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Simvastatin Effects on the Mevalonate Pathway and Cell Wall Integrity in Staphylococcus Aureus: Evidence of its Antimicrobial Action Mechanism

https://doi.org/10.2139/ssrn.4763550
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Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis
inferredcites →https://doi.org/10.1007/978-1-4939-3676-2_11openalex-extracted
Luciferase Reporter Gene System to Detect Cell Wall Stress Stimulon Induction in Staphylococcus aureus
inferredcites →https://doi.org/10.1016/0014-5793(76)80996-9openalex-extracted
Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity
inferredcites →https://doi.org/10.1016/j.atherosclerosissup.2004.08.033openalex-extracted
The origin of the statins
inferredcites →https://doi.org/10.1016/j.bbalip.2013.03.003openalex-extracted
Regulation of mevalonate metabolism in cancer and immune cells
inferredcites →https://doi.org/10.1016/j.juro.2012.10.030openalex-extracted
Simvastatin Induces Apoptosis in Castrate Resistant Prostate Cancer Cells by Deregulating Nuclear Factor-κB Pathway
inferredcites →https://doi.org/10.1016/j.metabol.2006.01.013openalex-extracted
The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus
inferredcites →https://doi.org/10.1016/j.tibs.2007.03.002openalex-extracted
Bacterial response regulators: versatile regulatory strategies from common domains
inferredcites →https://doi.org/10.1016/s0002-9343(02)01088-4openalex-extracted
A look to the future: new treatment guidelines and a perspective on statins
inferredcites →https://doi.org/10.1016/s0022-2275(20)42221-7openalex-extracted
Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.
inferredcites →https://doi.org/10.1038/343425a0openalex-extracted
Regulation of the mevalonate pathway
inferredcites →https://doi.org/10.1042/bj20121899openalex-extracted
Metabolic plasticity for isoprenoid biosynthesis in bacteria
inferredcites →https://doi.org/10.1046/j.1365-2958.2003.03599.xopenalex-extracted
Two‐component system VraSR positively modulates the regulation of cell‐wall biosynthesis pathway in Staphylococcus aureus
inferredcites →https://doi.org/10.1074/jbc.m710010200openalex-extracted
A Close-up View of the VraSR Two-component System
inferredcites →https://doi.org/10.1080/09168451.2017.1401915openalex-extracted
Undecaprenyl phosphate metabolism in Gram-negative and Gram-positive bacteria
inferredcites →https://doi.org/10.1093/jac/dkm496openalex-extracted
Unexpected antimicrobial effect of statins
inferredcites →https://doi.org/10.1093/molbev/msq177openalex-extracted
Origins and Early Evolution of the Mevalonate Pathway of Isoprenoid Biosynthesis in the Three Domains of Life
inferredcites →https://doi.org/10.1099/mic.0.051599-0openalex-extracted
Isoprenoid biosynthesis in bacterial pathogens
inferredcites →https://doi.org/10.1099/mic.0.26426-0openalex-extracted
Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon
inferredcites →https://doi.org/10.1111/j.1365-2958.2009.06648.xopenalex-extracted
The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors
inferredcites →https://doi.org/10.1111/j.1574-6968.2012.02603.xopenalex-extracted
Deletion of hypothetical wall teichoic acid ligases in Staphylococcus aureus activates the cell wall stress response
inferredcites →https://doi.org/10.1128/aac.00124-10openalex-extracted
Damage of the Bacterial Cell Envelope by Antimicrobial Peptides Gramicidin S and PGLa as Revealed by Transmission and Scanning Electron Microscopy
inferredcites →https://doi.org/10.1128/aac.00356-06openalex-extracted
Role of VraSR in Antibiotic Resistance and Antibiotic-Induced Stress Response in Staphylococcus aureus
inferredcites →https://doi.org/10.1128/aac.00726-13openalex-extracted
The Mevalonate Auxotrophic Mutant of Staphylococcus aureus Can Adapt to Mevalonate Depletion
inferredcites →https://doi.org/10.1128/aac.01213-10openalex-extracted
Mutational Analyses of Open Reading Frames within the vraSR Operon and Their Roles in the Cell Wall Stress Response of Staphylococcus aureus
inferredcites →https://doi.org/10.1128/jb.01357-08openalex-extracted
The Mevalonate Pathway ofStaphylococcus aureus
inferredcites →https://doi.org/10.1128/jb.01439-06openalex-extracted
Extensive and Genome-Wide Changes in the Transcription Profile ofStaphylococcus aureusInduced by Modulating the Transcription of the Cell Wall Synthesis GenemurF
inferredcites →https://doi.org/10.1128/jb.01489-09openalex-extracted
The Pneumococcal Cell Envelope Stress-Sensing System LiaFSR Is Activated by Murein Hydrolases and Lipid II-Interacting Antibiotics
inferredcites →https://doi.org/10.1128/jb.06143-11openalex-extracted
Roles of DNA Sequence and Sigma A Factor in Transcription of the vraSR Operon
inferredcites →https://doi.org/10.1128/jb.103.1.191-198.1970openalex-extracted
Carotenoid Formation by Staphylococcus aureus
inferredcites →https://doi.org/10.1128/jb.182.15.4319-4327.2000openalex-extracted
Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci
inferredcites →https://doi.org/10.1185/030079906x80521openalex-extracted
The effect of simvastatin on triglyceride-rich lipoproteins in patients with type 2 diabetic dyslipidemia: a SILHOUETTE Trial Sub-study
inferredcites →https://doi.org/10.1186/1471-2164-7-296openalex-extracted
Exploring glycopeptide-resistance in Staphylococcus aureus: a combined proteomics and transcriptomics approach for the identification of resistance-related markers
inferredcites →https://doi.org/10.1186/1471-2180-11-16openalex-extracted
Induction kinetics of the Staphylococcus aureus cell wall stress stimulon in response to different cell wall active antibiotics
inferredcites →https://doi.org/10.1186/s12866-019-1529-0openalex-extracted
The dimerization interface in VraR is essential for induction of the cell wall stress response in Staphylococcus aureus: a potential druggable target
inferredcites →https://doi.org/10.1371/journal.pone.0024394openalex-extracted
Studies on the Antibacterial Effects of Statins - In Vitro and In Vivo
inferredcites →https://doi.org/10.1371/journal.pone.0128098openalex-extracted
Statins and Antimicrobial Effects: Simvastatin as a Potential Drug against Staphylococcus aureus Biofilm
inferredcites →https://doi.org/10.1373/clinchem.2008.112797openalex-extracted
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
inferredcites →https://doi.org/10.2147/idr.s126254openalex-extracted
Effect of a small molecule Lipid II binder on bacterial cell wall stress
inferredcites →https://doi.org/10.2174/1574892812666171129141211openalex-extracted
Targeting Mevalonate Pathway in Cancer Treatment: Repurposing of Statins
inferredcites →https://doi.org/10.3389/fmicb.2018.01539openalex-extracted
Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus
inferredcites →https://doi.org/10.3727/096504013x13657689382897openalex-extracted
Simvastatin Inhibits Proliferation and Induces Apoptosis in Human Lung Cancer Cells
inferredcites →https://doi.org/10.4065/74.9.928openalex-extracted
Vancomycin
inferredcites →https://doi.org/10.4103/0976-237x.137959openalex-extracted
Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: An in vitro study
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