression
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A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression
inferredcites →https://doi.org/10.1038/ncomms11624openalex-extracted
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
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Social stress induces neurovascular pathology promoting depression
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Real-time in vivo two-photon imaging study reveals decreased cerebro-vascular volume and increased blood-brain barrier permeability in chronically stressed mice
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The Proinflammatory Cytokines Interleukin-1beta and Tumor Necrosis Factor-Alpha Activate Serotonin Transporters
inferredcites →https://doi.org/10.1093/ijnp/pyy091openalex-extracted
Antidepressant Effects of Rhodomyrtone in Mice with Chronic Unpredictable Mild Stress-Induced Depression
inferredcites →https://doi.org/10.1097/mjt.0000000000000180openalex-extracted
Trimetazidine in Practice
inferredcites →https://doi.org/10.1101/cshperspect.a020412openalex-extracted
The Blood–Brain Barrier
inferredcites →https://doi.org/10.1111/acel.12572openalex-extracted
Melatonin alleviates lipopolysaccharide-compromised integrity of blood-brain barrier through activating AMP-activated protein kinase in old mice
inferredcites →https://doi.org/10.1111/bdi.13319openalex-extracted
Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression
inferredcites →https://doi.org/10.1111/bph.15261openalex-extracted
Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways
inferredcites →https://doi.org/10.1111/cns.12170openalex-extracted
Involvement of Inflammasome Activation in Lipopolysaccharide‐induced Mice Depressive‐like Behaviors
inferredcites →https://doi.org/10.1111/cns.13569openalex-extracted
Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms
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ANTI‐OXIDANT ACTIVITY MEDIATED NEUROPROTECTIVE POTENTIAL OF TRIMETAZIDINE ON FOCAL CEREBRAL ISCHAEMIA–REPERFUSION INJURY IN RATS
inferredcites →https://doi.org/10.1126/sciadv.1500472openalex-extracted
Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier
inferredcites →https://doi.org/10.1155/2017/8416763openalex-extracted
Oxidative Stress: Harms and Benefits for Human Health
inferredcites →https://doi.org/10.1159/000520990openalex-extracted
Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice
inferredcites →https://doi.org/10.1177/02698811211069110openalex-extracted
Modulation of microglial activation by antidepressants
inferredcites →https://doi.org/10.1186/s12974-020-01836-yopenalex-extracted
Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat
inferredcites →https://doi.org/10.1186/s12987-019-0123-zopenalex-extracted
Claudin-5: gatekeeper of neurological function
inferredcites →https://doi.org/10.1515/chem-2022-0336openalex-extracted
A phytoconstituent 6-aminoflavone ameliorates lipopolysaccharide-induced oxidative stress mediated synapse and memory dysfunction via p-Akt/NF-kB pathway in albino mice
inferredcites →https://doi.org/10.15761/jcmm.1000123openalex-extracted
Rosiglitazone attenuates lipopolysaccharide-induced depressive-like behavior and cognitive deficits in mice
inferredcites →https://doi.org/10.17877/de290r-3029openalex-extracted
The effects of trimetazidine on lipopolysaccharide-induced oxidative stress in mice
inferredcites →https://doi.org/10.18632/oncotarget.11178openalex-extracted
Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis
inferredcites →https://doi.org/10.2147/jir.s252659openalex-extracted
Pristimerin Inhibits MMP-9 Expression and Cell Migration Through Attenuating NOX/ROS-Dependent NF-κB Activation in Rat Brain Astrocytes Challenged with LPS
inferredcites →https://doi.org/10.2147/jir.s276925openalex-extracted
Galangin Inhibits LPS-Induced MMP-9 Expression via Suppressing Protein Kinase-Dependent AP-1 and FoxO1 Activation in Rat Brain Astrocytes
inferredcites →https://doi.org/10.3389/fimmu.2019.01511openalex-extracted
Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
inferredcites →https://doi.org/10.3389/fphar.2019.00318openalex-extracted
The Involvement of Renin-Angiotensin System in Lipopolysaccharide-Induced Behavioral Changes, Neuroinflammation, and Disturbed Insulin Signaling
inferredcites →https://doi.org/10.3390/antiox12020470openalex-extracted
Oxidative Stress in Depression: The Link with the Stress Response, Neuroinflammation, Serotonin, Neurogenesis and Synaptic Plasticity
inferredcites →https://doi.org/10.3390/antiox12040817openalex-extracted
The Nrf2 Pathway in Depressive Disorders: A Systematic Review of Animal and Human Studies
inferredcites →https://doi.org/10.3390/brainsci12080972openalex-extracted
Lipopolysaccharide Exposure Differentially Alters Plasma and Brain Inflammatory Markers in Adult Male and Female Rats
inferredcites →https://doi.org/10.3390/genes11091089openalex-extracted
Blues in the Brain and Beyond: Molecular Bases of Major Depressive Disorder and Relative Pharmacological and Non-Pharmacological Treatments
inferredcites →https://doi.org/10.3390/molecules24112035openalex-extracted
Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model
inferredcites →https://doi.org/10.3390/nu12123809openalex-extracted
Anti-Inflammatory Effects of Asian Fawn Lily (Erythronium japonicum) Extract on Lipopolysaccharide-Induced Depressive-Like Behavior in Mice
inferredcites →https://doi.org/10.3892/mmr.2019.10439openalex-extracted
TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats
inferredcites →https://doi.org/10.5114/aoms.2019.87412openalex-extracted
The protective effects of salvianolic acid A against hepatic ischemia-reperfusion injury via inhibiting expression of toll-like receptor 4 in rats
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