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Generalized Additive Modeling as a Tool for the Analysis of the Time Course of Tail Coiling Behavior in Zebrafish (Danio Rerio) Embryos – a Proof-of-Concept Study with Nicotine, a Known Developmental Neurotoxicant

https://doi.org/10.2139/ssrn.5052599
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Migration of Zebrafish Spinal Motor Nerves into the Periphery Requires Multiple Myotome-Derived Cues
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The sensitivity of the zebrafish embryo coiling assay for the detection of neurotoxicity by compounds with diverse modes of action
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Ultrastructural changes at the motor end-plate produced by an irreversible cholinesterase inhibitor
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Quantification of birefringence readily measures the level of muscle damage in zebrafish
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Time-course of coiling activity in zebrafish (Danio rerio) embryos exposed to ethanol as an endpoint for developmental neurotoxicity (DNT) – Hidden potential and underestimated challenges
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Analysis of tail coiling activity of zebrafish (Danio rerio) embryos allows for the differentiation of neurotoxicants with different modes of action
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Generalized additive models: Building evidence of air pollution, climate change and human health
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Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine
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Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®
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Zebrafish embryos as an alternative to animal experiments—A commentary on the definition of the onset of protected life stages in animal welfare regulations
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Uncoupling nicotine mediated motoneuron axonal pathfinding errors and muscle degeneration in zebrafish
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Acute nicotine exposure and modulation of a spinal motor circuit in embryonic zebrafish
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Motoneuron axon pathfinding errors in zebrafish: Differential effects related to concentration and timing of nicotine exposure
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Behavioral screening of the LOPAC1280 library in zebrafish embryos
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The Role of Behavioral Ecotoxicology in Environmental Protection
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Rapid Zebrafish Behavioral Profiling Assay Accelerates the Identification of Environmental Neurodevelopmental Toxicants
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Zebrafish Larvae Rapidly Recover from Locomotor Effects and Neuromuscular Alterations Induced by Cholinergic Insecticides
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Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo
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Embryonic motor activity and implications for regulating motoneuron axonal pathfinding in zebrafish
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Hypo- or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior changes
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Generalized Additive Models
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Increased neuromuscular activity causes axonal defects and muscular degeneration
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Inter-Individual and Inter-Strain Variations in Zebrafish Locomotor Ontogeny
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Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use
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Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays
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Development and axonal outgrowth of identified motoneurons in the zebrafish
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Pathfinding by Identified Zebrafish Motoneurons in the Absence of Muscle Pioneers
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Motoneuron Activity Patterns Related to the Earliest Behavior of the Zebrafish Embryo
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Nicotinic Receptors Mediate Changes in Spinal Motoneuron Development and Axonal Pathfinding in Embryonic Zebrafish Exposed to Nicotine
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Fitting Linear Mixed-Effects Models Using lme4
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Literature review on in vitro and alternative Developmental Neurotoxicity (DNT) testing methods
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Toward a Better Testing Paradigm for Developmental Neurotoxicity: OECD Efforts and Regulatory Considerations
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Assessing Combined Effects for Mixtures of Similar and Dissimilar Acting Neuroactive Substances on Zebrafish Embryo Movement
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Tail Coiling Assay in Zebrafish (Danio rerio) Embryos: Stage of Development, Promising Positive Control Candidates, and Selection of an Appropriate Organic Solvent for Screening of Developmental Neurotoxicity (DNT)
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Analysis of Skeletal Muscle Defects in Larval Zebrafish by Birefringence and Touch-evoke Escape Response Assays
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Analysis of Skeletal Muscle Defects in Larval Zebrafish by Birefringence and Touch-evoke Escape Response Assays
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Sample Size and its Importance in Research
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