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Combining Network Pharmacology, Transcriptomics, and Metabolomics to Explore the Mechanism of Action of Lang Chuang Wan in Improving Lupus Nephritis in Mrl/Lpr Mice

https://doi.org/10.2139/ssrn.5049481
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Precision medicine in lupus nephritis
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Increased levels of IL-17 and autoantibodies following Bisphenol A exposure were associated with activation of PI3K/AKT/mTOR pathway and abnormal autophagy in MRL/lpr mice
inferredcites →https://doi.org/10.1016/j.ecoenv.2023.115786openalex-snapshot
Low beauvericin concentrations promote PC-12 cell survival under oxidative stress by regulating lipid metabolism and PI3K/AKT/mTOR signaling
inferredcites →https://doi.org/10.1016/j.ejphar.2023.175823openalex-snapshot
Luteolin attenuates lupus nephritis by regulating macrophage oxidative stress via HIF-1α pathway
inferredcites →https://doi.org/10.1016/j.ekir.2024.01.052openalex-snapshot
Clinical Relevance of Anti-C3 and Anti-C4 Autoantibodies in Lupus Nephritis
inferredcites →https://doi.org/10.1016/j.intimp.2020.107027openalex-snapshot
Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice
inferredcites →https://doi.org/10.1016/j.kint.2023.09.002openalex-snapshot
KDIGO 2024 Clinical Practice Guideline for the management of LUPUS NEPHRITIS
inferredcites →https://doi.org/10.1016/j.lfs.2020.118713openalex-snapshot
Taxifolin improves disorders of glucose metabolism and water-salt metabolism in kidney via PI3K/AKT signaling pathway in metabolic syndrome rats
inferredcites →https://doi.org/10.1016/j.mcna.2020.10.003openalex-snapshot
Antinuclear Antibody Testing for the Diagnosis of Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1016/j.phyplu.2022.100220openalex-snapshot
Focus on the high therapeutic potentials of quercetin and its derivatives
inferredcites →https://doi.org/10.1021/ac8019366openalex-snapshot
Development of a Robust and Repeatable UPLC−MS Method for the Long-Term Metabolomic Study of Human Serum
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Global metabolic profiling of animal and human tissues via UPLC-MS
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An update on the lipid nephrotoxicity hypothesis
inferredcites →https://doi.org/10.1038/s41374-021-00591-9openalex-snapshot
TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway
inferredcites →https://doi.org/10.1038/s41423-023-01101-1openalex-snapshot
Interleukin-10 multitasking in allergic airway inflammation
inferredcites →https://doi.org/10.1038/s41577-022-00746-9openalex-snapshot
IL-17 and IL-17-producing cells in protection versus pathology
inferredcites →https://doi.org/10.1038/s41598-018-28611-7openalex-snapshot
Lupus nephritis pathology prediction with clinical indices
inferredcites →https://doi.org/10.1038/s41598-024-77897-3openalex-snapshot
Network pharmacology to unveil the mechanism of Astragali Radix in the treatment of lupus nephritis via PI3K/AKT/mTOR pathway
inferredcites →https://doi.org/10.1038/srep37390openalex-snapshot
Structured plant metabolomics for the simultaneous exploration of multiple factors
inferredcites →https://doi.org/10.1089/jir.2015.0082openalex-snapshot
TLR2 Plays a Critical Role in HMGB1-Induced Glomeruli Cell Proliferation Through the FoxO1 Signaling Pathway in Lupus Nephritis
inferredcites →https://doi.org/10.1093/ndt/gfq496openalex-snapshot
The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin
inferredcites →https://doi.org/10.1093/ndt/gfq860openalex-snapshot
The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis
inferredcites →https://doi.org/10.1097/bor.0000000000000381openalex-snapshot
Treatment of lupus nephritis: current paradigms and emerging strategies
inferredcites →https://doi.org/10.1097/bor.0000000000000887openalex-snapshot
Pathogenesis of lupus nephritis: the contribution of immune and kidney resident cells
inferredcites →https://doi.org/10.1111/vcp.12333openalex-snapshot
Renal biomarkers in domestic species
inferredcites →https://doi.org/10.1152/ajprenal.00649.2016openalex-snapshot
(5R)-5-hydroxytriptolide ameliorates lupus nephritis in MRL/lprmice by preventing infiltration of immune cells
inferredcites →https://doi.org/10.1172/jci73939openalex-snapshot
mTOR: a pharmacologic target for autophagy regulation
inferredcites →https://doi.org/10.1172/jci97650openalex-snapshot
iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling
inferredcites →https://doi.org/10.1371/journal.pcbi.1005457openalex-snapshot
Transcriptomics technologies
inferredcites →https://doi.org/10.3389/fcell.2019.00192openalex-snapshot
Pleiotropic Effects of mTOR and Autophagy During Development and Aging
inferredcites →https://doi.org/10.3389/fphar.2020.01035openalex-snapshot
Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model
inferredcites →https://doi.org/10.3389/fphar.2020.512877openalex-snapshot
A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.3389/fphar.2022.926901openalex-snapshot
Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19
inferredcites →https://doi.org/10.3389/fphar.2024.1324540openalex-snapshot
Urinary biomarkers associated with podocyte injury in lupus nephritis
inferredcites →https://doi.org/10.3390/antiox11112238openalex-snapshot
Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo
inferredcites →https://doi.org/10.3390/ijms232214317openalex-snapshot
Renal Fibrosis in Lupus Nephritis
inferredcites →https://doi.org/10.3390/ijms241612665openalex-snapshot
The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity
inferredcites →https://doi.org/10.3390/ijms25084226openalex-snapshot
Precise Targeting of Autoantigen-Specific B Cells in Lupus Nephritis with Chimeric Autoantibody Receptor T Cells
inferredcites →https://doi.org/10.3390/ijms25116162openalex-snapshot
Mitochondrial Dysfunction in Systemic Lupus Erythematosus with a Focus on Lupus Nephritis
inferredcites →https://doi.org/10.3390/metabo11030142openalex-snapshot
Lipidomics Revealed Aberrant Metabolism of Lipids Including FAHFAs in Renal Tissue in the Progression of Lupus Nephritis in a Murine Model
inferredcites →https://doi.org/10.3390/metabo13090987openalex-snapshot
Metabolite Alterations in Autoimmune Diseases: A Systematic Review of Metabolomics Studies
inferredcites →https://doi.org/10.7759/cureus.66270openalex-snapshot
Anti-Smith Antibodies as a Predictive Factor for Developing Lupus Nephritis in Systemic Lupus Erythematosus Patients: A Systematic Review
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