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Single-Cell Transcriptomics Reveals a Mhc-Ii + Neuronal Subtype and Autoreactive T Cells in Diabetes-Induced Cognitive Impairment

https://doi.org/10.2139/ssrn.4806434
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Diabetes type 1: Can it be treated as an autoimmune disorder?
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Role of microglia-neuron interactions in diabetic encephalopathy
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Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies
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Molecular and spatial signatures of mouse brain aging at single-cell resolution
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DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors
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An updated meta-analysis of cohort studies: Diabetes and risk of Alzheimer's disease
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Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation
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Astrocytes: Key Regulators of Neuroinflammation
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Association of diabetes with amnestic and nonamnestic mild cognitive impairment
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Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease
inferredcites →https://doi.org/10.1038/nbt.4096openalex-extracted
Integrating single-cell transcriptomic data across different conditions, technologies, and species
inferredcites →https://doi.org/10.1038/nn1629openalex-extracted
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
inferredcites →https://doi.org/10.1038/nrn3484openalex-extracted
Emerging roles of astrocytes in neural circuit development
inferredcites →https://doi.org/10.1038/s41467-020-16904-3openalex-extracted
An entropy-based metric for assessing the purity of single cell populations
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The heterogeneous pathogenesis of type 1 diabetes mellitus
inferredcites →https://doi.org/10.1038/s41586-019-1895-7openalex-extracted
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41590-020-0623-7openalex-extracted
The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides
inferredcites →https://doi.org/10.1038/s41593-017-0056-2openalex-extracted
Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing
inferredcites →https://doi.org/10.1038/s41593-019-0491-3openalex-extracted
Single-cell transcriptomic profiling of the aging mouse brain
inferredcites →https://doi.org/10.1073/pnas.0402268101openalex-extracted
T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
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CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging
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A circadian gene expression atlas in mammals: Implications for biology and medicine
inferredcites →https://doi.org/10.1073/pnas.2109548118openalex-extracted
IL-27–producing B-1a cells suppress neuroinflammation and CNS autoimmune diseases
inferredcites →https://doi.org/10.1080/14397595.2018.1481565openalex-extracted
Iguratimod, a synthetic disease modifying anti-rheumatic drug inhibiting the activation of NF-κB and production of RANKL: Its efficacy, radiographic changes, safety and predictors over two years’ treatment for Japanese rheumatoid arthritis patients
inferredcites →https://doi.org/10.1093/brain/awac064openalex-extracted
Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity
inferredcites →https://doi.org/10.1096/fj.202101297ropenalex-extracted
Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood‐brain barrier: Therapeutic avenues
inferredcites →https://doi.org/10.1111/1440-1681.13461openalex-extracted
Dihydroartemisinin attenuated the symptoms of mice model of systemic lupus erythematosus by restoring the Treg/Th17 balance
inferredcites →https://doi.org/10.1155/2015/356040openalex-extracted
Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis
inferredcites →https://doi.org/10.1186/s12974-021-02331-8openalex-extracted
Tonicity-responsive enhancer-binding protein promotes diabetic neuroinflammation and cognitive impairment via upregulation of lipocalin-2
inferredcites →https://doi.org/10.1186/s13059-020-1950-6openalex-extracted
Decontamination of ambient RNA in single-cell RNA-seq with DecontX
inferredcites →https://doi.org/10.1192/bjp.bp.109.067942openalex-extracted
Risk of developing dementia in people with diabetes and mild cognitive impairment
inferredcites →https://doi.org/10.1210/jc.2019-00198openalex-extracted
Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline
inferredcites →https://doi.org/10.1371/journal.pone.0298396openalex-extracted
Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice
inferredcites →https://doi.org/10.2337/db10-0539openalex-extracted
Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes
inferredcites →https://doi.org/10.2337/dc19-0120openalex-extracted
The Association of Late-Life Diabetes Status and Hyperglycemia With Incident Mild Cognitive Impairment and Dementia: The ARIC Study
inferredcites →https://doi.org/10.2337/dc22-s013openalex-extracted
13. Older Adults: Standards of Medical Care in Diabetes—2022
inferredcites →https://doi.org/10.3389/fimmu.2019.02392openalex-extracted
Augmented Brain Infiltration and Activation of Leukocytes After Cerebral Ischemia in Type 2 Diabetic Mice
inferredcites →https://doi.org/10.3389/fimmu.2023.1062919openalex-extracted
Efficacy and safety of Iguratimod as an add-on therapy for refractory lupus nephritis: A preliminary investigational study
inferredcites →https://doi.org/10.3389/fnins.2018.00930openalex-extracted
Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier
inferredcites →https://doi.org/10.3389/fphar.2020.00073openalex-extracted
Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape
inferredcites →https://doi.org/10.5281/zenodo.3628062openalex-snapshot
Decontamination of ambient RNA in single-cell RNA-seq with DecontX
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