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Identification of Adenosine Analogues as Nsp14 N7‑Methyltransferase Inhibitors for Treating Coronaviruses

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inferredcites →https://doi.org/10.1002/path.4454openalex-extracted
Molecular pathology of emerging coronavirus infections
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RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review
inferredcites →https://doi.org/10.1007/s00228-022-03370-7openalex-extracted
COVID-19 and antiepileptic drugs: an approach to guide practices when nirmatrelvir/ritonavir is co-prescribed
inferredcites →https://doi.org/10.1007/s11427-021-1964-4openalex-extracted
Overview of SARS-CoV-2 genome-encoded proteins
inferredcites →https://doi.org/10.1016/j.ejmech.2020.112557openalex-extracted
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase
inferredcites →https://doi.org/10.1016/j.ejmech.2023.115113openalex-extracted
Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses
inferredcites →https://doi.org/10.1016/j.gene.2020.145313openalex-extracted
Essential functional molecules associated with SARS-CoV-2 infection: Potential therapeutic targets for COVID-19
inferredcites →https://doi.org/10.1016/j.tim.2013.05.005openalex-extracted
Interspecies transmission and emergence of novel viruses: lessons from bats and birds
inferredcites →https://doi.org/10.1021/acs.jcim.1c01451openalex-extracted
Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance
inferredcites →https://doi.org/10.1021/acs.jmedchem.2c00120openalex-extracted
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues
inferredcites →https://doi.org/10.1021/acscentsci.0c00489openalex-extracted
Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
inferredcites →https://doi.org/10.1021/acsinfecdis.1c00131openalex-extracted
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors
inferredcites →https://doi.org/10.1021/acsmedchemlett.2c00265openalex-extracted
Bisubstrate Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 Nsp14 Methyltransferase
inferredcites →https://doi.org/10.1038/s41392-023-01310-0openalex-extracted
Preclinical characterization and anti-SARS-CoV-2 efficacy of ATV014: an oral cyclohexanecarboxylate prodrug of 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside
inferredcites →https://doi.org/10.1038/s44259-023-00009-0openalex-extracted
Rapid resistance profiling of SARS-CoV-2 protease inhibitors
inferredcites →https://doi.org/10.1056/nejmoa030781openalex-extracted
A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
inferredcites →https://doi.org/10.1073/pnas.0400762101openalex-extracted
A previously undescribed coronavirus associated with respiratory disease in humans
inferredcites →https://doi.org/10.1073/pnas.2101161118openalex-extracted
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
inferredcites →https://doi.org/10.1073/pnas.2108709118openalex-extracted
Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication
inferredcites →https://doi.org/10.1080/07391102.2020.1778535openalex-extracted
Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19
inferredcites →https://doi.org/10.1093/ve/veab061openalex-extracted
Adaptation of the endemic coronaviruses HCoV-OC43 and HCoV-229E to the human host
inferredcites →https://doi.org/10.1111/cbdd.14425openalex-extracted
Progress of SARS‐CoV‐2 Main protease peptide‐like inhibitors
inferredcites →https://doi.org/10.1126/sciadv.ade8778openalex-extracted
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
inferredcites →https://doi.org/10.1126/scitranslmed.abl7430openalex-extracted
A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus
inferredcites →https://doi.org/10.1128/mbio.03662-21openalex-extracted
N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition
inferredcites →https://doi.org/10.1177/24725552211026261openalex-extracted
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
inferredcites →https://doi.org/10.3390/v13081618openalex-extracted
Prevalence of Neutralising Antibodies to HCoV-NL63 in Healthy Adults in Australia
inferredcites →https://doi.org/10.3906/sag-2004-127openalex-extracted
Coronaviruses and SARS-COV-2
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