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Network Pharmacology and Phytochemical Composition Combined with Validation in Vivo Reveal the Mechanism of Platycodonis Radix Ameliorating Pm2.5-Induced Acute Lung Injury

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Exposure interval to ambient fine particulate matter (PM2.5) collected in Southwest China induced pulmonary damage through the Janus tyrosine protein kinase‐2/signal transducer and activator of transcription‐3 signaling pathway both in vivo and in vitro
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Roles of oxidative stress in signaling and inflammation induced by particulate matter
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PI3K/AKT/mTOR and TLR4/MyD88/NF-κB Signaling Inhibitors Attenuate Pathological Mechanisms of Allergic Asthma
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Air Pollution and Cardiac Arrhythmias: A Comprehensive Review
inferredcites →https://doi.org/10.1016/j.cpsurg.2020.100777openalex-snapshot
Acute lung injury
inferredcites →https://doi.org/10.1016/j.cytogfr.2016.05.001openalex-snapshot
STAT3 signaling in immunity
inferredcites →https://doi.org/10.1016/j.envint.2020.105755openalex-snapshot
Circular RNA 406961 interacts with ILF2 to regulate PM2.5-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways
inferredcites →https://doi.org/10.1016/j.fct.2023.114362openalex-snapshot
Oxidative stress is the pivot for PM2.5-induced lung injury
inferredcites →https://doi.org/10.1016/j.foodchem.2020.127029openalex-snapshot
Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics
inferredcites →https://doi.org/10.1016/j.intimp.2015.05.005openalex-snapshot
Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro
inferredcites →https://doi.org/10.1016/j.intimp.2022.109186openalex-snapshot
Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5-mediated lung injury in mice
inferredcites →https://doi.org/10.1016/j.jep.2015.01.052openalex-snapshot
Platycodon grandiflorus – An Ethnopharmacological, phytochemical and pharmacological review
inferredcites →https://doi.org/10.1016/j.jep.2019.112076openalex-snapshot
Protective effect of Jie-Geng-Tang against Staphylococcus aureus induced acute lung injury in mice and discovery of its effective constituents
inferredcites →https://doi.org/10.1016/j.lfs.2004.10.042openalex-snapshot
Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-κB activation in RAW 264.7 cells
inferredcites →https://doi.org/10.1016/j.molimm.2012.05.007openalex-snapshot
Inhibition of the transcription factor c-Jun by the MAPK family, and not the NF-κB pathway, suggests that peanut extract has anti-inflammatory properties
inferredcites →https://doi.org/10.1016/j.phrs.2020.105224openalex-snapshot
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms
inferredcites →https://doi.org/10.1016/s0955-0674(98)80143-9openalex-snapshot
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
inferredcites →https://doi.org/10.1023/a:1015905010086openalex-snapshot
Oxidative stress and TNF-α induce histone acetylation and NF-κB/AP-1 activation in alveolar epithelial cells: Potential mechanism in gene transcription in lung inflammation
inferredcites →https://doi.org/10.1038/nm1284openalex-snapshot
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
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Mechanism of quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus
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Mechanisms of Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation
inferredcites →https://doi.org/10.1042/bsr20193738openalex-snapshot
Ma xing shi gan decoction eliminates PM2.5-induced lung injury by reducing pulmonary cell apoptosis through Akt/mTOR/p70S6K pathway in rats
inferredcites →https://doi.org/10.1073/pnas.0904073106openalex-snapshot
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage
inferredcites →https://doi.org/10.1080/21655979.2022.2033381openalex-snapshot
Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model
inferredcites →https://doi.org/10.1093/nar/gkac1000openalex-snapshot
The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
inferredcites →https://doi.org/10.1152/ajplung.00281.2016openalex-snapshot
Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury
inferredcites →https://doi.org/10.1186/s12931-021-01781-1openalex-snapshot
Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach
inferredcites →https://doi.org/10.1186/s13020-023-00739-3openalex-snapshot
Liquiritin exhibits anti-acute lung injury activities through suppressing the JNK/Nur77/c-Jun pathway
inferredcites →https://doi.org/10.1186/s13287-021-02276-yopenalex-snapshot
Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6–p-STAT3–p63–JAG2 pathway
inferredcites →https://doi.org/10.18632/aging.204254openalex-snapshot
MiR-217-5p inhibits smog (PM2.5)-induced inflammation and oxidative stress response of mouse lung tissues and macrophages through targeting STAT1
inferredcites →https://doi.org/10.19852/j.cnki.jtcm.20220408.003openalex-snapshot
Integration strategy of network pharmacology in Traditional Chinese Medicine: a narrative review.
inferredcites →https://doi.org/10.21037/apm-21-1469openalex-snapshot
Integration of network pharmacology and molecular docking technology reveals the mechanism of the herbal pairing of Codonopsis Pilosula (Franch.) Nannf and Astragalus Membranaceus (Fisch.) Bge on chronic heart failure
inferredcites →https://doi.org/10.33549/physiolres.934602openalex-snapshot
Acute Lung Injury – From Pathophysiology to Treatment
inferredcites →https://doi.org/10.3389/fphar.2022.717271openalex-snapshot
Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway
inferredcites →https://doi.org/10.3390/ijerph19127511openalex-snapshot
Recent Insights into Particulate Matter (PM2.5)-Mediated Toxicity in Humans: An Overview
inferredcites →https://doi.org/10.3390/molecules28135213openalex-snapshot
Platycodonis Radix Alleviates LPS-Induced Lung Inflammation through Modulation of TRPA1 Channels
inferredcites →https://doi.org/10.7150/ijms.46421openalex-snapshot
PM2.5-related cell death patterns
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